MX342481B - Nuevos compuestos y composiciones para la inhibicion de nampt. - Google Patents

Nuevos compuestos y composiciones para la inhibicion de nampt.

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Publication number
MX342481B
MX342481B MX2013002431A MX2013002431A MX342481B MX 342481 B MX342481 B MX 342481B MX 2013002431 A MX2013002431 A MX 2013002431A MX 2013002431 A MX2013002431 A MX 2013002431A MX 342481 B MX342481 B MX 342481B
Authority
MX
Mexico
Prior art keywords
aminocarbonyl
pyridin
cancer
therapy
benzene
Prior art date
Application number
MX2013002431A
Other languages
English (en)
Other versions
MX2013002431A (es
Inventor
Jian Lin
Alexandre J Buckmelter
Kenneth W Bair
Bingsong Han
Dominic J Reynolds
Chase C Smith
Zhongguo Wang
Xiaozhang Zheng
Timm R Baumeister
Karl H Clodfelter
Po-Wai Yuen
Original Assignee
Genentech Inc *
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc * filed Critical Genentech Inc *
Publication of MX2013002431A publication Critical patent/MX2013002431A/es
Publication of MX342481B publication Critical patent/MX342481B/es

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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Abstract

La presente invención se refiere a compuestos y composiciones para la inhibición de NAMPT, sus síntesis, aplicaciones y antídotos. A continuación se muestra un compuesto ilustrativo de la invención: (Ver Formula).
MX2013002431A 2010-09-03 2011-09-02 Nuevos compuestos y composiciones para la inhibicion de nampt. MX342481B (es)

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US37981910P 2010-09-03 2010-09-03
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US38604410P 2010-09-24 2010-09-24
US201161478995P 2011-04-26 2011-04-26
US201161480423P 2011-04-29 2011-04-29
PCT/US2011/050320 WO2012031196A1 (en) 2010-09-03 2011-09-02 4- { [ ( pyridin- 3 - yl -methyl) aminocarbonyl] amino} benzene - sulfone derivatives as nampt inhibitors for therapy of diseases such as cancer

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US20180291000A1 (en) 2018-10-11
RU2013114844A (ru) 2014-10-10
US10329275B2 (en) 2019-06-25
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JP6038792B2 (ja) 2016-12-07
TW201217359A (en) 2012-05-01
AR082887A1 (es) 2013-01-16
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US20130273034A1 (en) 2013-10-17
US20200283403A1 (en) 2020-09-10
CA2809391A1 (en) 2012-03-08
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BR112013004858A2 (pt) 2016-06-07
US10647695B2 (en) 2020-05-12
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US11279687B2 (en) 2022-03-22
BR112013004858A8 (pt) 2018-01-02

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