AR020934A1 - Compuestos trombopoyeticos - Google Patents
Compuestos trombopoyeticosInfo
- Publication number
- AR020934A1 AR020934A1 ARP990105333A AR020934A1 AR 020934 A1 AR020934 A1 AR 020934A1 AR P990105333 A ARP990105333 A AR P990105333A AR 020934 A1 AR020934 A1 AR 020934A1
- Authority
- AR
- Argentina
- Prior art keywords
- compounds
- thrombopoyetic
- polypeptides
- peptides
- platelet
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 4
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 1
- 210000003593 megakaryocyte Anatomy 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 230000001361 thrombopoietic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/524—Thrombopoietin, i.e. C-MPL ligand
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10534898P | 1998-10-23 | 1998-10-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR020934A1 true AR020934A1 (es) | 2002-06-05 |
Family
ID=22305310
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990105333 AR020934A1 (es) | 1998-10-23 | 1999-10-22 | Compuestos trombopoyeticos |
Country Status (36)
Families Citing this family (158)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7091311B2 (en) * | 1996-06-07 | 2006-08-15 | Smithkline Beecham Corporation | Peptides and compounds that bind to a receptor |
| ATE348163T1 (de) | 1998-10-23 | 2007-01-15 | Amgen Inc | Thrombopoietin substitute |
| US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| US6808902B1 (en) * | 1999-11-12 | 2004-10-26 | Amgen Inc. | Process for correction of a disulfide misfold in IL-1Ra Fc fusion molecules |
| MXPA02010351A (es) * | 2000-04-21 | 2003-04-25 | Amgen Inc | Antagonistas de integrina/adhesion. |
| US20020090646A1 (en) * | 2000-05-03 | 2002-07-11 | Amgen Inc. | Calcitonin-related molecules |
| AU2001269762C1 (en) * | 2000-06-09 | 2005-12-22 | The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Pegylation of linkers improves antitumor activity and reduces toxicity of immunoconjugates |
| US7396917B2 (en) * | 2000-12-05 | 2008-07-08 | Alexion Pharmaceuticals, Inc. | Rationally designed antibodies |
| ES2316919T3 (es) | 2000-12-05 | 2009-04-16 | Alexion Pharmaceuticals, Inc. | Anticuerpos diseñados racionalmente. |
| US20040018203A1 (en) * | 2001-06-08 | 2004-01-29 | Ira Pastan | Pegylation of linkers improves antitumor activity and reduces toxicity of immunoconjugates |
| JP4402455B2 (ja) | 2001-08-17 | 2010-01-20 | エンカム ファーマシューティカルズ アクティーゼルスカブ | 細胞の分化、増殖、再生、可塑性及び生存に影響を及ぼすことができる化合物 |
| US7332474B2 (en) | 2001-10-11 | 2008-02-19 | Amgen Inc. | Peptides and related compounds having thrombopoietic activity |
| US20030191056A1 (en) | 2002-04-04 | 2003-10-09 | Kenneth Walker | Use of transthyretin peptide/protein fusions to increase the serum half-life of pharmacologically active peptides/proteins |
| CA2499625A1 (en) * | 2002-09-18 | 2004-04-01 | Ortho-Mcneil Pharmaceutical, Inc. | Methods of increasing platelet and hematopoietic stem cell production |
| TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
| MXPA05012313A (es) | 2003-05-12 | 2006-04-18 | Affymax Inc | Peptidos que se unen al receptor de eritropoyetina. |
| CN1849141A (zh) | 2003-05-12 | 2006-10-18 | 阿费麦克斯公司 | 用于聚(乙二醇)修饰的肽的间隔臂部分 |
| RS51130B (sr) | 2003-05-12 | 2010-10-31 | Affymax Inc. | Novi peptidi koji se vezuju za eritropoietinski receptor |
| DE602004028725D1 (de) * | 2003-05-12 | 2010-09-30 | Affymax Inc | Neue poly(ethylenglycol) modifizierte erythropoietinagonisten und deren verwendungen |
| ES2390082T5 (es) * | 2004-06-30 | 2018-01-19 | Nektar Therapeutics | Conjugados de resto de Factor IX y polímeros |
| CA2572765C (en) * | 2004-07-08 | 2013-05-21 | Amgen Inc. | Compound having improved bioefficiency when administered in a multidose regimen |
| US7442778B2 (en) | 2004-09-24 | 2008-10-28 | Amgen Inc. | Modified Fc molecules |
| US7550433B2 (en) | 2005-06-03 | 2009-06-23 | Affymax, Inc. | Erythropoietin receptor peptide formulations and uses |
| EA200800109A1 (ru) * | 2005-06-23 | 2008-06-30 | Аплаген Гмбх | Суправалентные соединения |
| US8008453B2 (en) | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
| WO2007075899A2 (en) * | 2005-12-21 | 2007-07-05 | Maxygen, Inc. | Dual agonist compounds and uses thereof |
| US9012605B2 (en) | 2006-01-23 | 2015-04-21 | Amgen Inc. | Crystalline polypeptides |
| EP1986677A2 (en) * | 2006-01-25 | 2008-11-05 | Amgen Inc. | Thrombopoietic compounds |
| US9283260B2 (en) | 2006-04-21 | 2016-03-15 | Amgen Inc. | Lyophilized therapeutic peptibody formulations |
| US7981425B2 (en) | 2006-06-19 | 2011-07-19 | Amgen Inc. | Thrombopoietic compounds |
| AU2007278748B2 (en) * | 2006-07-24 | 2013-08-15 | The University Of Queensland | Method of producing a population of cells |
| WO2008095004A2 (en) | 2007-01-31 | 2008-08-07 | Affymax, Inc. | Nitrogen-based linkers for attaching modifying groups to polypeptides and other macromolecules |
| JP5591691B2 (ja) | 2007-05-22 | 2014-09-17 | アムジエン・インコーポレーテツド | 生物活性を有する融合タンパク質を作製するための組成物及び方法 |
| US20090054332A1 (en) * | 2007-06-21 | 2009-02-26 | Conjuchem Biotechnologies, Inc. | Thombopoietin peptide conjugates |
| EP2197421A1 (en) * | 2007-08-31 | 2010-06-23 | Amgen, Inc | Solid-state protein formulation |
| WO2009043049A2 (en) | 2007-09-27 | 2009-04-02 | Amgen Inc. | Pharmaceutical formulations |
| EP2219602A1 (en) | 2007-11-15 | 2010-08-25 | Amgen, Inc | Aqueous formulation of erythropoiesis stimulating protein stablised by antioxidants for parenteral administration |
| US8470964B2 (en) | 2007-11-28 | 2013-06-25 | Enkam Pharmaceuticals A/S | Peptides derived from NCAM (FGLs) |
| CA2755336C (en) | 2009-03-20 | 2015-07-14 | Amgen Inc. | Carrier immunoglobulins and uses thereof |
| EP2414391B1 (en) | 2009-04-02 | 2018-11-28 | Roche Glycart AG | Multispecific antibodies comprising full length antibodies and single chain fab fragments |
| US20120302737A1 (en) | 2009-09-16 | 2012-11-29 | Genentech, Inc. | Coiled coil and/or tether containing protein complexes and uses thereof |
| US20120253009A1 (en) * | 2009-10-16 | 2012-10-04 | Amgen Inc. | Thrombopoietic compounds |
| US9662271B2 (en) | 2009-10-23 | 2017-05-30 | Amgen Inc. | Vial adapter and system |
| WO2011098095A1 (en) | 2010-02-09 | 2011-08-18 | Aplagen Gmbh | Peptides binding the tpo receptor |
| TW201138821A (en) | 2010-03-26 | 2011-11-16 | Roche Glycart Ag | Bispecific antibodies |
| BR112012027001A2 (pt) | 2010-04-23 | 2016-07-19 | Genentech Inc | produção de proteínas heteromultiméricas |
| PT2575935E (pt) | 2010-06-07 | 2015-10-20 | Amgen Inc | Dispositivo de administração de medicamento |
| BR112013003279A2 (pt) | 2010-08-13 | 2016-06-14 | Genentech In | “métodos para tratar uma doença, método para neutralizar ou bloquear a atividade de il-1ß e/ou il-18, anticorpo, usos de um anticorpo e usos de um anticorpo monoclonal” |
| WO2012025530A1 (en) | 2010-08-24 | 2012-03-01 | F. Hoffmann-La Roche Ag | Bispecific antibodies comprising a disulfide stabilized - fv fragment |
| MX383982B (es) | 2010-09-22 | 2025-03-14 | Amgen Inc | Inmunoglobulinas portadoras y usos de las mismas. |
| EP2655413B1 (en) | 2010-12-23 | 2019-01-16 | F.Hoffmann-La Roche Ag | Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery |
| BR112013019499B1 (pt) | 2011-02-04 | 2023-01-10 | Genentech, Inc. | Proteína heteromultimérica variante ou anticorpo igg modificado, método para produzir uma proteína heteromultimérica variante ou anticorpo igg modificado, composição, método para preparar uma proteína heteromultimérica e proteína heteromultimérica variante |
| US10689447B2 (en) | 2011-02-04 | 2020-06-23 | Genentech, Inc. | Fc variants and methods for their production |
| CA2831100C (en) | 2011-03-31 | 2020-02-18 | Mark Dominis Holt | Vial adapter and system |
| ES2926520T3 (es) | 2011-04-20 | 2022-10-26 | Amgen Inc | Aparato autoinyector |
| HK1202878A1 (en) | 2011-10-11 | 2015-10-09 | F. Hoffmann-La Roche Ag | Improved assembly of bispecific antibodies |
| TR201807808T4 (tr) | 2011-10-14 | 2018-06-21 | Amgen Inc | Enjektör ve montaj yöntemi. |
| JP6486686B2 (ja) | 2012-02-10 | 2019-03-20 | ジェネンテック, インコーポレイテッド | 単鎖抗体及び他のヘテロ多量体 |
| CN102552184A (zh) * | 2012-02-16 | 2012-07-11 | 山东泉港药业有限公司 | 一种血小板生成素拟肽冻干制剂 |
| BR112014028368A2 (pt) | 2012-06-27 | 2017-11-14 | Hoffmann La Roche | método de produção de conjugado de região fc de anticorpo, conjugado de região fc de anticorpo e formulação farmacêutica |
| RU2639287C2 (ru) | 2012-06-27 | 2017-12-20 | Ф. Хоффманн-Ля Рош Аг | Способ отбора и получения высокоселективных и мультиспецифичных нацеливающих групп с заданными свойствами, включающих по меньшей мере две различные связывающие группировки, и их применения |
| EP3072548B1 (en) | 2012-11-21 | 2019-03-06 | Amgen, Inc | Drug delivery device |
| TWI592183B (zh) | 2013-03-15 | 2017-07-21 | 安美基公司 | 本體輪廓可調適之自動注射器裝置 |
| CN104046642B (zh) * | 2013-03-15 | 2018-07-06 | 兰州大学 | 发酵生产二聚体化融合蛋白的方法 |
| US10092703B2 (en) | 2013-03-15 | 2018-10-09 | Amgen Inc. | Drug cassette, autoinjector, and autoinjector system |
| EP3593839A1 (en) | 2013-03-15 | 2020-01-15 | Amgen Inc. | Drug cassette |
| CN104045715B (zh) * | 2013-03-15 | 2018-05-01 | 兰州大学 | 二聚体化融合蛋白的制备及应用 |
| JP6670740B2 (ja) | 2013-03-22 | 2020-03-25 | アムジエン・インコーポレーテツド | 注入器および組み立て法 |
| US10668053B2 (en) | 2013-05-03 | 2020-06-02 | Selecta Biosciences, Inc. | Tolerogenic synthetic nanocarriers to reduce or prevent anaphylaxis in response to a non-allergenic antigen |
| PL3060275T3 (pl) | 2013-10-24 | 2019-12-31 | Amgen Inc. | Wstrzykiwacz i sposób montażu |
| AU2014340174B2 (en) | 2013-10-24 | 2019-09-12 | Amgen Inc. | Drug delivery system with temperature-sensitive control |
| US10994112B2 (en) | 2014-02-05 | 2021-05-04 | Amgen Inc. | Drug delivery system with electromagnetic field generator |
| CN105017408B (zh) * | 2014-04-30 | 2019-11-05 | 重庆派金生物科技有限公司 | 聚乙二醇化血小板生成素模拟肽同源四聚体及其用途 |
| EP3140392B1 (en) | 2014-05-06 | 2023-07-26 | F. Hoffmann-La Roche AG | Production of heteromultimeric proteins using mammalian cells |
| CA3193070A1 (en) | 2014-05-07 | 2015-11-12 | Amgen Inc. | Autoinjector with shock reducing elements |
| EP4362039A3 (en) | 2014-06-03 | 2024-08-07 | Amgen Inc. | Controllable drug delivery system and method of use |
| JP6655011B2 (ja) * | 2014-06-23 | 2020-02-26 | 東亞合成株式会社 | 細胞の多核化を誘導するペプチドおよびその利用 |
| TN2017000109A1 (en) * | 2014-09-26 | 2018-07-04 | Bayer Pharma AG | Stabilized adrenomedullin derivatives and use thereof |
| JP6766040B2 (ja) | 2014-10-14 | 2020-10-07 | アムジエン・インコーポレーテツド | 視覚および可聴インジケータを備える薬剤注射装置 |
| CN107001482B (zh) | 2014-12-03 | 2021-06-15 | 豪夫迈·罗氏有限公司 | 多特异性抗体 |
| US11357916B2 (en) | 2014-12-19 | 2022-06-14 | Amgen Inc. | Drug delivery device with live button or user interface field |
| EP3848072A1 (en) | 2014-12-19 | 2021-07-14 | Amgen Inc. | Drug delivery device with proximity sensor |
| WO2016129656A1 (ja) * | 2015-02-12 | 2016-08-18 | 国立大学法人岩手大学 | 哺乳動物細胞に対する外来遺伝子の導入効率の向上剤 |
| WO2016133947A1 (en) | 2015-02-17 | 2016-08-25 | Amgen Inc. | Drug delivery device with vacuum assisted securement and/or feedback |
| EP3261690B1 (en) | 2015-02-27 | 2021-12-15 | Amgen Inc. | Drug delivery device having a needle guard mechanism with a tunable threshold of resistance to needle guard movement |
| WO2017039786A1 (en) | 2015-09-02 | 2017-03-09 | Amgen Inc. | Syringe assembly adapter for a syringe |
| EP3386573B1 (en) | 2015-12-09 | 2019-10-02 | Amgen Inc. | Auto-injector with signaling cap |
| US11154661B2 (en) | 2016-01-06 | 2021-10-26 | Amgen Inc. | Auto-injector with signaling electronics |
| ES2814287T3 (es) | 2016-03-15 | 2021-03-26 | Amgen Inc | Reducir la probabilidad de rotura de cristal en dispositivos de administración de fármaco |
| WO2017189089A1 (en) | 2016-04-29 | 2017-11-02 | Amgen Inc. | Drug delivery device with messaging label |
| US11389588B2 (en) | 2016-05-02 | 2022-07-19 | Amgen Inc. | Syringe adapter and guide for filling an on-body injector |
| US10988284B2 (en) | 2016-05-13 | 2021-04-27 | Amgen Inc. | Vial sleeve assembly |
| WO2017200989A1 (en) | 2016-05-16 | 2017-11-23 | Amgen Inc. | Data encryption in medical devices with limited computational capability |
| WO2017209899A1 (en) | 2016-06-03 | 2017-12-07 | Amgen Inc. | Impact testing apparatuses and methods for drug delivery devices |
| US11285266B2 (en) | 2016-07-01 | 2022-03-29 | Amgen Inc. | Drug delivery device having minimized risk of component fracture upon impact events |
| US20190328965A1 (en) | 2016-08-17 | 2019-10-31 | Amgen Inc. | Drug delivery device with placement detection |
| WO2018081234A1 (en) | 2016-10-25 | 2018-05-03 | Amgen Inc. | On-body injector |
| CN108264547B (zh) * | 2016-12-30 | 2021-09-21 | 四川科伦博泰生物医药股份有限公司 | 一种纯化蛋白的方法以及试剂盒 |
| CA3049780A1 (en) | 2017-01-17 | 2018-07-26 | Amgen Inc. | Injection devices and related methods of use and assembly |
| CA3052204A1 (en) | 2017-02-17 | 2018-08-23 | Amgen Inc. | Insertion mechanism for drug delivery device |
| US11752258B2 (en) | 2017-02-17 | 2023-09-12 | Amgen Inc. | Drug delivery device with sterile fluid flowpath and related method of assembly |
| AU2018231107B2 (en) | 2017-03-06 | 2023-04-20 | Amgen Inc. | Drug delivery device with activation prevention feature |
| WO2018164829A1 (en) | 2017-03-07 | 2018-09-13 | Amgen Inc. | Needle insertion by overpressure |
| IL303449B2 (en) | 2017-03-09 | 2024-08-01 | Amgen Inc | Insertion mechanism for a drug delivery device |
| HUE072005T2 (hu) | 2017-03-11 | 2025-10-28 | Cartesian Therapeutics Inc | Gyulladásgátlókkal és immunszupresszánst tartalmazó szintetikus nanohordozókkal történõ kombinált kezeléssel összefüggõ eljárások és készítmények |
| LT3600491T (lt) | 2017-03-28 | 2023-10-10 | Amgen Inc. | Stūmoklio koto ir švirkšto konstrukcinė sistema ir būdas |
| US11904143B2 (en) | 2017-06-08 | 2024-02-20 | Amgen Inc. | Torque driven drug delivery device |
| AU2018280054B2 (en) | 2017-06-08 | 2023-07-13 | Amgen Inc. | Syringe assembly for a drug delivery device and method of assembly |
| US11541183B2 (en) | 2017-06-22 | 2023-01-03 | Amgen Inc. | Device activation impact/shock reduction |
| US11395880B2 (en) | 2017-06-23 | 2022-07-26 | Amgen Inc. | Electronic drug delivery device |
| EP3651832B1 (en) | 2017-07-14 | 2023-12-13 | Amgen Inc. | Needle insertion-retraction system having dual torsion spring system |
| US11672733B2 (en) | 2017-07-21 | 2023-06-13 | Amgen Inc. | Gas permeable sealing member for drug container and methods of assembly |
| WO2019022950A1 (en) | 2017-07-25 | 2019-01-31 | Amgen Inc. | DRUG DELIVERY DEVICE WITH CONTAINER ACCESS SYSTEM AND ASSEMBLY METHOD THEREOF |
| EP4085942A1 (en) | 2017-07-25 | 2022-11-09 | Amgen Inc. | Drug delivery device with gear module and related method of assembly |
| EP3664863A2 (en) | 2017-08-09 | 2020-06-17 | Amgen Inc. | Hydraulic-pneumatic pressurized chamber drug delivery system |
| EP3668567A1 (en) | 2017-08-18 | 2020-06-24 | Amgen Inc. | Wearable injector with sterile adhesive patch |
| US11103636B2 (en) | 2017-08-22 | 2021-08-31 | Amgen Inc. | Needle insertion mechanism for drug delivery device |
| EP3691717B1 (en) | 2017-10-04 | 2023-02-08 | Amgen Inc. | Flow adapter for drug delivery device |
| WO2019070552A1 (en) | 2017-10-06 | 2019-04-11 | Amgen Inc. | DRUG DELIVERY DEVICE COMPRISING A LOCKOUT ASSEMBLY AND ASSOCIATED ASSEMBLY METHOD |
| MA50348A (fr) | 2017-10-09 | 2020-08-19 | Amgen Inc | Dispositif d'administration de médicament comprenant un ensemble d'entraînement et procédé d'assemblage associé |
| US11826480B2 (en) | 2017-11-03 | 2023-11-28 | Amgen Inc. | Systems and approaches for sterilizing a drug delivery device |
| MA50569A (fr) | 2017-11-06 | 2020-09-16 | Amgen Inc | Ensembles de remplissage-finition et procédés associés |
| WO2019089178A1 (en) | 2017-11-06 | 2019-05-09 | Amgen Inc. | Drug delivery device with placement and flow sensing |
| MX2020004736A (es) | 2017-11-10 | 2020-08-13 | Amgen Inc | Embolos para dispositivos de administracion de farmacos. |
| SG11202002772VA (en) | 2017-11-16 | 2020-04-29 | Amgen Inc | Autoinjector with stall and end point detection |
| EP3710090A1 (en) | 2017-11-16 | 2020-09-23 | Amgen Inc. | Door latch mechanism for drug delivery device |
| US10835685B2 (en) | 2018-05-30 | 2020-11-17 | Amgen Inc. | Thermal spring release mechanism for a drug delivery device |
| US11083840B2 (en) | 2018-06-01 | 2021-08-10 | Amgen Inc. | Modular fluid path assemblies for drug delivery devices |
| EP3586860A1 (en) * | 2018-06-22 | 2020-01-01 | Universität Ulm | Complement inhibitors and uses thereof |
| WO2020023336A1 (en) | 2018-07-24 | 2020-01-30 | Amgen Inc. | Hybrid drug delivery devices with grip portion |
| MX2021000749A (es) | 2018-07-24 | 2021-03-29 | Amgen Inc | Dispositivos de suministro para administrar farmacos. |
| WO2020023220A1 (en) | 2018-07-24 | 2020-01-30 | Amgen Inc. | Hybrid drug delivery devices with tacky skin attachment portion and related method of preparation |
| CA3103681A1 (en) | 2018-07-24 | 2020-01-30 | Amgen Inc. | Delivery devices for administering drugs |
| EP3829692A1 (en) | 2018-07-31 | 2021-06-09 | Amgen Inc. | Fluid path assembly for a drug delivery device |
| AU2019347710B2 (en) | 2018-09-24 | 2025-05-08 | Amgen Inc. | Interventional dosing systems and methods |
| EP3856283A1 (en) | 2018-09-28 | 2021-08-04 | Amgen Inc. | Muscle wire escapement activation assembly for a drug delivery device |
| WO2020072577A1 (en) | 2018-10-02 | 2020-04-09 | Amgen Inc. | Injection systems for drug delivery with internal force transmission |
| CA3112214A1 (en) | 2018-10-05 | 2020-04-09 | Amgen Inc. | Drug delivery device having dose indicator |
| MX2021002791A (es) | 2018-10-15 | 2021-05-12 | Amgen Inc | Proceso de ensamblaje de plataforma para un dispositivo de administracion de farmacos. |
| US12053617B2 (en) | 2018-10-15 | 2024-08-06 | Amgen Inc. | Drug delivery device having damping mechanism |
| CN112888453A (zh) * | 2018-10-26 | 2021-06-01 | 协和麒麟株式会社 | 用于治疗再生障碍性贫血的药物组合物 |
| TWI831847B (zh) | 2018-11-01 | 2024-02-11 | 美商安進公司 | 部分針頭縮回之藥物遞送裝置及其操作方法 |
| WO2020091956A1 (en) | 2018-11-01 | 2020-05-07 | Amgen Inc. | Drug delivery devices with partial drug delivery member retraction |
| US12485219B2 (en) | 2018-11-01 | 2025-12-02 | Amgen Inc. | Drug delivery devices with partial drug delivery member retraction |
| MX2021012557A (es) | 2019-04-24 | 2021-11-12 | Amgen Inc | Conjuntos y metodos de verificacion de esterilizacion de jeringuillas. |
| WO2020223303A1 (en) | 2019-04-29 | 2020-11-05 | The Children's Hospital Of Philadelphia | Compositions and methods for increasing megakaryocyte production |
| MX2022002149A (es) | 2019-08-23 | 2022-03-17 | Amgen Inc | Dispositivo de suministro de farmacos con componentes de acoplamiento de capuchon de aguja configurable y metodos relacionados. |
| AU2021399935A1 (en) | 2020-12-18 | 2023-06-29 | Richter Gedeon Nyrt. | Methods for the purification of refolded fc-peptide fusion protein |
| US20240156973A1 (en) * | 2021-02-24 | 2024-05-16 | Purdue Research Foundation | Osteotropic compositions and uses thereof |
| CN113402614A (zh) * | 2021-04-22 | 2021-09-17 | 山东泉港药业有限公司 | 血小板生成素拟肽融合蛋白(fc-tmp)编码基因与应用 |
| BR112023024278A2 (pt) | 2021-05-21 | 2024-01-30 | Amgen Inc | Método de otimizar uma receita de enchimento para um recipiente de fármacos |
| WO2023044774A1 (en) * | 2021-09-24 | 2023-03-30 | Sichuan Clover Biopharmaceuticals, Inc. | Tpo mimetic fusion proteins and methods of use submission of sequence listing as ascii text file |
| CN118973600A (zh) | 2022-02-02 | 2024-11-15 | 国立大学法人筑波大学 | 用于脐带血移植后的血细胞恢复的药物组合物 |
| MX2024010846A (es) | 2022-03-24 | 2024-09-11 | Richter Gedeon Nyrt | Metodo para la preparacion de biofarmacos. |
| US20240148841A1 (en) | 2022-08-11 | 2024-05-09 | Selecta Biosciences Inc. | Compositions and methods related to immunoglobulin proteases and fusions thereof |
| WO2025037108A2 (en) | 2023-08-15 | 2025-02-20 | Board Of Trustees Of The Leland Stanford Junior University | Modified thrombopoietin |
| CN117986346B (zh) * | 2024-04-07 | 2024-07-26 | 中国人民解放军军事科学院军事医学研究院 | 一种tpo模拟肽及其应用 |
| CN119780301B (zh) * | 2025-01-10 | 2025-08-01 | 山东泉港药业有限公司 | 一种血小板生成素拟肽的肽图检测分析方法 |
Family Cites Families (178)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3694016A (en) * | 1969-09-01 | 1972-09-26 | John Patrick Scallan | Cover-lock for containers |
| US3691016A (en) | 1970-04-17 | 1972-09-12 | Monsanto Co | Process for the preparation of insoluble enzymes |
| CA1023287A (en) | 1972-12-08 | 1977-12-27 | Boehringer Mannheim G.M.B.H. | Process for the preparation of carrier-bound proteins |
| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US3941763A (en) | 1975-03-28 | 1976-03-02 | American Home Products Corporation | PGlu-D-Met-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH2 and intermediates |
| US4002531A (en) | 1976-01-22 | 1977-01-11 | Pierce Chemical Company | Modifying enzymes with polyethylene glycol and product produced thereby |
| US4195128A (en) | 1976-05-03 | 1980-03-25 | Bayer Aktiengesellschaft | Polymeric carrier bound ligands |
| US4330440A (en) | 1977-02-08 | 1982-05-18 | Development Finance Corporation Of New Zealand | Activated matrix and method of activation |
| CA1093991A (en) | 1977-02-17 | 1981-01-20 | Hideo Hirohara | Enzyme immobilization with pullulan gel |
| US4229537A (en) | 1978-02-09 | 1980-10-21 | New York University | Preparation of trichloro-s-triazine activated supports for coupling ligands |
| US4289872A (en) | 1979-04-06 | 1981-09-15 | Allied Corporation | Macromolecular highly branched homogeneous compound based on lysine units |
| JPS6023084B2 (ja) | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
| US4640835A (en) | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
| US4503235A (en) | 1983-03-11 | 1985-03-05 | Warner-Lambert Company | Process for producing 4-carbamoyl-1H-imidazolium-5-olate |
| US4496689A (en) | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
| EP0154316B1 (en) | 1984-03-06 | 1989-09-13 | Takeda Chemical Industries, Ltd. | Chemically modified lymphokine and production thereof |
| EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
| EP0206448B1 (en) | 1985-06-19 | 1990-11-14 | Ajinomoto Co., Inc. | Hemoglobin combined with a poly(alkylene oxide) |
| US5017691A (en) * | 1986-07-03 | 1991-05-21 | Schering Corporation | Mammalian interleukin-4 |
| US5985599A (en) | 1986-05-29 | 1999-11-16 | The Austin Research Institute | FC receptor for immunoglobulin |
| US4791192A (en) | 1986-06-26 | 1988-12-13 | Takeda Chemical Industries, Ltd. | Chemically modified protein with polyethyleneglycol |
| JP2876058B2 (ja) | 1986-08-18 | 1999-03-31 | エミスフィア・テクノロジーズ・インコーポレイテッド | 薬物送達システム |
| US5229490A (en) | 1987-05-06 | 1993-07-20 | The Rockefeller University | Multiple antigen peptide system |
| US5336603A (en) | 1987-10-02 | 1994-08-09 | Genentech, Inc. | CD4 adheson variants |
| ATE106249T1 (de) | 1987-11-05 | 1994-06-15 | Hybritech Inc | Polysaccharidmodifizierte immunglobuline mit reduziertem immunogenem potential oder verbesserter pharmakokinetik. |
| US4904584A (en) | 1987-12-23 | 1990-02-27 | Genetics Institute, Inc. | Site-specific homogeneous modification of polypeptides |
| DE68926888T2 (de) | 1988-01-22 | 1997-01-09 | Zymogenetics Inc | Verfahren zur Herstellung von sekretierten Rezeptoranalogen |
| CA1340810C (en) | 1988-03-31 | 1999-11-02 | Motoo Yamasaki | Polypeptide derivatives of human granulocyte colony stimulating factor |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| GB8824591D0 (en) | 1988-10-20 | 1988-11-23 | Royal Free Hosp School Med | Fractionation process |
| AU638964B2 (en) | 1988-12-22 | 1993-07-15 | Genentech Inc. | Method for preparing water soluble polypeptides |
| DE68925966T2 (de) | 1988-12-22 | 1996-08-29 | Kirin Amgen Inc | Chemisch modifizierte granulocytenkolonie erregender faktor |
| US4902502A (en) | 1989-01-23 | 1990-02-20 | Cetus Corporation | Preparation of a polymer/interleukin-2 conjugate |
| US5089261A (en) | 1989-01-23 | 1992-02-18 | Cetus Corporation | Preparation of a polymer/interleukin-2 conjugate |
| US5225538A (en) | 1989-02-23 | 1993-07-06 | Genentech, Inc. | Lymphocyte homing receptor/immunoglobulin fusion proteins |
| US5116964A (en) | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
| US5098833A (en) | 1989-02-23 | 1992-03-24 | Genentech, Inc. | DNA sequence encoding a functional domain of a lymphocyte homing receptor |
| US5216131A (en) | 1989-02-23 | 1993-06-01 | Genentech, Inc. | Lymphocyte homing receptors |
| US5627262A (en) | 1989-07-05 | 1997-05-06 | The Board Of Regents Of The University Of Oklahoma | Method and composition for the treatment of septic shock |
| DE59010908D1 (de) | 1989-09-12 | 2000-08-10 | Hoffmann La Roche | TNF-bindende Proteine |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| JPH04218000A (ja) | 1990-02-13 | 1992-08-07 | Kirin Amgen Inc | 修飾ポリペプチド |
| US5723286A (en) | 1990-06-20 | 1998-03-03 | Affymax Technologies N.V. | Peptide library and screening systems |
| AU665190B2 (en) | 1990-07-10 | 1995-12-21 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| WO1992001718A2 (en) | 1990-07-17 | 1992-02-06 | Board Of Regents Of The University Of Oklahoma | Functionally active selectin-derived peptides and ligand for gmp-140 |
| IE912365A1 (en) | 1990-07-23 | 1992-01-29 | Zeneca Ltd | Continuous release pharmaceutical compositions |
| US5252714A (en) | 1990-11-28 | 1993-10-12 | The University Of Alabama In Huntsville | Preparation and use of polyethylene glycol propionaldehyde |
| WO1992016192A1 (en) | 1991-03-15 | 1992-10-01 | Amgen Inc. | Pulmonary administration of granulocyte colony stimulating factor |
| GEP20033082B (en) | 1991-03-15 | 2003-10-27 | Amgen Inc | Pegylation of Polypeptides |
| US5595732A (en) | 1991-03-25 | 1997-01-21 | Hoffmann-La Roche Inc. | Polyethylene-protein conjugates |
| US6139843A (en) | 1991-04-02 | 2000-10-31 | Albert Einstein College Of Medicine Of Yeshiva University | Peptide compositions for the treatment of HIV |
| US5281698A (en) | 1991-07-23 | 1994-01-25 | Cetus Oncology Corporation | Preparation of an activated polymer ester for protein conjugation |
| US5362852A (en) | 1991-09-27 | 1994-11-08 | Pfizer Inc. | Modified peptide derivatives conjugated at 2-hydroxyethylamine moieties |
| US5270170A (en) | 1991-10-16 | 1993-12-14 | Affymax Technologies N.V. | Peptide library and screening method |
| US5733731A (en) | 1991-10-16 | 1998-03-31 | Affymax Technologies N.V. | Peptide library and screening method |
| NZ244778A (en) | 1991-10-21 | 1994-03-25 | Ortho Pharma Corp | Peg imidates and protein derivatives thereof |
| CA2312667C (en) * | 1991-10-25 | 2002-11-19 | Immunex Corporation | Novel cytokine |
| US5376367A (en) | 1991-11-22 | 1994-12-27 | Immunex Corporation | Fusion proteins comprising MGF and IL-3 |
| CA2118130A1 (en) | 1992-04-14 | 1993-10-28 | Jean M. J. Frechet | Dendritic based macromolecules and method of production |
| CA2131003A1 (en) | 1992-05-26 | 1993-12-09 | Raymond G. Goodwin | Novel cytokine that binds cd30 |
| US5792451A (en) | 1994-03-02 | 1998-08-11 | Emisphere Technologies, Inc. | Oral drug delivery compositions and methods |
| EP0671926B1 (en) | 1992-08-11 | 2002-11-13 | President And Fellows Of Harvard College | Immunomodulatory peptides |
| DE69334287D1 (de) | 1992-09-25 | 2009-07-09 | Avipep Pty Ltd | Zielmoleküle-bindende Polypeptide bestehend aus einer IG-artigen VL Domäne die an eine IG-artige VH Domäne gebunden ist |
| GB9225448D0 (en) | 1992-12-04 | 1993-01-27 | Erba Carlo Spa | Improved synthesis of polymer bioactive conjugates |
| NZ247231A (en) * | 1993-03-23 | 1994-10-26 | Holyoake Ind Ltd | Diffuser for air conditioning system; outlet air direction thermostatically controlled |
| WO1995009917A1 (en) | 1993-10-07 | 1995-04-13 | The Regents Of The University Of California | Genetically engineered bispecific tetravalent antibodies |
| US5922545A (en) | 1993-10-29 | 1999-07-13 | Affymax Technologies N.V. | In vitro peptide and antibody display libraries |
| US5773569A (en) | 1993-11-19 | 1998-06-30 | Affymax Technologies N.V. | Compounds and peptides that bind to the erythropoietin receptor |
| US5981478A (en) | 1993-11-24 | 1999-11-09 | La Jolla Cancer Research Foundation | Integrin-binding peptides |
| GB2285446B (en) | 1994-01-03 | 1999-07-28 | Genentech Inc | Thrombopoietin |
| US5786331A (en) | 1994-02-02 | 1998-07-28 | Affymax Technologies N.V. | Peptides and compounds that bind to the IL-1 receptor |
| US5880096A (en) | 1994-02-02 | 1999-03-09 | Affymax Technologies N.V. | Peptides and compounds that bind to the IL-1 receptor |
| US5608035A (en) | 1994-02-02 | 1997-03-04 | Affymax Technologies N.V. | Peptides and compounds that bind to the IL-1 receptor |
| WO1995021919A2 (en) | 1994-02-14 | 1995-08-17 | Kirin Brewery Company, Limited | Protein having tpo activity |
| BR9505781A (pt) * | 1994-02-14 | 1996-03-05 | Kirin Brewery | Proteina tendo atividade TPO |
| NZ271230A (en) | 1994-02-14 | 1998-03-25 | Zymogenetics Inc | Hematopoietic proteins, production and use |
| US5795569A (en) * | 1994-03-31 | 1998-08-18 | Amgen Inc. | Mono-pegylated proteins that stimulate megakaryocyte growth and differentiation |
| CN1229385C (zh) | 1994-03-31 | 2005-11-30 | 安姆根有限公司 | 刺激巨核细胞生长和分化的组合物及方法 |
| US6309853B1 (en) | 1994-08-17 | 2001-10-30 | The Rockfeller University | Modulators of body weight, corresponding nucleic acids and proteins, and diagnostic and therapeutic uses thereof |
| IL111196A0 (en) | 1994-10-07 | 1994-12-29 | Yeda Res & Dev | Peptides and pharmaceutical compositions comprising them |
| US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| AU693478B2 (en) | 1994-11-10 | 1998-07-02 | Metabolic Pharmaceuticals Limited | Treatment of obesity |
| IL116026A (en) | 1994-11-22 | 2005-08-31 | Rhone Poulenc Rorer Sa | Peptides capable of linking to the sh3 domain of gap, nucleotide sequences encoding the same, their preparation and uses |
| JP3511321B2 (ja) * | 1994-11-29 | 2004-03-29 | 出光興産株式会社 | スチレン系重合体の分子量制御方法 |
| US5641655A (en) * | 1994-11-30 | 1997-06-24 | Zymogenetics, Inc. | Methods for producing thrombopoietin polypeptides using a mammalian tissue plasminogen activator secretory peptide |
| AU700605B2 (en) | 1994-12-07 | 1999-01-07 | Bionebraska, Inc. | Production of peptides using recombinant fusion protein constructs |
| JPH11501506A (ja) | 1994-12-12 | 1999-02-09 | ベス イスラエル デアコネス メディカル センター | キメラ型サイトカインおよびその利用 |
| US5888763A (en) | 1994-12-30 | 1999-03-30 | The Rockefeller University | Peptides specific for the first Crk-SH3 domain |
| AU3204895A (en) | 1995-02-01 | 1996-08-21 | University Of Massachusetts Medical Center | Methods of selecting a random peptide that binds to a target protein |
| IL113159A0 (en) | 1995-03-28 | 1995-06-29 | Yeda Res & Dev | Synthetic peptides and pharmaceutical compositions comprising them |
| US6096871A (en) | 1995-04-14 | 2000-08-01 | Genentech, Inc. | Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life |
| US5739277A (en) | 1995-04-14 | 1998-04-14 | Genentech Inc. | Altered polypeptides with increased half-life |
| YU34196A (sh) * | 1995-06-07 | 1999-03-04 | Glaxo Group Limited | Peptidi i jedinjenja koja se vezuju za receptor |
| US5869451A (en) * | 1995-06-07 | 1999-02-09 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
| US6251864B1 (en) * | 1995-06-07 | 2001-06-26 | Glaxo Group Limited | Peptides and compounds that bind to a receptor |
| US5767078A (en) | 1995-06-07 | 1998-06-16 | Johnson; Dana L. | Agonist peptide dimers |
| KR100436680B1 (ko) | 1995-06-07 | 2004-09-18 | 글락소 그룹 리미티드 | 트롬보포이에틴 수용체에 결합하는 펩티드 및 화합물 |
| IL118524A (en) | 1995-06-19 | 2004-02-19 | Akzo Nobel Nv | Peptides and pharmaceutical preparations containing them useful in the treatment of peptide tolerance |
| PT1516628E (pt) | 1995-07-27 | 2013-09-24 | Genentech Inc | Formulação de proteína liofilizada isotónica estável |
| US5746516A (en) | 1995-08-11 | 1998-05-05 | Hitachi Powdered Metals Co., Ltd. | Porous bearing system having internal grooves and electric motor provided with the same |
| WO1997008553A1 (en) | 1995-08-22 | 1997-03-06 | The Regents Of The University Of California | Targeting of proteins to the cell wall of gram-positive bacteria |
| US5817750A (en) | 1995-08-28 | 1998-10-06 | La Jolla Cancer Research Foundation | Structural mimics of RGD-binding sites |
| JPH09151200A (ja) | 1995-09-29 | 1997-06-10 | Ajinomoto Co Inc | ヒト胃癌に対する免疫応答を誘導できるペプチド及び該ペプチドを含むヒト胃癌治療、予防剤 |
| US5670110A (en) | 1995-12-21 | 1997-09-23 | The Procter & Gamble Company | Method for making three-dimensional macroscopically-expanded webs having improved functional surfaces |
| US6369027B1 (en) | 1995-12-22 | 2002-04-09 | Amgen Inc. | Osteoprotegerin |
| CN1154971A (zh) * | 1996-01-19 | 1997-07-23 | 北京医科大学 | 血小板生长因子(tpo)及其制备方法和用途 |
| US5714577A (en) | 1996-01-26 | 1998-02-03 | University Of Pittsburgh | Antimicrobial peptides |
| EP0904112B1 (en) | 1996-02-09 | 2009-11-18 | Amgen Inc., | Composition comprising il-1ra as interleukin-1 inhibitor and hyaluronan as controlled release polymer |
| IL117223A0 (en) | 1996-02-22 | 1996-06-18 | Yeda Res & Dev | Antipathogenic polypeptides and compositions comprising them |
| JP4046354B2 (ja) | 1996-03-18 | 2008-02-13 | ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム | 増大した半減期を有する免疫グロブリン様ドメイン |
| JP4088344B2 (ja) | 1996-03-28 | 2008-05-21 | カイロン コーポレイション | ウロキナーゼレセプターのペプチドリガンド |
| IL118003A0 (en) | 1996-04-23 | 1996-08-04 | Yeda Res & Dev | Novel vip fragments and pharmaceutical compositions comprising them |
| FR2748028B1 (fr) | 1996-04-30 | 1998-08-14 | Lab Francais Du Fractionnement | Peptides derives du facteur von willebrand et leur utilisation comme anticoagulant |
| US6100071A (en) | 1996-05-07 | 2000-08-08 | Genentech, Inc. | Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production |
| WO1997046668A1 (en) | 1996-06-07 | 1997-12-11 | Takeda Chemical Industries, Ltd. | Novel peptide, process for the production of the same, and use of the same |
| US6126939A (en) | 1996-09-03 | 2000-10-03 | Yeda Research And Development Co. Ltd. | Anti-inflammatory dipeptide and pharmaceutical composition thereof |
| AU4412297A (en) | 1996-09-10 | 1998-04-02 | Burnham Institute, The | Tumor homing molecules, conjugates derived therefrom, and methods of using sa me |
| US5932546A (en) | 1996-10-04 | 1999-08-03 | Glaxo Wellcome Inc. | Peptides and compounds that bind to the thrombopoietin receptor |
| AU736876B2 (en) | 1996-12-06 | 2001-08-02 | Amgen, Inc. | Combination therapy using an IL-1 inhibitor for treating IL-1 mediated diseases |
| KR100937550B1 (ko) | 1996-12-20 | 2010-01-19 | 암젠 인코포레이티드 | Ob 융합 단백질 조성물과 이 단백질의 제조 방법 |
| KR19980066046A (ko) | 1997-01-18 | 1998-10-15 | 정용훈 | 고역가의 CTLA4-Ig 융합단백질 |
| US5955431A (en) | 1997-02-05 | 1999-09-21 | Brigham And Women's Hospital, Inc. | Mast cell protease peptide inhibitors |
| US5863735A (en) | 1997-02-24 | 1999-01-26 | Incyte Pharmaceuticals, Inc. | Human transmembrane 4 superfamily protein |
| NZ500253A (en) | 1997-04-16 | 2002-09-27 | Amgen Inc | Osteoprotegerin binding proteins and receptors |
| ES2183351T3 (es) | 1997-04-17 | 2003-03-16 | Amgen Inc | Composicones que comprenden conjugados de proteina ob humana activa estable con una cadena fc de inmunoglobulinas y metodos. |
| US6265535B1 (en) | 1997-05-30 | 2001-07-24 | The Trustees Of The University Of Pennsylvania | Peptides and peptide analogues designed from binding sites of tumor necrosis factor receptor superfamily and their uses |
| WO1998055620A1 (en) | 1997-06-06 | 1998-12-10 | Regeneron Pharmaceuticals, Inc. | Ntn-2 member of tnf ligand family |
| EP0998577B1 (en) | 1997-07-24 | 2004-10-27 | Perseptive Biosystems, Inc. | Conjugates of transporter peptides and nucleic acid analogs, and their use |
| US6342220B1 (en) | 1997-08-25 | 2002-01-29 | Genentech, Inc. | Agonist antibodies |
| US6238667B1 (en) | 1997-09-19 | 2001-05-29 | Heinz Kohler | Method of affinity cross-linking biologically active immunogenic peptides to antibodies |
| CA2306246A1 (en) | 1997-10-06 | 1999-04-15 | Millennium Pharmaceuticals, Inc. | Signal peptide containing proteins and uses therefor |
| CN1138472C (zh) | 1997-10-10 | 2004-02-18 | 西托维亚公司 | 二肽型编程性细胞死亡抑制剂及其用途 |
| ES2173641T3 (es) | 1997-11-07 | 2002-10-16 | Conjuchem Inc | Composicion de derivados opiaceos para la fabricacion de medicamentos. |
| WO1999038526A1 (en) | 1998-01-29 | 1999-08-05 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Variant peptide ligands that selectively induce apoptosis |
| US6162613A (en) | 1998-02-18 | 2000-12-19 | Vertex Pharmaceuticals, Inc. | Methods for designing inhibitors of serine/threonine-kinases and tyrosine kinases |
| JP2002505338A (ja) | 1998-03-05 | 2002-02-19 | カイロン コーポレイション | 生物学的に活性な分子の血清半減期を増加するための方法 |
| US6235872B1 (en) | 1998-03-12 | 2001-05-22 | The Burnham Institute | Proapoptotic peptides dependence polypeptides and methods of use |
| JP4361684B2 (ja) | 1998-03-20 | 2009-11-11 | 中外製薬株式会社 | エリトロポエチン受容体のためのペプチドリガンド |
| EP0947524A1 (en) | 1998-03-30 | 1999-10-06 | Upither B.V. | Novel peptides for the treatment of autoimmune diseases |
| DE69925829D1 (de) | 1998-04-06 | 2005-07-21 | Advanced Immunitt Inc | Kurzes peptid zur behandlung neurodegenerativer erkrankungen |
| DE69925830T2 (de) | 1998-04-28 | 2006-05-04 | Applied Research Systems Ars Holding N.V. | Peg-lhrh analog konjugate |
| EP0972780A1 (en) | 1998-05-18 | 2000-01-19 | Applied Research Systems ARS Holding N.V. | Il-6 antagonist peptides |
| EP0958829B1 (en) | 1998-05-21 | 2004-05-19 | Tecnogen S.C.P.A. | Use of a peptide compound in the treatment of systemic lupus erythematosus |
| AU764277B2 (en) | 1998-05-22 | 2003-08-14 | Abbvie Inc. | Peptide antiangiogenic drugs |
| US5932548A (en) | 1998-06-03 | 1999-08-03 | Deghenghi; Romano | Lysine containing peptides for treatment of heart disease |
| WO2000001402A1 (en) | 1998-07-02 | 2000-01-13 | Envision Biomedical Consulting | Antiproliferative and antiviral proteins and peptides |
| US6168785B1 (en) | 1998-07-16 | 2001-01-02 | Institut Pasteur | Biological applications of new peptides of IL-2 and derivatives and use as therapeutic agents |
| WO2000009560A2 (en) | 1998-08-17 | 2000-02-24 | Abgenix, Inc. | Generation of modified molecules with increased serum half-lives |
| US6906170B1 (en) | 1998-08-21 | 2005-06-14 | Yeda Research And Development Co. Ltd. | Anti-inflammatory peptides derived from IL-2 and analogues thereof |
| US7488590B2 (en) | 1998-10-23 | 2009-02-10 | Amgen Inc. | Modified peptides as therapeutic agents |
| ATE348163T1 (de) | 1998-10-23 | 2007-01-15 | Amgen Inc | Thrombopoietin substitute |
| US6660843B1 (en) | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
| AU2880400A (en) | 1999-02-12 | 2000-08-29 | Amgen, Inc. | Tnf-related proteins |
| US6635646B1 (en) | 1999-05-04 | 2003-10-21 | Schering Corporation | Pegylated interferon alfa-CCR5 antagonist combination HIV therapy |
| WO2001002440A1 (en) | 1999-07-02 | 2001-01-11 | Genentech, Inc. | Fusion peptides comprising a peptide ligand domain and a multimerization domain |
| US6586398B1 (en) | 2000-04-07 | 2003-07-01 | Amgen, Inc. | Chemically modified novel erythropoietin stimulating protein compositions and methods |
| AU2001259432B2 (en) | 2000-05-03 | 2005-04-21 | Amgen Inc. | Modified peptides, comprising an FC domain, as therapeutic agents |
| ES2316919T3 (es) | 2000-12-05 | 2009-04-16 | Alexion Pharmaceuticals, Inc. | Anticuerpos diseñados racionalmente. |
| US7396917B2 (en) | 2000-12-05 | 2008-07-08 | Alexion Pharmaceuticals, Inc. | Rationally designed antibodies |
| AU2002307062A1 (en) | 2001-04-02 | 2002-10-15 | Purdue Pharma L.P. | Thrombopoietin (tpo) synthebody for stimulation of platelet production |
| US7205275B2 (en) | 2001-10-11 | 2007-04-17 | Amgen Inc. | Methods of treatment using specific binding agents of human angiopoietin-2 |
| US7138370B2 (en) | 2001-10-11 | 2006-11-21 | Amgen Inc. | Specific binding agents of human angiopoietin-2 |
| US7332474B2 (en) | 2001-10-11 | 2008-02-19 | Amgen Inc. | Peptides and related compounds having thrombopoietic activity |
| CA2490409A1 (en) | 2002-06-28 | 2004-01-08 | Centocor, Inc. | Mammalian ch1 deleted mimetibodies, compositions, methods and uses |
| JP2005536992A (ja) | 2002-06-28 | 2005-12-08 | セントカー・インコーポレーテツド | 哺乳動物のepo模倣ch1欠失ミメティボディ、組成物、方法および使用 |
| US6919426B2 (en) | 2002-09-19 | 2005-07-19 | Amgen Inc. | Peptides and related molecules that modulate nerve growth factor activity |
| AU2003291689A1 (en) | 2002-10-31 | 2004-05-25 | Protein Design Labs, Inc. | Stable liquid pharmaceutical formulation of antibodies that are prone to isomerization |
| WO2004058988A2 (en) | 2002-12-20 | 2004-07-15 | Amgen, Inc. | Binding agents which inhibit myostatin |
| CN1871022B (zh) | 2003-08-28 | 2011-07-06 | 奥索-麦克尼尔药品公司 | 结合血小板生成素受体的肽和化合物 |
| CA2572765C (en) | 2004-07-08 | 2013-05-21 | Amgen Inc. | Compound having improved bioefficiency when administered in a multidose regimen |
| US7442778B2 (en) | 2004-09-24 | 2008-10-28 | Amgen Inc. | Modified Fc molecules |
| JP5517450B2 (ja) | 2005-03-10 | 2014-06-11 | バイオンテック アーゲー | 二量体または多量体のマイクロタンパク質 |
| US8008453B2 (en) | 2005-08-12 | 2011-08-30 | Amgen Inc. | Modified Fc molecules |
| EP1986677A2 (en) | 2006-01-25 | 2008-11-05 | Amgen Inc. | Thrombopoietic compounds |
| US9283260B2 (en) | 2006-04-21 | 2016-03-15 | Amgen Inc. | Lyophilized therapeutic peptibody formulations |
| US7981425B2 (en) | 2006-06-19 | 2011-07-19 | Amgen Inc. | Thrombopoietic compounds |
| US8197642B2 (en) * | 2007-07-26 | 2012-06-12 | Nichiha Corporation | Inorganic board and method for manufacturing the same |
| US10534898B2 (en) | 2017-01-18 | 2020-01-14 | International Business Machines Corporation | Code identification |
-
1999
- 1999-10-22 AT AT99970998T patent/ATE348163T1/de active
- 1999-10-22 HK HK02103927.0A patent/HK1042114B/zh not_active IP Right Cessation
- 1999-10-22 WO PCT/US1999/024834 patent/WO2000024770A2/en not_active Ceased
- 1999-10-22 SI SI9931072T patent/SI2319928T1/sl unknown
- 1999-10-22 TW TW88118317A patent/TWI250988B/zh not_active IP Right Cessation
- 1999-10-22 SK SK496-2001A patent/SK287737B6/sk not_active IP Right Cessation
- 1999-10-22 DK DK99970998T patent/DK1124961T3/da active
- 1999-10-22 AU AU12239/00A patent/AU773891C/en not_active Expired
- 1999-10-22 EP EP19990970998 patent/EP1124961B9/en not_active Expired - Lifetime
- 1999-10-22 CN CNB998125172A patent/CN1250721C/zh not_active Expired - Lifetime
- 1999-10-22 ES ES10011689T patent/ES2422231T3/es not_active Expired - Lifetime
- 1999-10-22 PT PT06022333T patent/PT1783222E/pt unknown
- 1999-10-22 CA CA 2346996 patent/CA2346996C/en not_active Expired - Lifetime
- 1999-10-22 EA EA200100465A patent/EA003998B1/ru not_active IP Right Cessation
- 1999-10-22 KR KR1020017004723A patent/KR100719202B1/ko not_active Expired - Lifetime
- 1999-10-22 BR BRPI9914698A patent/BRPI9914698B8/pt not_active IP Right Cessation
- 1999-10-22 MY MYPI99004566A patent/MY126795A/en unknown
- 1999-10-22 DK DK06022333T patent/DK1783222T3/da active
- 1999-10-22 SI SI9931068T patent/SI1783222T1/sl unknown
- 1999-10-22 PT PT99970998T patent/PT1124961E/pt unknown
- 1999-10-22 CN CN2006100044518A patent/CN1810832B/zh not_active Expired - Lifetime
- 1999-10-22 CZ CZ20011287A patent/CZ302155B6/cs not_active IP Right Cessation
- 1999-10-22 ES ES06022333T patent/ES2388341T3/es not_active Expired - Lifetime
- 1999-10-22 JP JP2000578340A patent/JP3820105B2/ja not_active Expired - Lifetime
- 1999-10-22 ME MEP42108 patent/MEP42108A/xx unknown
- 1999-10-22 ES ES99970998T patent/ES2279649T3/es not_active Expired - Lifetime
- 1999-10-22 PT PT100116896T patent/PT2319928E/pt unknown
- 1999-10-22 PL PL348041A patent/PL219605B1/pl unknown
- 1999-10-22 EP EP20060022333 patent/EP1783222B1/en not_active Expired - Lifetime
- 1999-10-22 EP EP20100011689 patent/EP2319928B9/en not_active Expired - Lifetime
- 1999-10-22 IL IL14202399A patent/IL142023A0/xx active Protection Beyond IP Right Term
- 1999-10-22 ME MEP-2008-421A patent/ME00238B/me unknown
- 1999-10-22 TW TW94140160A patent/TWI257394B/zh not_active IP Right Cessation
- 1999-10-22 DK DK10011689T patent/DK2319928T3/da active
- 1999-10-22 NZ NZ510529A patent/NZ510529A/en not_active IP Right Cessation
- 1999-10-22 DE DE1999634425 patent/DE69934425T2/de not_active Expired - Lifetime
- 1999-10-22 SI SI9930953T patent/SI1124961T1/sl unknown
- 1999-10-22 AR ARP990105333 patent/AR020934A1/es active IP Right Grant
- 1999-10-22 US US09/422,838 patent/US6835809B1/en not_active Expired - Lifetime
- 1999-10-22 HU HU0104327A patent/HU228582B1/hu unknown
- 1999-10-22 DE DE200912000039 patent/DE122009000039I1/de active Pending
- 1999-10-22 RS YU24301 patent/RS51237B/sr unknown
-
2001
- 2001-03-14 ZA ZA200102102A patent/ZA200102102B/en unknown
- 2001-04-03 BG BG105401A patent/BG65663B1/bg unknown
- 2001-04-03 BG BG11022101A patent/BG110221A/en unknown
- 2001-04-20 NO NO20011962A patent/NO331027B1/no not_active IP Right Cessation
-
2004
- 2004-09-02 US US10/933,133 patent/US8044174B2/en not_active Expired - Fee Related
-
2006
- 2006-01-19 US US11/335,878 patent/US9145450B2/en not_active Expired - Lifetime
- 2006-04-10 JP JP2006107321A patent/JP4332163B2/ja not_active Expired - Lifetime
- 2006-12-22 US US11/644,757 patent/US20070142295A1/en not_active Abandoned
-
2007
- 2007-03-12 CY CY20071100334T patent/CY1107526T1/el unknown
-
2008
- 2008-09-16 BG BG10110221A patent/BG66190B1/bg unknown
-
2009
- 2009-03-13 US US12/404,047 patent/US7994117B2/en not_active Expired - Fee Related
- 2009-07-29 LT LTPA2009006C patent/LTC1124961I2/lt unknown
- 2009-07-30 FR FR09C0030C patent/FR09C0030I2/fr active Active
- 2009-07-30 LU LU91598C patent/LU91598I2/fr unknown
- 2009-08-03 NL NL300398C patent/NL300398I2/nl unknown
- 2009-08-03 CY CY2009012C patent/CY2009012I1/el unknown
-
2011
- 2011-10-20 US US13/278,137 patent/US8748571B2/en not_active Expired - Fee Related
-
2012
- 2012-03-12 NO NO2012005C patent/NO2012005I2/no unknown
- 2012-04-27 US US13/458,744 patent/US8618044B2/en not_active Expired - Fee Related
- 2012-09-05 CY CY20121100797T patent/CY1113107T1/el unknown
-
2013
- 2013-06-14 CY CY20131100482T patent/CY1114940T1/el unknown
-
2014
- 2014-04-30 US US14/266,563 patent/US9534032B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR020934A1 (es) | Compuestos trombopoyeticos | |
| BR0116831A (pt) | Composição oral e seu uso | |
| BR8900950A (pt) | Composicao dentifricia listrada estavel | |
| MX167330B (es) | Composiciones microbiocidas estabilizadas con fenol | |
| ES2173284T3 (es) | Agentes endoparasicitidas. | |
| FI863797A7 (fi) | N-terminaaliselle metioniinille spesifinen peptidaasi, sen tuottaminen ja käyttö. | |
| FR2654932B1 (fr) | Composition anorexigene. | |
| FI904444A0 (fi) | Aktiva limkompositioner. | |
| FI904801A0 (fi) | Komposition. | |
| DE58904645D1 (de) | Tensidkombination. | |
| DE68923863D1 (de) | Ein-/Ausgabecachespeicherung. | |
| DE68908500D1 (de) | Dentalzusammensetzung. | |
| DE69012702D1 (de) | Dentalzusammensetzung. | |
| DE68921181D1 (de) | Bleichmittelzusammensetzung. | |
| DE69034070D1 (de) | Racemisches Huperzin A | |
| AR244544A1 (es) | Composicion desodorante. | |
| IT8920068A0 (it) | Composizione deodorante. | |
| DE60109179D1 (de) | Quantenkaskadierter laser | |
| DE69023059D1 (de) | Verschmutzungsverhindernde Zusammensetzung. | |
| AR244941A1 (es) | Compuesto, composicion, procedimiento y uso antimicrobiano. | |
| FI900862A0 (fi) | Hoegeffektiva polarisatorer. | |
| ATE359768T1 (de) | Pflaster | |
| ES2044100T3 (es) | Ciertas combinaciones de antagonistas del "paf" y antihistaminicos y metodos. | |
| DE68919488D1 (de) | Antimikrobielle Zusammensetzung. | |
| DE68919500D1 (de) | Bleichmittelzusammensetzung. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |