BR112013028281A2 - compostos e composições para inibição de nampt - Google Patents
compostos e composições para inibição de namptInfo
- Publication number
- BR112013028281A2 BR112013028281A2 BR112013028281A BR112013028281A BR112013028281A2 BR 112013028281 A2 BR112013028281 A2 BR 112013028281A2 BR 112013028281 A BR112013028281 A BR 112013028281A BR 112013028281 A BR112013028281 A BR 112013028281A BR 112013028281 A2 BR112013028281 A2 BR 112013028281A2
- Authority
- BR
- Brazil
- Prior art keywords
- nampt
- compositions
- inhibiting compounds
- inhibiting
- compounds
- Prior art date
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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- A61K31/5375—1,4-Oxazines, e.g. morpholine
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
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Abstract
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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US201161482537P | 2011-05-04 | 2011-05-04 | |
PCT/US2011/050301 WO2012150952A1 (en) | 2011-05-04 | 2011-09-02 | Novel compounds and compositions for the inhibition of nampt |
Publications (1)
Publication Number | Publication Date |
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BR112013028281A2 true BR112013028281A2 (pt) | 2017-01-10 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112013028281A BR112013028281A2 (pt) | 2011-05-04 | 2011-09-02 | compostos e composições para inibição de nampt |
Country Status (12)
Country | Link |
---|---|
US (1) | US9169209B2 (pt) |
JP (2) | JP5978293B2 (pt) |
KR (1) | KR20140027366A (pt) |
CN (1) | CN103717574B (pt) |
AR (1) | AR082888A1 (pt) |
AU (1) | AU2011367222B2 (pt) |
BR (1) | BR112013028281A2 (pt) |
CA (1) | CA2834746A1 (pt) |
MX (1) | MX2013012760A (pt) |
RU (2) | RU2017112522A (pt) |
TW (1) | TW201245152A (pt) |
WO (1) | WO2012150952A1 (pt) |
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WO2012031197A1 (en) | 2010-09-03 | 2012-03-08 | Forma Therapeutics, Inc. | Novel compounds and compositions for the inhibition of nampt |
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AU2011367222B2 (en) * | 2011-05-04 | 2017-04-13 | Forma Tm, Llc | Novel compounds and compositions for the inhibition of NAMPT |
IN2013MN02014A (pt) | 2011-05-09 | 2015-06-12 | Forma Tm Llc | |
EP2820018A4 (en) | 2012-03-02 | 2015-09-02 | Genentech Inc | AMIDO-BENZYLIC SULFOXIDE AND SULFONES DERIVATIVES |
JP6404717B2 (ja) | 2012-03-02 | 2018-10-17 | ジェネンテック, インコーポレイテッド | アミドスピロ環状アミド及びスルホンアミド誘導体 |
BR112014025564B8 (pt) * | 2012-04-17 | 2021-03-30 | Fujifilm Corp | composto heterocíclico contendo nitrogênio ou sal do mesmo, composição farmacêutica e uso da mesma |
WO2014085607A1 (en) * | 2012-11-29 | 2014-06-05 | Karyopharm Therapeutics Inc. | Substituted 2,3-dihydrobenzofuranyl compounds and uses thereof |
US10233179B2 (en) | 2013-04-22 | 2019-03-19 | Abbvie Inc. | Thiazoles and uses thereof |
CN105492437B (zh) | 2013-07-03 | 2018-05-11 | 卡尔约药物治疗公司 | 取代的苯并呋喃基和苯并噁唑基化合物及其用途 |
WO2015042414A1 (en) | 2013-09-20 | 2015-03-26 | Karyopharm Therapeutics Inc. | Multicyclic compounds and methods of using same |
DK3059227T3 (da) | 2013-10-16 | 2019-08-26 | Fujifilm Corp | Salt af en nitrogen-holdig heterocyklisk forbindelse eller krystal deraf, farmaceutisk sammensætning og flt3-hæmmer |
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SG11201700039TA (en) | 2014-07-23 | 2017-02-27 | Aurigene Discovery Tech Ltd | 4,5-dihydroisoxazole derivatives as nampt inhibitors |
BR112017003186A2 (pt) | 2014-08-22 | 2017-11-28 | Fujifilm Corp | composição farmacêutica para tratamento de cancer positivo para mutação em flt3, inibidor de flt3 mutante e usos dos mesmos |
CN104557863B (zh) * | 2014-12-18 | 2017-03-15 | 中国科学院广州生物医药与健康研究院 | 一种新型烟酰胺磷酸核糖转移酶抑制剂及其合成方法与应用 |
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CN106085996A (zh) * | 2016-06-17 | 2016-11-09 | 上海理工大学 | 复合稳定剂及添加该复合稳定剂的nmn转移酶的酶活测定方法 |
BR112019006778A2 (pt) | 2016-10-18 | 2019-10-15 | Seattle Genetics Inc | Composição de conjugado de aglutinante-fármaco, formulação, uso da mesma, método para preparar uma composição ou composto de conjugado de aglutinantefármaco,e, composto de ligante de fármaco |
WO2018085379A2 (en) * | 2016-11-02 | 2018-05-11 | Sanford Burnham Prebys Medical Discovery Institute | Dual-activity nicotinamide phosphoribosyltransferase inhibitors |
US11931414B2 (en) | 2017-04-27 | 2024-03-19 | Seagen Inc. | Quaternized nicotinamide adenine dinucleotide salvage pathway inhibitor conjugates |
US10471045B2 (en) * | 2017-07-21 | 2019-11-12 | The University Of Hong Kong | Compounds and methods for the treatment of microbial infections |
WO2019031902A2 (ko) | 2017-08-11 | 2019-02-14 | (주)아모레퍼시픽 | (r)-n-[1-(3,5-다이플루오로-4-메테인설폰일아미노-페닐)-에틸]-3-(2-프로필-6-트라이플루오로메틸-피리딘-3-일)-아크릴아마이드를 함유하는 약학 조성물 |
CN107814788B (zh) * | 2017-12-22 | 2018-08-31 | 博奥信生物技术(南京)有限公司 | 一种磺酰胺衍生物、制备方法及其作为nampt抑制剂的应用 |
CN107915721A (zh) * | 2017-12-22 | 2018-04-17 | 田立志 | 一种磺酰胺衍生物及其作为烟酰胺磷酸核糖转移酶抑制剂在抗肿瘤药物中的应用 |
CN107987060A (zh) * | 2017-12-22 | 2018-05-04 | 田立志 | 一种磺酰胺衍生物及其作为nampt抑制剂在抗肿瘤药物中的应用 |
AU2019214858B2 (en) | 2018-01-30 | 2023-02-02 | Metro International Biotech, Llc | Nicotinamide riboside analogs, pharmaceutical compositions, and uses thereof |
EP3749306A4 (en) * | 2018-02-05 | 2022-01-12 | The Trustees of Indiana University | NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE INHIBITORS AND METHODS OF USE THEREOF |
KR102518632B1 (ko) | 2018-04-18 | 2023-04-06 | (주)아모레퍼시픽 | (r)-n-[1-(3,5-다이플루오로-4-메테인설폰일아미노-페닐)-에틸]-3-(2-프로필-6-트라이플루오로메틸-피리딘-3-일)-아크릴아마이드를 함유하는 약학 조성물 |
WO2020010252A1 (en) * | 2018-07-05 | 2020-01-09 | Daiichi Sankyo Company, Limited | Fused ring compound having urea structure |
US10618927B1 (en) | 2019-03-22 | 2020-04-14 | Metro International Biotech, Llc | Compositions and methods for modulation of nicotinamide adenine dinucleotide |
US11939348B2 (en) | 2019-03-22 | 2024-03-26 | Metro International Biotech, Llc | Compositions comprising a phosphorus derivative of nicotinamide riboside and methods for modulation of nicotinamide adenine dinucleotide |
FR3103702B1 (fr) * | 2019-11-28 | 2022-02-11 | Nuvamid Sa | Utilisation de NMN pour la prévention et/ou le traitement de la spondylarthrite ankylosante et compositions correspondantes |
KR20240020716A (ko) | 2021-05-27 | 2024-02-15 | 메트로 인터내셔널 바이오테크 엘엘씨 | 니코틴산 모노뉴클레오타이드 및 이의 에스터의 결정질 고체 및 제조 및 사용 방법 |
CN114540844B (zh) * | 2022-02-24 | 2024-02-20 | 青岛科技大学 | 一种电催化下苯并噻吩衍生物的制备方法 |
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ITMI20050261A1 (it) * | 2005-02-21 | 2006-08-22 | Carlo Ghisalberti | Analoghi strutturali di avenatramidi loro uso in composizioni utili nel trattamento di disordini dermatologici |
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FR2943675A1 (fr) | 2009-03-24 | 2010-10-01 | Sanofi Aventis | Composes anticancereux, leur preparation et leur application en therapeutique |
FR2943669B1 (fr) | 2009-03-24 | 2011-05-06 | Sanofi Aventis | Derives de nicotinamide,leur preparation et leur application en therapeutique |
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AU2011367222B2 (en) * | 2011-05-04 | 2017-04-13 | Forma Tm, Llc | Novel compounds and compositions for the inhibition of NAMPT |
-
2011
- 2011-09-02 AU AU2011367222A patent/AU2011367222B2/en not_active Ceased
- 2011-09-02 CN CN201180072114.1A patent/CN103717574B/zh not_active Expired - Fee Related
- 2011-09-02 US US14/115,623 patent/US9169209B2/en active Active
- 2011-09-02 BR BR112013028281A patent/BR112013028281A2/pt not_active Application Discontinuation
- 2011-09-02 MX MX2013012760A patent/MX2013012760A/es unknown
- 2011-09-02 RU RU2017112522A patent/RU2017112522A/ru not_active Application Discontinuation
- 2011-09-02 WO PCT/US2011/050301 patent/WO2012150952A1/en active Application Filing
- 2011-09-02 AR ARP110103221A patent/AR082888A1/es unknown
- 2011-09-02 CA CA2834746A patent/CA2834746A1/en not_active Abandoned
- 2011-09-02 JP JP2014509277A patent/JP5978293B2/ja not_active Expired - Fee Related
- 2011-09-02 KR KR1020137031759A patent/KR20140027366A/ko not_active Application Discontinuation
- 2011-09-02 TW TW100131862A patent/TW201245152A/zh unknown
- 2011-09-02 RU RU2013153529A patent/RU2616612C2/ru active IP Right Revival
-
2016
- 2016-06-03 JP JP2016112149A patent/JP2016199556A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
TW201245152A (en) | 2012-11-16 |
CA2834746A1 (en) | 2012-11-08 |
MX2013012760A (es) | 2014-03-12 |
JP2014513119A (ja) | 2014-05-29 |
AU2011367222A1 (en) | 2013-11-21 |
WO2012150952A1 (en) | 2012-11-08 |
RU2017112522A (ru) | 2019-01-24 |
AR082888A1 (es) | 2013-01-16 |
JP5978293B2 (ja) | 2016-08-24 |
RU2616612C2 (ru) | 2017-04-18 |
CN103717574A (zh) | 2014-04-09 |
RU2013153529A (ru) | 2015-06-10 |
CN103717574B (zh) | 2017-02-22 |
US9169209B2 (en) | 2015-10-27 |
JP2016199556A (ja) | 2016-12-01 |
US20140275057A1 (en) | 2014-09-18 |
AU2011367222B2 (en) | 2017-04-13 |
KR20140027366A (ko) | 2014-03-06 |
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