ES2113378T3 - Metodo de sintesis mejorado. - Google Patents

Metodo de sintesis mejorado.

Info

Publication number
ES2113378T3
ES2113378T3 ES91910929T ES91910929T ES2113378T3 ES 2113378 T3 ES2113378 T3 ES 2113378T3 ES 91910929 T ES91910929 T ES 91910929T ES 91910929 T ES91910929 T ES 91910929T ES 2113378 T3 ES2113378 T3 ES 2113378T3
Authority
ES
Spain
Prior art keywords
metoxi
omeprazole
synthesis method
aqueous phase
improved synthesis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91910929T
Other languages
English (en)
Inventor
Arne Elof Brandstrom
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
Astra AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra AB filed Critical Astra AB
Application granted granted Critical
Publication of ES2113378T3 publication Critical patent/ES2113378T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

LA PRESENTE INVENCION SE REFIERE A UN METODO MEJORADO PARA LA SINTESIS DEL OMEPRAZOL, QUE CONSISTE EN LOS PASOS DE HACER REACCIONAR 5-METOXI-2-[(4-METOXI-3,5-DIMETIL-2-PIRIDINIL)METILTIO]-1H-BENCIMIDAZOL CON ACIDO M-CLOROPEROXI-BENZOICO EN UNA SOLUCION DE CLORURO DE METILENO A UN PH SUSTANCIALMENTE CONSTANTE DE 8,0 A 8,6 APROXIMADAMENTE; EXTRAER LA MEZCLA DE REACCION CON NAOH ACUOSO; SEPARAR LA FASE ACUOSA DE LA FASE ORGANICA; Y AÑADIR UN FORMIATO DE ALKILO A LA FASE ACUOSA, LO QUE DA COMO RESULTADO LA CRISTALIZACION DEL OMEPRAZOL.
ES91910929T 1990-06-07 1991-06-05 Metodo de sintesis mejorado. Expired - Lifetime ES2113378T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9002043A SE9002043D0 (sv) 1990-06-07 1990-06-07 Improved method for synthesis

Publications (1)

Publication Number Publication Date
ES2113378T3 true ES2113378T3 (es) 1998-05-01

Family

ID=20379708

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91910929T Expired - Lifetime ES2113378T3 (es) 1990-06-07 1991-06-05 Metodo de sintesis mejorado.

Country Status (42)

Country Link
US (1) US5386032A (es)
EP (1) EP0533752B1 (es)
JP (1) JP2993122B2 (es)
KR (1) KR0178045B1 (es)
CN (1) CN1040536C (es)
AP (1) AP216A (es)
AT (1) ATE162790T1 (es)
AU (1) AU640246B2 (es)
BG (1) BG61265B1 (es)
CA (1) CA2083605C (es)
CZ (1) CZ279928B6 (es)
DE (1) DE69128832T2 (es)
DK (1) DK0533752T3 (es)
DZ (1) DZ1504A1 (es)
EG (1) EG19392A (es)
ES (1) ES2113378T3 (es)
FI (1) FI102967B (es)
GR (1) GR3026642T3 (es)
HK (1) HK1003831A1 (es)
HR (1) HRP920770B1 (es)
HU (1) HU214323B (es)
IE (1) IE911845A1 (es)
IL (1) IL98274A (es)
IS (1) IS1752B (es)
LT (1) LT3584B (es)
LV (1) LV10271B (es)
MA (1) MA22171A1 (es)
NO (1) NO300541B1 (es)
NZ (1) NZ238224A (es)
PL (1) PL165433B1 (es)
PT (1) PT97873B (es)
RO (1) RO111366B1 (es)
RU (1) RU2061693C1 (es)
SA (1) SA91120027B1 (es)
SE (1) SE9002043D0 (es)
SG (1) SG48053A1 (es)
SK (1) SK278505B6 (es)
TN (1) TNSN91042A1 (es)
UA (1) UA32524C2 (es)
WO (1) WO1991018895A1 (es)
YU (1) YU47570B (es)
ZA (1) ZA913779B (es)

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US6096340A (en) * 1997-11-14 2000-08-01 Andrx Pharmaceuticals, Inc. Omeprazole formulation
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US6174548B1 (en) 1998-08-28 2001-01-16 Andrx Pharmaceuticals, Inc. Omeprazole formulation
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US6369087B1 (en) 1999-08-26 2002-04-09 Robert R. Whittle Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6316020B1 (en) 1999-08-26 2001-11-13 Robert R. Whittle Pharmaceutical formulations
US6262086B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Pharmaceutical unit dosage form
US6326384B1 (en) 1999-08-26 2001-12-04 Robert R. Whittle Dry blend pharmaceutical unit dosage form
US6312723B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Pharmaceutical unit dosage form
US6312712B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Method of improving bioavailability
US6262085B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6780880B1 (en) 1999-08-26 2004-08-24 Robert R. Whittle FT-Raman spectroscopic measurement
US6268385B1 (en) 1999-08-26 2001-07-31 Robert R. Whittle Dry blend pharmaceutical formulations
DE19951960C2 (de) * 1999-10-28 2002-06-27 Gruenenthal Gmbh Verfahren zur Herstellung als Ulkustherapeutika geeigneter Benzimidazol-Derivate
CN100347167C (zh) * 2001-02-02 2007-11-07 特瓦制药工业有限公司 取代的2－(2－吡啶基甲基)亚磺酰基－1h－苯并咪唑化合物的生产方法
KR100783020B1 (ko) * 2001-03-23 2007-12-07 동아제약주식회사 2-메틸클로라이드 피리딘 유도체 및 이를 이용한 벤즈이미다졸 유도체의 제조 방법
CN1235899C (zh) * 2001-07-16 2006-01-11 詹森药业有限公司 苯并咪唑型化合物的改进制备方法
US20040006111A1 (en) * 2002-01-25 2004-01-08 Kenneth Widder Transmucosal delivery of proton pump inhibitors
SE0203092D0 (en) 2002-10-18 2002-10-18 Astrazeneca Ab Method for the synthesis of a benzimidazole compound
US20040248942A1 (en) * 2003-02-20 2004-12-09 Bonnie Hepburn Novel formulation, omeprazole antacid complex-immediate release for rapid and sustained suppression of gastric acid
MXPA06000529A (es) * 2003-07-18 2006-08-11 Santarus Inc Formulaciones farmaceuticas utiles para inhibir la secrecion de acido y metodos para elaborarlas y utilizarlas.
CA2531566C (en) * 2003-07-18 2013-05-07 Santarus, Inc. Pharmaceutical formulation and method for treating acid-caused gastrointestinal disorders
US8993599B2 (en) * 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US20070292498A1 (en) * 2003-11-05 2007-12-20 Warren Hall Combinations of proton pump inhibitors, sleep aids, buffers and pain relievers
US8906940B2 (en) * 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8815916B2 (en) * 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
WO2006030936A1 (ja) 2004-09-13 2006-03-23 Takeda Pharmaceutical Company Limited 酸化化合物の製造方法及び製造装置
SI1802584T1 (sl) * 2004-10-11 2010-01-29 Ranbaxy Lab Ltd Postopki za pripravo substituiranih sulfoksidov
KR100641534B1 (ko) 2005-07-28 2006-11-01 한미약품 주식회사 에스오메프라졸 및 그의 염의 제조방법
KR101068180B1 (ko) 2005-12-01 2011-09-28 오스펙스 파마슈티칼스, 인코포레이티드 세로토닌성 및/또는 노르에피네프린성 활성을 갖는 치환된펜에틸아민
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US20090092658A1 (en) * 2007-10-05 2009-04-09 Santarus, Inc. Novel formulations of proton pump inhibitors and methods of using these formulations
EA200900985A1 (ru) 2007-01-31 2009-12-30 Крка, Товарна Здравил, Д. Д., Ново Место Способ получения оптически чистого омепразола
WO2008140859A1 (en) 2007-03-15 2008-11-20 Auspex Pharmaceuticals, Inc. Deuterated venlafaxines and 0-desmetylvenlafaxines with serotoninergic and / or norepinephrinergic activity
CN102066396B (zh) * 2008-03-31 2014-03-12 科学与工业研究委员会 用作抗胃液分泌或抗溃疡剂的药物组合物
WO2010134099A1 (en) 2009-05-21 2010-11-25 Cadila Healthcare Limited One pot process for preparing omeprazole and related compounds
CN102786513A (zh) * 2011-05-18 2012-11-21 中国医学科学院药物研究所 奥美拉唑晶e型物质及制备方法与在药品和保健品中应用
WO2013108068A1 (en) 2012-01-21 2013-07-25 Jubilant Life Sciences Limited Process for the preparation of 2-pyridinylmethylsulfinyl benzimidazoles, their analogs and optically active enantiomers
MX2022002949A (es) 2019-09-24 2022-04-06 Prolacta Bioscience Inc Composiciones y metodos para el tratamiento de enfermedades inflamatorias e inmunes.

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Also Published As

Publication number Publication date
AP9100274A0 (en) 1991-07-31
IS1752B (is) 2000-07-21
IL98274A0 (en) 1992-06-21
DK0533752T3 (da) 1998-06-02
CN1040536C (zh) 1998-11-04
HU9203855D0 (en) 1993-03-29
AU8080791A (en) 1991-12-31
NZ238224A (en) 1993-11-25
EP0533752A1 (en) 1993-03-31
FI925529A (fi) 1992-12-04
DZ1504A1 (fr) 2004-09-13
LTIP1711A (en) 1995-07-25
HUT63408A (en) 1993-08-30
ZA913779B (en) 1992-02-26
FI102967B1 (fi) 1999-03-31
UA32524C2 (uk) 2001-02-15
SE9002043D0 (sv) 1990-06-07
MA22171A1 (fr) 1991-12-31
YU99291A (sh) 1993-11-16
WO1991018895A1 (en) 1991-12-12
PL165433B1 (pl) 1994-12-30
PT97873B (pt) 1998-10-30
FI102967B (fi) 1999-03-31
AP216A (en) 1992-09-02
CZ279928B6 (cs) 1995-08-16
LV10271B (en) 1995-04-20
RU2061693C1 (ru) 1996-06-10
TNSN91042A1 (fr) 1992-10-25
HK1003831A1 (en) 1998-11-06
CN1058211A (zh) 1992-01-29
US5386032A (en) 1995-01-31
CA2083605C (en) 1998-12-08
JPH05507699A (ja) 1993-11-04
LT3584B (en) 1995-12-27
YU47570B (sh) 1995-10-03
DE69128832T2 (de) 1998-05-28
CS172691A3 (en) 1992-01-15
CA2083605A1 (en) 1991-12-08
SG48053A1 (en) 1998-04-17
BG61265B1 (en) 1997-04-30
SK278505B6 (en) 1997-08-06
RO111366B1 (ro) 1996-09-30
HRP920770A2 (en) 1995-12-31
SA91120027B1 (ar) 2002-06-03
FI925529A0 (fi) 1992-12-04
LV10271A (lv) 1994-10-20
PT97873A (pt) 1992-04-30
HU214323B (hu) 1998-03-02
AU640246B2 (en) 1993-08-19
DE69128832D1 (de) 1998-03-05
KR0178045B1 (en) 1999-03-20
HRP920770B1 (en) 2000-06-30
ATE162790T1 (de) 1998-02-15
EG19392A (en) 1995-06-29
NO924682L (no) 1992-12-04
IE911845A1 (en) 1991-12-18
GR3026642T3 (en) 1998-07-31
NO924682D0 (no) 1992-12-04
IS3711A7 (is) 1991-12-08
IL98274A (en) 1995-03-30
JP2993122B2 (ja) 1999-12-20
EP0533752B1 (en) 1998-01-28
NO300541B1 (no) 1997-06-16

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