ATE29727T1 - Reifes menschliches leukozyteninterferon a, verfahren zu seiner mikrobiellen produktion, zwischenprodukte dazu und es enthaltende zusammensetzungen. - Google Patents

Reifes menschliches leukozyteninterferon a, verfahren zu seiner mikrobiellen produktion, zwischenprodukte dazu und es enthaltende zusammensetzungen.

Info

Publication number
ATE29727T1
ATE29727T1 AT81105067T AT81105067T ATE29727T1 AT E29727 T1 ATE29727 T1 AT E29727T1 AT 81105067 T AT81105067 T AT 81105067T AT 81105067 T AT81105067 T AT 81105067T AT E29727 T1 ATE29727 T1 AT E29727T1
Authority
AT
Austria
Prior art keywords
interferon
compositions containing
intermediate products
mature human
microbial production
Prior art date
Application number
AT81105067T
Other languages
German (de)
English (en)
Inventor
David Van Norman Goeddel
Sidney Pestka
Original Assignee
Hoffmann La Roche
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27496622&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE29727(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/256,204 external-priority patent/US6610830B1/en
Application filed by Hoffmann La Roche, Genentech Inc filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE29727T1 publication Critical patent/ATE29727T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/56—IFN-alpha
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/71—Expression systems using regulatory sequences derived from the trp-operon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
AT81105067T 1980-07-01 1981-06-30 Reifes menschliches leukozyteninterferon a, verfahren zu seiner mikrobiellen produktion, zwischenprodukte dazu und es enthaltende zusammensetzungen. ATE29727T1 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US16498680A 1980-07-01 1980-07-01
US18490980A 1980-09-08 1980-09-08
US20557880A 1980-11-10 1980-11-10
US06/256,204 US6610830B1 (en) 1980-07-01 1981-04-21 Microbial production of mature human leukocyte interferons
EP81105067A EP0043980B1 (en) 1980-07-01 1981-06-30 Mature human leukocyte interferon a, process for its microbial preparation, intermediates therefor and compositions containing it.

Publications (1)

Publication Number Publication Date
ATE29727T1 true ATE29727T1 (de) 1987-10-15

Family

ID=27496622

Family Applications (3)

Application Number Title Priority Date Filing Date
AT81105067T ATE29727T1 (de) 1980-07-01 1981-06-30 Reifes menschliches leukozyteninterferon a, verfahren zu seiner mikrobiellen produktion, zwischenprodukte dazu und es enthaltende zusammensetzungen.
AT0290981A AT380272B (de) 1980-07-01 1981-06-30 Verfahren zur herstellung von mikroorganismen
AT86105365T ATE79901T1 (de) 1980-07-01 1981-06-30 Reife menschliche leukozyten-interferone, verfahren zu ihrer bacteriellen herstellung, zwischenprodukte hierfuer und zusammensetzungen diese enthaltend.

Family Applications After (2)

Application Number Title Priority Date Filing Date
AT0290981A AT380272B (de) 1980-07-01 1981-06-30 Verfahren zur herstellung von mikroorganismen
AT86105365T ATE79901T1 (de) 1980-07-01 1981-06-30 Reife menschliche leukozyten-interferone, verfahren zu ihrer bacteriellen herstellung, zwischenprodukte hierfuer und zusammensetzungen diese enthaltend.

Country Status (36)

Country Link
EP (2) EP0043980B1 (enExample)
AR (1) AR242833A1 (enExample)
AT (3) ATE29727T1 (enExample)
AU (1) AU552004B2 (enExample)
BG (1) BG42189A3 (enExample)
BR (1) BR8104189A (enExample)
CH (2) CH651308A5 (enExample)
CS (1) CS273152B2 (enExample)
DD (3) DD210305A5 (enExample)
DE (3) DE3176448D1 (enExample)
DK (1) DK173543B1 (enExample)
DZ (1) DZ312A1 (enExample)
ES (1) ES8207514A1 (enExample)
FI (1) FI82712C (enExample)
FR (1) FR2486098B1 (enExample)
GB (1) GB2079291B (enExample)
GE (1) GEP19960519B (enExample)
GR (1) GR75714B (enExample)
HK (1) HK49285A (enExample)
HU (1) HU196457B (enExample)
IE (1) IE49255B1 (enExample)
IT (1) IT1137272B (enExample)
KE (1) KE3534A (enExample)
LU (1) LU83461A1 (enExample)
MC (1) MC1396A1 (enExample)
MY (1) MY8700711A (enExample)
NL (1) NL8103151A (enExample)
NO (1) NO159392C (enExample)
NZ (1) NZ197572A (enExample)
PH (1) PH18036A (enExample)
PL (3) PL148276B1 (enExample)
PT (1) PT73289B (enExample)
RO (1) RO87590A (enExample)
SE (2) SE8104093L (enExample)
SU (1) SU1414319A3 (enExample)
YU (1) YU47700B (enExample)

Families Citing this family (53)

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ZA811368B (en) * 1980-03-24 1982-04-28 Genentech Inc Bacterial polypedtide expression employing tryptophan promoter-operator
YU45104B (en) 1980-04-03 1992-03-10 Biogen Nv Process for producing recombinant dnk molecule, capable of inducting polypeptide expression in an one-cell host
EP0042246B1 (en) * 1980-06-12 1987-03-18 The Cancer Institute Of Japanese Foundation For Cancer Research Plasmid
DK489481A (da) * 1980-11-10 1982-05-11 Searle & Co Plasmidvektor og frmgangsmaade til fremstilling deraf
NZ199722A (en) * 1981-02-25 1985-12-13 Genentech Inc Dna transfer vector for expression of exogenous polypeptide in yeast;transformed yeast strain
WO1983000693A1 (en) * 1981-08-14 1983-03-03 Berg, Kurt, Frimann SUBJECTS RELATING TO HUMAN INTEFERON-'alpha' SUBTYPE PROTEINS AND CORRESPONDING ANTIBODIES
JPS58110548A (ja) * 1981-12-24 1983-07-01 Asahi Chem Ind Co Ltd 新規な生理活性ペプチド
US4973479A (en) * 1982-01-15 1990-11-27 Cetus Corporation Interferon-α61
US4975276A (en) * 1982-01-15 1990-12-04 Cetus Corporation Interferon-alpha 54
US5098703A (en) * 1982-01-15 1992-03-24 Cetus Corporation Interferon-alpha 76
IE54592B1 (en) * 1982-03-08 1989-12-06 Genentech Inc Anumal interferons, processes involved in their production, compositions containing them, dna sequences coding therefor and espression vehicles containing such sequences and cells transformed thereby
US6432677B1 (en) 1982-03-08 2002-08-13 Genentech, Inc. Non-human animal interferons
US5827694A (en) * 1982-03-08 1998-10-27 Genentech, Inc. DNA encoding non-human animal interferons, vectors and hosts therefor, and recombinant production of IFN polypeptides
US4775622A (en) * 1982-03-08 1988-10-04 Genentech, Inc. Expression, processing and secretion of heterologous protein by yeast
DE3382317D1 (de) * 1982-03-15 1991-07-25 Schering Corp Hybride dns, damit hergestellte bindungszusammensetzung und verfahren dafuer.
US4695543A (en) * 1982-03-23 1987-09-22 Bristol-Myers Company Alpha Interferon GX-1
US4748233A (en) * 1982-03-23 1988-05-31 Bristol-Myers Company Alpha-interferon Gx-1
CA1210714A (en) * 1982-03-23 1986-09-02 Alan Sloma .alpha.-INTERFERON GX-1
US6936694B1 (en) * 1982-05-06 2005-08-30 Intermune, Inc. Manufacture and expression of large structural genes
US5831023A (en) * 1982-11-01 1998-11-03 Genentech, Inc. Recombinant animal interferon polypeptides
DE3490055T1 (de) * 1983-02-24 1985-05-02 Institut bioorganičeskoj chimii imeni M.M. Šemjakina Akademii nauk SSSR, Moskau/Moskva Menschliches Leukozyteninterferon N und Verfahren zu dessen Herstellung in Bakterienzellen
EP0165942A1 (en) * 1983-12-23 1986-01-02 Monash University PRODUCTION OF HUMAN INTERFERON-$g(a)
SU1364343A1 (ru) * 1984-07-13 1988-01-07 Всесоюзный научно-исследовательский институт генетики и селекции промышленных микроорганизмов Способ получени человеческого лейкоцитарного интерферона альфа-2
WO1986002068A1 (fr) * 1984-09-26 1986-04-10 Takeda Chemical Industries, Ltd. Separation mutuelle de proteines
IL76360A0 (en) 1984-09-26 1986-01-31 Takeda Chemical Industries Ltd Mutual separation of proteins
US5196323A (en) * 1985-04-27 1993-03-23 Boehringer Ingelheim International Gmbh Process for preparing and purifying alpha-interferon
DE3515336C2 (de) * 1985-04-27 1994-01-20 Boehringer Ingelheim Int Verfahren zur Herstellung und Reinigung von â-Interferon
JP2514950B2 (ja) * 1986-03-10 1996-07-10 エフ・ホフマン―ラ ロシユ アーゲー 化学修飾蛋白質，その製造法および中間体
JPS6463395A (en) * 1987-05-04 1989-03-09 Oncogen Oncostatin m and novel composition having antitumor activity
CA1309044C (en) * 1987-11-09 1992-10-20 Toshiya Takano Method of producing foreign gene products
GB8813032D0 (en) * 1988-06-02 1988-07-06 Boehringer Ingelheim Int Antiviral pharmaceutical composition
WO1991003251A1 (en) * 1989-09-08 1991-03-21 California Institute Of Biological Research Cr2 ligand compositions and methods for modulating immune cell functions
DE3932311A1 (de) * 1989-09-28 1991-04-11 Boehringer Ingelheim Int Verfahren zur reinigung von beta-interferon
DK0741577T3 (da) * 1994-03-07 2003-02-17 Imperial College Anvendelsen af enterferon, subtype alfa 8, til fremstilling af lægemidler til behandling af virusinfektioner i leveren
ATE205256T1 (de) * 1994-04-09 2001-09-15 Hoffmann La Roche Verfahren zur herstellung von alpha-interferon
GB9609932D0 (en) * 1996-05-13 1996-07-17 Hoffmann La Roche Use of IL-12 and IFN alpha for the treatment of infectious diseases
US20030190307A1 (en) 1996-12-24 2003-10-09 Biogen, Inc. Stable liquid interferon formulations
JP2001526033A (ja) 1997-12-08 2001-12-18 ジェネンテク・インコーポレイテッド ヒトインターフェロン−イプシロンというｉ型インターフェロン
ZA9811070B (en) 1997-12-08 2000-07-03 Genentech Inc Type I interferons.
US6783965B1 (en) 2000-02-10 2004-08-31 Mountain View Pharmaceuticals, Inc. Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates
ATE498409T1 (de) 1998-08-06 2011-03-15 Mountain View Pharmaceuticals Peg-uricase konjugate und verwendung davon
US6268178B1 (en) 1999-05-25 2001-07-31 Phage Biotechnology Corp. Phage-dependent super-production of biologically active protein and peptides
JP2004537964A (ja) * 2000-11-03 2004-12-24 ペストカ バイオメディカル ラボラトリーズ インコーポレイテッド インターフェロン、それに関する使用及び組成物
FR2822845B1 (fr) 2001-03-30 2003-12-12 Genodyssee Nouveaux polynucleotides comportant des polymorphismes de type snp fonctionnels dans la sequence nucleotidique du gene ifn-alpha-21 ainsi que de nouveaux polypeptides codes par ces polynucleotides et leurs utilisations therapeutiques
FR2823220B1 (fr) 2001-04-04 2003-12-12 Genodyssee Nouveaux polynucleotides et polypeptides de l'erythropoietine (epo)
FR2825716B1 (fr) 2001-06-11 2004-09-24 Genodyssee Nouveaux polynucleotides et polypeptides de l'ifn alpha 7
NZ562292A (en) 2005-04-11 2009-11-27 Savient Pharmaceuticals Inc Variant forms of urate oxidase and use thereof
US20110034672A1 (en) * 2008-01-18 2011-02-10 Roberto Falkenstein Purification of not-glycosylated polypeptides
KR101861547B1 (ko) 2009-06-25 2018-07-02 크레알타 파마슈티칼스 엘엘씨 페길화된 유리카아제 치료 중에 혈청 요산을 모니터링하여 주입 반응의 위험성 및 반응의 항체­매개 상실을 예측하는 방법 및 키트
EP3538135A4 (en) 2016-11-11 2020-07-29 Horizon Pharma Rheumatology LLC POLYTHERAPIES OF PREDNISONE AND URICASE MOLECULES AND THEIR USES
US20200237881A1 (en) 2019-01-30 2020-07-30 Horizon Pharma Rheumatology Llc Reducing immunogenicity to pegloticase
WO2018087345A1 (en) 2016-11-14 2018-05-17 F. Hoffmann-La Roche Ag COMBINATION THERAPY OF AN HBsAg INHIBITOR, A NUCLEOS(T)IDE ANALOGUE AND AN INTERFERON
US12269875B2 (en) 2023-08-03 2025-04-08 Jeff R. Peterson Gout flare prevention methods using IL-1BETA blockers

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN150740B (enExample) * 1978-11-24 1982-12-04 Hoffmann La Roche
FI77877C (fi) * 1979-04-20 1989-05-10 Technobiotic Ltd Foerfarande foer framstaellning och rening av human le-formig interferonprotein.
DK170236B1 (da) * 1980-01-08 1995-07-10 Biogen Inc Rekombinante DNA-molekyler, fremgangsmåde til fremstilling af et polypeptid af IFN-alfa typen og fremgangsmåde til udvælgelse af DNA-sekvenser, der koder for polypeptider af IFN-alfa typen
DE3005897A1 (de) * 1980-02-16 1981-09-03 Hoechst Ag, 6000 Frankfurt Genprodukt eines hoeheren organismus aus einem dieses gen enhtaltenden mikroorganismus
EP0042246B1 (en) * 1980-06-12 1987-03-18 The Cancer Institute Of Japanese Foundation For Cancer Research Plasmid
ES506955A0 (es) * 1980-11-10 1983-02-01 Genentech Inc Un procedimiento para producir un polipeptido antiviral.
FI64813C (fi) * 1980-12-31 1984-01-10 Ilkka Antero Palva Foerfarande foer producering av ett utvalt aeggviteaemne och vid foerfarandet anvaenda rekombinantplasmidvektorer
EP0062971B1 (en) * 1981-03-27 1990-03-07 Imperial Chemical Industries Plc Genetically modified microorganisms

Also Published As

Publication number Publication date
YU162281A (en) 1984-02-29
PT73289A (en) 1981-07-01
IT1137272B (it) 1986-09-03
EP0043980A3 (en) 1982-09-15
EP0043980B1 (en) 1987-09-16
IE811463L (en) 1982-01-01
PL231940A1 (en) 1983-07-18
AU7246281A (en) 1982-01-07
CH651308A5 (de) 1985-09-13
FI82712C (fi) 1991-04-10
LU83461A1 (de) 1983-04-06
DK291081A (da) 1982-01-02
ES503528A0 (es) 1982-10-01
ES8207514A1 (es) 1982-10-01
KE3534A (en) 1985-06-07
PH18036A (en) 1985-03-06
IT8122682A0 (it) 1981-07-01
DD210305A5 (de) 1984-06-06
GB2079291A (en) 1982-01-20
NZ197572A (en) 1985-07-31
PT73289B (en) 1983-05-11
MY8700711A (en) 1987-12-31
DD210304A5 (de) 1984-06-06
EP0043980A2 (en) 1982-01-20
DE3177288D1 (de) 1992-10-01
RO87590A (ro) 1986-07-30
HK49285A (en) 1985-07-05
FI812067L (fi) 1982-01-02
GB2079291B (en) 1984-06-13
SE465223C5 (sv) 1998-02-10
GR75714B (enExample) 1984-08-02
DK173543B1 (da) 2001-02-05
AU552004B2 (en) 1986-05-22
FR2486098A1 (fr) 1982-01-08
DZ312A1 (fr) 2004-09-13
SE8104093L (sv) 1982-01-02
BR8104189A (pt) 1982-03-16
HU196457B (en) 1988-11-28
ATE79901T1 (de) 1992-09-15
ATA290981A (de) 1985-09-15
BG42189A3 (en) 1987-10-15
AR242833A1 (es) 1993-05-31
MC1396A1 (fr) 1982-04-27
CS273152B2 (en) 1991-03-12
EP0211148A1 (en) 1987-02-25
AT380272B (de) 1986-05-12
PL148276B1 (en) 1989-09-30
CS503781A2 (en) 1990-07-12
GEP19960519B (en) 1996-07-02
NO159392B (no) 1988-09-12
SU1414319A3 (ru) 1988-07-30
DE3177288T2 (de) 1992-12-10
PL148260B1 (en) 1989-09-30
EP0211148B2 (en) 1999-11-24
FR2486098B1 (fr) 1985-12-27
DD202307A5 (de) 1983-09-07
PL148261B1 (en) 1989-09-30
DE3125706C2 (de) 1995-05-24
CH657141A5 (de) 1986-08-15
NO159392C (no) 1988-12-21
DE3125706A1 (de) 1982-04-15
YU47700B (sh) 1996-01-08
DE3177288T3 (de) 2000-03-16
NL8103151A (nl) 1982-02-01
DE3176448D1 (en) 1987-10-22
EP0211148B1 (en) 1992-08-26
SE465223B (sv) 1991-08-12
NO812247L (no) 1982-01-04
FI82712B (fi) 1990-12-31
IE49255B1 (en) 1985-09-04

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