AR008386A1 - DERIVADOS DE BENZIMIDAZOL CON ACTIVIDAD ANTIHISTAMINICA Y COMPOSICIoN FARMACÉUTICA ANTIHISTAMINICA QUE LOS CONTIENE. - Google Patents

DERIVADOS DE BENZIMIDAZOL CON ACTIVIDAD ANTIHISTAMINICA Y COMPOSICIoN FARMACÉUTICA ANTIHISTAMINICA QUE LOS CONTIENE.

Info

Publication number
AR008386A1
AR008386A1 ARP970102441A ARP970102441A AR008386A1 AR 008386 A1 AR008386 A1 AR 008386A1 AR P970102441 A ARP970102441 A AR P970102441A AR P970102441 A ARP970102441 A AR P970102441A AR 008386 A1 AR008386 A1 AR 008386A1
Authority
AR
Argentina
Prior art keywords
antihistamine
pharmaceutical composition
composition containing
benzimidazole derivatives
activity
Prior art date
Application number
ARP970102441A
Other languages
English (en)
Spanish (es)
Original Assignee
Faes Farma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Faes Farma Sa filed Critical Faes Farma Sa
Publication of AR008386A1 publication Critical patent/AR008386A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ARP970102441A 1996-06-04 1997-06-05 DERIVADOS DE BENZIMIDAZOL CON ACTIVIDAD ANTIHISTAMINICA Y COMPOSICIoN FARMACÉUTICA ANTIHISTAMINICA QUE LOS CONTIENE. AR008386A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09601236A ES2124167B1 (es) 1996-06-04 1996-06-04 Nuevos derivados del bencimidazol con actividad antihistaminica.

Publications (1)

Publication Number Publication Date
AR008386A1 true AR008386A1 (es) 2000-01-19

Family

ID=8295035

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970102441A AR008386A1 (es) 1996-06-04 1997-06-05 DERIVADOS DE BENZIMIDAZOL CON ACTIVIDAD ANTIHISTAMINICA Y COMPOSICIoN FARMACÉUTICA ANTIHISTAMINICA QUE LOS CONTIENE.

Country Status (27)

Country Link
US (1) US5877187A (cg-RX-API-DMAC10.html)
EP (1) EP0818454B1 (cg-RX-API-DMAC10.html)
JP (1) JP4218991B2 (cg-RX-API-DMAC10.html)
CN (1) CN1105716C (cg-RX-API-DMAC10.html)
AR (1) AR008386A1 (cg-RX-API-DMAC10.html)
AT (1) ATE264317T1 (cg-RX-API-DMAC10.html)
AU (1) AU725700B2 (cg-RX-API-DMAC10.html)
BR (1) BR9703276A (cg-RX-API-DMAC10.html)
CA (1) CA2206754C (cg-RX-API-DMAC10.html)
CZ (1) CZ289278B6 (cg-RX-API-DMAC10.html)
DE (2) DE69728608T2 (cg-RX-API-DMAC10.html)
DK (1) DK0818454T3 (cg-RX-API-DMAC10.html)
ES (1) ES2124167B1 (cg-RX-API-DMAC10.html)
FR (1) FR11C0023I2 (cg-RX-API-DMAC10.html)
HR (1) HRP970307B1 (cg-RX-API-DMAC10.html)
HU (1) HU227598B1 (cg-RX-API-DMAC10.html)
IN (1) IN186319B (cg-RX-API-DMAC10.html)
LU (1) LU91798I2 (cg-RX-API-DMAC10.html)
MX (1) MXPA97004127A (cg-RX-API-DMAC10.html)
NO (2) NO313195B1 (cg-RX-API-DMAC10.html)
PL (1) PL188908B1 (cg-RX-API-DMAC10.html)
PT (1) PT818454E (cg-RX-API-DMAC10.html)
RU (1) RU2182150C2 (cg-RX-API-DMAC10.html)
SI (1) SI0818454T1 (cg-RX-API-DMAC10.html)
TR (1) TR199700464A3 (cg-RX-API-DMAC10.html)
TW (1) TW438794B (cg-RX-API-DMAC10.html)
ZA (1) ZA974893B (cg-RX-API-DMAC10.html)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1314899A (zh) 1998-07-01 2001-09-26 武田药品工业株式会社 视黄酸类相关的受体机能调节剂
PT1133477E (pt) 1998-11-27 2004-06-30 Abbott Gmbh & Co Kg Benzimidazois substituidos e a utilizacao dos mesmos como inibidores da parp
ES2151442B1 (es) * 1999-01-11 2001-07-01 Espanola Prod Quimicos Nuevo derivado del bencenoetanol.
US6826561B2 (en) 2000-05-22 2004-11-30 Broadcom Corporation Method and apparatus for performing a binary search on an expanded tree
CN1290843C (zh) * 2002-04-19 2006-12-20 费斯制药股份有限公司 4－[2－[4－[1－(2－乙氧基乙基)－1H－苯并咪唑－2－基]－1－哌啶基]乙基]－α,α－二甲基苯乙酸的多晶型物
RU2288917C2 (ru) * 2002-04-19 2006-12-10 Фаэс Фарма, С.А. Полиморф 4-[2-[4-[1-(2-этоксиэтил)-1h-бензимидазол-2-ил]-1-пиперидинил]этил]-альфа, альфа-диметилбензолуксусной кислоты, способ его получения, фармацевтический препарат на его основе и его применение
US7727992B2 (en) * 2002-06-13 2010-06-01 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US20070188330A1 (en) * 2006-01-24 2007-08-16 Morhard Robert C System and method for detecting, monitoring, tracking and identifying explosive materials using ID marks
US7247623B2 (en) * 2005-08-19 2007-07-24 Inspire Pharmaceuticals, Inc. Method of treating dry eye disease with non-drying antihistamines
KR101123903B1 (ko) * 2008-02-12 2012-03-23 주식회사유한양행 2-메틸-2'-페닐프로피온산 유도체의 제조 방법 및 이에 사용되는 신규한 중간체 화합물
JP2010013472A (ja) * 2009-09-09 2010-01-21 Faes Farma Sa ４−［２−［１−（２−エトキシエチル）−１Ｈ−ベンズイミダゾール−２−イル］−１−ピペリジニル］エチル］−α，α−ジメチルベンゼノ酢酸の多形体
CN102675101B (zh) * 2012-05-16 2014-01-29 王蕾 2-(4-卤乙基)苯基-2-甲基丙酸酯的制备方法及合成比拉斯汀的方法
CZ307500B6 (cs) 2012-08-15 2018-10-24 Zentiva, K.S. Způsob přípravy derivátu 2-methyl-2´-fenylpropionové kyseliny využívající nové intermediáty
KR102066476B1 (ko) * 2013-03-15 2020-01-15 허큘레스 엘엘씨 개선된 침적 특성을 가진 조성물 및 개선된 침적 특성을 가진 개인 관리 조성물의 제조 방법
CN103214454A (zh) * 2013-03-30 2013-07-24 北京万全德众医药生物技术有限公司 一种比拉斯汀晶型及制备方法
CN103214455B (zh) * 2013-03-30 2018-08-31 北京万全德众医药生物技术有限公司 一种比拉斯汀的制备方法
WO2014188453A2 (en) * 2013-05-24 2014-11-27 Msn Laboratories Private Limited Novel process for the preparation of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl) phenyl]-2-methylpropanoic acid
CN103351380B (zh) * 2013-06-30 2019-01-22 北京万全德众医药生物技术有限公司 一种制备比拉斯汀的方法
CN104447683A (zh) * 2013-09-12 2015-03-25 天津市汉康医药生物技术有限公司 一种稳定的比拉斯汀化合物
CN103896915A (zh) * 2014-04-01 2014-07-02 中国药科大学 苯并咪唑类衍生物、其制备方法及其在医药上的应用
EP3040334A1 (en) 2014-12-29 2016-07-06 Faes Farma, S.A. New benzimidazole derivatives as antihistamine agents
CN106349214B (zh) * 2015-07-13 2020-11-03 南京长澳医药科技有限公司 一种比拉斯汀杂质的制备方法
PL3327012T3 (pl) * 2015-07-24 2021-11-22 Urquima, S.A. Krystaliczne postacie bilastyny i sposoby ich wytwarzania
CN105272977A (zh) * 2015-09-19 2016-01-27 万全万特制药江苏有限公司 一种制备比拉斯汀中间体的方法
EP3170816A1 (en) 2015-11-20 2017-05-24 Faes Farma, S.A. Supersaturated compositions of benzimidazole compounds
EP3170817A1 (en) 2015-11-20 2017-05-24 Faes Farma, S.A. Co-crystals of benzimidazole compounds
WO2017167949A1 (en) 2016-04-01 2017-10-05 Krka, D.D., Novo Mesto Crystalline forms of bilastine
EP3452462A4 (en) * 2016-05-05 2019-10-23 MSN Laboratories Private Limited, R&D Center Solid state forms of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl)phenyl]-2-methylpropanoic acid and process for preparation thereof
CN107365298A (zh) * 2017-03-14 2017-11-21 罗欣生物科技（上海）有限公司 一种2‑甲基‑2’‑苯基丙酸衍生物的制备方法
CN109456316A (zh) * 2017-09-06 2019-03-12 万全万特制药江苏有限公司 一种比拉斯汀杂质的制备方法
ES2813561T3 (es) 2017-09-07 2021-03-24 Tiefenbacher Alfred E Gmbh & Co Kg Composición farmacéutica en comprimido que comprende bilastina
HRP20210260T1 (hr) 2017-10-16 2021-04-02 Faes Farma, S.A. Vodeni sastavi koji sadrže bilastin i mometazon
ES2864176T3 (es) 2017-12-18 2021-10-13 Tiefenbacher Alfred E Gmbh & Co Kg Composición farmacéutica en comprimido que comprende la forma 3 de bilastina y una carga soluble en agua
EP3470062B1 (en) 2017-12-18 2020-10-28 Alfred E. Tiefenbacher (GmbH & Co. KG) Pharmaceutical tablet composition comprising bilastine polymorphic form 3 and magnesium aluminometasilicate
EP3740191B1 (en) 2018-01-18 2021-04-28 Faes Farma, S.A. Ophthalmic compositions comprising bilastine, a beta-cyclodextrin and at least one gelling agent
CN109081827A (zh) * 2018-11-06 2018-12-25 北京天弘天达医药科技股份有限公司 一种比拉斯汀的制备方法及应用
EP3725298A1 (en) 2019-04-16 2020-10-21 Faes Farma, S.A. Stable and preserved pharmaceutical compositions of bilastine
CR20230109A (es) 2020-07-30 2023-05-11 Faes Farma Sa Sistema de liberación de fármacos descongestivos y bilastina
CN112110893A (zh) * 2020-10-28 2020-12-22 山东齐环医药科技有限公司 一种比拉斯汀的制备方法
JP2023549381A (ja) 2020-11-18 2023-11-24 バイオファーマ・シナジーズ，エス．エル． 抗ヒスタミン活性化合物を含む口内分散性粉末組成物
WO2022135863A1 (en) 2020-12-23 2022-06-30 Biohorm, S.L. A non-micronized bilastine composition
US20250228836A1 (en) 2022-02-17 2025-07-17 Faes Farma, S.A. Bilastine composition for once-daily parenteral administration
WO2024224308A1 (en) * 2023-04-27 2024-10-31 Leiutis Pharmaceuticals Llp Liquid parenteral formulations of bilastine free of cyclodextrins
WO2024224326A1 (en) * 2023-04-27 2024-10-31 Leiutis Pharmaceuticals Llp Liquid parenteral formulations of bilastine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8904174D0 (en) * 1989-02-23 1989-04-05 British Bio Technology Compounds
CA2077897A1 (en) * 1990-04-13 1991-10-14 Robert G. Franz Substituted benzimidazoles
ES2048109B1 (es) * 1992-07-20 1994-12-16 Espanola Prod Quimicos Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol.
RO116043B1 (ro) * 1992-08-03 2000-10-30 Sepracor Inc Compozitie farmaceutica
EP2261208A1 (en) * 1993-06-25 2010-12-15 Aventisub II Inc. Intermediates for the preparation of antihistaminic 4-diphenylmethyl/diphenylmethoxy piperidine derivatives

Also Published As

Publication number Publication date
ES2124167B1 (es) 1999-09-16
ATE264317T1 (de) 2004-04-15
AU725700B2 (en) 2000-10-19
NO2011008I1 (no) 2011-06-06
JP4218991B2 (ja) 2009-02-04
HU227598B1 (en) 2011-09-28
HUP9700997A1 (hu) 1999-09-28
PL188908B1 (pl) 2005-05-31
DK0818454T3 (da) 2004-07-12
DE122011000006I1 (de) 2011-06-16
US5877187A (en) 1999-03-02
RU2182150C2 (ru) 2002-05-10
PT818454E (pt) 2004-08-31
TW438794B (en) 2001-06-07
CA2206754A1 (en) 1997-12-04
LU91798I2 (fr) 2011-05-23
TR199700464A2 (xx) 1997-12-21
HU9700997D0 (en) 1997-07-28
CZ172397A3 (en) 1997-12-17
CN1176964A (zh) 1998-03-25
FR11C0023I2 (fr) 2012-03-16
EP0818454B1 (en) 2004-04-14
BR9703276A (pt) 2004-08-17
AU2467297A (en) 1997-12-11
HRP970307B1 (en) 2002-02-28
CA2206754C (en) 2007-01-23
CN1105716C (zh) 2003-04-16
ES2124167A1 (es) 1999-01-16
SI0818454T1 (en) 2004-08-31
NO2011008I2 (no) 2012-05-14
DE69728608T2 (de) 2005-04-21
MXPA97004127A (es) 2005-07-25
CZ289278B6 (cs) 2001-12-12
EP0818454A1 (en) 1998-01-14
NO972525D0 (no) 1997-06-03
DE69728608D1 (de) 2004-05-19
IN186319B (cg-RX-API-DMAC10.html) 2001-08-04
HRP970307A2 (en) 1998-04-30
NO972525L (no) 1997-12-05
FR11C0023I1 (cg-RX-API-DMAC10.html) 2011-08-19
JPH1059961A (ja) 1998-03-03
TR199700464A3 (tr) 1997-12-21
PL320358A1 (en) 1997-12-08
ZA974893B (en) 1997-12-30
NO313195B1 (no) 2002-08-26

Similar Documents

Publication Publication Date Title
AR008386A1 (es) DERIVADOS DE BENZIMIDAZOL CON ACTIVIDAD ANTIHISTAMINICA Y COMPOSICIoN FARMACÉUTICA ANTIHISTAMINICA QUE LOS CONTIENE.
AR029216A1 (es) Compuestos inhibidores no peptidicos de la union celular dependiente de vla-4 utiles en el tratamiento de enfermedades inflamatorias, autoinmunes y respiratorias; composicion farmaceutica y procedimiento de tratamiento
IT1264451B1 (it) 3-(carbossimetossifenil)-benzofuran-2-oni come agenti stabilizzanti
PE20010286A1 (es) Derivados de indoloxoacetil piperazina como agentes antivirales
NZ189418A (en) Propanolamine and morpholine derivatives pharmaceutical compositions
ATE327977T1 (de) Tetrahydrochinolin-derivate als crth2 antagonisten
ES2230719T3 (es) Compuestos basados en azabencimidazol para modular una funcion de proteina-quinasa de serina/treonina.
ECSP066967A (es) Derivados de tetrahidroquinolina y un procedimiento para preparar los mismos
IT1264453B1 (it) 3-(alcossifenil) benzofuran -2-oni come stabilizzanti
AU2003301020A1 (en) Isoquinolinone derivatives and their use as therapeutic agents
PA8480101A1 (es) Derivados de quinolin-2-ona alquinilsustituidos utiles como agentes anticancerosos
ES2196806T3 (es) Derivados de fenilurea y de feniltiourea.
ES2095976T3 (es) Compuestos de pirazolopiridina y procedimiento para su preparacion.
ES2169248T3 (es) Compuestos aromaticos y composiciones farmaceuticas que los contienen.
ATE25682T1 (de) Indol-3-carboxamid-derivate.
AR024998A1 (es) Nuevos retinoides para el tratamiento del enfisema
AR007021A1 (es) Derivados de 3-descladinosa-2,3-anhidroeritromicina, procedimientos para su preparacion, compuestos para su exclusivo uso en dichos procedimientosy procedimiento para su preparacion, una composicion farmaceutica para tratar infecciones bacterianas y el uso de estos compuestos para preparar medicamentos
AR027578A1 (es) Derivados de indano
ATE239722T1 (de) Benzofurylpiperazine als serotonin-agonisten
ES2153019T3 (es) Derivados de benzo-dioxano, su procedimiento de preparacion y las composiciones farmaceuticas que los contienen.
AR025351A1 (es) Agonistas retinoides selectivos par
MX9305719A (es) Agente antiarritmico.
FI923841A0 (fi) Substituerade mandelsyraderivat, foerfarande foer deras framstaellning och deras anvaendning som laekemedel.
FI945582A0 (fi) Substituoidut (aryylialkyyliaminobentsyyli) aminopropioniamidijohdannaiset, niiden valmistus ja käyttö anti-epileptisinä, neuroprotektiivisina ja antidepressiivisina aineina
HRP20010885B1 (en) Ethanesulfonyl-piperidine derivatives

Legal Events

Date Code Title Description
FG Grant, registration