TR199700464A3 - Antihistaminik etkili yeni benzimidazole türevleri. - Google Patents

Antihistaminik etkili yeni benzimidazole türevleri.

Info

Publication number
TR199700464A3
TR199700464A3 TR97/00464A TR9700464A TR199700464A3 TR 199700464 A3 TR199700464 A3 TR 199700464A3 TR 97/00464 A TR97/00464 A TR 97/00464A TR 9700464 A TR9700464 A TR 9700464A TR 199700464 A3 TR199700464 A3 TR 199700464A3
Authority
TR
Turkey
Prior art keywords
benzimidazole derivatives
antihistamine effect
new benzimidazole
new
antihistamine
Prior art date
Application number
TR97/00464A
Other languages
English (en)
Turkish (tr)
Other versions
TR199700464A2 (xx
Inventor
Orjales Aurelio
Rubio Victor
Bordell Maravillas
Original Assignee
Fabrica Espanola De Productos Quimicos Y Farmaceuticos,
S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fabrica Espanola De Productos Quimicos Y Farmaceuticos,, S.A. filed Critical Fabrica Espanola De Productos Quimicos Y Farmaceuticos,
Publication of TR199700464A2 publication Critical patent/TR199700464A2/xx
Publication of TR199700464A3 publication Critical patent/TR199700464A3/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
TR97/00464A 1996-06-04 1997-06-04 Antihistaminik etkili yeni benzimidazole türevleri. TR199700464A3 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES09601236A ES2124167B1 (es) 1996-06-04 1996-06-04 Nuevos derivados del bencimidazol con actividad antihistaminica.

Publications (2)

Publication Number Publication Date
TR199700464A2 TR199700464A2 (xx) 1997-12-21
TR199700464A3 true TR199700464A3 (tr) 1997-12-21

Family

ID=8295035

Family Applications (1)

Application Number Title Priority Date Filing Date
TR97/00464A TR199700464A3 (tr) 1996-06-04 1997-06-04 Antihistaminik etkili yeni benzimidazole türevleri.

Country Status (27)

Country Link
US (1) US5877187A (cg-RX-API-DMAC10.html)
EP (1) EP0818454B1 (cg-RX-API-DMAC10.html)
JP (1) JP4218991B2 (cg-RX-API-DMAC10.html)
CN (1) CN1105716C (cg-RX-API-DMAC10.html)
AR (1) AR008386A1 (cg-RX-API-DMAC10.html)
AT (1) ATE264317T1 (cg-RX-API-DMAC10.html)
AU (1) AU725700B2 (cg-RX-API-DMAC10.html)
BR (1) BR9703276A (cg-RX-API-DMAC10.html)
CA (1) CA2206754C (cg-RX-API-DMAC10.html)
CZ (1) CZ289278B6 (cg-RX-API-DMAC10.html)
DE (2) DE69728608T2 (cg-RX-API-DMAC10.html)
DK (1) DK0818454T3 (cg-RX-API-DMAC10.html)
ES (1) ES2124167B1 (cg-RX-API-DMAC10.html)
FR (1) FR11C0023I2 (cg-RX-API-DMAC10.html)
HR (1) HRP970307B1 (cg-RX-API-DMAC10.html)
HU (1) HU227598B1 (cg-RX-API-DMAC10.html)
IN (1) IN186319B (cg-RX-API-DMAC10.html)
LU (1) LU91798I2 (cg-RX-API-DMAC10.html)
MX (1) MXPA97004127A (cg-RX-API-DMAC10.html)
NO (2) NO313195B1 (cg-RX-API-DMAC10.html)
PL (1) PL188908B1 (cg-RX-API-DMAC10.html)
PT (1) PT818454E (cg-RX-API-DMAC10.html)
RU (1) RU2182150C2 (cg-RX-API-DMAC10.html)
SI (1) SI0818454T1 (cg-RX-API-DMAC10.html)
TR (1) TR199700464A3 (cg-RX-API-DMAC10.html)
TW (1) TW438794B (cg-RX-API-DMAC10.html)
ZA (1) ZA974893B (cg-RX-API-DMAC10.html)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1314899A (zh) 1998-07-01 2001-09-26 武田药品工业株式会社 视黄酸类相关的受体机能调节剂
PT1133477E (pt) 1998-11-27 2004-06-30 Abbott Gmbh & Co Kg Benzimidazois substituidos e a utilizacao dos mesmos como inibidores da parp
ES2151442B1 (es) * 1999-01-11 2001-07-01 Espanola Prod Quimicos Nuevo derivado del bencenoetanol.
US6826561B2 (en) 2000-05-22 2004-11-30 Broadcom Corporation Method and apparatus for performing a binary search on an expanded tree
CN1290843C (zh) * 2002-04-19 2006-12-20 费斯制药股份有限公司 4－[2－[4－[1－(2－乙氧基乙基)－1H－苯并咪唑－2－基]－1－哌啶基]乙基]－α,α－二甲基苯乙酸的多晶型物
RU2288917C2 (ru) * 2002-04-19 2006-12-10 Фаэс Фарма, С.А. Полиморф 4-[2-[4-[1-(2-этоксиэтил)-1h-бензимидазол-2-ил]-1-пиперидинил]этил]-альфа, альфа-диметилбензолуксусной кислоты, способ его получения, фармацевтический препарат на его основе и его применение
US7727992B2 (en) * 2002-06-13 2010-06-01 Vertex Pharmaceuticals Incorporated Gyrase inhibitors and uses thereof
US20070188330A1 (en) * 2006-01-24 2007-08-16 Morhard Robert C System and method for detecting, monitoring, tracking and identifying explosive materials using ID marks
US7247623B2 (en) * 2005-08-19 2007-07-24 Inspire Pharmaceuticals, Inc. Method of treating dry eye disease with non-drying antihistamines
KR101123903B1 (ko) * 2008-02-12 2012-03-23 주식회사유한양행 2-메틸-2'-페닐프로피온산 유도체의 제조 방법 및 이에 사용되는 신규한 중간체 화합물
JP2010013472A (ja) * 2009-09-09 2010-01-21 Faes Farma Sa ４−［２−［１−（２−エトキシエチル）−１Ｈ−ベンズイミダゾール−２−イル］−１−ピペリジニル］エチル］−α，α−ジメチルベンゼノ酢酸の多形体
CN102675101B (zh) * 2012-05-16 2014-01-29 王蕾 2-(4-卤乙基)苯基-2-甲基丙酸酯的制备方法及合成比拉斯汀的方法
CZ307500B6 (cs) 2012-08-15 2018-10-24 Zentiva, K.S. Způsob přípravy derivátu 2-methyl-2´-fenylpropionové kyseliny využívající nové intermediáty
KR102066476B1 (ko) * 2013-03-15 2020-01-15 허큘레스 엘엘씨 개선된 침적 특성을 가진 조성물 및 개선된 침적 특성을 가진 개인 관리 조성물의 제조 방법
CN103214454A (zh) * 2013-03-30 2013-07-24 北京万全德众医药生物技术有限公司 一种比拉斯汀晶型及制备方法
CN103214455B (zh) * 2013-03-30 2018-08-31 北京万全德众医药生物技术有限公司 一种比拉斯汀的制备方法
WO2014188453A2 (en) * 2013-05-24 2014-11-27 Msn Laboratories Private Limited Novel process for the preparation of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl) phenyl]-2-methylpropanoic acid
CN103351380B (zh) * 2013-06-30 2019-01-22 北京万全德众医药生物技术有限公司 一种制备比拉斯汀的方法
CN104447683A (zh) * 2013-09-12 2015-03-25 天津市汉康医药生物技术有限公司 一种稳定的比拉斯汀化合物
CN103896915A (zh) * 2014-04-01 2014-07-02 中国药科大学 苯并咪唑类衍生物、其制备方法及其在医药上的应用
EP3040334A1 (en) 2014-12-29 2016-07-06 Faes Farma, S.A. New benzimidazole derivatives as antihistamine agents
CN106349214B (zh) * 2015-07-13 2020-11-03 南京长澳医药科技有限公司 一种比拉斯汀杂质的制备方法
PL3327012T3 (pl) * 2015-07-24 2021-11-22 Urquima, S.A. Krystaliczne postacie bilastyny i sposoby ich wytwarzania
CN105272977A (zh) * 2015-09-19 2016-01-27 万全万特制药江苏有限公司 一种制备比拉斯汀中间体的方法
EP3170816A1 (en) 2015-11-20 2017-05-24 Faes Farma, S.A. Supersaturated compositions of benzimidazole compounds
EP3170817A1 (en) 2015-11-20 2017-05-24 Faes Farma, S.A. Co-crystals of benzimidazole compounds
WO2017167949A1 (en) 2016-04-01 2017-10-05 Krka, D.D., Novo Mesto Crystalline forms of bilastine
EP3452462A4 (en) * 2016-05-05 2019-10-23 MSN Laboratories Private Limited, R&D Center Solid state forms of 2-[4-(2-{4-[1-(2-ethoxyethyl)-1h-benzimidazol-2-yl]-1-piperidinyl}ethyl)phenyl]-2-methylpropanoic acid and process for preparation thereof
CN107365298A (zh) * 2017-03-14 2017-11-21 罗欣生物科技（上海）有限公司 一种2‑甲基‑2’‑苯基丙酸衍生物的制备方法
CN109456316A (zh) * 2017-09-06 2019-03-12 万全万特制药江苏有限公司 一种比拉斯汀杂质的制备方法
ES2813561T3 (es) 2017-09-07 2021-03-24 Tiefenbacher Alfred E Gmbh & Co Kg Composición farmacéutica en comprimido que comprende bilastina
HRP20210260T1 (hr) 2017-10-16 2021-04-02 Faes Farma, S.A. Vodeni sastavi koji sadrže bilastin i mometazon
ES2864176T3 (es) 2017-12-18 2021-10-13 Tiefenbacher Alfred E Gmbh & Co Kg Composición farmacéutica en comprimido que comprende la forma 3 de bilastina y una carga soluble en agua
EP3470062B1 (en) 2017-12-18 2020-10-28 Alfred E. Tiefenbacher (GmbH & Co. KG) Pharmaceutical tablet composition comprising bilastine polymorphic form 3 and magnesium aluminometasilicate
EP3740191B1 (en) 2018-01-18 2021-04-28 Faes Farma, S.A. Ophthalmic compositions comprising bilastine, a beta-cyclodextrin and at least one gelling agent
CN109081827A (zh) * 2018-11-06 2018-12-25 北京天弘天达医药科技股份有限公司 一种比拉斯汀的制备方法及应用
EP3725298A1 (en) 2019-04-16 2020-10-21 Faes Farma, S.A. Stable and preserved pharmaceutical compositions of bilastine
CR20230109A (es) 2020-07-30 2023-05-11 Faes Farma Sa Sistema de liberación de fármacos descongestivos y bilastina
CN112110893A (zh) * 2020-10-28 2020-12-22 山东齐环医药科技有限公司 一种比拉斯汀的制备方法
JP2023549381A (ja) 2020-11-18 2023-11-24 バイオファーマ・シナジーズ，エス．エル． 抗ヒスタミン活性化合物を含む口内分散性粉末組成物
WO2022135863A1 (en) 2020-12-23 2022-06-30 Biohorm, S.L. A non-micronized bilastine composition
US20250228836A1 (en) 2022-02-17 2025-07-17 Faes Farma, S.A. Bilastine composition for once-daily parenteral administration
WO2024224308A1 (en) * 2023-04-27 2024-10-31 Leiutis Pharmaceuticals Llp Liquid parenteral formulations of bilastine free of cyclodextrins
WO2024224326A1 (en) * 2023-04-27 2024-10-31 Leiutis Pharmaceuticals Llp Liquid parenteral formulations of bilastine

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8904174D0 (en) * 1989-02-23 1989-04-05 British Bio Technology Compounds
CA2077897A1 (en) * 1990-04-13 1991-10-14 Robert G. Franz Substituted benzimidazoles
ES2048109B1 (es) * 1992-07-20 1994-12-16 Espanola Prod Quimicos Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol.
RO116043B1 (ro) * 1992-08-03 2000-10-30 Sepracor Inc Compozitie farmaceutica
EP2261208A1 (en) * 1993-06-25 2010-12-15 Aventisub II Inc. Intermediates for the preparation of antihistaminic 4-diphenylmethyl/diphenylmethoxy piperidine derivatives

Also Published As

Publication number Publication date
ES2124167B1 (es) 1999-09-16
ATE264317T1 (de) 2004-04-15
AU725700B2 (en) 2000-10-19
NO2011008I1 (no) 2011-06-06
JP4218991B2 (ja) 2009-02-04
HU227598B1 (en) 2011-09-28
HUP9700997A1 (hu) 1999-09-28
PL188908B1 (pl) 2005-05-31
DK0818454T3 (da) 2004-07-12
DE122011000006I1 (de) 2011-06-16
US5877187A (en) 1999-03-02
RU2182150C2 (ru) 2002-05-10
PT818454E (pt) 2004-08-31
TW438794B (en) 2001-06-07
CA2206754A1 (en) 1997-12-04
LU91798I2 (fr) 2011-05-23
TR199700464A2 (xx) 1997-12-21
HU9700997D0 (en) 1997-07-28
CZ172397A3 (en) 1997-12-17
CN1176964A (zh) 1998-03-25
FR11C0023I2 (fr) 2012-03-16
EP0818454B1 (en) 2004-04-14
BR9703276A (pt) 2004-08-17
AU2467297A (en) 1997-12-11
HRP970307B1 (en) 2002-02-28
CA2206754C (en) 2007-01-23
CN1105716C (zh) 2003-04-16
ES2124167A1 (es) 1999-01-16
SI0818454T1 (en) 2004-08-31
NO2011008I2 (no) 2012-05-14
DE69728608T2 (de) 2005-04-21
MXPA97004127A (es) 2005-07-25
CZ289278B6 (cs) 2001-12-12
EP0818454A1 (en) 1998-01-14
NO972525D0 (no) 1997-06-03
DE69728608D1 (de) 2004-05-19
IN186319B (cg-RX-API-DMAC10.html) 2001-08-04
HRP970307A2 (en) 1998-04-30
NO972525L (no) 1997-12-05
FR11C0023I1 (cg-RX-API-DMAC10.html) 2011-08-19
JPH1059961A (ja) 1998-03-03
PL320358A1 (en) 1997-12-08
AR008386A1 (es) 2000-01-19
ZA974893B (en) 1997-12-30
NO313195B1 (no) 2002-08-26

Similar Documents

Publication Publication Date Title
TR199700464A3 (tr) Antihistaminik etkili yeni benzimidazole türevleri.
MA26504A1 (fr) Derives benzimidazole.
DE59501802D1 (de) Substituierte 1H-3-Aryl-pyrrolidin-2,4-dion-Derivate
DE69716468D1 (de) 2-(purin-9-)-tetrahydrofuran-3,4-diol-derivate
TR199700090A2 (tr) Yeni heteroaril-oksazolidinonlar.
DE69525418D1 (de) Benzimidazol-derivate
IS4963A (is) Setnar 6,5-heteró-bísýklískar afleiður
TR199501463A2 (tr) Triazolil türevleri.
NL300203I2 (nl) Antiviraal werkzame heterocyclische azahexaan-derivaten.
NO970174D0 (no) 2-okso- og 2-tio-1,2-dihydrochinolinyl-oksazolidinoner
FI915148A7 (fi) Indol- och bensimidazolsubstituerade imidazol- och bensimidazolderivat.
DK0922050T3 (da) 3-Descladinose-2,3-anhydroerythromycin-derivater
DK1030850T3 (da) Azolinderivater
TR28915A (tr) Naftokinon türevleri.
TR199801683A3 (tr) Yeni üre türevleri.
TR199700219A3 (tr) 1,25-Dihidroksi-16, 22, 23-Trisdihidro-kolkalsiferol türevleri.
IS4320A (is) Ný súbstitúeruð bensimidasól
FI972885A0 (fi) Anordning foer utfoering av en divisionoperation, saerskilt i en tredimensionell grafik
TR199700927A3 (tr) N-Benzilazolyum türevleri.
ES1033398Y (es) Calcetin reversible.
ES1036664Y (es) Compensador bimateria perfeccionado.
ES1033250Y (es) Nueva lapida.
ES1033877Y (es) Nueva caperuza-precinto.
FI941905A0 (fi) Vid fartyg fastmonterbart, utloesbart oljebomsystem
TR199802196A3 (tr) Heterosiklik bilesimler.