AP216A - Improved method for synthesis. - Google Patents

Improved method for synthesis. Download PDF

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Publication number
AP216A
AP216A APAP/P/1991/000274A AP9100274A AP216A AP 216 A AP216 A AP 216A AP 9100274 A AP9100274 A AP 9100274A AP 216 A AP216 A AP 216A
Authority
AP
ARIPO
Prior art keywords
omeprazole
phase
reaction mixture
compound
aqueous phase
Prior art date
Application number
APAP/P/1991/000274A
Other languages
English (en)
Other versions
AP9100274A0 (en
Inventor
Arne Elof Brandstrom
Original Assignee
Ab Astra
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ab Astra filed Critical Ab Astra
Publication of AP9100274A0 publication Critical patent/AP9100274A0/xx
Application granted granted Critical
Publication of AP216A publication Critical patent/AP216A/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
APAP/P/1991/000274A 1990-06-07 1991-06-07 Improved method for synthesis. AP216A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9002043A SE9002043D0 (sv) 1990-06-07 1990-06-07 Improved method for synthesis

Publications (2)

Publication Number Publication Date
AP9100274A0 AP9100274A0 (en) 1991-07-31
AP216A true AP216A (en) 1992-09-02

Family

ID=20379708

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1991/000274A AP216A (en) 1990-06-07 1991-06-07 Improved method for synthesis.

Country Status (42)

Country Link
US (1) US5386032A (fr)
EP (1) EP0533752B1 (fr)
JP (1) JP2993122B2 (fr)
KR (1) KR0178045B1 (fr)
CN (1) CN1040536C (fr)
AP (1) AP216A (fr)
AT (1) ATE162790T1 (fr)
AU (1) AU640246B2 (fr)
BG (1) BG61265B1 (fr)
CA (1) CA2083605C (fr)
CZ (1) CZ279928B6 (fr)
DE (1) DE69128832T2 (fr)
DK (1) DK0533752T3 (fr)
DZ (1) DZ1504A1 (fr)
EG (1) EG19392A (fr)
ES (1) ES2113378T3 (fr)
FI (1) FI102967B (fr)
GR (1) GR3026642T3 (fr)
HK (1) HK1003831A1 (fr)
HR (1) HRP920770B1 (fr)
HU (1) HU214323B (fr)
IE (1) IE911845A1 (fr)
IL (1) IL98274A (fr)
IS (1) IS1752B (fr)
LT (1) LT3584B (fr)
LV (1) LV10271B (fr)
MA (1) MA22171A1 (fr)
NO (1) NO300541B1 (fr)
NZ (1) NZ238224A (fr)
PL (1) PL165433B1 (fr)
PT (1) PT97873B (fr)
RO (1) RO111366B1 (fr)
RU (1) RU2061693C1 (fr)
SA (1) SA91120027B1 (fr)
SE (1) SE9002043D0 (fr)
SG (1) SG48053A1 (fr)
SK (1) SK278505B6 (fr)
TN (1) TNSN91042A1 (fr)
UA (1) UA32524C2 (fr)
WO (1) WO1991018895A1 (fr)
YU (1) YU47570B (fr)
ZA (1) ZA913779B (fr)

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US6489346B1 (en) 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US6645988B2 (en) * 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
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US6437139B1 (en) 1997-05-06 2002-08-20 Pdi-Research Laboratories, Inc. Synthesis of pharmaceutically useful pyridine derivatives
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SE9704183D0 (sv) 1997-11-14 1997-11-14 Astra Ab New process
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US6174548B1 (en) 1998-08-28 2001-01-16 Andrx Pharmaceuticals, Inc. Omeprazole formulation
SI20019A (sl) * 1998-07-13 2000-02-29 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Izboljšan postopek sinteze 5-metoksi -2-/(4-metoksi-3,5-dimetil-2-piridil)metil/ sulfinil-1H-benzimidazola
US6166213A (en) * 1998-08-11 2000-12-26 Merck & Co., Inc. Omeprazole process and compositions thereof
US6191148B1 (en) 1998-08-11 2001-02-20 Merck & Co., Inc. Omerazole process and compositions thereof
US6733778B1 (en) 1999-08-27 2004-05-11 Andrx Pharmaceuticals, Inc. Omeprazole formulation
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US6362202B1 (en) 1999-03-02 2002-03-26 Sepracor Inc. Methods and compositions using (−) norcisapride in combination with proton pump inhibitors or H2 receptor antagonists
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US6268385B1 (en) 1999-08-26 2001-07-31 Robert R. Whittle Dry blend pharmaceutical formulations
US6326384B1 (en) 1999-08-26 2001-12-04 Robert R. Whittle Dry blend pharmaceutical unit dosage form
US6262085B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6369087B1 (en) * 1999-08-26 2002-04-09 Robert R. Whittle Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6316020B1 (en) 1999-08-26 2001-11-13 Robert R. Whittle Pharmaceutical formulations
US6780880B1 (en) 1999-08-26 2004-08-24 Robert R. Whittle FT-Raman spectroscopic measurement
US6312712B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Method of improving bioavailability
US6312723B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Pharmaceutical unit dosage form
US6262086B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Pharmaceutical unit dosage form
DE19951960C2 (de) 1999-10-28 2002-06-27 Gruenenthal Gmbh Verfahren zur Herstellung als Ulkustherapeutika geeigneter Benzimidazol-Derivate
MXPA03006904A (es) 2001-02-02 2004-12-06 Teva Pharma Procesos para la produccion de 2-(2-piridilmetil) sulfinil - 1h - bencimidazoles sustituidos.
KR100783020B1 (ko) * 2001-03-23 2007-12-07 동아제약주식회사 2-메틸클로라이드 피리딘 유도체 및 이를 이용한 벤즈이미다졸 유도체의 제조 방법
EP1409478B1 (fr) 2001-07-16 2006-03-29 Janssen Pharmaceutica N.V. Procede ameliore de preparation de composes de type benzimidazole
MXPA04007169A (es) * 2002-01-25 2004-10-29 Santarus Inc Suministro transmucosal de inhibidores de bomba de protones.
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CA2517005A1 (fr) * 2003-02-20 2004-09-02 Santarus, Inc. Liberation immediate d'un complexe antacide d'omeprazole presentant une nouvelle formulation pour une elimination rapide et prolongee d'acide gastrique
US8993599B2 (en) * 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
JP2006528182A (ja) * 2003-07-18 2006-12-14 サンタラス インコーポレイティッド 薬学的製剤および酸に起因する消化器疾患の治療法
EP1648416A4 (fr) * 2003-07-18 2012-03-28 Santarus Inc Formulations pharmaceutiques utilisees pour inhiber une secretion acide et procede de fabrication associe
US20070292498A1 (en) * 2003-11-05 2007-12-20 Warren Hall Combinations of proton pump inhibitors, sleep aids, buffers and pain relievers
US8815916B2 (en) * 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8906940B2 (en) * 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
EP1790647B1 (fr) 2004-09-13 2013-05-08 Takeda Pharmaceutical Company Limited Procede destines a produire un compose oxyde
PL1802584T3 (pl) * 2004-10-11 2010-03-31 Ranbaxy Laboratories Ltd Sposób wytwarzania podstawionych sulfotlenków
KR100641534B1 (ko) 2005-07-28 2006-11-01 한미약품 주식회사 에스오메프라졸 및 그의 염의 제조방법
KR101068180B1 (ko) 2005-12-01 2011-09-28 오스펙스 파마슈티칼스, 인코포레이티드 세로토닌성 및/또는 노르에피네프린성 활성을 갖는 치환된펜에틸아민
EP1801110A1 (fr) 2005-12-22 2007-06-27 KRKA, tovarna zdravil, d.d., Novo mesto Sel d'arginine d'ésoméprazole
WO2007129328A2 (fr) * 2006-05-09 2007-11-15 Cadila Healthcare Limited Méthode de préparation de benzimidazones substitués 2-[pyridinyl]sulfinyle
US20090092658A1 (en) * 2007-10-05 2009-04-09 Santarus, Inc. Novel formulations of proton pump inhibitors and methods of using these formulations
EP2114919A2 (fr) 2007-01-31 2009-11-11 Krka Tovarna Zdravil, D.D., Novo Mesto Procédé de préparation d'oméprazole optiquement pur
ES2693948T3 (es) 2007-03-15 2018-12-14 Auspex Pharmaceuticals, Inc. Fenetilamina sustituida con actividad serotoninérgica y/o norepinefrinérgica
US8513226B2 (en) * 2008-03-31 2013-08-20 Council Of Scientific And Industrial Research Simultaneous method for the preparation of a mixture of 3-acetoxy-17-acetamido-16-formyl-androst-5,17-diene and 3-acetoxy-2'-chloro-5-androsteno[17,16-b]pyridine
WO2010134099A1 (fr) 2009-05-21 2010-11-25 Cadila Healthcare Limited Procédé de préparation dans un récipient unique d'oméprazole
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CN104203938A (zh) 2012-01-21 2014-12-10 朱比兰特生命科学有限公司 用于制备2-吡啶基甲基亚硫酰基苯并咪唑、它们的类似物和光学活性对映体的方法
AU2020354581A1 (en) 2019-09-24 2022-03-03 Prolacta Bioscience, Inc. Compositions and methods for treatment of inflammatory and immune diseases

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DE3404610A1 (de) * 1983-02-11 1984-08-16 Aktiebolaget Hässle, Mölndal Benzimidazolderivate, verfahren zu deren herstellung und sie enthaltende arzneimittel
EP0197013A1 (fr) * 1985-03-01 1986-10-08 Aktiebolaget Hässle Benzimidazoles substitués pour la fabrication d'un médicament pour le traitement de maladies intestinales inflammatoires
EP0242341A1 (fr) * 1986-02-14 1987-10-21 Aktiebolaget Hässle Dérivés du benzimidazole, procédé pour leur obtention et médicaments contenant ces dérivés

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ZW4585A1 (en) * 1984-04-19 1985-11-20 Hoffmann La Roche Imidazole derivatives
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DE3404610A1 (de) * 1983-02-11 1984-08-16 Aktiebolaget Hässle, Mölndal Benzimidazolderivate, verfahren zu deren herstellung und sie enthaltende arzneimittel
GB2174988A (en) * 1983-02-11 1986-11-19 Haessle Ab Intermediates for pyridyl alkylthio-benzimidazole derivatives
EP0197013A1 (fr) * 1985-03-01 1986-10-08 Aktiebolaget Hässle Benzimidazoles substitués pour la fabrication d'un médicament pour le traitement de maladies intestinales inflammatoires
EP0242341A1 (fr) * 1986-02-14 1987-10-21 Aktiebolaget Hässle Dérivés du benzimidazole, procédé pour leur obtention et médicaments contenant ces dérivés

Also Published As

Publication number Publication date
MA22171A1 (fr) 1991-12-31
FI925529A0 (fi) 1992-12-04
DK0533752T3 (da) 1998-06-02
NO924682D0 (no) 1992-12-04
CZ279928B6 (cs) 1995-08-16
LTIP1711A (en) 1995-07-25
PT97873A (pt) 1992-04-30
YU47570B (sh) 1995-10-03
YU99291A (sh) 1993-11-16
EP0533752B1 (fr) 1998-01-28
HRP920770A2 (en) 1995-12-31
SE9002043D0 (sv) 1990-06-07
IL98274A0 (en) 1992-06-21
PL165433B1 (pl) 1994-12-30
LV10271A (lv) 1994-10-20
WO1991018895A1 (fr) 1991-12-12
SA91120027B1 (ar) 2002-06-03
ES2113378T3 (es) 1998-05-01
HU9203855D0 (en) 1993-03-29
HRP920770B1 (en) 2000-06-30
HUT63408A (en) 1993-08-30
CS172691A3 (en) 1992-01-15
TNSN91042A1 (fr) 1992-10-25
CN1058211A (zh) 1992-01-29
GR3026642T3 (en) 1998-07-31
BG97146A (bg) 1993-12-24
NO924682L (no) 1992-12-04
UA32524C2 (uk) 2001-02-15
AU8080791A (en) 1991-12-31
HK1003831A1 (en) 1998-11-06
BG61265B1 (en) 1997-04-30
US5386032A (en) 1995-01-31
LV10271B (en) 1995-04-20
RU2061693C1 (ru) 1996-06-10
FI102967B1 (fi) 1999-03-31
IS3711A7 (is) 1991-12-08
HU214323B (hu) 1998-03-02
IS1752B (is) 2000-07-21
JPH05507699A (ja) 1993-11-04
DE69128832D1 (de) 1998-03-05
KR0178045B1 (en) 1999-03-20
RO111366B1 (ro) 1996-09-30
DE69128832T2 (de) 1998-05-28
PT97873B (pt) 1998-10-30
CA2083605A1 (fr) 1991-12-08
SG48053A1 (en) 1998-04-17
FI925529A (fi) 1992-12-04
DZ1504A1 (fr) 2004-09-13
EG19392A (en) 1995-06-29
NO300541B1 (no) 1997-06-16
LT3584B (en) 1995-12-27
CN1040536C (zh) 1998-11-04
IE911845A1 (en) 1991-12-18
CA2083605C (fr) 1998-12-08
IL98274A (en) 1995-03-30
ATE162790T1 (de) 1998-02-15
EP0533752A1 (fr) 1993-03-31
ZA913779B (en) 1992-02-26
NZ238224A (en) 1993-11-25
AU640246B2 (en) 1993-08-19
JP2993122B2 (ja) 1999-12-20
SK278505B6 (en) 1997-08-06
AP9100274A0 (en) 1991-07-31
FI102967B (fi) 1999-03-31

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