AR037929A1 - Un compuesto derivado funcional del acido hidroxamico o caloxilico, composiciones farmaceuticas y el uso de dichos compuestos para la fabricacion de un medicamento para el tratamiento de trastornos inflamatorios - Google Patents
Un compuesto derivado funcional del acido hidroxamico o caloxilico, composiciones farmaceuticas y el uso de dichos compuestos para la fabricacion de un medicamento para el tratamiento de trastornos inflamatoriosInfo
- Publication number
- AR037929A1 AR037929A1 ARP020105015A ARP020105015A AR037929A1 AR 037929 A1 AR037929 A1 AR 037929A1 AR P020105015 A ARP020105015 A AR P020105015A AR P020105015 A ARP020105015 A AR P020105015A AR 037929 A1 AR037929 A1 AR 037929A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- nr24r25
- alkyl
- independently selected
- aryl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- NEAQRZUHTPSBBM-UHFFFAOYSA-N 2-hydroxy-3,3-dimethyl-7-nitro-4h-isoquinolin-1-one Chemical compound C1=C([N+]([O-])=O)C=C2C(=O)N(O)C(C)(C)CC2=C1 NEAQRZUHTPSBBM-UHFFFAOYSA-N 0.000 title abstract 2
- 208000027866 inflammatory disease Diseases 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title 1
- 229940126601 medicinal product Drugs 0.000 title 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 19
- 125000003118 aryl group Chemical group 0.000 abstract 18
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 17
- 125000000217 alkyl group Chemical group 0.000 abstract 15
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 15
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 10
- 125000004366 heterocycloalkenyl group Chemical group 0.000 abstract 10
- 125000001475 halogen functional group Chemical group 0.000 abstract 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 4
- 229910052799 carbon Inorganic materials 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 4
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 4
- 125000002947 alkylene group Chemical group 0.000 abstract 3
- 125000006340 pentafluoro ethyl group Chemical group FC(F)(F)C(F)(F)* 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000000732 arylene group Chemical group 0.000 abstract 2
- 125000002993 cycloalkylene group Chemical group 0.000 abstract 2
- 125000005549 heteroarylene group Chemical group 0.000 abstract 2
- 125000006588 heterocycloalkylene group Chemical group 0.000 abstract 2
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 2
- XXJGBENTLXFVFI-UHFFFAOYSA-N 1-amino-methylene Chemical compound N[CH2] XXJGBENTLXFVFI-UHFFFAOYSA-N 0.000 abstract 1
- 101100173726 Arabidopsis thaliana OR23 gene Proteins 0.000 abstract 1
- 102000002274 Matrix Metalloproteinases Human genes 0.000 abstract 1
- 108010000684 Matrix Metalloproteinases Proteins 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 125000004446 heteroarylalkyl group Chemical group 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
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- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/08—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of rings other than six-membered aromatic rings
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- C07C279/08—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by singly-bound oxygen atoms
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- C07C69/757—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
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- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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| US7977322B2 (en) | 2004-08-20 | 2011-07-12 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
| US7676590B2 (en) * | 2004-05-03 | 2010-03-09 | Microsoft Corporation | Background transcoding |
| TWI350168B (en) | 2004-05-07 | 2011-10-11 | Incyte Corp | Amido compounds and their use as pharmaceuticals |
| EP1773773A4 (en) * | 2004-06-24 | 2009-07-29 | Incyte Corp | AMID COMPOUNDS AND THEIR USE AS MEDICAMENTS |
| JP2008504276A (ja) * | 2004-06-24 | 2008-02-14 | インサイト・コーポレイション | アミド化合物およびその医薬としての使用 |
| WO2006050122A1 (en) * | 2004-10-29 | 2006-05-11 | Sandoz Ag | Processes for preparing glatiramer |
| AU2005315975A1 (en) * | 2004-12-14 | 2006-06-22 | Sanofi-Aventis Deutschland Gmbh | Use of substituted cyclopropane acid derivatives for producing drugs for use in the treatment of metabolic syndrome |
| ATE518853T1 (de) | 2005-08-12 | 2011-08-15 | Schering Corp | Verbindungen zur behandlung entzündlicher erkrankungen |
| BRPI0619446A2 (pt) | 2005-12-05 | 2011-10-04 | Incyte Corp | compostos de lactama, suas composições e método de modulação da atividade de 11bhsd1 |
| US7998959B2 (en) | 2006-01-12 | 2011-08-16 | Incyte Corporation | Modulators of 11-β hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same |
| EP2018378A2 (en) | 2006-05-17 | 2009-01-28 | Incyte Corporation | Heterocyclic inhibitors of 11-b hydroxyl steroid dehydrogenase type i and methods of using the same |
| US8153166B2 (en) * | 2006-06-08 | 2012-04-10 | Chih-Hsiung Lin | Composition for prophylaxis or treatment of urinary system infection and method thereof |
| JP5203360B2 (ja) | 2006-06-23 | 2013-06-05 | アボット・ラボラトリーズ | ヒスタミンh3受容体調節剤としてのシクロプロピルアミン誘導体 |
| US9108948B2 (en) * | 2006-06-23 | 2015-08-18 | Abbvie Inc. | Cyclopropyl amine derivatives |
| WO2010108187A2 (en) * | 2009-03-20 | 2010-09-23 | Brandeis University | Compounds and methods for treating mammalian gastrointestinal microbial infections |
| US9186353B2 (en) | 2009-04-27 | 2015-11-17 | Abbvie Inc. | Treatment of osteoarthritis pain |
| CN102241627B (zh) * | 2010-05-14 | 2014-07-02 | 中国人民解放军总医院 | 脲类化合物及其医药用途 |
| WO2012037258A1 (en) | 2010-09-16 | 2012-03-22 | Abbott Laboratories | Processes for preparing 1,2-substituted cyclopropyl derivatives |
| SI2790687T1 (sl) * | 2011-12-16 | 2019-01-31 | Poseida Therapeutics, Inc. | TRPC4 modulatorji za uporabo pri zdravljenju ali preprečevanju bolečine |
| EP3074375B1 (en) * | 2013-11-28 | 2018-04-04 | Boehringer Ingelheim International GmbH | New indanyloxyphenylcyclopropanecarboxylic acids |
| RU2016148863A (ru) | 2014-05-14 | 2018-06-18 | Дзе Риджентс Оф Дзе Юниверсити Оф Колорадо, Э Боди Корпорейт | Гетероциклические гидроксамовые кислоты в качестве ингибиторов протеин-деацетилазы и двойных ингибиторов протеин-деацетилазы-протеин-киназы и способы их применения |
| KR20220164216A (ko) * | 2021-06-04 | 2022-12-13 | 에스티팜 주식회사 | 신규한 에르고스텐올 유도체 및 이의 용도 |
Family Cites Families (223)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3740412A (en) | 1970-04-08 | 1973-06-19 | Synvar Ass | Imidazoline-3-oxide-1-oxyl derivatives |
| US3997223A (en) | 1975-04-30 | 1976-12-14 | Dynascan Corporation | Apparatus and method for rejuvenating cathode ray tubes |
| US4166452A (en) | 1976-05-03 | 1979-09-04 | Generales Constantine D J Jr | Apparatus for testing human responses to stimuli |
| US4256108A (en) | 1977-04-07 | 1981-03-17 | Alza Corporation | Microporous-semipermeable laminated osmotic system |
| US4267333A (en) | 1979-09-26 | 1981-05-12 | Union Carbide Agricultural Products Company, Inc. | Preparation of 2-trifluoromethyl cinchoninic acids |
| US4265874A (en) | 1980-04-25 | 1981-05-05 | Alza Corporation | Method of delivering drug with aid of effervescent activity generated in environment of use |
| US4435419A (en) * | 1981-07-01 | 1984-03-06 | American Cyanamid Company | Method of treating depression using azabicyclohexanes |
| US4431661A (en) | 1981-08-20 | 1984-02-14 | American Cyanamid Company | 5-Aryl-3-azabicyclo[3.2.0]heptan-6-one acetals, and analgesic use therefor |
| AU534404B2 (en) | 1981-09-01 | 1984-01-26 | American Cyanamid Company | Cyclopropane derivatives |
| US4490055A (en) | 1982-06-30 | 1984-12-25 | International Business Machines Corporation | Automatically adjustable delay function for timed typamatic |
| US4544665A (en) | 1983-11-21 | 1985-10-01 | American Cyanamid Company | 1-Aryl-3-azabicyclo[3.2.0]heptanes |
| GB2200628A (en) | 1987-02-06 | 1988-08-10 | Shell Int Research | Diphenyl ether herbicides |
| US5089633A (en) | 1987-04-28 | 1992-02-18 | Georgia Tech Research Corporation | Substituted isocoumarins |
| GB8827305D0 (en) | 1988-11-23 | 1988-12-29 | British Bio Technology | Compounds |
| JPH032797A (ja) | 1989-05-30 | 1991-01-09 | Meidensha Corp | 音声合成装置の抑揚制御方式 |
| US5037853A (en) | 1989-12-28 | 1991-08-06 | Abbott Laboratories | Cyclopropyl derivative lipoxygenase inhibitors |
| US5120752A (en) | 1989-12-28 | 1992-06-09 | Abbott Laboratories | Cyclopropyl derivative lipoxygenase inhibitors |
| US5114953A (en) | 1990-11-21 | 1992-05-19 | University Of Florida | Treatment for tissue ulceration |
| GB9102635D0 (en) | 1991-02-07 | 1991-03-27 | British Bio Technology | Compounds |
| US5256657A (en) | 1991-08-19 | 1993-10-26 | Sterling Winthrop, Inc. | Succinamide derivative matrix-metalloprotease inhibitors |
| JP3333510B2 (ja) | 1991-10-02 | 2002-10-15 | スミスクライン・ビーチャム・コーポレイション | 抗アレルギー、抗炎症および腫瘍壊死因子抑制活性を有するシクロペンタンおよびシクロペンテン誘導体 |
| JPH05262698A (ja) | 1992-03-24 | 1993-10-12 | Dainippon Ink & Chem Inc | 光学活性トリフルオロメチルシクロプロパン誘導体、その合成中間体、それを含む液晶組成物及び液晶表示素子 |
| AU3899193A (en) | 1992-04-07 | 1993-11-08 | British Bio-Technology Limited | Hydroxamic acid based collagenase and cytokine inhibitors |
| US5674901A (en) | 1995-06-01 | 1997-10-07 | Wisconsin Alumni Research Foundation | Methods of treating animals to maintain or increase CD-4 and CD-8 cell populations |
| US5318964A (en) | 1992-06-11 | 1994-06-07 | Hoffmann-La Roche Inc. | Hydroxamic derivatives and pharmaceutical compositions |
| JPH07508650A (ja) | 1992-06-25 | 1995-09-28 | カイロン コーポレーション | タンパク質ホルモン形成の阻害のための組成物およびその使用 |
| GB9215665D0 (en) | 1992-07-23 | 1992-09-09 | British Bio Technology | Compounds |
| GB9223904D0 (en) | 1992-11-13 | 1993-01-06 | British Bio Technology | Inhibition of cytokine production |
| US5646167A (en) | 1993-01-06 | 1997-07-08 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamix acids |
| US5506242A (en) | 1993-01-06 | 1996-04-09 | Ciba-Geigy Corporation | Arylsufonamido-substituted hydroxamic acids |
| US5552419A (en) | 1993-01-06 | 1996-09-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
| US5455258A (en) | 1993-01-06 | 1995-10-03 | Ciba-Geigy Corporation | Arylsulfonamido-substituted hydroxamic acids |
| TW290541B (enExample) | 1993-03-18 | 1996-11-11 | Otsuka Pharma Factory Inc | |
| GB9307956D0 (en) | 1993-04-17 | 1993-06-02 | Walls Alan J | Hydroxamic acid derivatives |
| JPH072797A (ja) | 1993-04-19 | 1995-01-06 | Sankyo Co Ltd | コラゲナーゼ阻害剤 |
| GB9311282D0 (en) | 1993-06-01 | 1993-07-21 | Rhone Poulenc Rorer Ltd | New compositions of matter |
| US5594106A (en) | 1993-08-23 | 1997-01-14 | Immunex Corporation | Inhibitors of TNF-α secretion |
| FI960803L (fi) | 1993-08-23 | 1996-04-22 | Immunex Corp | TNF-alfa-sekreetion inhibiittoreita |
| GB9320660D0 (en) | 1993-10-07 | 1993-11-24 | British Bio Technology | Inhibition of cytokine production |
| EP0822186B1 (en) | 1994-01-20 | 2000-03-15 | British Biotech Pharmaceuticals Limited | L-tert-leucine-2-pyridylamide |
| GB9401129D0 (en) | 1994-01-21 | 1994-03-16 | British Bio Technology | Hydroxamic acid derivatives as metalloproteinase inhibitors |
| ES2139183T3 (es) | 1994-01-22 | 2000-02-01 | British Biotech Pharm | Inhibidores de las metaloproteinasas. |
| US5514716A (en) | 1994-02-25 | 1996-05-07 | Sterling Winthrop, Inc. | Hydroxamic acid and carboxylic acid derivatives, process for their preparation and use thereof |
| JPH10504441A (ja) | 1994-03-07 | 1998-05-06 | カイロン コーポレイション | Tnf形成阻害のための組成物およびその使用 |
| GB9501737D0 (en) | 1994-04-25 | 1995-03-22 | Hoffmann La Roche | Hydroxamic acid derivatives |
| WO1995029892A1 (en) | 1994-04-28 | 1995-11-09 | The Du Pont Merck Pharmaceutical Company | Hydroxamic acid and amino acid derivatives and their use as anti-arthritic agents |
| US5817822A (en) | 1994-06-24 | 1998-10-06 | Novartis Corporation | Certain alpha-azacycloalkyl substituted arylsulfonamido acetohydroxamic acids |
| US5840698A (en) | 1994-10-27 | 1998-11-24 | Affymax Technologies N.V. | Inhibitors of collagenase-1 and stormelysin-I metalloproteases, pharmaceutical compositions comprising same and methods of their use |
| JP2902318B2 (ja) | 1994-12-28 | 1999-06-07 | 呉羽化学工業株式会社 | エスクレチン誘導体、その製造方法及びマトリックスメタロプロテアーゼ阻害剤 |
| US5703092A (en) | 1995-04-18 | 1997-12-30 | The Dupont Merck Pharmaceutical Company | Hydroxamic acid compounds as metalloprotease and TNF inhibitors |
| US5691381A (en) | 1995-04-18 | 1997-11-25 | The Dupont Merck Pharmaceutical Company | Hydroxamic and carbocyclic acids as metalloprotease inhibitors |
| US5880141A (en) | 1995-06-07 | 1999-03-09 | Sugen, Inc. | Benzylidene-Z-indoline compounds for the treatment of disease |
| GB2303130A (en) | 1995-07-10 | 1997-02-12 | Secr Defence | Cyclic oligomers of substituted cyclic ethers |
| GB9514867D0 (en) | 1995-07-20 | 1995-09-20 | British Biotech Pharm | Metalloproteinase inhibitors |
| KR980009238A (ko) | 1995-07-28 | 1998-04-30 | 우에노 도시오 | 설포닐아미노산 유도체 |
| EP0848957A1 (en) | 1995-09-08 | 1998-06-24 | Kanebo Ltd. | Fas LIGAND SOLUBILIZATION INHIBITOR |
| KR100472752B1 (ko) | 1995-10-05 | 2006-01-27 | 다윈 디스커버리 리미티드 | 금속단백질 가수분해 효소 및 티엔에프 유리에 대한 억제제로서의 티오-치환펩티드 |
| EP0863885A2 (en) | 1995-11-14 | 1998-09-16 | The Du Pont Merck Pharmaceutical Company | Novel macrocyclic compounds as metalloprotease inhibitors |
| US5665777A (en) | 1995-11-14 | 1997-09-09 | Abbott Laboratories | Biphenyl hydroxamate inhibitors of matrix metalloproteinases |
| ATE205184T1 (de) | 1995-11-23 | 2001-09-15 | British Biotech Pharm | Metalloproteinase inhibitoren |
| US5753653A (en) | 1995-12-08 | 1998-05-19 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses |
| AP1368A (en) | 1995-12-08 | 2005-04-21 | Agouron Pharma | Metalloproteinase inhibitors, pharmaceutical compositisions containing them and their pharmaceutical uses, and methods and intermediates useful for their preparations. |
| TW453995B (en) | 1995-12-15 | 2001-09-11 | Novartis Ag | Certain alpha-substituted arylsulfonamido acetohydroxamic acids |
| PT780386E (pt) | 1995-12-20 | 2003-02-28 | Hoffmann La Roche | Inibidores de metaloprotease de matriz |
| ATE262899T1 (de) | 1996-01-02 | 2004-04-15 | Aventis Pharma Inc | Substituierte (aryl, heteroaryl, arylmethyl oder heteroarylmethyl) hydroxamisaeureverbindungen |
| JPH09202774A (ja) * | 1996-01-25 | 1997-08-05 | Green Cross Corp:The | 2−アリールキノリン類およびその製造方法 |
| TW448172B (en) | 1996-03-08 | 2001-08-01 | Pharmacia & Upjohn Co Llc | Novel hydroxamic acid derivatives useful for the treatment of diseases related to connective tissue degradation |
| PT900211E (pt) | 1996-04-23 | 2003-10-31 | Upjohn Co | Tiadiazolil(tio)ureias uteis como inibidores de metaloproteases com matriz |
| AU2645497A (en) | 1996-05-06 | 1997-11-26 | Zeneca Limited | Thio derivatives of hydroxamic acids |
| IT1283637B1 (it) | 1996-05-14 | 1998-04-23 | Italfarmaco Spa | Composti ad attivita' antinfiammatoria ed immunosoppressiva |
| EP0912746A2 (en) | 1996-07-12 | 1999-05-06 | Schering Corporation | MAMMALIAN TNF-$g(a) CONVERTASES |
| EP0818442A3 (en) | 1996-07-12 | 1998-12-30 | Pfizer Inc. | Cyclic sulphone derivatives as inhibitors of metalloproteinases and of the production of tumour necrosis factor |
| US5853977A (en) | 1996-07-12 | 1998-12-29 | Schering Corporation | Mammalian TNF-α convertases |
| AU712973B2 (en) | 1996-07-18 | 1999-11-18 | Pfizer Inc. | Phosphinate based inhibitors of matrix metalloproteases |
| KR20000067963A (ko) | 1996-07-22 | 2000-11-25 | 죤 에이치. 뷰센 | 티올 술폰 메탈로프로테아제 저해제 |
| AU711585B2 (en) | 1996-08-23 | 1999-10-14 | Pfizer Inc. | Arylsulfonylamino hydroxamic acid derivatives |
| ATE226573T1 (de) | 1996-08-28 | 2002-11-15 | Procter & Gamble | Heterozyklische metalloproteaseinhibitoren |
| DK0927168T3 (da) | 1996-08-28 | 2003-03-10 | Procter & Gamble | 1,3-diheterocykliske metalloproteaseinhibitorer |
| AU4073997A (en) | 1996-08-28 | 1998-03-19 | Procter & Gamble Company, The | 1,4-heterocyclic metallprotease inhibitors |
| PL331854A1 (en) | 1996-08-28 | 1999-08-16 | Procter & Gamble | Phosphinamides as inhibitors of metaloprotease matrix |
| CA2264798A1 (en) | 1996-09-04 | 1998-03-12 | Pfizer Inc. | Indazole derivatives and their use as inhibitors of phosphodiesterase (pde) type iv and the production of tumor necrosis factor (tnf) |
| WO1998009957A1 (en) | 1996-09-04 | 1998-03-12 | Warner-Lambert Company | Compounds for and a method of inhibiting matrix metalloproteinases |
| IL129035A0 (en) | 1996-09-19 | 2000-02-17 | Hoechst Marion Roussel Inc | 3-Mercaptoacetylamino-1,5-substituted-2-oxo- azepan derivatives useful as inhibitors of matrix metalloproteinase |
| EP0929519B1 (en) | 1996-09-27 | 2005-02-23 | PHARMACIA & UPJOHN COMPANY | Beta-sulfonyl hydroxamic acids as matrix metalloproteinases inhibitors |
| WO1998015525A1 (en) | 1996-10-07 | 1998-04-16 | Sumitomo Pharmaceuticals Co., Ltd. | Hydroxamic acids |
| AU731737B2 (en) | 1996-10-16 | 2001-04-05 | Wyeth Holdings Corporation | The preparation and use of ortho-sulfonamido aryl hydroxamic acids as matrix metalloproteinase and tace inhibitors |
| IL129148A0 (en) | 1996-10-16 | 2000-02-17 | American Cyanamid Co | The preparation and use of ortho-sulfonamide aryl hydroxamic acids as matrix metalloproteinase and tace inhibitors |
| US6548524B2 (en) | 1996-10-16 | 2003-04-15 | American Cyanamid Company | Preparation and use of ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloproteinase and TACE inhibitors |
| US5962481A (en) | 1996-10-16 | 1999-10-05 | American Cyanamid Company | Preparation and use of ortho-sulfonamido heteroaryl hydroxamic acids as matrix metalloproteinase and tace inhibitors |
| AU743901B2 (en) | 1996-10-16 | 2002-02-07 | Wyeth Holdings Corporation | Ortho-sulfonamido bicyclic heteroaryl hydroxamic acids as matrix metalloprote inase and tace inhibitors |
| KR20000049198A (ko) | 1996-10-16 | 2000-07-25 | 윌리암 에이취 캘넌, 에곤 이 버그 | 매트릭스 메탈로프로티나아제 및 tace 억제제로서의 베타-설폰아미도 하이드록스암산 |
| US5977408A (en) | 1996-10-16 | 1999-11-02 | American Cyanamid Company | Preparation and use of β-sulfonamido hydroxamic acids as matrix metalloproteinase and TACE inhibitors |
| GB9621814D0 (en) | 1996-10-19 | 1996-12-11 | British Biotech Pharm | Metalloproteinase inhibitors |
| US6008243A (en) | 1996-10-24 | 1999-12-28 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them, and their use |
| MY117687A (en) | 1996-10-31 | 2004-07-31 | Bayer Corp | Substituted 4-biphenyl-4-hydroxybutric acid derivatives as matrix metalloprotease inhibitors |
| JPH10130217A (ja) | 1996-11-01 | 1998-05-19 | Kotobuki Seiyaku Kk | カルボン酸及びその誘導体及びその製造法並びにこれを含有する医薬組成物 |
| GB9624817D0 (en) | 1996-11-28 | 1997-01-15 | British Biotech Pharm | Metalloproteinase inhibitors |
| US5840974A (en) | 1996-12-04 | 1998-11-24 | Britisch Biotech Pharmaceuticals, Ltd. | Metalloproteinase inhibitors |
| US6333324B1 (en) | 1996-12-17 | 2001-12-25 | Fujisawa Pharmaceutical Co., Ltd. | Piperazine compounds as inhibitors of MMP or TNF |
| AU5131998A (en) | 1997-01-06 | 1998-08-03 | Pfizer Inc. | Cyclic sulfone derivatives |
| ZA9818B (en) | 1997-01-07 | 1998-07-02 | Abbott Lab | C-terminal ketone inhibitors of matrix metalloproteinases and tnf alpha secretion |
| ZA9820B (en) | 1997-01-07 | 1998-07-02 | Abbott Lab | Macrocyclic inhibitors of matrix metalloproteinases and tnf x secretion |
| US5837696A (en) | 1997-01-15 | 1998-11-17 | The Research Foundation Of State University Of New York | Method of inhibiting cancer growth |
| JPH10204054A (ja) | 1997-01-21 | 1998-08-04 | Ono Pharmaceut Co Ltd | フェニルスルホンアミド誘導体 |
| JPH10204059A (ja) | 1997-01-22 | 1998-08-04 | Ono Pharmaceut Co Ltd | フェニルスルホンアミド誘導体 |
| NZ336625A (en) | 1997-01-23 | 2001-04-27 | Agouron Pharma | Sulfamide-metalloprotease inhibitors and their use in treating rheumatoid arthritis and other related diseases |
| GB9702088D0 (en) | 1997-01-31 | 1997-03-19 | Pharmacia & Upjohn Spa | Matrix metalloproteinase inhibitors |
| US6403587B1 (en) | 1997-02-26 | 2002-06-11 | Pfizer Inc. | Heteroaryl-hexanoic acid amide derivatives, their preparation and their use as selective inhibitors of MIP-1-α binding to its CCR 1 receptor |
| AU6822398A (en) | 1997-02-26 | 1998-09-18 | Glaxo Group Limited | Reverse hydroxamate derivatives as metalloprotease inhibitors |
| ATE256107T1 (de) | 1997-02-27 | 2003-12-15 | Wyeth Corp | N-hydroxy-2-(alkyl, aryl oder heteroaryl sulfanyl,sulfinyl oder sulfonyl)-3-substituierte alkyl, aryl oder heteroarylamide als matrix metalloproteinase als matrix metalloproteinase inhibitoren |
| US6172057B1 (en) | 1997-02-27 | 2001-01-09 | American Cyanamid Company | N-Hydroxy-2-(alkyl, aryl, or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors |
| US6197791B1 (en) | 1997-02-27 | 2001-03-06 | American Cyanamid Company | N-hdroxy-2-(alkyl, aryl, or heteroaryl, sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors |
| KR100417612B1 (ko) | 1997-03-11 | 2004-02-05 | 레 라보라뚜와르 제떼르나 인코오포레이티드 | 상어 연골 추출물 및 항신생물제를 포함하는 암치료용 조성물 |
| US6034136A (en) | 1997-03-20 | 2000-03-07 | Novartis Ag | Certain cyclic thio substituted acylaminoacid amide derivatives |
| US6251913B1 (en) | 1997-03-28 | 2001-06-26 | Zeneca Limited | Hydroxamic acids substituted by heterocycles useful for inhibition of tumor necrosis factor |
| US5985900A (en) | 1997-04-01 | 1999-11-16 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses |
| EP0973748A1 (en) | 1997-04-01 | 2000-01-26 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses |
| AT404904B (de) | 1997-04-03 | 1999-03-25 | Prior Eng Ag | Vorrichtung zur kontinuierlichen annularen chromatographie |
| GB9707333D0 (en) | 1997-04-11 | 1997-05-28 | British Biotech Pharm | Metalloproteinase inhibitors |
| DE19719621A1 (de) | 1997-05-09 | 1998-11-12 | Hoechst Ag | Sulfonylaminocarbonsäuren |
| DE59802394D1 (de) | 1997-05-09 | 2002-01-24 | Hoechst Ag | Substituierte Diaminocarbonsäuren |
| WO1998050348A1 (en) | 1997-05-09 | 1998-11-12 | Agouron Pharmaceuticals, Inc. | Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses |
| US5804581A (en) | 1997-05-15 | 1998-09-08 | Bayer Corporation | Inhibition of matrix metalloproteases by substituted phenalkyl compounds |
| GB9710490D0 (en) | 1997-05-21 | 1997-07-16 | British Biotech Pharm | Metalloproteinase inhibitors |
| EP0887077A1 (de) | 1997-06-27 | 1998-12-30 | Roche Diagnostics GmbH | Verwendung von Azulenderivaten als Metalloproteaseinhibitoren |
| AU8858398A (en) | 1997-07-10 | 1999-02-08 | Pharmacia & Upjohn S.P.A. | Matrix metalloproteinase inhibitors |
| AU8766498A (en) | 1997-08-04 | 1999-02-22 | Amgen, Inc. | Hydroxamic acid substituted fused heterocyclic metalloproteinase inhibitors |
| ES2176913T3 (es) | 1997-08-08 | 2002-12-01 | Pfizer Prod Inc | Derivados de acidos arilsulfonilaminohidroxamicos. |
| ZA988967B (en) | 1997-10-03 | 2000-04-03 | Du Pont Pharm Co | Lactam metalloprotease inhibitors. |
| US6399612B1 (en) | 1997-10-06 | 2002-06-04 | Warner-Lambert Company | Heteroaryl butyric acids and their derivatives as inhibitors of matrix metalloproteinases |
| RU2202546C2 (ru) | 1997-10-06 | 2003-04-20 | Американ Цианамид Компани | ПОЛУЧЕНИЕ И ПРИМЕНЕНИЕ ОРТО-СУЛЬФОНАМИДОБИЦИКЛИЧЕСКИХ ГЕТЕРОАРИЛЬНЫХ ГИДРОКСАМОВЫХ КИСЛОТ В КАЧЕСТВЕ ИНГИБИТОРОВ МЕТАЛЛОПРОТЕИНАЗ МАТРИКСА И ТАСЕ (TNF-α-ПРЕВРАЩАЮЩЕГО ФЕРМЕНТА) |
| EP1024134A4 (en) | 1997-10-09 | 2003-05-14 | Ono Pharmaceutical Co | DERIVATIVES OF AMINOBUTANIC ACID |
| ES2237850T3 (es) | 1997-10-14 | 2005-08-01 | Mitsubishi Pharma Corporation | Compuestos de piperazina y su uso medicinal. |
| GB9723905D0 (en) | 1997-11-12 | 1998-01-07 | Chiroscience Ltd | Heterocyclic compounds having MMP and TNF inhibitory activity |
| ATE286892T1 (de) | 1997-11-12 | 2005-01-15 | Darwin Discovery Ltd | Hydroxam- und carbonsäurederivate mit mmp- und tnf-hemmender aktivität |
| DE69811111T2 (de) | 1997-11-12 | 2003-07-24 | Darwin Discovery Ltd., Cambridge | Hydroxamsäure- und carbonsäurederivate mit mmp und tnf hemmender wirkung |
| GB2333524A (en) | 1997-11-13 | 1999-07-28 | British Biotech Pharm | Metalloproteinase inhibitors |
| FR2771095B1 (fr) | 1997-11-14 | 1999-12-17 | Adir | Nouveaux inhibiteurs de metalloproteases, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| BR9813554A (pt) | 1997-12-12 | 2001-07-24 | Fuji Yakuhin Kogyo Kk | Composto, uso do mesmo, processo para produzi-lo, composição farmacêutica ou veterinária, e, inibidor de metaloproteinase |
| EP0922702A1 (de) | 1997-12-13 | 1999-06-16 | Roche Diagnostics GmbH | Neue Azulenderivate und diese enthaltende Arzneimittel |
| US6335329B1 (en) | 1997-12-19 | 2002-01-01 | Amgen Inc. | Carboxylic acid substituted heterocycles, derivatives thereof and methods of use |
| US6107291A (en) | 1997-12-19 | 2000-08-22 | Amgen Inc. | Azepine or larger medium ring derivatives and methods of use |
| DE69830513T2 (de) | 1997-12-22 | 2006-03-16 | Bayer Pharmaceuticals Corp., West Haven | HEMMUNG DER p38 KINASE UNTER VERWENDUNG VON SYMMETRISCHEN UND ASYMMETRISCHEN DIPHENYLHARNSTOFFEN |
| WO1999032413A1 (en) | 1997-12-23 | 1999-07-01 | Spectran Corporation | Method of making large scale optical fiber preforms with improved properties |
| IL137162A0 (en) | 1998-01-27 | 2001-07-24 | American Cyanamid Co | 2,3,4,5-tetrahydro -1h- [1,4]-benzodiazepine -3- hydroxamic acids as matrix metalloproteinase inhibitors |
| US6071903A (en) | 1998-01-27 | 2000-06-06 | American Cyanamid Company | 2,3,4,5-tetrahydro-1H-[1,4]-benzodiazepine-3-hydroxyamic acids |
| GB9801690D0 (en) | 1998-01-27 | 1998-03-25 | Pfizer Ltd | Therapeutic agents |
| HUP0100597A3 (en) | 1998-01-30 | 2001-12-28 | Darwin Discovery Ltd Cambridge | Hydroxamic and carboxylic acid derivatives |
| EP1053226A1 (en) | 1998-02-04 | 2000-11-22 | Novartis AG | Sulfonylamino derivatives which inhibit matrix-degrading metalloproteinases |
| CN1290260A (zh) | 1998-02-06 | 2001-04-04 | 达尔文发现有限公司 | 异羟肟酸和羧酸衍生物 |
| IL137566A0 (en) | 1998-02-19 | 2001-07-24 | American Cyanamid Co | N-hydroxy-2-(alkyl, aryl or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted-alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors |
| DK0952148T3 (da) | 1998-04-10 | 2004-09-20 | Pfizer Prod Inc | Cyclobutylaryloxyarylsulfonylaminohydroxamsyrederivater |
| PA8469401A1 (es) | 1998-04-10 | 2000-05-24 | Pfizer Prod Inc | Derivados biciclicos del acido hidroxamico |
| JP2002514644A (ja) | 1998-05-14 | 2002-05-21 | デュポン ファーマシューティカルズ カンパニー | メタロプロテイナーゼ阻害剤としての置換アリールヒドロキサム酸 |
| CA2330108A1 (en) | 1998-05-14 | 1999-11-18 | Dupont Pharmaceuticals Company | Novel substituted aryl hydroxamic acids as metalloproteinase inhibitors |
| US6288063B1 (en) | 1998-05-27 | 2001-09-11 | Bayer Corporation | Substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors |
| CA2333554A1 (en) | 1998-06-17 | 1999-12-23 | Chu-Baio Xue | Cyclic hydroxamic acids as metalloproteinase inhibitors |
| FR2780402B1 (fr) | 1998-06-30 | 2001-04-27 | Adir | Nouveaux composes acides carboxyliques et hydroxamiques inhibiteurs de metalloproteases, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| DE19831980A1 (de) | 1998-07-16 | 2000-01-20 | Hoechst Marion Roussel De Gmbh | Sulfonylaminophosphin- und phosphonsäurederivate |
| US6350885B1 (en) | 1998-07-30 | 2002-02-26 | Warner-Lambert Company | Tricyclic heteroaromatics and their derivatives as inhibitors of matrix metalloproteinases |
| NZ509439A (en) | 1998-07-30 | 2002-10-25 | Warner Lambert Co | Tricyclic sulfonamides and their derivatives as inhibitors of matrix metalloproteinases |
| UA59453C2 (uk) | 1998-08-12 | 2003-09-15 | Пфайзер Продактс Інк. | Похідні гідроксипіпеколат гідроксамової кислоти як інгібітори матричних металопротеїназ |
| JP2002523454A (ja) | 1998-08-26 | 2002-07-30 | グラクソ グループ リミテッド | 治療剤としてのホルムアミド類 |
| WO2000012466A1 (en) | 1998-08-26 | 2000-03-09 | Glaxo Group Limited | Formamide compounds as therapeutic agents |
| WO2000012082A1 (en) | 1998-08-26 | 2000-03-09 | Glaxo Group Limited | Formamide compounds as therapeutic agents |
| EP1107953A1 (en) | 1998-08-29 | 2001-06-20 | British Biotech Pharmaceuticals Limited | Hydroxamic acid derivatives as proteinase inhibitors |
| GB9919776D0 (en) | 1998-08-31 | 1999-10-27 | Zeneca Ltd | Compoujnds |
| JP4748338B2 (ja) | 1998-09-11 | 2011-08-17 | 味の素株式会社 | ベンゼン誘導体及びその医薬用途 |
| CN1319007A (zh) | 1998-09-22 | 2001-10-24 | 石原产业株式会社 | 含有硝基乙烯胺衍生物或其盐作为有效成分的医药组合物 |
| PT1123281E (pt) | 1998-10-23 | 2004-03-31 | Dow Agrosciences Llc | Compostos 3-(fenil substituido)-5-(ciclopropil substituido)1,2,4-triazole |
| DK1004578T3 (da) | 1998-11-05 | 2004-06-28 | Pfizer Prod Inc | 5-oxo-pyrrolidin-2-carboxylsyrehydroxamidderivater |
| GB9826153D0 (en) | 1998-11-27 | 1999-01-20 | Hoffmann La Roche | Hydrazine derivatives |
| WO2000035885A1 (en) | 1998-12-11 | 2000-06-22 | F. Hoffmann-La Roche Ag | Cyclic hydrazine derivatives as tnf-alpha inhibitors |
| WO2000037433A1 (en) | 1998-12-18 | 2000-06-29 | Abbott Laboratories | Inhibitors of matrix metalloproteinases |
| US6372747B1 (en) | 1998-12-18 | 2002-04-16 | Schering Corporation | Farnesyl protein transferase inhibitors |
| JP2002536964A (ja) | 1998-12-22 | 2002-11-05 | サブサイダリー ナンバースリー インコーポレイテッド | ヒト免疫不全ウイルスに対する遺伝子抑制エレメント |
| WO2000040564A1 (en) | 1998-12-31 | 2000-07-13 | Aventis Pharmaceuticals Inc. | N-carboxymethyl substituted benzolactams as inhibitors of matrix metalloproteinase |
| PT1150976E (pt) | 1998-12-31 | 2003-07-31 | Aventis Pharma Inc | Lactamas 3-(tio amido substituidas) uteis como inibidores da metaloproteinase da matriz |
| KR20010102968A (ko) | 1999-01-07 | 2001-11-17 | 후지야마 아키라 | 시클릭 화합물 |
| JP3542968B2 (ja) | 1999-01-14 | 2004-07-14 | シーエイティーエックス インコーポレイテッド | 病気または罹病性の特徴を検出するための免疫学的検定法 |
| US6294539B1 (en) | 1999-01-19 | 2001-09-25 | Advanced Syntech, Llc | Heterocyclic hydroxamic acid derivatives as MMP inhibitors |
| FR2788525B1 (fr) | 1999-01-19 | 2002-11-29 | Commissariat Energie Atomique | Pseudo-peptides phosphiniques, utilisables comme inhibiteurs des metalloproteases a zinc matricielles |
| AR035313A1 (es) | 1999-01-27 | 2004-05-12 | Wyeth Corp | Inhibidores de tace acetilenicos de acido hidroxamico de sulfonamida a base de alfa-aminoacidos, composiciones farmaceuticas y el uso de los mismos para la manufactura de medicamentos. |
| US6277885B1 (en) | 1999-01-27 | 2001-08-21 | American Cyanamid Company | Acetylenic aryl sulfonamide and phosphinic acid amide hydroxamic acid TACE inhibitors |
| US6313123B1 (en) | 1999-01-27 | 2001-11-06 | American Cyanamid Company | Acetylenic sulfonamide thiol tace inhibitors |
| AR022423A1 (es) | 1999-01-27 | 2002-09-04 | American Cyanamid Co | Compuestos derivados de acidos 2,3,4,5-tetrahidro-1h-[1,4]benzodiazepina-3-hidroxamicos, composicion farmaceutica que los comprenden, y el uso de losmismos para la manufactura de un medicamento |
| US6200996B1 (en) | 1999-01-27 | 2001-03-13 | American Cyanamid Company | Heteroaryl acetylenic sulfonamide and phosphinic acid amide hydroxamic acid tace inhibitors |
| AR022422A1 (es) | 1999-01-27 | 2002-09-04 | American Cyanamid Co | Inhibidores de tace acetilenicos de acido hidroxamico de heteroarilfulfonamida y amida del acido fosfinico |
| AR035478A1 (es) | 1999-01-27 | 2004-06-02 | Wyeth Corp | Acido amida-hidroxamico, acido acetilenico, beta-sulfonamido y fosfinico como inhibidores de la tace, uso de los mismos para la manufactura de un medicamento y composicion farmaceutica que los contiene |
| US6225311B1 (en) | 1999-01-27 | 2001-05-01 | American Cyanamid Company | Acetylenic α-amino acid-based sulfonamide hydroxamic acid tace inhibitors |
| AR035311A1 (es) | 1999-01-27 | 2004-05-12 | Wyeth Corp | Derivados de acido hidroxamico que contienen alquinilo, como inhibidores de las metalloproteinasas de matriz y de la tace, composicion farmaceutica y el uso de los mismos para la manufactura de un medicamento |
| US6326516B1 (en) | 1999-01-27 | 2001-12-04 | American Cyanamid Company | Acetylenic β-sulfonamido and phosphinic acid amide hydroxamic acid TACE inhibitors |
| WO2000044723A1 (en) | 1999-01-27 | 2000-08-03 | American Cyanamid Company | Alkynyl containing hydroxamic acid derivatives, their preparation and their use as matrix metalloproteinase (mmp) inhibitors/tnf-alpha converting enzyme (tace) inhibitors |
| AR022424A1 (es) | 1999-01-27 | 2002-09-04 | American Cyanamid Co | Compuestos derivados de acidos ortosulfonamido acetilenico e hidroxamico biciclico heteroarilo amido de acido fosfinico como inhibidores tace, composicionfarmaceutica que los comprende y el uso de los mismos para la manufactura de un medicamento |
| DK1149074T3 (da) | 1999-01-27 | 2005-01-10 | Wyeth Corp | Acetyleniske sulfonamid-thiol-TACE-inhibitirer |
| AU2320500A (en) | 1999-02-02 | 2000-08-25 | Shionogi & Co., Ltd. | Sulfonamide derivatives having cyclic structures |
| US6448250B1 (en) | 1999-02-08 | 2002-09-10 | G. D. Searle & Company | Sulfamato hydroxamic acid metalloprotease inhibitor |
| US6177077B1 (en) | 1999-02-24 | 2001-01-23 | Edward L. Tobinick | TNT inhibitors for the treatment of neurological disorders |
| AU773273B2 (en) | 1999-02-26 | 2004-05-20 | Bristol-Myers Squibb Company | Novel sulfonamide compounds and uses thereof |
| WO2000058280A1 (en) | 1999-03-26 | 2000-10-05 | Shionogi & Co., Ltd. | Carbocyclic sulfonamide derivatives |
| WO2000058278A1 (fr) | 1999-03-26 | 2000-10-05 | Shionogi & Co., Ltd. | Derives d'acides amines $g(b) |
| WO2000058304A1 (en) | 1999-03-26 | 2000-10-05 | Shionogi & Co., Ltd. | Heterocyclic sulfonamide derivatives |
| ATE245152T1 (de) | 1999-03-31 | 2003-08-15 | Pfizer Prod Inc | Dioxocyclopentylhydroxamsäure |
| CA2366264A1 (en) * | 1999-04-02 | 2000-10-12 | Bristol-Myers Squibb Company | Novel amide derivatives as inhibitors of matrix metalloproteinases, tnf-.alpha., and aggrecanase |
| AUPP982399A0 (en) | 1999-04-19 | 1999-05-13 | Fujisawa Pharmaceutical Co., Ltd. | Mmp inhibitor |
| AU4249700A (en) | 1999-04-19 | 2000-11-02 | Sumitomo Pharmaceuticals Company, Limited | Hydroxamic acid derivative |
| EP1172361A4 (en) | 1999-04-19 | 2002-05-08 | Shionogi & Co | SULFONAMIDE DERIVATIVES HAVING OXADIAZOLE CORES |
| GB9911071D0 (en) | 1999-05-12 | 1999-07-14 | Darwin Discovery Ltd | Hydroxamic and carboxylic acid derivatives |
| KR20020003568A (ko) | 1999-05-17 | 2002-01-12 | 추후제출 | 신규한 히드록삼산 유도체 |
| EP1081137A1 (en) | 1999-08-12 | 2001-03-07 | Pfizer Products Inc. | Selective inhibitors of aggrecanase in osteoarthritis treatment |
| GB9922825D0 (en) | 1999-09-25 | 1999-11-24 | Smithkline Beecham Biolog | Medical use |
| US6632667B1 (en) | 1999-10-28 | 2003-10-14 | Isis Pharmaceuticals, Inc. | Modulation of L-selectin shedding via inhibition of tumor necrosis factor-α converting enzyme (TACE) |
| GB0004153D0 (en) | 2000-02-23 | 2000-04-12 | Astrazeneca Uk Ltd | Novel use |
| US7912651B2 (en) | 2000-03-06 | 2011-03-22 | Bioseek Llc | Function homology screening |
| IL151018A0 (en) | 2000-03-17 | 2003-02-12 | Bristol Myers Squibb Pharma Co | Beta-amino acid derivatives as inhibitors of matrix metalloproteases and tnf-alpha |
| JP2003528072A (ja) | 2000-03-17 | 2003-09-24 | ブリストル−マイヤーズ スクイブ ファーマ カンパニー | マトリックスメタロプロテアーゼおよびTNF−αの阻害剤としての環状β−アミノ酸誘導体 |
| ES2208595T3 (es) | 2000-05-15 | 2004-06-16 | Darwin Discovery Limited | Derivados del acido hidroxamico. |
| US6620823B2 (en) | 2000-07-11 | 2003-09-16 | Bristol-Myers Squibb Pharme Company | Lactam metalloprotease inhibitors |
| CA2423733A1 (en) | 2000-08-31 | 2003-02-14 | Terukage Hirata | Novel propenohydroxamic acid derivatives |
| WO2002096426A1 (en) | 2001-05-25 | 2002-12-05 | Bristol-Myers Squibb Company | Hydantion derivatives as inhibitors of matrix metalloproteinases |
| SE519050C2 (sv) | 2001-05-28 | 2003-01-07 | Fazer Ab Oy Karl | Påfyllnadsanordning för varor |
| US6770647B2 (en) | 2001-08-17 | 2004-08-03 | Bristol-Myers Squibb Pharma Company | Bicyclic hydroxamates as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE) |
| AU2002341715A1 (en) | 2001-09-17 | 2003-04-01 | Bristol-Myers Squibb Company | Cyclic hydroxamic acids as inhibitors of matrix metalloproteinases and/or tnf-alpha converting enzyme (tace) |
-
2002
- 2002-12-13 PE PE2002001221A patent/PE20030701A1/es not_active Application Discontinuation
- 2002-12-18 TW TW091136497A patent/TW200306809A/zh unknown
- 2002-12-19 WO PCT/US2002/040453 patent/WO2003053915A2/en not_active Ceased
- 2002-12-19 HU HU0500016A patent/HUP0500016A2/hu unknown
- 2002-12-19 MX MXPA04006031A patent/MXPA04006031A/es active IP Right Grant
- 2002-12-19 KR KR10-2004-7009533A patent/KR20040068599A/ko not_active Withdrawn
- 2002-12-19 AR ARP020105015A patent/AR037929A1/es unknown
- 2002-12-19 AU AU2002357885A patent/AU2002357885A1/en not_active Abandoned
- 2002-12-19 JP JP2003554632A patent/JP4439265B2/ja not_active Expired - Fee Related
- 2002-12-19 EP EP02792429A patent/EP1458676A2/en not_active Withdrawn
- 2002-12-19 CA CA002470620A patent/CA2470620A1/en not_active Abandoned
- 2002-12-19 CN CNA028281705A patent/CN1620424A/zh active Pending
- 2002-12-19 US US10/323,511 patent/US6838466B2/en not_active Expired - Fee Related
- 2002-12-19 IL IL16248502A patent/IL162485A0/xx unknown
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2003
- 2003-11-19 US US10/716,890 patent/US7034057B2/en not_active Expired - Fee Related
-
2004
- 2004-06-09 ZA ZA200404586A patent/ZA200404586B/en unknown
-
2005
- 2005-10-20 US US11/255,130 patent/US7598242B2/en not_active Expired - Fee Related
-
2009
- 2009-08-14 JP JP2009188147A patent/JP2010006817A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JP4439265B2 (ja) | 2010-03-24 |
| JP2005513125A (ja) | 2005-05-12 |
| IL162485A0 (en) | 2005-11-20 |
| US7598242B2 (en) | 2009-10-06 |
| US20040102418A1 (en) | 2004-05-27 |
| EP1458676A2 (en) | 2004-09-22 |
| HUP0500016A2 (hu) | 2005-04-28 |
| KR20040068599A (ko) | 2004-07-31 |
| US20060063843A1 (en) | 2006-03-23 |
| TW200306809A (en) | 2003-12-01 |
| PE20030701A1 (es) | 2003-08-21 |
| MXPA04006031A (es) | 2004-09-27 |
| WO2003053915A3 (en) | 2003-09-18 |
| US6838466B2 (en) | 2005-01-04 |
| US7034057B2 (en) | 2006-04-25 |
| CN1620424A (zh) | 2005-05-25 |
| JP2010006817A (ja) | 2010-01-14 |
| WO2003053915A2 (en) | 2003-07-03 |
| ZA200404586B (en) | 2005-08-23 |
| CA2470620A1 (en) | 2003-07-03 |
| AU2002357885A1 (en) | 2003-07-09 |
| US20040038941A1 (en) | 2004-02-26 |
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