ATE530521T1 - Hemmer des 5-lipoxygenase aktivierenden proteins (flap) - Google Patents
Hemmer des 5-lipoxygenase aktivierenden proteins (flap)Info
- Publication number
- ATE530521T1 ATE530521T1 AT06836773T AT06836773T ATE530521T1 AT E530521 T1 ATE530521 T1 AT E530521T1 AT 06836773 T AT06836773 T AT 06836773T AT 06836773 T AT06836773 T AT 06836773T AT E530521 T1 ATE530521 T1 AT E530521T1
- Authority
- AT
- Austria
- Prior art keywords
- flap
- lipoxygenase
- inhibitors
- compounds
- activate protein
- Prior art date
Links
- 102000001381 Arachidonate 5-Lipoxygenase Human genes 0.000 title 1
- 108010093579 Arachidonate 5-lipoxygenase Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000002617 leukotrienes Chemical class 0.000 abstract 2
- 102000004023 5-Lipoxygenase-Activating Proteins Human genes 0.000 abstract 1
- 108090000411 5-Lipoxygenase-Activating Proteins Proteins 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000000241 respiratory effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Hospice & Palliative Care (AREA)
- Toxicology (AREA)
- Psychology (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Otolaryngology (AREA)
- Obesity (AREA)
- Ophthalmology & Optometry (AREA)
- Oncology (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73403005P | 2005-11-04 | 2005-11-04 | |
US74717406P | 2006-05-12 | 2006-05-12 | |
US82334406P | 2006-08-23 | 2006-08-23 | |
US11/553,946 US7977359B2 (en) | 2005-11-04 | 2006-10-27 | 5-lipdxygenase-activating protein (FLAP) inhibitors |
PCT/US2006/042690 WO2007056021A2 (en) | 2005-11-04 | 2006-10-30 | 5-lipoxygenase-activating protein (flap) inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE530521T1 true ATE530521T1 (de) | 2011-11-15 |
Family
ID=38004604
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT06836773T ATE530521T1 (de) | 2005-11-04 | 2006-10-30 | Hemmer des 5-lipoxygenase aktivierenden proteins (flap) |
Country Status (27)
Country | Link |
---|---|
US (3) | US7977359B2 (de) |
EP (2) | EP2404904A1 (de) |
JP (3) | JP4705986B2 (de) |
KR (1) | KR101031766B1 (de) |
CN (1) | CN102295637A (de) |
AT (1) | ATE530521T1 (de) |
AU (2) | AU2006311973B9 (de) |
BR (1) | BRPI0618046A2 (de) |
CA (1) | CA2628490C (de) |
CR (1) | CR9942A (de) |
CY (1) | CY1112383T1 (de) |
DK (1) | DK1943219T3 (de) |
EA (2) | EA015495B1 (de) |
ES (1) | ES2373977T3 (de) |
HK (1) | HK1114099A1 (de) |
HR (1) | HRP20120033T1 (de) |
IL (2) | IL190873A0 (de) |
MA (1) | MA29931B1 (de) |
MY (1) | MY151159A (de) |
NO (1) | NO342361B1 (de) |
NZ (2) | NZ592541A (de) |
PL (1) | PL1943219T3 (de) |
PT (1) | PT1943219E (de) |
RS (1) | RS52189B (de) |
SG (1) | SG166813A1 (de) |
SI (1) | SI1943219T1 (de) |
WO (1) | WO2007056021A2 (de) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070225285A1 (en) * | 2005-11-04 | 2007-09-27 | Amira Pharmaceuticals, Inc. | 5-lipoxygenase-activating protein (flap) inhibitors |
GB2431927B (en) * | 2005-11-04 | 2010-03-17 | Amira Pharmaceuticals Inc | 5-Lipoxygenase-activating protein (FLAP) inhibitors |
US7977359B2 (en) | 2005-11-04 | 2011-07-12 | Amira Pharmaceuticals, Inc. | 5-lipdxygenase-activating protein (FLAP) inhibitors |
US20070244128A1 (en) * | 2005-11-04 | 2007-10-18 | Amira Pharmaceuticals, Inc. | 5-lipoxygenase-activating protein (flap) inhibitors |
US8399666B2 (en) * | 2005-11-04 | 2013-03-19 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
US20070219206A1 (en) * | 2005-11-04 | 2007-09-20 | Amira Pharmaceuticals, Inc. | 5-lipoxygenase-activating protein (flap) inhibitors |
EP2086531A4 (de) | 2006-11-30 | 2009-09-30 | Amira Pharmaceuticals Inc | Zusammensetzungen und behandlungsverfahren mit 5-lipoxygenase-aktivierenden proteinhemmern und stickoxid-modulatoren |
TW200920369A (en) * | 2007-10-26 | 2009-05-16 | Amira Pharmaceuticals Inc | 5-lipoxygenase activating protein (flap) inhibitor |
WO2010068311A1 (en) * | 2008-05-23 | 2010-06-17 | Amira Pharmaceuticals, Inc. | 5-lipoxygenase-activating protein inhibitor |
WO2010027762A1 (en) * | 2008-09-04 | 2010-03-11 | Boehringer Ingelheim International Gmbh | Indolizine inhibitors of leukotriene production |
US8546431B2 (en) | 2008-10-01 | 2013-10-01 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
CA2744898A1 (en) * | 2008-12-23 | 2010-07-01 | Amira Pharmaceuticals, Inc. | Topical formulations of flap inhibitors for administration to an eye |
US20110311613A1 (en) * | 2008-12-23 | 2011-12-22 | Amira Pharmaceutical, Inc. | Topical formulations of flap inhibitors for the treatment of dermatological conditions |
NZ624963A (en) | 2009-04-29 | 2016-07-29 | Amarin Pharmaceuticals Ie Ltd | Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same |
EP2462128B1 (de) | 2009-08-04 | 2016-09-21 | Amira Pharmaceuticals, Inc. | Verbindungen als lysophosphatidsäure-rezeptorantagonisten |
EP2480547A4 (de) * | 2009-09-23 | 2013-02-20 | Panmira Pharmaceuticals Llc | Indolizinhemmer aus 5-lipoxygenase |
EP2480548A4 (de) * | 2009-09-23 | 2013-02-20 | Panmira Pharmaceuticals Llc | Indolizinhemmer aus 5-lipoxygenase |
GB2474120B (en) | 2009-10-01 | 2011-12-21 | Amira Pharmaceuticals Inc | Compounds as Lysophosphatidic acid receptor antagonists |
CA2779786A1 (en) * | 2009-11-03 | 2011-05-12 | Claire Frances Crawford | Novel processes |
PE20130751A1 (es) | 2010-08-16 | 2013-06-21 | Boehringer Ingelheim Int | Inhibidores de oxadiazol de la produccion de leucotrieno |
EP2609092B1 (de) * | 2010-08-26 | 2015-04-01 | Boehringer Ingelheim International GmbH | Oxadiazolhemmer der leukotrienproduktion |
US8580825B2 (en) | 2010-09-23 | 2013-11-12 | Boehringer Ingelheim International Gmbh | Oxadiazole inhibitors of leukotriene production |
SG188604A1 (en) * | 2010-09-23 | 2013-04-30 | Boehringer Ingelheim Int | Oxadiazole inhibitors of leukotriene production |
MX2013006040A (es) | 2010-12-07 | 2013-08-26 | Amira Pharmaceuticals Inc | Antagonistas del receptor de acido lisofosfatidico y su uso en el tratamiento de fibrosis. |
EA024967B1 (ru) | 2010-12-07 | 2016-11-30 | Амира Фармасьютикалс, Инк. | Полициклический lpaантагонист и его применение |
RU2593990C2 (ru) | 2011-01-30 | 2016-08-10 | Мейдзи Сейка Фарма Ко., Лтд. | Местное противогрибковое средство |
JP2014513077A (ja) | 2011-04-05 | 2014-05-29 | アミラ ファーマシューティカルス,インコーポレーテッド | 線維症、疼痛、癌、ならびに呼吸器、アレルギー性、神経系または心血管疾患の治療に有用な3−または5−ビフェニル−4−イルイソキサゾールに基づく化合物 |
EP2714680B1 (de) | 2011-05-27 | 2015-11-25 | Amira Pharmaceuticals, Inc. | Heterocyclische autotaxin-inhibitoren und ihre verwendungen |
AR089853A1 (es) | 2012-02-01 | 2014-09-24 | Boehringer Ingelheim Int | Inhibidores de oxadiazol de la produccion de leucotrienos para terapia de combinacion, composicion farmaceutica, uso |
US20150209301A1 (en) | 2012-07-30 | 2015-07-30 | Nichiban Company Limited | Patch for anti-dermatophytosis |
TW201410239A (zh) | 2012-07-30 | 2014-03-16 | Meiji Seika Pharma Co Ltd | 抗白癬菌症外用液劑 |
WO2014031586A2 (en) * | 2012-08-20 | 2014-02-27 | Tallikut Pharmaceuticals, Inc. | Methods for treating cardiovascular diseases |
ES2878405T3 (es) | 2014-02-04 | 2021-11-18 | Bioscience Pharma Partners Llc | Uso de inhibidores de flap para reducir la lesión mediada por neuroinflamación en el sistema nervioso central |
US9533951B2 (en) * | 2014-10-20 | 2017-01-03 | Eastman Chemical Company | Heterocyclic amphoteric compounds |
EP3265456B1 (de) | 2015-03-06 | 2020-11-18 | Pharmakea, Inc. | Fluorierte lysyloxidase-like-2-inhibitoren und verwendungen davon |
CN105085401B (zh) * | 2015-08-17 | 2018-02-13 | 北京大学 | 六氢吲唑类15‑脂氧合酶激活剂及应用 |
EA201990621A1 (ru) | 2016-09-07 | 2019-09-30 | Фармакеа, Инк. | Кристаллические формы ингибитора лизилоксидаза-подобного белка 2 и способы получения |
KR102615565B1 (ko) | 2016-09-07 | 2023-12-18 | 파마케아, 인크. | 리실 옥시다제 유사 2 억제제의 용도 |
MX2019004574A (es) * | 2016-10-28 | 2019-08-21 | Astrazeneca Ab | Forma cristalina de (1r,2r)-2-[4-(3-metil-1h-pirazol-5-il)benzoil- n-(4-oxo-4,5,6,7-tetrahidropirazolo[1,5-a]pirazin-3-il)ciclohexan ocarboxamida. |
US20200147064A1 (en) * | 2017-02-16 | 2020-05-14 | Autoimmune Pharma Llc | Reduction of Pro-Inflammatory HDL Using a Leukotriene Inhibitor |
EP3628669A1 (de) * | 2018-09-28 | 2020-04-01 | GenKyoTex Suisse SA | Neuartige verbindungen als nadph-oxidase-inhibitoren |
WO2023009347A1 (en) * | 2021-07-30 | 2023-02-02 | The Regents Of The University Of California | Compounds for modulating epithelial 15-(s)-lipoxygenase-2 and methods of use for same |
Family Cites Families (207)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2431491A1 (fr) | 1978-07-18 | 1980-02-15 | Delalande Sa | Nouveaux derives aminoalkoxy-5 benzofurannes et indoles, leur procede de preparation et leur application en therapeutique |
DK151884C (da) * | 1979-03-07 | 1988-06-13 | Pfizer | Analogifremgangsmaade til fremstilling af 3-(1-imidazolylalkyl)indolderivater eller farmaceutisk acceptable syreadditionssalte deraf |
JPS60123485A (ja) * | 1983-12-08 | 1985-07-02 | Yoshitomi Pharmaceut Ind Ltd | インド−ル−3−カルボキサミド誘導体 |
US5109009A (en) * | 1985-03-08 | 1992-04-28 | Leo Pharmaceutical Products Ltd. | Quinoline and pyridine compounds and inhibition of 5-lipoxygenases therewith |
IE58870B1 (en) * | 1985-03-08 | 1993-11-17 | Leo Pharm Prod Ltd | Pyridine derivatives |
DE3632411A1 (de) | 1986-09-24 | 1988-04-07 | Merck Patent Gmbh | Verfahren zur herstellung von ethanderivaten |
US5081138A (en) * | 1986-12-17 | 1992-01-14 | Merck Frosst Canada, Inc. | 3-hetero-substituted-n-benzyl-indoles and prevention of leucotriene synthesis therewith |
IL84796A (en) | 1986-12-17 | 1992-03-29 | Merck Frosst Canada Inc | Substituted n-benzyl-indoles and pharmaceutical compositions containing them |
US5225421A (en) * | 1986-12-17 | 1993-07-06 | Merck Frosst Canada, Inc. | 3-hetero-substituted-N-benzyl-indoles and medical methods of use therefor |
MY103259A (en) | 1987-04-15 | 1993-05-29 | Ici America Inc | Aliphatic carboxamides |
ZA892675B (en) | 1988-04-13 | 1989-12-27 | Ici America Inc | Cyclic amides |
US5232916A (en) * | 1988-06-27 | 1993-08-03 | Merck Frosst Canada, Inc. | Quinoline ether alkanoic acids |
US5272145A (en) * | 1989-08-22 | 1993-12-21 | Merck Frosst Canada, Inc. | (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes |
CA1337427C (en) | 1989-08-22 | 1995-10-24 | Merck Frosst Canada Incorporated | (quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes |
NZ234883A (en) | 1989-08-22 | 1995-01-27 | Merck Frosst Canada Inc | Quinolin-2-ylmethoxy indole derivatives, preparation and pharmaceutical compositions thereof |
NZ248177A (en) | 1989-08-22 | 1995-01-27 | Merck Frosst Canada Inc | Benzyl phenyl hydrazine derivatives |
US5204344A (en) * | 1989-08-22 | 1993-04-20 | Merck Frosst Canada, Inc. | (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes |
US5252585A (en) * | 1992-02-03 | 1993-10-12 | Merck Frosst Canada, Inc. | Fluorinated quinoline indoles as inhibitors of the biosynthesis of leukotrienes |
US5229516A (en) * | 1989-10-27 | 1993-07-20 | American Home Products Corporation | Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase |
PT95692A (pt) | 1989-10-27 | 1991-09-13 | American Home Prod | Processo para a preparacao de derivados de acidos indole-,indeno-,piranoindole- e tetra-hidrocarbazole-alcanoicos, ou quais sao uteis como inibidores de pla2 e da lipoxigenase |
US5420289A (en) * | 1989-10-27 | 1995-05-30 | American Home Products Corporation | Substituted indole-, indene-, pyranoindole- and tetrahydrocarbazole-alkanoic acid derivatives as inhibitors of PLA2 and lipoxygenase |
CA2032253C (en) | 1989-12-15 | 2000-11-28 | John W. Gillard | 5-lipoxygenase activating protein |
US5093356A (en) * | 1990-01-16 | 1992-03-03 | Merck Frosst Canada, Inc. | Indenyl hydroxamic acids and hydroxy ureas as inhibitors of 5-lipoxygenase |
US5081145A (en) * | 1990-02-01 | 1992-01-14 | Merck Frosst Canada, Inc. | Indole-2-alkanoic acids compositions of and anti allergic use thereof |
US5095031A (en) | 1990-08-20 | 1992-03-10 | Abbott Laboratories | Indole derivatives which inhibit leukotriene biosynthesis |
JPH0764841B2 (ja) * | 1990-10-03 | 1995-07-12 | ファイザー製薬株式会社 | インドール誘導体およびその用途 |
US5182367A (en) * | 1990-11-30 | 1993-01-26 | Merck & Co., Inc. | 5-lipoxygenase activating protein |
GB9108811D0 (en) | 1991-04-24 | 1991-06-12 | Erba Carlo Spa | N-imidazolyl derivatives of substituted indole |
US5202321A (en) * | 1991-06-13 | 1993-04-13 | Merck Frosst Canada, Inc. | Thiopyrano[2,3,4-c,d]indoles as inhibitors of leukotriene biosynthesis |
JPH06100551A (ja) | 1991-09-06 | 1994-04-12 | Dainippon Ink & Chem Inc | 光学活性な2,5置換テトラヒドロフラン誘導体、その製造方法、その誘導体を含む液晶組成物及び液晶表示素子 |
US5389650A (en) * | 1991-09-30 | 1995-02-14 | Merck Frosst Canada, Inc. | (Azaarylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
US5308850A (en) * | 1991-09-30 | 1994-05-03 | Merck Frosst Canada, Inc. | (Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
CA2079374C (en) | 1991-09-30 | 2003-08-05 | Merck Frosst Canada Incorporated | (bicyclic-azaarylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
US5290798A (en) * | 1991-09-30 | 1994-03-01 | Merck Frosst Canada, Inc. | (hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
US5273980A (en) * | 1991-09-30 | 1993-12-28 | Merck Frosst Canada Inc. | Bicyclic-azaarylmethoxy) indoles as inhibitors of leukotriene biosynthesis |
US5190968A (en) * | 1991-09-30 | 1993-03-02 | Merck Frosst Canada, Inc. | (Polycyclic-arylmethoxy) indoles as inhibitors of leukotriene biosynthesis |
ZA928276B (en) | 1991-10-31 | 1993-05-06 | Daiichi Seiyaku Co | Aromatic amidine derivates and salts thereof. |
US5254567A (en) * | 1991-11-15 | 1993-10-19 | Merck Frosst Canada, Inc. | Amorphous (quinolin-2-ylmethoxy)indole compounds which have useful pharmaceutical utility |
AU3488693A (en) | 1992-02-13 | 1993-09-03 | Merck Frosst Canada Inc. | (Azaaromaticalkoxy)indoles as inhibitors of leukotriene biosynthesis |
CH683522A5 (de) | 1992-03-13 | 1994-03-31 | Hoffmann La Roche | Verfahren zur Herstellung von Diarylen. |
AU658729B2 (en) | 1992-03-27 | 1995-04-27 | Kyoto Pharmaceutical Industries, Ltd. | 3-(1H-imidazol-1-ylmethyl)-1H-indole derivatives |
IL104869A (en) | 1992-05-13 | 1997-11-20 | Syntex Inc | SUBSTITUTED INDOLE, AZAINDOLE AND TETRAHYDRO-1H-PYRROLO- £2,3-c| PYRIDIN-7-ONE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
JPH0658881A (ja) | 1992-06-12 | 1994-03-04 | Mitsubishi Rayon Co Ltd | 光学活性化合物の絶対配置判定法、絶対配置判定用試薬及び絶対配置判定装置 |
US5334719A (en) * | 1992-06-17 | 1994-08-02 | Merck Frosst Canada, Inc. | Bicyclic(azaaromatic)indoles as inhibitors of leukotriene bisynthesis |
AU4413893A (en) | 1992-06-22 | 1994-01-24 | Merck Frosst Canada Inc. | Fluorinated quinoline indoles as inhibitors of the biosynthesis of leukotrienes |
US5314898A (en) * | 1992-06-29 | 1994-05-24 | Merck & Co., Inc. | Aryl thiopyrano[4,3,2-cd]indoles as inhibitors of leukotriene biosynthesis |
US5314900A (en) | 1992-11-19 | 1994-05-24 | Merck Frosst Canada, Inc. | Aryl thiopyrano[2,3,4-C,D]indoles as inhibitors of leukotriene biosynthesis |
US5288743A (en) | 1992-11-20 | 1994-02-22 | Abbott Laboratories | Indole carboxylate derivatives which inhibit leukotriene biosynthesis |
ZA939516B (en) | 1992-12-22 | 1994-06-06 | Smithkline Beecham Corp | Endothelin receptor antagonists |
JP3457694B2 (ja) | 1993-02-04 | 2003-10-20 | 第一製薬株式会社 | インフルエンザ感染予防・治療薬 |
US5374635A (en) * | 1993-03-29 | 1994-12-20 | Merck Frosst Canada, Inc. | Furo[3,2-b]pyridines and thieno[3,2-b]pyridines as inhibitors of leukotriene biosynthesis |
IL109309A (en) | 1993-04-16 | 2000-06-29 | Lilly Co Eli | 1-H-indole-3-acetic acid hydrazide SPLA2 inhibitors and pharmaceutical compositions containing them |
JPH075651A (ja) | 1993-06-14 | 1995-01-10 | Fuji Photo Film Co Ltd | ハロゲン化銀カラー写真感光材料の処理方法 |
PL312005A1 (en) | 1993-06-14 | 1996-04-01 | Pfizer | Binary amines as antidiabetic and antiobesitic agents |
EP0716650B1 (de) | 1993-09-03 | 1999-03-24 | Smithkline Beecham Plc | Indol- und indolin-derivate als 5ht1d rezeptor antagonisten |
DE4338770A1 (de) | 1993-11-12 | 1995-05-18 | Matthias Dr Lehr | Indol-2-alkansäuren und ihre Derivate als Hemmstoffe der Phospholipase A¶2¶ |
US5399699A (en) * | 1994-01-24 | 1995-03-21 | Abbott Laboratories | Indole iminooxy derivatives which inhibit leukotriene biosynthesis |
US5420282A (en) * | 1994-02-15 | 1995-05-30 | Abbott Laboratories | Thiopyrano(2,3,4-c,d) indolyloxime ether alkylcarboxylates |
US5696076A (en) | 1994-06-22 | 1997-12-09 | Human Genome Sciences, Inc. | 5-lipoxygenase-activating protein II |
FR2721610B1 (fr) * | 1994-06-28 | 1996-08-23 | Adir | Nouveaux dérivés (thia)cycloalkyl [b] indoles, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
JPH0820532A (ja) | 1994-07-05 | 1996-01-23 | Dai Ichi Seiyaku Co Ltd | 抗膵炎剤 |
CZ24197A3 (en) | 1994-07-27 | 1997-08-13 | Sankyo Co | Heterocyclic compounds, usable as allosteric efectors in muscarine receptors |
TW396200B (en) * | 1994-10-19 | 2000-07-01 | Sumitomo Chemical Co | Liquid crystal composition and liquid crystal element containing such composition |
TW321649B (de) | 1994-11-12 | 1997-12-01 | Zeneca Ltd | |
JPH10510538A (ja) | 1994-12-13 | 1998-10-13 | スミスクライン・ビーチャム・コーポレイション | 新規化合物 |
EP0820441B1 (de) | 1995-04-10 | 2002-06-26 | Fujisawa Pharmaceutical Co., Ltd. | INDOLDERIVATE ALS cGMP-PDE INHIBITOREN |
US5702637A (en) * | 1995-04-19 | 1997-12-30 | Minnesota Mining And Manufacturing Company | Liquid crystal compounds having a chiral fluorinated terminal portion |
JPH11504648A (ja) | 1995-05-10 | 1999-04-27 | ファイザー・インコーポレーテッド | β−アドレナリン作動性アゴニスト |
JPH092977A (ja) | 1995-06-21 | 1997-01-07 | Dai Ichi Seiyaku Co Ltd | 経口投与用医薬組成物 |
GB9523946D0 (en) | 1995-11-23 | 1996-01-24 | Bayer Ag | Leukotriene antagonistic benzoic acid derivatives |
KR19990076788A (ko) | 1996-01-22 | 1999-10-15 | 후지야마 아키라 | 티아졸릴벤조푸란 유도체 및 그를 함유하는 약제학적 조성물 |
KR19980703369A (ko) | 1996-01-29 | 1998-10-15 | 후루따 다께시 | 카르보닐 화합물의 환원 방법 |
US5756531A (en) | 1996-04-30 | 1998-05-26 | Abbott Laboratories | Iminoxy derivatives of indole and indene compounds as inhibitors of prostaglandin biosynthesis |
US5750558A (en) * | 1996-06-06 | 1998-05-12 | Abbott Laboratories | Oxime derivatives of indole and indene compounds as inhibitors of prostaglandin biosynthesis |
KR20000067946A (ko) | 1996-07-23 | 2000-11-25 | 스즈키 다다시 | 흡수 촉진제 |
US5877329A (en) * | 1996-08-13 | 1999-03-02 | Merck & Co., Inc. | Palladium catalyzed indolization |
US6291489B1 (en) | 1996-11-14 | 2001-09-18 | Pfizer Inc. | Process for substituted pyridines |
GB9710523D0 (en) | 1997-05-23 | 1997-07-16 | Smithkline Beecham Plc | Novel compounds |
WO1998056757A1 (fr) | 1997-06-11 | 1998-12-17 | Sankyo Company, Limited | Derives de benzylamine |
JPH1180032A (ja) | 1997-09-12 | 1999-03-23 | Dai Ichi Seiyaku Co Ltd | 複合体 |
US6548490B1 (en) | 1997-10-28 | 2003-04-15 | Vivus, Inc. | Transmucosal administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction |
DK1042287T3 (da) | 1997-12-24 | 2005-08-15 | Aventis Pharma Gmbh | Indolderivater som inhibitorer af faktor Xa |
EP1043020A1 (de) | 1997-12-25 | 2000-10-11 | Daiichi Pharmaceutical Co., Ltd. | Pharmazuetische zusammenstellung zur perkutanen verabreichung |
JPH11193265A (ja) | 1997-12-26 | 1999-07-21 | Dai Ichi Seiyaku Co Ltd | 3−(7−アミジノ−2−ナフチル)−2−フェニルプロピオン酸誘導体の塩 |
JPH11189531A (ja) | 1997-12-26 | 1999-07-13 | Dai Ichi Seiyaku Co Ltd | 経粘膜投与用医薬組成物 |
CA2260499A1 (en) | 1998-01-29 | 1999-07-29 | Sumitomo Pharmaceuticals Company Limited | Pharmaceutical compositions for the treatment of ischemic brain damage |
TR200002445T2 (tr) | 1998-02-25 | 2000-12-21 | Genetics Institute, Inc. | Fosfolipaz inhibitörleri. |
US6500853B1 (en) * | 1998-02-28 | 2002-12-31 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
JP4472173B2 (ja) | 1998-04-15 | 2010-06-02 | セローノ ジェネティクス インスティテュート ソシエテ アノニム | 5−リポキシゲナーゼ活性化タンパク(flap)のゲノム配列、その多型マーカーおよび喘息の検出方法 |
BR9911069A (pt) | 1998-05-22 | 2001-02-06 | Scios Inc | Compostos heterocìclicos e métodos para tratar insuficiência cardìaca e outros distúrbios |
US6867209B1 (en) * | 1998-05-22 | 2005-03-15 | Scios, Inc. | Indole-type derivatives as inhibitors of p38 kinase |
JP2000007590A (ja) | 1998-06-23 | 2000-01-11 | Daicel Chem Ind Ltd | 置換芳香族化合物の製造方法 |
CA2350415A1 (en) | 1998-11-18 | 2000-05-25 | Incyte Pharmaceuticals, Inc. | Inflammation-associated genes |
UA73492C2 (en) | 1999-01-19 | 2005-08-15 | Aromatic heterocyclic compounds as antiinflammatory agents | |
JP2000302671A (ja) | 1999-04-27 | 2000-10-31 | Hitoshi Sezaki | 経口投与用医薬組成物 |
ATE376547T1 (de) | 1999-05-21 | 2007-11-15 | Scios Inc | Derivate des indol-typs als p38 kinase inhibitoren |
WO2001021594A1 (en) | 1999-09-21 | 2001-03-29 | Astrazeneca Ab | Quinazoline compounds and pharmaceutical compositions containing them |
DE19948417A1 (de) * | 1999-10-07 | 2001-04-19 | Morphochem Ag | Imidazol-Derivate und ihre Verwendung als Arzneimittel |
WO2001032621A1 (fr) | 1999-10-29 | 2001-05-10 | Wakunaga Pharmaceutical Co., Ltd. | Nouveaux derives d'indole, et medicaments contenant lesdits derives comme principe actif |
JP2001139462A (ja) | 1999-11-10 | 2001-05-22 | Dai Ichi Seiyaku Co Ltd | 新規製剤 |
MXPA02004879A (es) | 1999-11-16 | 2002-08-30 | Boehringer Ingelheim Pharma | Derivados de urea como agentes antiinflamatorios. |
WO2001044184A1 (en) | 1999-12-16 | 2001-06-21 | Eli Lilly And Company | Synthesis of indole-containing spla2 inhibitors |
US7345051B2 (en) | 2000-01-31 | 2008-03-18 | Genaera Corporation | Mucin synthesis inhibitors |
GB0003079D0 (en) | 2000-02-10 | 2000-03-29 | Glaxo Group Ltd | Novel protein |
EP1254115A2 (de) | 2000-02-11 | 2002-11-06 | Bristol-Myers Squibb Company | Cannabinoid-rezeptor modulatoren, verfahren zu ihrer herstellung, und verwendung der cannabinoid-rezeptor modulatoren um respiratorische und nicht respiratorische krankheiten zu behandeln |
US6436965B1 (en) | 2000-03-02 | 2002-08-20 | Merck Frosst Canada & Co. | PDE IV inhibiting amides, compositions and methods of treatment |
EP1262475A4 (de) | 2000-03-09 | 2005-01-05 | Ono Pharmaceutical Co | Indolderivate, verfahren zu ihrer herstellung und deren verwendung |
US6476037B1 (en) | 2000-03-23 | 2002-11-05 | The Regents Of The University Of California | L-arginine and phosphodiesterase (PDE) inhibitor synergism |
US20010039037A1 (en) * | 2000-04-05 | 2001-11-08 | Lee Harland | Novel polypeptide |
EP1274841A2 (de) | 2000-04-07 | 2003-01-15 | Bayer Aktiengesellschaft | Regulation des menschlichen cyslt2-ähnlichen g-protein gekoppelten rezeptorproteins |
JP2004503553A (ja) * | 2000-06-14 | 2004-02-05 | ワーナー−ランバート・カンパニー、リミテッド、ライアビリティ、カンパニー | 6,5−縮合二環式複素環 |
JPWO2002000621A1 (ja) | 2000-06-29 | 2004-04-22 | 塩野義製薬株式会社 | X型sPLA2阻害作用を有する化合物 |
DE10037310A1 (de) | 2000-07-28 | 2002-02-07 | Asta Medica Ag | Neue Indolderivate und deren Verwendung als Arzneimittel |
MXPA03003002A (es) | 2000-10-05 | 2004-12-06 | Fujisawa Pharmaceutical Co | Compuestos de benzamina como inhibidores de la secrecion de la apo b. |
WO2002051397A1 (fr) | 2000-12-22 | 2002-07-04 | Ishihara Sangyo Kaisha, Ltd. | Derives d'aniline ou sels de ceux-ci, ainsi qu'inhibiteurs de production de cytokine contenant ces derives |
CA2432654A1 (en) | 2000-12-22 | 2002-07-04 | Wyeth | Heterocyclindazole and azaindazole compounds as 5-hydroxytryptamine-6 ligands |
EP1425010B8 (de) * | 2001-01-29 | 2012-03-28 | Janssen Pharmaceuticals, Inc. | Substituierte indole und ihre verwendung als integrin-antagonisten |
JP2002226429A (ja) | 2001-02-06 | 2002-08-14 | Fuji Photo Film Co Ltd | アクリル酸エステル化合物の製造方法 |
US6627646B2 (en) | 2001-07-17 | 2003-09-30 | Sepracor Inc. | Norastemizole polymorphs |
EP1424325A4 (de) | 2001-09-07 | 2005-12-21 | Ono Pharmaceutical Co | Indolderivate, verfahren zu deren herstellung und arzneimittel, die diese als wirkstoff enthalten |
JPWO2003022814A1 (ja) | 2001-09-07 | 2004-12-24 | 小野薬品工業株式会社 | インドール誘導体化合物 |
BR0212613A (pt) | 2001-09-19 | 2004-08-31 | Pharmacia Corp | Compostos de indazol substituìdos para o tratamento de inflamação |
DE10147672A1 (de) | 2001-09-27 | 2003-04-10 | Bayer Ag | Substituierte 2,5-Diamidoindole und ihre Verwendung |
EP1314733A1 (de) | 2001-11-22 | 2003-05-28 | Aventis Pharma Deutschland GmbH | Indol-2-carbonsäureamide als Faktor-Xa-Hemmer |
AU2002226401A1 (en) | 2001-12-11 | 2003-06-23 | Rhodia Chimie | Catalytic pgm mixture for hydrosilylation |
USH2153H1 (en) * | 2002-04-24 | 2006-04-04 | Smithkline Beecham Corp. | Association of asthma with polymorphisms in the cysteinyl leukotriene 2 receptor |
AU2003235236A1 (en) | 2002-05-13 | 2003-11-11 | Daiichi Pharmaceutical Co., Ltd. | Lyophilization product |
AR037647A1 (es) | 2002-05-29 | 2004-12-01 | Novartis Ag | Derivados de diarilurea utiles para el tratamiento de enfermedades dependientes de la cinasa de proteina |
AU2003244320A1 (en) | 2002-06-20 | 2004-01-06 | Kyowa Hakko Kogyo Co., Ltd. | Process for production of vinyl perfluoroalkanesulfonate derivatives |
DK1539742T3 (da) | 2002-06-24 | 2006-12-27 | Schering Corp | Indolderivater, der er nyttige som histamin H3-antagonister |
CA2495903A1 (en) | 2002-08-23 | 2004-03-04 | University Of Connecticut | Novel biphenyl and biphenyl-like cannabinoids |
CA2495682A1 (en) | 2002-08-26 | 2004-03-04 | Merck & Co., Inc. | Method for the prevention and/or treatment of atherosclerosis |
PT1537078E (pt) | 2002-08-29 | 2010-06-18 | Merck Sharp & Dohme | Indoles que possuem actividade antidiabética |
US7851486B2 (en) | 2002-10-17 | 2010-12-14 | Decode Genetics Ehf. | Susceptibility gene for myocardial infarction, stroke, and PAOD; methods of treatment |
WO2004048331A1 (en) | 2002-11-28 | 2004-06-10 | Suven Life Sciences Limited | N-arylalkyl-3-aminoalkoxyindoles and their use as 5-ht ligands |
US7642277B2 (en) | 2002-12-04 | 2010-01-05 | Boehringer Ingelheim International Gmbh | Non-nucleoside reverse transcriptase inhibitors |
US20040198800A1 (en) * | 2002-12-19 | 2004-10-07 | Geoffrey Allan | Lipoxygenase inhibitors as hypolipidemic and anti-hypertensive agents |
GB0301350D0 (en) | 2003-01-21 | 2003-02-19 | Merck Sharp & Dohme | Therapeutic agents |
JP4513351B2 (ja) | 2003-02-12 | 2010-07-28 | チッソ株式会社 | 結合基にフッ素化されたアルキル基を有する液晶性化合物、液晶組成物および液晶表示素子 |
WO2004078719A1 (ja) | 2003-03-06 | 2004-09-16 | Ono Pharmaceutical Co., Ltd. | インドール誘導体化合物およびその化合物を有効成分とする薬剤 |
EP1479677A1 (de) | 2003-05-19 | 2004-11-24 | Aventis Pharma Deutschland GmbH | Neue Indolderivate als Faktor Xa-Inhibitoren |
WO2004108671A1 (en) | 2003-06-06 | 2004-12-16 | Suven Life Sciences Limited | Substituted indoles with serotonin receptor affinity, process for their preparation and pharmaceutical compositions containing them |
WO2005009951A2 (en) | 2003-07-24 | 2005-02-03 | Merck & Co., Inc. | Diphenyl substituted cycloalkanes, compositions containing such compounds and methods of use |
JP4949027B2 (ja) | 2003-08-25 | 2012-06-06 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 液晶媒体 |
BRPI0414136A (pt) | 2003-09-04 | 2006-10-31 | Aventis Pharma Inc | indóis substituìdos como inibidores de poli(adp-ribose) polimerase (parp) |
EP1680424A2 (de) | 2003-09-05 | 2006-07-19 | Neurogen Corporation | Heteroarylkondensierte pyridine, pyrazine und pyrimidine als crf1-rezeptorliganden |
JP4363133B2 (ja) | 2003-09-09 | 2009-11-11 | 東洋インキ製造株式会社 | 有機エレクトロルミネッセンス用素子材料およびそれを用いた有機エレクトロルミネッセンス素子 |
US7268159B2 (en) | 2003-09-25 | 2007-09-11 | Wyeth | Substituted indoles |
KR100851802B1 (ko) | 2003-10-31 | 2008-08-13 | 오쓰까 세이야꾸 가부시키가이샤 | 결핵의 치료를 위한2,3-디히드로-6-니트로이미다조[2,1-b]옥사졸 화합물 |
JP2005170939A (ja) | 2003-11-20 | 2005-06-30 | Takeda Chem Ind Ltd | 糖尿病の予防・治療剤 |
DE602004011985T2 (de) | 2003-11-25 | 2009-03-05 | Eli Lilly And Co., Indianapolis | Modulatoren des peroxisomproliferatoraktivierten rezeptors |
US20070054902A1 (en) | 2003-12-02 | 2007-03-08 | Shionogi & Co., Ltd. | Isoxazole derivatives as peroxisome proliferator-activated receptors agonists |
CN1886372A (zh) | 2003-12-03 | 2006-12-27 | 默克公司 | 用于治疗阿尔茨海默病及相关病症的1-烷基-3-硫-取代的吲哚-2-链烷酸 |
US20050137234A1 (en) | 2003-12-19 | 2005-06-23 | Syrrx, Inc. | Histone deacetylase inhibitors |
JP5142450B2 (ja) | 2003-12-25 | 2013-02-13 | 徹也 西尾 | ジアミノ化合物、ビニル化合物、高分子化合物、配向膜、該配向膜を用いた有機半導体装置、導電性高分子、該導電性高分子を使用したエレクトロルミネッセンス素子、液晶配向膜、及び該液晶配向膜を用いた光学素子 |
US7064203B2 (en) | 2003-12-29 | 2006-06-20 | Bristol Myers Squibb Company | Di-substituted pyrrolotriazine compounds |
WO2005066157A1 (en) | 2004-01-02 | 2005-07-21 | Suven Life Sciences | 3-(pyrolidin-3-l) indoles as 5-ht6 receptor modulators |
JP2005194250A (ja) | 2004-01-09 | 2005-07-21 | Sumitomo Chemical Takeda Agro Co Ltd | トリアゾール化合物、その製造法および用途 |
US8158362B2 (en) | 2005-03-30 | 2012-04-17 | Decode Genetics Ehf. | Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype |
EP1727533A1 (de) | 2004-02-26 | 2006-12-06 | Merck & Co., Inc. | Verwendung von cysteinyl-leukotrien-2-rezeptorantagonisten |
WO2005097203A2 (en) | 2004-04-01 | 2005-10-20 | Cardiome Pharma Corp. | Serum protein conjugates of ion channel modulating compounds and uses thereof |
JP2007534702A (ja) | 2004-04-26 | 2007-11-29 | バンダービルト・ユニバーシティ | 胃腸毒性の低い治療薬としてのインドール酢酸、及びインデン酢酸誘導体 |
KR100893449B1 (ko) * | 2004-05-03 | 2009-04-17 | 에프. 호프만-라 로슈 아게 | 간-x-수용체 조절제로서의 인돌일 유도체 |
JP2008502670A (ja) | 2004-06-18 | 2008-01-31 | バイオリポックス エービー | 炎症の治療に有用なインドール類 |
CN1980659A (zh) | 2004-07-02 | 2007-06-13 | 默克公司 | 具有抗糖尿病活性的吲哚类 |
CA2577664A1 (en) | 2004-08-20 | 2006-03-02 | Bayer Pharmaceuticals Corporation | Novel heterocycles |
GB0420719D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
WO2006041961A1 (en) | 2004-10-05 | 2006-04-20 | GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTHAND HUMAN SERVICES | Arylthioindole tubulin polymerization inhibitors and methods of treating or preventing cancer using same |
DE602005013272D1 (de) | 2004-10-18 | 2009-04-23 | Merck & Co Inc | Diphenyl-substituierte alkane als flap-inhibitoren |
EP1844048B1 (de) | 2005-01-14 | 2010-05-26 | Janssen Pharmaceutica N.V. | Pyrazolopyrimidine als zellzyklus-kinasehemmer |
JP2008527028A (ja) | 2005-01-19 | 2008-07-24 | バイオリポックス エービー | 炎症の治療に有用なインドール類 |
AU2005325497A1 (en) | 2005-01-19 | 2006-07-27 | Biolipox Ab | Indoles useful in the treatment of inflammation |
US20080249091A1 (en) | 2005-01-19 | 2008-10-09 | Benjamin Pelcman | Indoles Useful in the Treatment of Inflammation |
CA2594777A1 (en) | 2005-01-19 | 2006-07-27 | Biolipox Ab | Indoles useful in the treatment of inflamation |
CN101137376A (zh) | 2005-03-09 | 2008-03-05 | 默克公司 | 二苯基取代的环烷、含有这种化合物的组合物和使用方法 |
RU2453540C2 (ru) | 2005-04-21 | 2012-06-20 | Лаборатуар Сероно С.А. | 2,3-замещенные пиразинсульфонамиды в качестве ингибиторов crth2 |
JP5846711B2 (ja) | 2005-06-09 | 2016-01-20 | メダ アーベー | 炎症性疾患の治療のための方法及び組成物 |
GB0516156D0 (en) | 2005-08-05 | 2005-09-14 | Eisai London Res Lab Ltd | JNK inhibitors |
JP2009504776A (ja) | 2005-08-18 | 2009-02-05 | アクセラロクス, インコーポレイテッド | アラキドン酸代謝経路またはシグナル伝達経路を調節することによる骨を処置するための方法 |
US7394658B2 (en) | 2005-09-01 | 2008-07-01 | Harman International Industries, Incorporated | Heat sink with twist lock mounting mechanism |
US7405302B2 (en) * | 2005-10-11 | 2008-07-29 | Amira Pharmaceuticals, Inc. | 5-lipoxygenase-activating protein (FLAP) inhibitors |
SI1945622T1 (sl) | 2005-10-11 | 2012-05-31 | Univ Pittsburgh | Izotopično markirane spojine benzfurana kot označevalne snovi za amiloidogenske proteine |
EP1947943A4 (de) | 2005-10-21 | 2009-11-25 | Univ Alabama | Kleinmolekülige hemmer der hiv-1-capsid-bildung |
US8399666B2 (en) | 2005-11-04 | 2013-03-19 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
UY29892A1 (es) | 2005-11-04 | 2007-06-29 | Astrazeneca Ab | Nuevos derivados de cromano, composiciones farmaceuticas conteniendolos, procesos de preparacion y aplicaciones |
UY29896A1 (es) | 2005-11-04 | 2007-06-29 | Astrazeneca Ab | Nuevos derivados de cromano, composiciones farmacéuticas conteniéndolos, procesos de preparación y aplicaciones |
US7977359B2 (en) | 2005-11-04 | 2011-07-12 | Amira Pharmaceuticals, Inc. | 5-lipdxygenase-activating protein (FLAP) inhibitors |
US20070244128A1 (en) | 2005-11-04 | 2007-10-18 | Amira Pharmaceuticals, Inc. | 5-lipoxygenase-activating protein (flap) inhibitors |
US20070219206A1 (en) * | 2005-11-04 | 2007-09-20 | Amira Pharmaceuticals, Inc. | 5-lipoxygenase-activating protein (flap) inhibitors |
NL2000284C2 (nl) | 2005-11-04 | 2007-09-28 | Pfizer Ltd | Pyrazine-derivaten. |
GB2431927B (en) | 2005-11-04 | 2010-03-17 | Amira Pharmaceuticals Inc | 5-Lipoxygenase-activating protein (FLAP) inhibitors |
US20070225285A1 (en) * | 2005-11-04 | 2007-09-27 | Amira Pharmaceuticals, Inc. | 5-lipoxygenase-activating protein (flap) inhibitors |
AR059901A1 (es) | 2006-03-20 | 2008-05-07 | Bayer Pharmaceuticals Corp | Compuestos de tetrahidropiridotienopirimidina utiles para tratar o prevenir trastornos proliferativos celulares. |
TW200815377A (en) | 2006-04-24 | 2008-04-01 | Astellas Pharma Inc | Oxadiazolidinedione compound |
AU2007265373B2 (en) | 2006-06-29 | 2013-02-21 | Atnx Spv, Llc | Biaryl compositions and methods for modulating a kinase cascade |
JP2009023986A (ja) | 2006-11-08 | 2009-02-05 | Pharma Ip | 抗癌剤としてのビアリール誘導体 |
SI2848610T1 (en) | 2006-11-15 | 2018-02-28 | Ym Biosciences Australia Pty Ltd | Inhibitors of kinase activity |
EP2086531A4 (de) | 2006-11-30 | 2009-09-30 | Amira Pharmaceuticals Inc | Zusammensetzungen und behandlungsverfahren mit 5-lipoxygenase-aktivierenden proteinhemmern und stickoxid-modulatoren |
WO2008097930A1 (en) | 2007-02-05 | 2008-08-14 | Amira Pharmaceuticals, Inc. | Reverse indoles as 5-lipoxygenase-activating protein (flap) inhibitors |
US8039505B2 (en) * | 2007-04-11 | 2011-10-18 | University Of Utah Research Foundation | Compounds for modulating T-cells |
WO2009002746A1 (en) | 2007-06-22 | 2008-12-31 | Decode Genetics Ehf. | Dosing schedules of leukotriene synthesis inhibitors for human therapy |
US8124605B2 (en) | 2007-07-06 | 2012-02-28 | Kinex Pharmaceuticals, Llc | Compositions and methods for modulating a kinase cascade |
JP2010540641A (ja) | 2007-10-05 | 2010-12-24 | アミラ ファーマシューティカルス,インコーポレーテッド | 5−リポキシゲナーゼ活性化タンパク質(flap)阻害剤 |
TW200920369A (en) | 2007-10-26 | 2009-05-16 | Amira Pharmaceuticals Inc | 5-lipoxygenase activating protein (flap) inhibitor |
EP2269076A4 (de) | 2008-03-14 | 2011-04-06 | Nat Jewish Health | Verfahren zur bestimmung der empfänglichkeit für eine behandlung mit leukotrienmodifikatoren |
WO2010068311A1 (en) | 2008-05-23 | 2010-06-17 | Amira Pharmaceuticals, Inc. | 5-lipoxygenase-activating protein inhibitor |
US8546431B2 (en) | 2008-10-01 | 2013-10-01 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
-
2006
- 2006-10-27 US US11/553,946 patent/US7977359B2/en not_active Expired - Fee Related
- 2006-10-30 SI SI200631225T patent/SI1943219T1/sl unknown
- 2006-10-30 CN CN201110179642A patent/CN102295637A/zh active Pending
- 2006-10-30 EA EA200801163A patent/EA015495B1/ru not_active IP Right Cessation
- 2006-10-30 PT PT06836773T patent/PT1943219E/pt unknown
- 2006-10-30 JP JP2008539007A patent/JP4705986B2/ja not_active Expired - Fee Related
- 2006-10-30 NZ NZ592541A patent/NZ592541A/xx not_active IP Right Cessation
- 2006-10-30 ES ES06836773T patent/ES2373977T3/es active Active
- 2006-10-30 AU AU2006311973A patent/AU2006311973B9/en not_active Ceased
- 2006-10-30 MY MYPI20081429 patent/MY151159A/en unknown
- 2006-10-30 SG SG201008041-4A patent/SG166813A1/en unknown
- 2006-10-30 WO PCT/US2006/042690 patent/WO2007056021A2/en active Application Filing
- 2006-10-30 PL PL06836773T patent/PL1943219T3/pl unknown
- 2006-10-30 EA EA201000584A patent/EA018616B1/ru not_active IP Right Cessation
- 2006-10-30 DK DK06836773.9T patent/DK1943219T3/da active
- 2006-10-30 NZ NZ567718A patent/NZ567718A/en not_active IP Right Cessation
- 2006-10-30 EP EP11171816A patent/EP2404904A1/de not_active Withdrawn
- 2006-10-30 RS RS20120006A patent/RS52189B/en unknown
- 2006-10-30 AT AT06836773T patent/ATE530521T1/de active
- 2006-10-30 CA CA2628490A patent/CA2628490C/en not_active Expired - Fee Related
- 2006-10-30 BR BRPI0618046-9A patent/BRPI0618046A2/pt not_active Application Discontinuation
- 2006-10-30 EP EP06836773A patent/EP1943219B8/de active Active
- 2006-10-30 KR KR1020087013547A patent/KR101031766B1/ko active IP Right Grant
-
2008
- 2008-04-15 IL IL190873A patent/IL190873A0/en not_active IP Right Cessation
- 2008-04-16 NO NO20081838A patent/NO342361B1/no not_active IP Right Cessation
- 2008-04-28 CR CR9942A patent/CR9942A/es unknown
- 2008-05-05 MA MA30900A patent/MA29931B1/fr unknown
- 2008-08-25 HK HK08109452.4A patent/HK1114099A1/xx not_active IP Right Cessation
-
2009
- 2009-12-04 JP JP2009276800A patent/JP5451347B2/ja not_active Expired - Fee Related
-
2010
- 2010-11-10 AU AU2010241356A patent/AU2010241356B2/en not_active Ceased
-
2011
- 2011-01-24 US US13/012,045 patent/US20110118315A1/en not_active Abandoned
- 2011-01-28 JP JP2011015870A patent/JP5506707B2/ja active Active
- 2011-05-24 IL IL213107A patent/IL213107A0/en unknown
-
2012
- 2012-01-10 HR HR20120033T patent/HRP20120033T1/hr unknown
- 2012-01-11 CY CY20121100021T patent/CY1112383T1/el unknown
-
2013
- 2013-07-16 US US13/942,934 patent/US8710081B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE530521T1 (de) | Hemmer des 5-lipoxygenase aktivierenden proteins (flap) | |
SG165387A1 (en) | 5-lipoxygenase-activating protein (flap) inhibitors | |
WO2007047207A3 (en) | 5-lipoxygenase-activating protein (flap) inhibitors | |
EA017150B9 (ru) | Ингибиторы белка, активирующего 5-липоксигеназу (flap) | |
ATE516286T1 (de) | 5-(ä1,3,4üoxadiazol-2-yl)-1h-indazol und 5-(ä1,3, 4üthiadiazol-2-yl)-1h-indazol derivate als sgk- inhibitoren zur behandlung von diabetes | |
EA201001204A1 (ru) | Методы и композиции, в которых применяют слитые полипептиды klotho-fgf | |
WO2007138116A3 (de) | Pharmazeutische zusammensetzung zur behandlung von virusinfektionen und/oder tumorerkrankungen durch inhibition der proteinfaltung und des proteinabbaus | |
WO2009045700A3 (en) | 5-lipoxygenase-activating protein (flap) inhibitors | |
ATE506951T1 (de) | Als inhibitoren von beta-secretase aktive tertiäre carbinamine mit substituierten heterocyclen zur behandlung der alzheimer- krankheit | |
UY31073A1 (es) | Inhibidores de la proteína activadora de la 5-lipoxigenasa (flap) | |
MX2009000285A (es) | Piperidinas sustituidas que incrementan la actividad de p53 y usos de las mismas. | |
DE602006010991D1 (de) | 3-(indazol-5-yl)-(1,2,4)triazinderivate und verwandte verbindungen als proteinkinaseinhibitoren zur behandlung von krebs | |
IL189178A0 (en) | Thiazolyl derivatives and pharmaceutical compositions containing the same | |
ATE447559T1 (de) | 4-(phenylamino)-6-oxo-1,6-dihydropyridazine-3- carboxamid derivate als mek inhibitoren zur behandlung von hyperproliferativen erkrankungen | |
EA200870019A1 (ru) | Лактамовые соединения и способы их применения | |
NO20053114L (no) | Astma og allergisk inflammasjonsmodulatorer. | |
EP2380591A3 (de) | Impfpeptidkombinationen gegen Katzenallergie | |
NO20084362L (no) | Difenylazetidinon derivater inneholdende kolesterol absorbsjonsinhibitor aktivitet | |
ATE548035T1 (de) | Formulierungen zur behandlung von lipoprotein- anormalitäten mit einem statin- und einem methylnicotinamid-derivat | |
DE602005013650D1 (de) | Proteinhydrolysat zur behandlung von müdigkeit | |
TW200806293A (en) | Methods of treatment with CETP inhibitors | |
ATE528299T1 (de) | Cyclische ketale als beta-sekretase-inhibitoren zur behandlung von alzheimer-krankheit | |
WO2006072951A3 (en) | Compositions and methods for regulating apoptosis |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
Ref document number: 1943219 Country of ref document: EP |