MX347459B - Nuevos compuestos y composiciones para la inhibición de nampt. - Google Patents
Nuevos compuestos y composiciones para la inhibición de nampt.Info
- Publication number
- MX347459B MX347459B MX2013013041A MX2013013041A MX347459B MX 347459 B MX347459 B MX 347459B MX 2013013041 A MX2013013041 A MX 2013013041A MX 2013013041 A MX2013013041 A MX 2013013041A MX 347459 B MX347459 B MX 347459B
- Authority
- MX
- Mexico
- Prior art keywords
- nampt
- inhibition
- compositions
- piperidine derivatives
- nicotinamide phosphoribosyltransferase
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
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- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
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- C07D—HETEROCYCLIC COMPOUNDS
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
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- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
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- C07D495/04—Ortho-condensed systems
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- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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Abstract
La presente invención se refiere a compuestos y composiciones para la inhibición de NAMPT, su síntesis, aplicaciones y antídotos. Se muestra a continuación un compuesto ilustrativo de la invención: (Ver Formula).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161483937P | 2011-05-09 | 2011-05-09 | |
US201161512546P | 2011-07-28 | 2011-07-28 | |
PCT/US2011/050303 WO2012154194A1 (en) | 2011-05-09 | 2011-09-02 | Piperidine derivatives and compositions for the inhibition of nicotinamide phosphoribosyltransferase (nampt) |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2013013041A MX2013013041A (es) | 2013-12-02 |
MX347459B true MX347459B (es) | 2017-04-26 |
Family
ID=44681420
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013013041A MX347459B (es) | 2011-05-09 | 2011-09-02 | Nuevos compuestos y composiciones para la inhibición de nampt. |
Country Status (13)
Country | Link |
---|---|
US (5) | US9555039B2 (es) |
JP (2) | JP5872027B2 (es) |
KR (1) | KR20140038443A (es) |
CN (2) | CN103874686B (es) |
AR (1) | AR082889A1 (es) |
AU (1) | AU2011367809B2 (es) |
BR (1) | BR112013028877A2 (es) |
CA (1) | CA2834745A1 (es) |
IN (1) | IN2013MN02014A (es) |
MX (1) | MX347459B (es) |
RU (1) | RU2617643C2 (es) |
TW (1) | TW201245188A (es) |
WO (1) | WO2012154194A1 (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20130114653A (ko) | 2010-09-03 | 2013-10-17 | 포르마 티엠, 엘엘씨. | 암과 같은 질환의 치료를 위한 nampt 억제제로서의 4-{[(피리딘-3-일-메틸)아미노카르보닐]아미노}벤젠-술폰 유도체 |
PE20140011A1 (es) | 2010-09-03 | 2014-01-31 | Forma Tm Llc | Compuestos y composiciones novedosos para la inhibicion de nampt |
US9555039B2 (en) | 2011-05-09 | 2017-01-31 | Forma Tm, Llc. | Piperidine derivatives and compositions for the inhibition of nicotinamide phosphoribosyltransferase (NAMPT) |
SG11201405054PA (en) | 2012-03-02 | 2014-09-26 | Genentech Inc | Amido-benzyl sulfone and sulfoxide derivatives |
WO2013127268A1 (en) * | 2012-03-02 | 2013-09-06 | Genentech,Inc. | Amido-benzyl sulfone and sulfonamide derivatives |
PT2820008T (pt) | 2012-03-02 | 2017-05-05 | Genentech Inc | Amidas amido-espirocíclicas e derivados de sulfonamidas |
CA2873060A1 (en) | 2012-05-11 | 2013-11-14 | Abbvie Inc. | Nampt inhibitors |
US10144742B2 (en) | 2014-04-18 | 2018-12-04 | Millennium Pharmaceuticals, Inc. | Quinoxaline compounds and uses thereof |
CA2954328A1 (en) | 2014-07-23 | 2016-01-28 | Aurigene Discovery Technologies Limited | 4,5-dihydroisoxazole derivatives as nampt inhibitors |
CN107438598A (zh) * | 2015-01-20 | 2017-12-05 | 米伦纽姆医药公司 | 喹唑啉和喹啉化合物及其用途 |
EP3452461B1 (en) | 2016-05-02 | 2021-09-08 | The Regents of The University of Michigan | Piperidines as menin inhibitors |
SG11201903013SA (en) | 2016-10-18 | 2019-05-30 | Seattle Genetics Inc | Targeted delivery of nicotinamide adenine dinucleotide salvage pathway inhibitors |
US11045448B2 (en) | 2017-03-31 | 2021-06-29 | The Regents Of The University Of Michigan | Piperidines as covalent menin inhibitors |
BR112019022445A2 (pt) | 2017-04-27 | 2020-05-12 | Seattle Genetics, Inc. | Composição de conjugado ligante-fármaco, formulação, método para inibir a multiplicação de uma célula tumoral ou célula cancerosa ou causar apoptose em uma célula tumoral ou cancerosa, e, composto de conector de fármaco |
JP2019137638A (ja) * | 2018-02-09 | 2019-08-22 | アピオン・ジャパン有限会社 | 新規nampt阻害剤およびそれを含有する抗腫瘍剤、新規nampt阻害剤のスクリーニング方法、新規naprt阻害剤およびそれを含有する抗腫瘍剤、新規naprt阻害剤のスクリーニング方法、腫瘍細胞に対して正常細胞の割合を増やすための方法、並びに抗腫瘍剤の処方を補助する方法 |
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WO2022109285A1 (en) * | 2020-11-20 | 2022-05-27 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Methods and materials for inhibiting nicotinamide phosphoribosyltransferase activity |
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- 2011-09-02 JP JP2014510294A patent/JP5872027B2/ja not_active Expired - Fee Related
- 2011-09-02 IN IN2014MUN2013 patent/IN2013MN02014A/en unknown
- 2011-09-02 TW TW100131859A patent/TW201245188A/zh unknown
- 2011-09-02 AU AU2011367809A patent/AU2011367809B2/en not_active Ceased
- 2011-09-02 RU RU2013154416A patent/RU2617643C2/ru active IP Right Revival
- 2011-09-02 CN CN201610403792.6A patent/CN106083886A/zh active Pending
- 2011-09-02 KR KR1020137032144A patent/KR20140038443A/ko not_active Application Discontinuation
- 2011-09-02 MX MX2013013041A patent/MX347459B/es active IP Right Grant
- 2011-09-02 BR BR112013028877A patent/BR112013028877A2/pt not_active Application Discontinuation
- 2011-09-02 WO PCT/US2011/050303 patent/WO2012154194A1/en active Application Filing
- 2011-09-02 AR ARP110103222A patent/AR082889A1/es unknown
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2016
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2018
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US20170137441A1 (en) | 2017-05-18 |
JP5872027B2 (ja) | 2016-03-01 |
JP2014516951A (ja) | 2014-07-17 |
CN103874686A (zh) | 2014-06-18 |
CA2834745A1 (en) | 2012-11-15 |
BR112013028877A2 (pt) | 2017-01-31 |
TW201245188A (en) | 2012-11-16 |
WO2012154194A1 (en) | 2012-11-15 |
RU2013154416A (ru) | 2015-06-20 |
US20190031686A1 (en) | 2019-01-31 |
IN2013MN02014A (es) | 2015-06-12 |
AR082889A1 (es) | 2013-01-16 |
AU2011367809B2 (en) | 2017-04-27 |
CN103874686B (zh) | 2016-08-17 |
RU2617643C2 (ru) | 2017-04-25 |
JP2016104787A (ja) | 2016-06-09 |
US20210246147A1 (en) | 2021-08-12 |
MX2013013041A (es) | 2013-12-02 |
US20230110003A1 (en) | 2023-04-13 |
AU2011367809A1 (en) | 2013-11-21 |
KR20140038443A (ko) | 2014-03-28 |
CN106083886A (zh) | 2016-11-09 |
US20140248240A1 (en) | 2014-09-04 |
US9555039B2 (en) | 2017-01-31 |
US11479564B2 (en) | 2022-10-25 |
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