MX2013013041A - Nuevos compuestos y composiciones para la inhibicion de nampt. - Google Patents

Nuevos compuestos y composiciones para la inhibicion de nampt.

Info

Publication number
MX2013013041A
MX2013013041A MX2013013041A MX2013013041A MX2013013041A MX 2013013041 A MX2013013041 A MX 2013013041A MX 2013013041 A MX2013013041 A MX 2013013041A MX 2013013041 A MX2013013041 A MX 2013013041A MX 2013013041 A MX2013013041 A MX 2013013041A
Authority
MX
Mexico
Prior art keywords
nampt
inhibition
compositions
piperidine derivatives
nicotinamide phosphoribosyltransferase
Prior art date
Application number
MX2013013041A
Other languages
English (en)
Other versions
MX347459B (es
Inventor
Jian Lin
Alexandre J Buckmelter
Kenneth W Bair
Bingsong Han
Dominic J Reynolds
Chase C Smith
Zhongguo Wang
Xiaozhang Zheng
Karl H Clodfelter
Timm Baumeister
Judith D Kuntz
Original Assignee
Forma Tm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forma Tm Llc filed Critical Forma Tm Llc
Publication of MX2013013041A publication Critical patent/MX2013013041A/es
Publication of MX347459B publication Critical patent/MX347459B/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/47—Quinolines; Isoquinolines
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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Abstract

La presente invención se refiere a compuestos y composiciones para la inhibición de NAMPT, su síntesis, aplicaciones y antídotos. Se muestra a continuación un compuesto ilustrativo de la invención: (Ver Formula).
MX2013013041A 2011-05-09 2011-09-02 Nuevos compuestos y composiciones para la inhibición de nampt. MX347459B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161483937P 2011-05-09 2011-05-09
US201161512546P 2011-07-28 2011-07-28
PCT/US2011/050303 WO2012154194A1 (en) 2011-05-09 2011-09-02 Piperidine derivatives and compositions for the inhibition of nicotinamide phosphoribosyltransferase (nampt)

Publications (2)

Publication Number Publication Date
MX2013013041A true MX2013013041A (es) 2013-12-02
MX347459B MX347459B (es) 2017-04-26

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MX2013013041A MX347459B (es) 2011-05-09 2011-09-02 Nuevos compuestos y composiciones para la inhibición de nampt.

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US (5) US9555039B2 (es)
JP (2) JP5872027B2 (es)
KR (1) KR20140038443A (es)
CN (2) CN106083886A (es)
AR (1) AR082889A1 (es)
AU (1) AU2011367809B2 (es)
BR (1) BR112013028877A2 (es)
CA (1) CA2834745A1 (es)
IN (1) IN2013MN02014A (es)
MX (1) MX347459B (es)
RU (1) RU2617643C2 (es)
TW (1) TW201245188A (es)
WO (1) WO2012154194A1 (es)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201217359A (en) 2010-09-03 2012-05-01 Forma Therapeutics Inc Novel compounds and compositions for the inhibition of NAMPT
PE20140011A1 (es) 2010-09-03 2014-01-31 Forma Tm Llc Compuestos y composiciones novedosos para la inhibicion de nampt
IN2013MN02014A (es) 2011-05-09 2015-06-12 Forma Tm Llc
EP2820018A4 (en) 2012-03-02 2015-09-02 Genentech Inc AMIDO-BENZYLIC SULFOXIDE AND SULFONES DERIVATIVES
WO2013127268A1 (en) * 2012-03-02 2013-09-06 Genentech,Inc. Amido-benzyl sulfone and sulfonamide derivatives
CN104520290B (zh) 2012-03-02 2020-10-09 基因科技股份有限公司 酰氨基螺环酰胺和磺酰胺衍生物
BR112014028042A2 (pt) * 2012-05-11 2017-06-27 Abbvie Inc inibidores de nampt
CA2946130A1 (en) 2014-04-18 2015-10-22 Millennium Pharmaceuticals, Inc. Quinoxaline compounds and uses thereof
CA2954328A1 (en) 2014-07-23 2016-01-28 Aurigene Discovery Technologies Limited 4,5-dihydroisoxazole derivatives as nampt inhibitors
CA2974078A1 (en) * 2015-01-20 2016-07-28 Millennium Pharmaceuticals, Inc. Quinazoline and quinoline compounds and uses thereof
BR112018072570A2 (pt) 2016-05-02 2019-02-19 Univ Michigan Regents piperidinas como inibidores de menina
US11638762B2 (en) 2016-10-18 2023-05-02 Seagen Inc. Targeted delivery of nicotinamide adenine dinucleotide salvage pathway inhibitors
WO2018183857A1 (en) 2017-03-31 2018-10-04 The Regents Of The University Of Michigan Piperidines as covalent menin inhibitors
WO2018201087A1 (en) 2017-04-27 2018-11-01 Seattle Genetics, Inc. Quaternized nicotinamide adenine dinucleotide salvage pathway inhibitor conjugates
JP2019137638A (ja) * 2018-02-09 2019-08-22 アピオン・ジャパン有限会社 新規ｎａｍｐｔ阻害剤およびそれを含有する抗腫瘍剤、新規ｎａｍｐｔ阻害剤のスクリーニング方法、新規ｎａｐｒｔ阻害剤およびそれを含有する抗腫瘍剤、新規ｎａｐｒｔ阻害剤のスクリーニング方法、腫瘍細胞に対して正常細胞の割合を増やすための方法、並びに抗腫瘍剤の処方を補助する方法
US20220160688A1 (en) * 2019-03-20 2022-05-26 The Johns Hopkins University Inhibition of nampt and/or sarm1 for the treatment of axonal degradation
US20230020507A1 (en) * 2019-10-04 2023-01-19 Parenchyma Biotech Inc. Compound and use thereof in treating autoimmune diseases
WO2022109285A1 (en) * 2020-11-20 2022-05-27 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods and materials for inhibiting nicotinamide phosphoribosyltransferase activity

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2777159B2 (ja) * 1988-12-22 1998-07-16 エーザイ株式会社 環状アミン誘導体を含有する医薬
DE19624704A1 (de) 1996-06-20 1998-01-08 Klinge Co Chem Pharm Fab Neue Pyridylalkansäureamide
DE19624668A1 (de) 1996-06-20 1998-02-19 Klinge Co Chem Pharm Fab Verwendung von Pyridylalkan-, Pyridylalken- bzw. Pyridylalkinsäureamiden
DE19624659A1 (de) 1996-06-20 1998-01-08 Klinge Co Chem Pharm Fab Neue Pyridylalken- und Pyridylalkinsäureamide
DE19756212A1 (de) 1997-12-17 1999-07-01 Klinge Co Chem Pharm Fab Neue, mit einem cyclischen Imid substituierte Pyridylalkan-, alken- und -alkincarbonsäureamide
DE19756235A1 (de) 1997-12-17 1999-07-01 Klinge Co Chem Pharm Fab Neue piperidinylsubstituierte Pyridylalkan- alken- und -alkincarbonsäureamide
DE19756236A1 (de) 1997-12-17 1999-07-01 Klinge Co Chem Pharm Fab Neue piperazinylsubstituierte Pyridylalkan-, alken- und -alkincarbonsäureamide
DE19756261A1 (de) 1997-12-17 1999-07-01 Klinge Co Chem Pharm Fab Neue arylsubstituierte Pyridylalkan-, alken- und alkincarbonsäureamide
EP1031564A1 (en) 1999-02-26 2000-08-30 Klinge Pharma GmbH Inhibitors of cellular nicotinamide mononucleotide formation and their use in cancer therapy
US6506901B2 (en) 2000-07-17 2003-01-14 Wyeth Substituted 2-(S)-hydroxy-3-(piperidin-4-yl-methylamino)-propyl ethers and substituted 2-aryl-2-(R)-hydroxy-1-(piperidin-4-yl-methyl)-ethylamine β-3 adrenergic receptor agonists
CA2449999C (en) 2001-06-11 2012-07-31 Shire Biochem Inc. Compounds and methods for the treatment or prevention of flavivirus infections
FR2831536A1 (fr) 2001-10-26 2003-05-02 Aventis Pharma Sa Nouveaux derives de benzimidazoles, leur procede de preparation, leur application a titre de medicament, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de kdr
EP1348434A1 (en) 2002-03-27 2003-10-01 Fujisawa Deutschland GmbH Use of pyridyl amides as inhibitors of angiogenesis
KR20050010018A (ko) 2002-05-31 2005-01-26 다케다 야쿠힌 고교 가부시키가이샤 피페리딘 유도체, 이의 제조 방법 및 용도
NZ552283A (en) * 2002-06-20 2008-07-31 Biovitrum Ab Publ New compounds useful for the treatment of obesity, type II diabetes and CNS disorders
US7491827B2 (en) 2002-12-23 2009-02-17 Millennium Pharmaceuticals, Inc. Aryl sulfonamides useful as inhibitors of chemokine receptor activity
WO2007056155A1 (en) * 2005-11-03 2007-05-18 Chembridge Research Laboratories, Inc. Heterocyclic compounds as tyrosine kinase modulators
CN101007814A (zh) * 2006-01-27 2007-08-01 上海恒瑞医药有限公司 吡咯并六元杂环化合物及其在医药上的用途
WO2008026018A1 (en) * 2006-09-01 2008-03-06 Topotarget Switzerland Sa New method for the treatment of inflammatory diseases
US8450348B2 (en) 2007-02-21 2013-05-28 Forma Tm, Llc Derivatives of squaric acid with anti-proliferative activity
EP2440527A1 (en) 2009-06-09 2012-04-18 Topo Target A/S Pyridinyl derivatives as inhibitors of enzyme nicotinamide phosphoribosyltransferase
TW201217359A (en) 2010-09-03 2012-05-01 Forma Therapeutics Inc Novel compounds and compositions for the inhibition of NAMPT
PE20140011A1 (es) 2010-09-03 2014-01-31 Forma Tm Llc Compuestos y composiciones novedosos para la inhibicion de nampt
AR082886A1 (es) * 2010-09-03 2013-01-16 Forma Therapeutics Inc Compuestos y composiciones farmaceuticas que los contienen
TW201238950A (en) * 2010-11-15 2012-10-01 Abbott Lab NAMPT and rock inhibitors
BR112013028281A2 (pt) * 2011-05-04 2017-01-10 Forma Tm Llc compostos e composições para inibição de nampt
IN2013MN02014A (es) * 2011-05-09 2015-06-12 Forma Tm Llc
CN104520290B (zh) 2012-03-02 2020-10-09 基因科技股份有限公司 酰氨基螺环酰胺和磺酰胺衍生物
SG11201405055TA (en) 2012-03-02 2014-09-26 Genentech Inc Pyridinyl and pyrimidinyl sulfoxide and sulfone derivatives
EP2820018A4 (en) 2012-03-02 2015-09-02 Genentech Inc AMIDO-BENZYLIC SULFOXIDE AND SULFONES DERIVATIVES

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