MX2013002461A - Compuestos y composiciones novedosos para la inhibición de nampt. - Google Patents

Compuestos y composiciones novedosos para la inhibición de nampt.

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Publication number
MX2013002461A
MX2013002461A MX2013002461A MX2013002461A MX2013002461A MX 2013002461 A MX2013002461 A MX 2013002461A MX 2013002461 A MX2013002461 A MX 2013002461A MX 2013002461 A MX2013002461 A MX 2013002461A MX 2013002461 A MX2013002461 A MX 2013002461A
Authority
MX
Mexico
Prior art keywords
nampt
inhibition
compositions
novel compounds
compounds
Prior art date
Application number
MX2013002461A
Other languages
English (en)
Other versions
MX347889B (es
Inventor
Jian Lin
Alexandre J Buckmelter
Francis Gosselin
Kenneth W Bair
Bingsong Han
Dominic J Reynolds
Chase C Smith
Zhongguo Wang
Xiaozhang Zheng
Timm R Baumeister
Karl H Clodfelter
Po-Wai Yuen
Peter DRAGOVICH
Bruce Roth
Original Assignee
Forma Tm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forma Tm Llc filed Critical Forma Tm Llc
Publication of MX2013002461A publication Critical patent/MX2013002461A/es
Publication of MX347889B publication Critical patent/MX347889B/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
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    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • C07D495/04—Ortho-condensed systems

Abstract

La presente invención se refiere a compuestos y a composiciones para la inhibición de NAMPT, a sus síntesis, aplicaciones y antídotos. A continuación se muestra un compuesto ilustrativo de la invención: (ver Fórmula (I)).
MX2013002461A 2010-09-03 2011-09-02 Compuestos y composiciones novedosos para la inhibición de nampt. MX347889B (es)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US37979610P 2010-09-03 2010-09-03
US37978910P 2010-09-03 2010-09-03
US38602810P 2010-09-24 2010-09-24
US38602310P 2010-09-24 2010-09-24
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