SI2790687T1 - TRPC4 modulatorji za uporabo pri zdravljenju ali preprečevanju bolečine - Google Patents

TRPC4 modulatorji za uporabo pri zdravljenju ali preprečevanju bolečine

Info

Publication number
SI2790687T1
SI2790687T1 SI201231425T SI201231425T SI2790687T1 SI 2790687 T1 SI2790687 T1 SI 2790687T1 SI 201231425 T SI201231425 T SI 201231425T SI 201231425 T SI201231425 T SI 201231425T SI 2790687 T1 SI2790687 T1 SI 2790687T1
Authority
SI
Slovenia
Prior art keywords
trpc4
modulators
pain
prevention
treatment
Prior art date
Application number
SI201231425T
Other languages
English (en)
Inventor
Eric M. Ostertag
John Stuart Crawford
Original Assignee
Poseida Therapeutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Poseida Therapeutics, Inc. filed Critical Poseida Therapeutics, Inc.
Publication of SI2790687T1 publication Critical patent/SI2790687T1/sl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38Nitrogen atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4709Non-condensed quinolines and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SI201231425T 2011-12-16 2012-12-14 TRPC4 modulatorji za uporabo pri zdravljenju ali preprečevanju bolečine SI2790687T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161576619P 2011-12-16 2011-12-16
EP12806318.7A EP2790687B1 (en) 2011-12-16 2012-12-14 Trpc4 modulators for use in the treatment or prevention of pain
PCT/US2012/069753 WO2013090722A1 (en) 2011-12-16 2012-12-14 Trpc4 modulators for use in the treatment or prevention of pain

Publications (1)

Publication Number Publication Date
SI2790687T1 true SI2790687T1 (sl) 2019-01-31

Family

ID=47430150

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201231425T SI2790687T1 (sl) 2011-12-16 2012-12-14 TRPC4 modulatorji za uporabo pri zdravljenju ali preprečevanju bolečine

Country Status (17)

Country Link
US (2) US10131634B2 (sl)
EP (2) EP2790687B1 (sl)
JP (3) JP2015500345A (sl)
AU (2) AU2012352083B2 (sl)
CA (1) CA2859283C (sl)
CY (1) CY1121293T1 (sl)
DK (1) DK2790687T3 (sl)
ES (1) ES2692546T3 (sl)
HR (1) HRP20181746T1 (sl)
HU (1) HUE041294T2 (sl)
LT (1) LT2790687T (sl)
PL (1) PL2790687T3 (sl)
PT (1) PT2790687T (sl)
RS (1) RS57919B1 (sl)
SI (1) SI2790687T1 (sl)
TR (1) TR201815535T4 (sl)
WO (1) WO2013090722A1 (sl)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013090722A1 (en) * 2011-12-16 2013-06-20 Transposagen Biopharmaceuticals, Inc. Trpc4 modulators for use in the treatment or prevention of pain
WO2020210597A1 (en) * 2019-04-11 2020-10-15 Amgen Inc. Benzimidazole derivatives and their uses

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
HU198036B (en) * 1983-08-22 1989-07-28 Hoechst Roussel Pharma Process for production of derivatives of 3-piperidil-/1h/-indasole and medical preparatives containing them
US5506337A (en) 1985-03-15 1996-04-09 Antivirals Inc. Morpholino-subunit combinatorial library and method
US5010175A (en) 1988-05-02 1991-04-23 The Regents Of The University Of California General method for producing and selecting peptides with specific properties
IE66205B1 (en) 1990-06-14 1995-12-13 Paul A Bartlett Polypeptide analogs
US5650489A (en) 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
DE69231467T2 (de) 1991-05-10 2001-01-25 Genentech Inc Auswählen von agonisten und antagonisten von liganden
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
US5288514A (en) 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
US5519134A (en) 1994-01-11 1996-05-21 Isis Pharmaceuticals, Inc. Pyrrolidine-containing monomers and oligomers
US5593853A (en) 1994-02-09 1997-01-14 Martek Corporation Generation and screening of synthetic drug libraries
US5539083A (en) 1994-02-23 1996-07-23 Isis Pharmaceuticals, Inc. Peptide nucleic acid combinatorial libraries and improved methods of synthesis
US5525735A (en) 1994-06-22 1996-06-11 Affymax Technologies Nv Methods for synthesizing diverse collections of pyrrolidine compounds
US5549974A (en) 1994-06-23 1996-08-27 Affymax Technologies Nv Methods for the solid phase synthesis of thiazolidinones, metathiazanones, and derivatives thereof
US5656449A (en) * 1995-03-06 1997-08-12 Molecular Probes, Inc. Neutral unsymmetrical cyanine dyes
CA2245835A1 (en) 1995-06-14 1997-01-03 The Regents Of The University Of California Novel high affinity human antibodies to tumor antigens
US5569588A (en) 1995-08-09 1996-10-29 The Regents Of The University Of California Methods for drug screening
DK0974111T3 (da) 1997-04-11 2003-04-22 California Inst Of Techn Apparat og metode til automatiseret design af proteiner
US6403312B1 (en) 1998-10-16 2002-06-11 Xencor Protein design automatic for protein libraries
WO2000064877A1 (en) * 1999-04-26 2000-11-02 Neurogen Corporation 2-aminoquinolinecarboxamides: neurokinin receptor ligands
US7375125B2 (en) * 1999-08-04 2008-05-20 Ore Pharmaceuticals, Inc. Melanocortin-4 receptor binding compounds and methods of use thereof
WO2001025277A1 (en) 1999-10-07 2001-04-12 Maxygen Aps Single-chain antagonist polypeptides
US20020072101A1 (en) 2000-01-21 2002-06-13 Gaughan Glen T. Novel human nucleic acid molecules and polypeptides encoding cation channels
CA2436941A1 (en) 2000-12-01 2002-06-06 Bristol-Myers Squibb Company Novel human nucleic acid molecules and polypeptides encoding a novel human ion channel expressed in spinal cord and brain
WO2002094999A2 (en) 2001-05-22 2002-11-28 Bristol-Myers Squibb Company Polynucleotide encoding a novel trp channel family member, trp-plik2, and splice variants thereof
US6740649B2 (en) * 2001-09-17 2004-05-25 Bristol-Myers Squibb Company Cyclic hydroxamic acids as inhibitors of matrix metalloproteinases and/or TNF- α converting enzyme (TACE)
PE20030701A1 (es) * 2001-12-20 2003-08-21 Schering Corp Compuestos para el tratamiento de trastornos inflamatorios
WO2003057843A2 (en) * 2001-12-31 2003-07-17 Algos Therapeutics, Inc. Methods and materials for modulating trpc4
US20050103029A1 (en) * 2002-01-15 2005-05-19 Keizou Kawahara Refrigerator having alarm device for alarming leakage of refrigerant
AU2003280654A1 (en) * 2002-10-31 2004-05-25 Kunihiro Tamura Golf club with which gravity rule is realized
US7256200B2 (en) 2003-02-10 2007-08-14 The Board Of Trustees Of The University Of Illinois, A Body Corporate And Politic Of The State Of Illinois Method and composition for potentiating an oplate analgesic
KR100561646B1 (ko) * 2003-10-23 2006-03-20 엘지.필립스 엘시디 주식회사 표시 소자용 박막 트랜지스터 기판 및 그 제조 방법
WO2005087742A1 (en) * 2004-03-08 2005-09-22 Exelixis, Inc. Metabolic kinase modulators and methods of use as pesticides
WO2005089206A2 (en) 2004-03-13 2005-09-29 Irm Llc Modulators of ion channel trpa1
US7524862B2 (en) 2004-04-14 2009-04-28 Boehringer Ingelheim International Gmbh Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds
DE102004017932A1 (de) * 2004-04-14 2005-11-03 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Alkin-Verbindungen mit MCH-antagonistischer Wirkung und diese Verbindungen enthaltende Arzneimittel
WO2007025613A2 (en) * 2005-07-15 2007-03-08 Laboratorios Del Dr. Esteve, S.A. Use of compounds binding to the sigma receptor for the treatment of diabetes-associated pain
CA2657702A1 (en) 2006-07-03 2008-01-10 Vereniging Voor Christelijk Hoger Onderwijs Wetenschappelijk Onderzoek E N Patieentenzorg Quinazolines and related heterocyclic comp0unds, and their therapeutic use
GB0615136D0 (en) 2006-07-29 2006-09-06 Univ Edinburgh Induction of analgesia in neuropathic pain
WO2008127603A2 (en) 2007-04-11 2008-10-23 The Board Of Regents Of The University Of Texas System Transient receptor potential vanilloid 1 and uses thereof
JP5241832B2 (ja) * 2007-06-27 2013-07-17 ドルビー ラボラトリーズ ライセンシング コーポレイション マルチメディアコンテンツの特定のためのシグネチャポインターを含む検索ツリーのインクレメンタル構造
EP2203411B1 (en) 2007-09-20 2016-01-06 Ramot at Tel-Aviv University Ltd. N-phenyl anthranilic acid derivatives and uses thereof
US8084616B2 (en) 2007-10-24 2011-12-27 Abbott Laboratories TRPV1 antagonists
US7998993B2 (en) 2007-10-25 2011-08-16 Abbott Laboratories TRPV1 antagonists
KR20090047637A (ko) 2007-11-08 2009-05-13 재단법인서울대학교산학협력재단 커큐민 또는 이의 약학적으로 허용가능한 염을유효성분으로 함유하는 통증 예방 및 치료용 조성물
EP2254879A4 (en) 2007-12-18 2012-10-31 Glenmark Pharmaceuticals Sa CHROMAN DERIVATIVES AS TRPV3 MODULATORS
AU2008345225A1 (en) * 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms
US8694515B2 (en) * 2008-12-19 2014-04-08 Panasonic Corporation Image search device and image search method
WO2011022634A2 (en) * 2009-08-20 2011-02-24 Transposagen Biopharmaceuticals, Inc. Genetically modified rat models for pain
EP2467398B1 (en) 2009-08-20 2019-10-09 Poseida Therapeutics, Inc. Trpc4 inhibitors and uses thereof
DE102009046649A1 (de) 2009-11-12 2011-05-19 Robert Bosch Gmbh Klimakompressor für ein Fahrzeug, Fahrzeug
US8497265B2 (en) * 2010-05-13 2013-07-30 Amgen Inc. Heteroaryloxyheterocyclyl compounds as PDE10 inhibitors
WO2013090722A1 (en) * 2011-12-16 2013-06-20 Transposagen Biopharmaceuticals, Inc. Trpc4 modulators for use in the treatment or prevention of pain

Also Published As

Publication number Publication date
EP2790687A1 (en) 2014-10-22
JP6534716B2 (ja) 2019-06-26
PT2790687T (pt) 2018-11-13
ES2692546T3 (es) 2018-12-04
EP2790687B1 (en) 2018-08-29
WO2013090722A1 (en) 2013-06-20
LT2790687T (lt) 2018-12-10
EP3485889B1 (en) 2023-09-06
US20140329856A1 (en) 2014-11-06
EP3485889A1 (en) 2019-05-22
AU2012352083B2 (en) 2018-01-04
JP6858808B2 (ja) 2021-04-14
AU2018202172B2 (en) 2019-12-19
AU2018202172A1 (en) 2018-04-26
DK2790687T3 (en) 2018-11-19
RS57919B1 (sr) 2019-01-31
CA2859283A1 (en) 2013-06-20
JP2018030875A (ja) 2018-03-01
CY1121293T1 (el) 2020-05-29
JP2015500345A (ja) 2015-01-05
PL2790687T3 (pl) 2019-03-29
JP2019135271A (ja) 2019-08-15
AU2012352083A1 (en) 2014-07-17
HRP20181746T1 (hr) 2018-12-28
US20190135759A1 (en) 2019-05-09
TR201815535T4 (tr) 2018-11-21
US10131634B2 (en) 2018-11-20
HUE041294T2 (hu) 2019-05-28
CA2859283C (en) 2021-03-09

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