MXPA04006031A - Compuestos para el tratamiento de trastornos inflamatorios. - Google Patents
Compuestos para el tratamiento de trastornos inflamatorios.Info
- Publication number
- MXPA04006031A MXPA04006031A MXPA04006031A MXPA04006031A MXPA04006031A MX PA04006031 A MXPA04006031 A MX PA04006031A MX PA04006031 A MXPA04006031 A MX PA04006031A MX PA04006031 A MXPA04006031 A MX PA04006031A MX PA04006031 A MXPA04006031 A MX PA04006031A
- Authority
- MX
- Mexico
- Prior art keywords
- compounds
- treatment
- inflammatory disorders
- formula
- mmps
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 208000027866 inflammatory disease Diseases 0.000 title 1
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 abstract 1
- 102000002274 Matrix Metalloproteinases Human genes 0.000 abstract 1
- 108010000684 Matrix Metalloproteinases Proteins 0.000 abstract 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 abstract 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
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- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
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- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/08—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to carbon atoms of rings other than six-membered aromatic rings
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- C07C279/08—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by singly-bound oxygen atoms
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| RU2006125441A (ru) * | 2003-12-15 | 2008-01-27 | Джапан Тобакко Инк. (Jp) | Производные циклопропана и их фармацевтическое применение |
| WO2005061448A1 (en) * | 2003-12-24 | 2005-07-07 | Monash University | Compositions and methods for treating vascular conditions |
| US8759335B2 (en) * | 2004-01-30 | 2014-06-24 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
| US7977322B2 (en) | 2004-08-20 | 2011-07-12 | Vertex Pharmaceuticals Incorporated | Modulators of ATP-binding cassette transporters |
| US7676590B2 (en) * | 2004-05-03 | 2010-03-09 | Microsoft Corporation | Background transcoding |
| TWI350168B (en) | 2004-05-07 | 2011-10-11 | Incyte Corp | Amido compounds and their use as pharmaceuticals |
| CA2589565A1 (en) * | 2004-06-24 | 2006-01-05 | Incyte Corporation | Amido compounds and their use as pharmaceuticals |
| JP2008504276A (ja) * | 2004-06-24 | 2008-02-14 | インサイト・コーポレイション | アミド化合物およびその医薬としての使用 |
| ES2331015T3 (es) * | 2004-10-29 | 2009-12-18 | Sandoz Ag | Proceso para la preparacion de un glatiramero. |
| RU2007126842A (ru) * | 2004-12-14 | 2009-01-27 | Санофи-Авентис Дойчланд Гмбх (De) | Применение замещенных производных циклопропановой кислоты для получения лекарственных средств для лечения метаболического синдрома |
| CN101282962A (zh) * | 2005-08-12 | 2008-10-08 | 先灵公司 | 用于治疗炎性疾病的化合物 |
| US8193207B2 (en) | 2005-12-05 | 2012-06-05 | Incyte Corporation | Lactam compounds and methods of using the same |
| US7998959B2 (en) | 2006-01-12 | 2011-08-16 | Incyte Corporation | Modulators of 11-β hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same |
| US7838544B2 (en) | 2006-05-17 | 2010-11-23 | Incyte Corporation | Heterocyclic inhibitors of 11-β hydroxyl steroid dehydrogenase type 1 and methods of using the same |
| US8153166B2 (en) * | 2006-06-08 | 2012-04-10 | Chih-Hsiung Lin | Composition for prophylaxis or treatment of urinary system infection and method thereof |
| RU2449989C2 (ru) | 2006-06-23 | 2012-05-10 | Эбботт Лэборетриз | Производные циклопропиламина в качестве модуляторов h3-гистаминового рецептора |
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-
2002
- 2002-12-13 PE PE2002001221A patent/PE20030701A1/es not_active Application Discontinuation
- 2002-12-18 TW TW091136497A patent/TW200306809A/zh unknown
- 2002-12-19 MX MXPA04006031A patent/MXPA04006031A/es active IP Right Grant
- 2002-12-19 CN CNA028281705A patent/CN1620424A/zh active Pending
- 2002-12-19 JP JP2003554632A patent/JP4439265B2/ja not_active Expired - Fee Related
- 2002-12-19 KR KR10-2004-7009533A patent/KR20040068599A/ko not_active Withdrawn
- 2002-12-19 CA CA002470620A patent/CA2470620A1/en not_active Abandoned
- 2002-12-19 WO PCT/US2002/040453 patent/WO2003053915A2/en not_active Ceased
- 2002-12-19 IL IL16248502A patent/IL162485A0/xx unknown
- 2002-12-19 US US10/323,511 patent/US6838466B2/en not_active Expired - Fee Related
- 2002-12-19 HU HU0500016A patent/HUP0500016A2/hu unknown
- 2002-12-19 AU AU2002357885A patent/AU2002357885A1/en not_active Abandoned
- 2002-12-19 AR ARP020105015A patent/AR037929A1/es unknown
- 2002-12-19 EP EP02792429A patent/EP1458676A2/en not_active Withdrawn
-
2003
- 2003-11-19 US US10/716,890 patent/US7034057B2/en not_active Expired - Fee Related
-
2004
- 2004-06-09 ZA ZA200404586A patent/ZA200404586B/en unknown
-
2005
- 2005-10-20 US US11/255,130 patent/US7598242B2/en not_active Expired - Fee Related
-
2009
- 2009-08-14 JP JP2009188147A patent/JP2010006817A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003053915A2 (en) | 2003-07-03 |
| AU2002357885A1 (en) | 2003-07-09 |
| TW200306809A (en) | 2003-12-01 |
| PE20030701A1 (es) | 2003-08-21 |
| CN1620424A (zh) | 2005-05-25 |
| KR20040068599A (ko) | 2004-07-31 |
| JP2010006817A (ja) | 2010-01-14 |
| US20060063843A1 (en) | 2006-03-23 |
| WO2003053915A3 (en) | 2003-09-18 |
| CA2470620A1 (en) | 2003-07-03 |
| US20040102418A1 (en) | 2004-05-27 |
| HUP0500016A2 (hu) | 2005-04-28 |
| JP2005513125A (ja) | 2005-05-12 |
| US6838466B2 (en) | 2005-01-04 |
| EP1458676A2 (en) | 2004-09-22 |
| AR037929A1 (es) | 2004-12-22 |
| JP4439265B2 (ja) | 2010-03-24 |
| US7034057B2 (en) | 2006-04-25 |
| ZA200404586B (en) | 2005-08-23 |
| US7598242B2 (en) | 2009-10-06 |
| IL162485A0 (en) | 2005-11-20 |
| US20040038941A1 (en) | 2004-02-26 |
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