AR008386A1 - DERIVADOS DE BENZIMIDAZOL CON ACTIVIDAD ANTIHISTAMINICA Y COMPOSICIoN FARMACÉUTICA ANTIHISTAMINICA QUE LOS CONTIENE. - Google Patents

DERIVADOS DE BENZIMIDAZOL CON ACTIVIDAD ANTIHISTAMINICA Y COMPOSICIoN FARMACÉUTICA ANTIHISTAMINICA QUE LOS CONTIENE.

Info

Publication number
AR008386A1
AR008386A1 ARP970102441A ARP970102441A AR008386A1 AR 008386 A1 AR008386 A1 AR 008386A1 AR P970102441 A ARP970102441 A AR P970102441A AR P970102441 A ARP970102441 A AR P970102441A AR 008386 A1 AR008386 A1 AR 008386A1
Authority
AR
Argentina
Prior art keywords
antihistamine
pharmaceutical composition
composition containing
benzimidazole derivatives
activity
Prior art date
Application number
ARP970102441A
Other languages
English (en)
Spanish (es)
Original Assignee
Faes Farma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Faes Farma Sa filed Critical Faes Farma Sa
Publication of AR008386A1 publication Critical patent/AR008386A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ARP970102441A 1996-06-04 1997-06-05 DERIVADOS DE BENZIMIDAZOL CON ACTIVIDAD ANTIHISTAMINICA Y COMPOSICIoN FARMACÉUTICA ANTIHISTAMINICA QUE LOS CONTIENE. AR008386A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09601236A ES2124167B1 (es) 1996-06-04 1996-06-04 Nuevos derivados del bencimidazol con actividad antihistaminica.

Publications (1)

Publication Number Publication Date
AR008386A1 true AR008386A1 (es) 2000-01-19

Family

ID=8295035

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970102441A AR008386A1 (es) 1996-06-04 1997-06-05 DERIVADOS DE BENZIMIDAZOL CON ACTIVIDAD ANTIHISTAMINICA Y COMPOSICIoN FARMACÉUTICA ANTIHISTAMINICA QUE LOS CONTIENE.

Country Status (27)

Country Link
US (1) US5877187A (forum.php)
EP (1) EP0818454B1 (forum.php)
JP (1) JP4218991B2 (forum.php)
CN (1) CN1105716C (forum.php)
AR (1) AR008386A1 (forum.php)
AT (1) ATE264317T1 (forum.php)
AU (1) AU725700B2 (forum.php)
BR (1) BR9703276A (forum.php)
CA (1) CA2206754C (forum.php)
CZ (1) CZ289278B6 (forum.php)
DE (2) DE122011000006I1 (forum.php)
DK (1) DK0818454T3 (forum.php)
ES (1) ES2124167B1 (forum.php)
FR (1) FR11C0023I2 (forum.php)
HR (1) HRP970307B1 (forum.php)
HU (1) HU227598B1 (forum.php)
IN (1) IN186319B (forum.php)
LU (1) LU91798I2 (forum.php)
MX (1) MXPA97004127A (forum.php)
NO (2) NO313195B1 (forum.php)
PL (1) PL188908B1 (forum.php)
PT (1) PT818454E (forum.php)
RU (1) RU2182150C2 (forum.php)
SI (1) SI0818454T1 (forum.php)
TR (1) TR199700464A2 (forum.php)
TW (1) TW438794B (forum.php)
ZA (1) ZA974893B (forum.php)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0102470A3 (en) 1998-07-01 2002-05-28 Takeda Chemical Industries Ltd 1,3-azole derivatives as retinoid-associated receptor regulators and their use
USRE39608E1 (en) 1998-11-27 2007-05-01 Abbott Gmbh & Co. Kg Substituted benzimidazoles and their use as PARP inhibitors
ES2151442B1 (es) * 1999-01-11 2001-07-01 Espanola Prod Quimicos Nuevo derivado del bencenoetanol.
US6826561B2 (en) 2000-05-22 2004-11-30 Broadcom Corporation Method and apparatus for performing a binary search on an expanded tree
RU2288917C2 (ru) * 2002-04-19 2006-12-10 Фаэс Фарма, С.А. Полиморф 4-[2-[4-[1-(2-этоксиэтил)-1h-бензимидазол-2-ил]-1-пиперидинил]этил]-альфа, альфа-диметилбензолуксусной кислоты, способ его получения, фармацевтический препарат на его основе и его применение
EP1505066B1 (en) * 2002-04-19 2006-12-06 Faes Farma, S.A. Polymorph of acid 4-[2-[4-[1-(2-ethoxyethyl)-1h-benzimidazole-2-il]-1-piperidinyl]ethyl]-alpha, alpha-dimethyl-benzeneacetic
US7727992B2 (en) * 2002-06-13 2010-06-01 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US20070188330A1 (en) * 2006-01-24 2007-08-16 Morhard Robert C System and method for detecting, monitoring, tracking and identifying explosive materials using ID marks
US7247623B2 (en) * 2005-08-19 2007-07-24 Inspire Pharmaceuticals, Inc. Method of treating dry eye disease with non-drying antihistamines
WO2009102155A2 (en) * 2008-02-12 2009-08-20 Yuhan Corporation Process for preparation of 2-methyl-2´-phenylpropionic acid derivatives and novel intermediate compounds
JP2010013472A (ja) * 2009-09-09 2010-01-21 Faes Farma Sa ４−［２−［１−（２−エトキシエチル）−１Ｈ−ベンズイミダゾール−２−イル］−１−ピペリジニル］エチル］−α，α−ジメチルベンゼノ酢酸の多形体
CN102675101B (zh) * 2012-05-16 2014-01-29 王蕾 2-(4-卤乙基)苯基-2-甲基丙酸酯的制备方法及合成比拉斯汀的方法
CZ307500B6 (cs) 2012-08-15 2018-10-24 Zentiva, K.S. Způsob přípravy derivátu 2-methyl-2´-fenylpropionové kyseliny využívající nové intermediáty
JP6284616B2 (ja) * 2013-03-15 2018-02-28 ハーキュリーズ・インコーポレーテッドＨｅｒｃｕｌｅｓ Ｉｎｃｏｒｐｏｒａｔｅｄ 沈着特性が改善されたパーソナルケア組成物を生成する組成物及び方法
CN103214454A (zh) * 2013-03-30 2013-07-24 北京万全德众医药生物技术有限公司 一种比拉斯汀晶型及制备方法
CN103214455B (zh) * 2013-03-30 2018-08-31 北京万全德众医药生物技术有限公司 一种比拉斯汀的制备方法
WO2014188453A2 (en) * 2013-05-24 2014-11-27 Msn Laboratories Private Limited Novel process for the preparation of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl) phenyl]-2-methylpropanoic acid
CN103351380B (zh) * 2013-06-30 2019-01-22 北京万全德众医药生物技术有限公司 一种制备比拉斯汀的方法
CN104447683A (zh) * 2013-09-12 2015-03-25 天津市汉康医药生物技术有限公司 一种稳定的比拉斯汀化合物
CN103896915A (zh) * 2014-04-01 2014-07-02 中国药科大学 苯并咪唑类衍生物、其制备方法及其在医药上的应用
EP3040334A1 (en) 2014-12-29 2016-07-06 Faes Farma, S.A. New benzimidazole derivatives as antihistamine agents
CN106349214B (zh) * 2015-07-13 2020-11-03 南京长澳医药科技有限公司 一种比拉斯汀杂质的制备方法
ES2874577T3 (es) * 2015-07-24 2021-11-05 Urquima Sa Formas cristalinas de bilastina y procedimientos para su preparación
CN105272977A (zh) * 2015-09-19 2016-01-27 万全万特制药江苏有限公司 一种制备比拉斯汀中间体的方法
EP3170817A1 (en) 2015-11-20 2017-05-24 Faes Farma, S.A. Co-crystals of benzimidazole compounds
EP3170816A1 (en) 2015-11-20 2017-05-24 Faes Farma, S.A. Supersaturated compositions of benzimidazole compounds
WO2017167949A1 (en) 2016-04-01 2017-10-05 Krka, D.D., Novo Mesto Crystalline forms of bilastine
WO2017191651A1 (en) * 2016-05-05 2017-11-09 Msn Laboratories Private Limited, R & D Center Solid state forms of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl)phenyl]-2-methylpropanoic acid and process for preparation thereof
CN107365298A (zh) * 2017-03-14 2017-11-21 罗欣生物科技（上海）有限公司 一种2‑甲基‑2’‑苯基丙酸衍生物的制备方法
CN109456316A (zh) * 2017-09-06 2019-03-12 万全万特制药江苏有限公司 一种比拉斯汀杂质的制备方法
ES2813561T3 (es) 2017-09-07 2021-03-24 Tiefenbacher Alfred E Gmbh & Co Kg Composición farmacéutica en comprimido que comprende bilastina
DK3681475T3 (da) 2017-10-16 2021-02-01 Faes Farma Sa Vandige sammensætninger omfattende bilastin og mometason
EP3641735B1 (en) 2017-12-18 2021-02-24 Alfred E. Tiefenbacher (GmbH & Co. KG) Pharmaceutical tablet composition comprising bilastine form 3 and a water-soluble filler
ES2835287T3 (es) 2017-12-18 2021-06-22 Tiefenbacher Alfred E Gmbh & Co Kg Composición farmacéutica de comprimido que comprende la forma polimórfica 3 de bilastina y aluminometasilicato de magnesio
JP7309729B2 (ja) 2018-01-18 2023-07-18 ファエス・ファルマ・ソシエダッド・アノニマ ビラスチン、β－シクロデキストリンおよび少なくとも１種のゲル化剤を含有する眼科用組成物
CN109081827A (zh) * 2018-11-06 2018-12-25 北京天弘天达医药科技股份有限公司 一种比拉斯汀的制备方法及应用
EP3725298A1 (en) 2019-04-16 2020-10-21 Faes Farma, S.A. Stable and preserved pharmaceutical compositions of bilastine
CR20230109A (es) 2020-07-30 2023-05-11 Faes Farma Sa Sistema de liberación de fármacos descongestivos y bilastina
CN112110893A (zh) * 2020-10-28 2020-12-22 山东齐环医药科技有限公司 一种比拉斯汀的制备方法
WO2022106923A1 (en) 2020-11-18 2022-05-27 BioPharma Synergies, S. L. Orodispersible powder composition comprising an antihistamine compound
WO2022135863A1 (en) 2020-12-23 2022-06-30 Biohorm, S.L. A non-micronized bilastine composition
MX2024009978A (es) 2022-02-17 2024-08-26 Faes Farma Sa Composicion de bilastina para administracion parenteral una vez al dia.
WO2024224326A1 (en) * 2023-04-27 2024-10-31 Leiutis Pharmaceuticals Llp Liquid parenteral formulations of bilastine
WO2024224308A1 (en) * 2023-04-27 2024-10-31 Leiutis Pharmaceuticals Llp Liquid parenteral formulations of bilastine free of cyclodextrins

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8904174D0 (en) * 1989-02-23 1989-04-05 British Bio Technology Compounds
AU7759591A (en) * 1990-04-13 1991-11-11 Smithkline Beecham Corporation Substituted benzimidazoles
ES2048109B1 (es) * 1992-07-20 1994-12-16 Espanola Prod Quimicos Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol.
DE69334008T2 (de) * 1992-08-03 2006-10-19 Sepracor Inc., Marlborough Terfenadin-Carboxylat und die Behandlung von allergischen Erkrankungen
EP1953142A1 (en) * 1993-06-25 2008-08-06 Aventis Inc. Process for the preparation of antihistaminic 4-diphenylmethyl piperidine derivatives

Also Published As

Publication number Publication date
DE69728608T2 (de) 2005-04-21
FR11C0023I2 (fr) 2012-03-16
TW438794B (en) 2001-06-07
MXPA97004127A (es) 2005-07-25
DK0818454T3 (da) 2004-07-12
US5877187A (en) 1999-03-02
FR11C0023I1 (forum.php) 2011-08-19
CZ289278B6 (cs) 2001-12-12
AU2467297A (en) 1997-12-11
CZ172397A3 (en) 1997-12-17
NO313195B1 (no) 2002-08-26
HU9700997D0 (en) 1997-07-28
TR199700464A3 (tr) 1997-12-21
JP4218991B2 (ja) 2009-02-04
HRP970307A2 (en) 1998-04-30
PL188908B1 (pl) 2005-05-31
JPH1059961A (ja) 1998-03-03
ZA974893B (en) 1997-12-30
ATE264317T1 (de) 2004-04-15
HU227598B1 (en) 2011-09-28
HUP9700997A1 (hu) 1999-09-28
AU725700B2 (en) 2000-10-19
DE69728608D1 (de) 2004-05-19
NO972525D0 (no) 1997-06-03
ES2124167B1 (es) 1999-09-16
CN1105716C (zh) 2003-04-16
SI0818454T1 (en) 2004-08-31
IN186319B (forum.php) 2001-08-04
CN1176964A (zh) 1998-03-25
NO2011008I1 (no) 2011-06-06
TR199700464A2 (xx) 1997-12-21
EP0818454A1 (en) 1998-01-14
PT818454E (pt) 2004-08-31
PL320358A1 (en) 1997-12-08
NO972525L (no) 1997-12-05
DE122011000006I1 (de) 2011-06-16
NO2011008I2 (no) 2012-05-14
HRP970307B1 (en) 2002-02-28
ES2124167A1 (es) 1999-01-16
CA2206754A1 (en) 1997-12-04
RU2182150C2 (ru) 2002-05-10
LU91798I2 (fr) 2011-05-23
BR9703276A (pt) 2004-08-17
CA2206754C (en) 2007-01-23
EP0818454B1 (en) 2004-04-14

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