BR112013004773A2 - compostos e composições para a inibição de nampt - Google Patents

compostos e composições para a inibição de nampt

Info

Publication number
BR112013004773A2
BR112013004773A2 BR112013004773A BR112013004773A BR112013004773A2 BR 112013004773 A2 BR112013004773 A2 BR 112013004773A2 BR 112013004773 A BR112013004773 A BR 112013004773A BR 112013004773 A BR112013004773 A BR 112013004773A BR 112013004773 A2 BR112013004773 A2 BR 112013004773A2
Authority
BR
Brazil
Prior art keywords
compositions
compounds
nampt
inhibiting nampt
inhibiting
Prior art date
Application number
BR112013004773A
Other languages
English (en)
Other versions
BR112013004773B1 (pt
Inventor
J Buckmelter Alexandre
Han Bingsong
Roth Bruce
C Smith Chase
J Reynolds Dominic
Gosselin Francis
Lin Jian
H Clodfelter Karl
W Bair Kenneth
Dragovich Peter
Yuen Po-Wai
Baumeister Timm
Zheng Xiaozhang
Wang Zhongguo
Original Assignee
Forma Tm Llc
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Forma Tm Llc, Genentech Inc filed Critical Forma Tm Llc
Publication of BR112013004773A2 publication Critical patent/BR112013004773A2/pt
Publication of BR112013004773B1 publication Critical patent/BR112013004773B1/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • C07D495/04—Ortho-condensed systems

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Abstract

compostos e composições para a inibição de nampt. a presente invenção refere-se a compostos e composições para a inibição de nampt, sua síntese, aplicações e antídotos. um composto ilustrativo da invenção é mostrado abaixo.
BR112013004773-9A 2010-09-03 2011-09-02 Compostos, seus usos, e composições para a inibição de nampt BR112013004773B1 (pt)

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US37979610P 2010-09-03 2010-09-03
US37978910P 2010-09-03 2010-09-03
US61/379,796 2010-09-03
US61/379,789 2010-09-03
US38602310P 2010-09-24 2010-09-24
US38602810P 2010-09-24 2010-09-24
US61/386,023 2010-09-24
US201161475813P 2011-04-15 2011-04-15
US61/475,813 2011-04-15
US201161483242P 2011-05-06 2011-05-06
US61/483,242 2011-05-06
PCT/US2011/050321 WO2012031197A1 (en) 2010-09-03 2011-09-02 Novel compounds and compositions for the inhibition of nampt

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US11547701B2 (en) 2023-01-10
EP2611804A1 (en) 2013-07-10
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JP2016138103A (ja) 2016-08-04
MY190351A (en) 2022-04-15
RU2013114846A (ru) 2014-10-10
CN103384668A (zh) 2013-11-06
CA2810038A1 (en) 2012-03-08
US20190388405A1 (en) 2019-12-26
US20190105307A1 (en) 2019-04-11
WO2012031197A1 (en) 2012-03-08
AR082885A1 (es) 2013-01-16
US10272072B2 (en) 2019-04-30
MX2013002461A (es) 2013-07-29
AU2011295725B2 (en) 2015-03-26
ZA201301329B (en) 2014-04-30
NZ607638A (en) 2015-04-24
RU2617988C2 (ru) 2017-05-02
US20140294805A1 (en) 2014-10-02
CR20130104A (es) 2013-06-27
US20210244717A1 (en) 2021-08-12
JP5881704B2 (ja) 2016-03-09
JP2013536869A (ja) 2013-09-26
KR20130114119A (ko) 2013-10-16
IN2013CN02463A (pt) 2015-08-07
BR112013004773B1 (pt) 2022-05-31
CN103384668B (zh) 2017-05-31
AU2011295725A1 (en) 2013-03-28
MX347889B (es) 2017-05-17
PE20140011A1 (es) 2014-01-31
SG188367A1 (en) 2013-04-30
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US20170368039A1 (en) 2017-12-28
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