ES8506022A1 - Un procedimiento para la preparacion de derivados de penem sustituidos. - Google Patents

Un procedimiento para la preparacion de derivados de penem sustituidos.

Info

Publication number
ES8506022A1
ES8506022A1 ES528017A ES528017A ES8506022A1 ES 8506022 A1 ES8506022 A1 ES 8506022A1 ES 528017 A ES528017 A ES 528017A ES 528017 A ES528017 A ES 528017A ES 8506022 A1 ES8506022 A1 ES 8506022A1
Authority
ES
Spain
Prior art keywords
group
preparation
penem derivatives
hydrogen
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES528017A
Other languages
English (en)
Other versions
ES528017A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL filed Critical Farmitalia Carlo Erba SRL
Publication of ES8506022A1 publication Critical patent/ES8506022A1/es
Publication of ES528017A0 publication Critical patent/ES528017A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Inks, Pencil-Leads, Or Crayons (AREA)
  • Medicinal Preparation (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DE PENEM SUSTITUIDOS.CONSISTE EN HACER REACCIONAR A UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (Y-H), EN UN DISOLVENTE ORGANICO COMO TETRAHIDROFURANO, ACETONA Y OTROS Y A UNA TEMPERATURA ENTRE C40 Y B40JC, PARA OBTENER UN COMPUESTO DE FORMULA (I) Y SUS SALES FARMACEUTICAMENTE ACEPTABLES. SIENDO; R1, H O UN GRUPO ORGANICO; R2 H O UN GRUPO PROTECTOR DE CARBOXI; Y UN GRUPO -S- HET, UN GRUPO FORMULOXI O ACILOXI CARBOXILICO DE C 2 A 6, UN GRUPO PIRIDILO OPCIONALMENTE SUSTITUIDO Y OTROS; HET ANILLO HETEROCICLICO SATURADO O INSATURADO OPCIONALMENTE SUSTITUIDO QUE CONTIENE O, S O N Y L, CL, BR Y OTROS.SE UTILIZAN COMO AGENTES ANTIBACTERIANOS CONTRA BACTERIAS GRAM C(B) Y GRAM C(C).
ES528017A 1982-04-08 1983-12-13 Un procedimiento para la preparacion de derivados de penem sustituidos. Granted ES528017A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8210410 1982-04-08

Publications (2)

Publication Number Publication Date
ES8506022A1 true ES8506022A1 (es) 1985-06-16
ES528017A0 ES528017A0 (es) 1985-06-16

Family

ID=10529606

Family Applications (2)

Application Number Title Priority Date Filing Date
ES521277A Expired ES8405798A1 (es) 1982-04-08 1983-04-06 Un procedimiento para la preparacion de derivados de penem sustituidos.
ES528017A Granted ES528017A0 (es) 1982-04-08 1983-12-13 Un procedimiento para la preparacion de derivados de penem sustituidos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES521277A Expired ES8405798A1 (es) 1982-04-08 1983-04-06 Un procedimiento para la preparacion de derivados de penem sustituidos.

Country Status (29)

Country Link
US (2) US4577016A (es)
JP (1) JPS58185591A (es)
KR (1) KR840004434A (es)
AT (1) AT381943B (es)
AU (1) AU563030B2 (es)
BE (1) BE896401A (es)
CA (1) CA1269364A (es)
CH (1) CH655933A5 (es)
CS (1) CS235317B2 (es)
DE (1) DE3312393A1 (es)
DK (1) DK153583A (es)
ES (2) ES8405798A1 (es)
FI (1) FI77866C (es)
FR (1) FR2524889B1 (es)
GR (1) GR77451B (es)
HU (1) HU194888B (es)
IE (1) IE54940B1 (es)
IL (1) IL68307A (es)
IT (1) IT1212083B (es)
LU (1) LU84738A1 (es)
NL (1) NL8301169A (es)
NO (2) NO831160L (es)
NZ (1) NZ203788A (es)
PH (1) PH21161A (es)
PT (1) PT76506B (es)
SE (1) SE454176B (es)
SU (1) SU1299512A3 (es)
YU (1) YU45884B (es)
ZA (1) ZA832385B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6051110A (ja) * 1983-08-01 1985-03-22 Nippon Nohyaku Co Ltd 家畜のケト−ジス治療剤
GB8416651D0 (en) * 1984-06-29 1984-08-01 Erba Farmitalia Penem derivatives
GB8416652D0 (en) * 1984-06-29 1984-08-01 Erba Farmitalia Penem derivatives
US4663451A (en) * 1985-05-09 1987-05-05 Farmitalia Carlo Erba S.P.A. Process for the synthesis of penems and penams
GB8509180D0 (en) * 1985-04-10 1985-05-15 Erba Farmitalia Penem derivatives
CA1339860C (en) * 1985-06-17 1998-05-12 Tsunehiko Soga Derivatives of penem
GB8605549D0 (en) * 1986-03-06 1986-04-09 Erba Farmitalia Penem derivatives
US5191075A (en) * 1988-10-19 1993-03-02 Pfizer Inc Process for the preparation of penems
US4992543A (en) * 1988-10-19 1991-02-12 Pfizer Inc. Penem derivatives
US6040321A (en) * 1997-11-12 2000-03-21 Bristol-Myers Squibb Company Aminothiazole inhibitors of cyclin dependent kinases
US6414156B2 (en) 1998-10-21 2002-07-02 Bristol-Myers Squibb Company Process for preparing azacycloalkanoylaminothiazoles
US6392053B2 (en) * 1999-12-15 2002-05-21 Bristol-Myers Squibb Company Process for preparing arylacetylaminothiazoles

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4301074A (en) * 1977-11-17 1981-11-17 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-substituted-pen-2-em-3-carboxylic acid
EP0003960B1 (de) * 1978-02-02 1983-06-29 Ciba-Geigy Ag 6-Substituierte Thia-Azaverbindungen, ihre Herstellung und diese enthaltende pharmazeutische Präparate
US4182711A (en) * 1978-04-27 1980-01-08 Bristol-Myers Company Antibacterial agents of the β-lactam type
AT365594B (de) * 1978-11-24 1982-01-25 Erba Farmitalia Verfahren zur herstellung von neuen 7-oxo-4-thia1-aza-bicyclo-(3,2,0)heptanderivaten
US4272437A (en) * 1978-12-18 1981-06-09 Bristol-Myers Company Antibacterial agents, and 4-thio azetidinone intermediates
US4282150A (en) * 1978-12-18 1981-08-04 Bristol-Myers Company 2,6-Disubstituted penem compounds
JPS5625110A (en) * 1978-12-18 1981-03-10 Bristol Myers Co Antibacterial
EP0013067A1 (en) * 1978-12-22 1980-07-09 Beecham Group Plc Bicyclic beta-lactam antibacterial agents, their use in pharmaceutical compositions, processes for their preparation and intermediates for use in such processes
ZA80993B (en) * 1979-02-24 1981-02-25 Erba Farmitalia -lactam-containing antibacterial agents and -lactamase inhibitors and preparation thereof
IT1193922B (it) * 1979-02-24 1988-08-31 Erba Farmitalia Agenti antibatterici ed inibitori di beta -lattamasi e loro preparazione
US4269771A (en) * 1979-04-06 1981-05-26 Farmitalia Carlo Erba Total synthesis of 7-oxo-4-thia-1-azabicyclo-[3,2,0]-heptane-2-carboxyl derivatives useful as β-lactamase inhibitors and antibacterial agents
US4386029A (en) * 1979-10-29 1983-05-31 Beecham Group Limited Process for the preparation of antibiotics
US4482565A (en) * 1980-02-22 1984-11-13 Farmitalia Carlo Erba S.P.A. β-Lactam-containing antibacterial agents and β-lactamase inhibitors
JPS57179190A (en) * 1981-04-27 1982-11-04 Yamanouchi Pharmaceut Co Ltd Novel penem compound
US4558042A (en) * 1981-05-06 1985-12-10 Farmitalia Carlo Erba S.P.A. β-Lactam-containing antibacterial agents and β-lactamase inhibitors
JPS588084A (ja) * 1981-07-08 1983-01-18 Takeda Chem Ind Ltd （６ｒ）−置換−（５ｒ）−ペネム−３−カルボン酸誘導体およびその製造法
SU1389680A3 (ru) * 1981-12-11 1988-04-15 Фармиталия Карло Эрба С.П.А. (Фирма) Способ получени оптически активных пенемов или их солей с щелочными металлами
GB2118181B (en) * 1982-04-08 1986-07-30 Erba Farmitalia Substituted penem derivatives and new process for their preparation
US4435412A (en) * 1982-11-29 1984-03-06 Schering Corporation 5R,6S,8R-2-(1-Methyl-2-imidazolylmethylthio)-6-(1-hydroxyethyl)penem-3-carboxylic acid
CA1221358A (en) * 1982-12-08 1987-05-05 Erba Farmitalia 2-THIACEPHEM AND (5R)-PENEM DERIVATIVES
JPS59152387A (ja) * 1983-02-10 1984-08-31 Shionogi & Co Ltd 新規ペネム化合物

Also Published As

Publication number Publication date
CA1269364A (en) 1990-05-22
IE830794L (en) 1983-10-08
LU84738A1 (fr) 1983-11-17
KR840004434A (ko) 1984-10-15
ES521277A0 (es) 1984-06-16
FR2524889B1 (fr) 1986-01-10
YU79883A (en) 1985-12-31
FI831148A0 (fi) 1983-04-05
AU563030B2 (en) 1987-06-25
PT76506A (en) 1983-05-01
FI77866C (fi) 1989-05-10
SE8301924L (sv) 1983-11-04
JPS58185591A (ja) 1983-10-29
IT8320495A0 (it) 1983-04-07
IE54940B1 (en) 1990-03-28
YU45884B (sh) 1992-09-07
AU1317883A (en) 1983-10-13
NZ203788A (en) 1986-06-11
IL68307A (en) 1986-12-31
CS235317B2 (en) 1985-05-15
FI831148L (fi) 1983-10-09
GR77451B (es) 1984-09-24
BE896401A (fr) 1983-10-07
PH21161A (en) 1987-08-05
ES8405798A1 (es) 1984-06-16
DK153583A (da) 1983-10-09
CH655933A5 (de) 1986-05-30
SU1299512A3 (ru) 1987-03-23
FI77866B (fi) 1989-01-31
FR2524889A1 (fr) 1983-10-14
HU194888B (en) 1988-03-28
DK153583D0 (da) 1983-04-06
IT1212083B (it) 1989-11-08
NL8301169A (nl) 1983-11-01
DE3312393A1 (de) 1983-10-13
IL68307A0 (en) 1983-07-31
NO842177L (no) 1983-10-10
ZA832385B (en) 1983-12-28
NO831160L (no) 1983-10-10
AT381943B (de) 1986-12-10
ES528017A0 (es) 1985-06-16
SE454176B (sv) 1988-04-11
US4577016A (en) 1986-03-18
US4729990A (en) 1988-03-08
ATA119483A (de) 1986-05-15
PT76506B (en) 1986-02-06
SE8301924D0 (sv) 1983-04-07

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19980202