AR082887A1 - Derivados de piridin-3-il-metil, y composiciones para la inhibicion de nampt - Google Patents

Derivados de piridin-3-il-metil, y composiciones para la inhibicion de nampt

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Publication number
AR082887A1
AR082887A1 ARP110103220A ARP110103220A AR082887A1 AR 082887 A1 AR082887 A1 AR 082887A1 AR P110103220 A ARP110103220 A AR P110103220A AR P110103220 A ARP110103220 A AR P110103220A AR 082887 A1 AR082887 A1 AR 082887A1
Authority
AR
Argentina
Prior art keywords
alkyl
heterocycloalkyl
aryl
cycloalkyl
haloalkyl
Prior art date
Application number
ARP110103220A
Other languages
English (en)
Original Assignee
Forma Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Forma Therapeutics Inc filed Critical Forma Therapeutics Inc
Publication of AR082887A1 publication Critical patent/AR082887A1/es

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals

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Abstract

Reivindicación 1: Compuestos de la fórmula (1) en donde: Ra es 1, 2, 3 ó 4 y pueden seleccionarse del grupo que consiste en hidrógeno, amino, oxo, halo, alcoxi, alquilo, haloalquilo, -N(alquil)2, -NH(CO)O-alquilo, 1H-pirazol, 1H-imidazol, y -C(O)NH2; y en donde dicha piridina puede comprender un N-óxido formado con su miembro N atómico; R1 es -NR3R4 en donde R3 es H, alquilo o -S(O)2alquilo y R4 es alquilo, hidroxialquilo, -S(O)2alquilo, -(CH2)q-cicloalquilo, -(CH2)q-heterocicloalquilo, arilo, arilalquilo-, -(CH2)q-heteroarilo; haloalquilo; cicloalquilo; arilo; heterocicloalquilo; o heteroarilo; en donde cada uno de dicho cicloalquilo, arilo, heterocicloalquilo o heteroarilo no está sustituido o está sustituido con 1, 2, 3, 4 ó 5 sustituyentes que pueden ser iguales o diferentes y se seleccionan en forma independiente del grupo que consiste en: halo, ciano, alquilo, hidroxilo, hidroxialquilo, hidroxialcoxi, haloalquilo, alcoxi, alquilalcoxi, haloalcoxi, arilalquenilo-, ariloxi, benciloxi, oxo, -(CH2)q-NRbRc, -(CH2)q-CONRbRc, -S(O)2-alquilo, -S(O)2NH-alquilo, -S(O)2-heterocicloalquilo, -S(O)2-CF3, -C(O)alquilo, -C(O)arilo, -C(O)alquilenilarilo, -C(O)O-alquilo, -(CH2)q-cicloalquilo, cicloalquilalcoxi-, arilo, arilalquilo-, -(CH2)q-heteroarilo, y -(CH2)q-heterocicloalquilo; en donde cada uno de dicho cicloalquilo, heterocicloalquilo, arilo o heteroarilo puede estar sustituido por uno o más halo, nitro, haloalquilo, haloalcoxi, oxo, ciano, alquilo, haloalquilo, o alcoxi; Rb y Rc se seleccionan en forma independiente del grupo que consiste en H, alquilo, hidroxialquilo, alcoxi, arilo, alcoxialquilo, -S(O)2alquilo y cicloalquilo; o Rb y Rc pueden formar un grupo heterocicloalquilo de 5 o 6 miembros junto con el átomo de nitrógeno al cual están unidos, en donde dicho grupo heterocicloalquilo puede contener uno o más heteroátomo(s) adicional(es) seleccionado(s) de N, S u O; q es 0 ó 1; y sales aceptables desde el punto de vista farmacéutico de los anteriores, con la salvedad de que los compuestos de la fórmula (1) no sean: N-[4-(fenilsulfonil)fenil]-N’-(3-piridinilmetil)urea; N,N-dietil-4-[[[(3-piridinilmetil)amino]carbonil]amino]bencensulfonamida; o 4-[[[(3-piridinilmetil)amino]carbonil]amino]bencensulfonamida.
ARP110103220A 2010-09-03 2011-09-02 Derivados de piridin-3-il-metil, y composiciones para la inhibicion de nampt AR082887A1 (es)

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