RU92016535A - Способ получения омепразола - Google Patents

Способ получения омепразола

Info

Publication number
RU92016535A
RU92016535A RU92016535/04A RU92016535A RU92016535A RU 92016535 A RU92016535 A RU 92016535A RU 92016535/04 A RU92016535/04 A RU 92016535/04A RU 92016535 A RU92016535 A RU 92016535A RU 92016535 A RU92016535 A RU 92016535A
Authority
RU
Russia
Prior art keywords
omeprazol
obtaining
methoxy
aqueous phase
aqueous
Prior art date
Application number
RU92016535/04A
Other languages
English (en)
Other versions
RU2061693C1 (ru
Inventor
Элоф Брендстрем Арне
Original Assignee
Актиеболагет Астра
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from SE9002043A external-priority patent/SE9002043D0/xx
Application filed by Актиеболагет Астра filed Critical Актиеболагет Астра
Publication of RU92016535A publication Critical patent/RU92016535A/ru
Application granted granted Critical
Publication of RU2061693C1 publication Critical patent/RU2061693C1/ru

Links

Claims (1)

  1. Предполагаемое изобретение относится к усовершенствованному способу синтеза омепразола, включающему стадии взаимодействия 5-метокси-2-[(4-метокси-3,5-диметил-2-пиридинил)-метилтио] - -IH-бензимидазола с м-хлорпероксибензойной кислотой в растворе метиленхлорида при практически постоянном pH около 8,0-8,6, экстракции реакционной смеси водным NaOH, отделения водной фазы от органической фазы и добавления алкилформата к водной фазе, в результате чего кристаллизуется смепразол.
RU9192016535A 1990-06-07 1991-06-05 Способ получения омепразола RU2061693C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE9002043-9 1990-06-07
SE9002043A SE9002043D0 (sv) 1990-06-07 1990-06-07 Improved method for synthesis
PCT/SE1991/000402 WO1991018895A1 (en) 1990-06-07 1991-06-05 Improved method for synthesis

Publications (2)

Publication Number Publication Date
RU92016535A true RU92016535A (ru) 1995-05-20
RU2061693C1 RU2061693C1 (ru) 1996-06-10

Family

ID=20379708

Family Applications (1)

Application Number Title Priority Date Filing Date
RU9192016535A RU2061693C1 (ru) 1990-06-07 1991-06-05 Способ получения омепразола

Country Status (42)

Country Link
US (1) US5386032A (ru)
EP (1) EP0533752B1 (ru)
JP (1) JP2993122B2 (ru)
KR (1) KR0178045B1 (ru)
CN (1) CN1040536C (ru)
AP (1) AP216A (ru)
AT (1) ATE162790T1 (ru)
AU (1) AU640246B2 (ru)
BG (1) BG61265B1 (ru)
CA (1) CA2083605C (ru)
CZ (1) CZ279928B6 (ru)
DE (1) DE69128832T2 (ru)
DK (1) DK0533752T3 (ru)
DZ (1) DZ1504A1 (ru)
EG (1) EG19392A (ru)
ES (1) ES2113378T3 (ru)
FI (1) FI102967B1 (ru)
GR (1) GR3026642T3 (ru)
HK (1) HK1003831A1 (ru)
HR (1) HRP920770B1 (ru)
HU (1) HU214323B (ru)
IE (1) IE911845A1 (ru)
IL (1) IL98274A (ru)
IS (1) IS1752B (ru)
LT (1) LT3584B (ru)
LV (1) LV10271B (ru)
MA (1) MA22171A1 (ru)
NO (1) NO300541B1 (ru)
NZ (1) NZ238224A (ru)
PL (1) PL165433B1 (ru)
PT (1) PT97873B (ru)
RO (1) RO111366B1 (ru)
RU (1) RU2061693C1 (ru)
SA (1) SA91120027B1 (ru)
SE (1) SE9002043D0 (ru)
SG (1) SG48053A1 (ru)
SK (1) SK278505B6 (ru)
TN (1) TNSN91042A1 (ru)
UA (1) UA32524C2 (ru)
WO (1) WO1991018895A1 (ru)
YU (1) YU47570B (ru)
ZA (1) ZA913779B (ru)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE521100C2 (sv) * 1995-12-15 2003-09-30 Astra Ab Förfarande för framställning av en bensimidazolförening
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
US6699885B2 (en) 1996-01-04 2004-03-02 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and methods of using same
US6645988B2 (en) * 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US6489346B1 (en) 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
SK283805B6 (sk) 1996-09-09 2004-02-03 Slovakofarma, A. S. Spôsob prípravy omeprazolu
CA2204580A1 (en) * 1997-05-06 1998-11-06 Michel Zoghbi Synthesis of pharmaceutically useful pyridine derivatives
US6437139B1 (en) 1997-05-06 2002-08-20 Pdi-Research Laboratories, Inc. Synthesis of pharmaceutically useful pyridine derivatives
KR100463031B1 (ko) * 1997-05-26 2005-04-06 동아제약주식회사 5-메톡시-2-[3,5-디메틸-4-메톡시피리딜메틸)설피닐]-1h-벤즈이미다졸의신규제조방법
US6096340A (en) * 1997-11-14 2000-08-01 Andrx Pharmaceuticals, Inc. Omeprazole formulation
US6174548B1 (en) 1998-08-28 2001-01-16 Andrx Pharmaceuticals, Inc. Omeprazole formulation
SE9704183D0 (sv) 1997-11-14 1997-11-14 Astra Ab New process
SI20019A (sl) 1998-07-13 2000-02-29 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Izboljšan postopek sinteze 5-metoksi -2-/(4-metoksi-3,5-dimetil-2-piridil)metil/ sulfinil-1H-benzimidazola
US6166213A (en) * 1998-08-11 2000-12-26 Merck & Co., Inc. Omeprazole process and compositions thereof
US6191148B1 (en) 1998-08-11 2001-02-20 Merck & Co., Inc. Omerazole process and compositions thereof
US6733778B1 (en) 1999-08-27 2004-05-11 Andrx Pharmaceuticals, Inc. Omeprazole formulation
UA72748C2 (en) * 1998-11-10 2005-04-15 Astrazeneca Ab A novel crystalline form of omeprazole
IL142703A (en) 1998-11-10 2006-04-10 Astrazeneca Ab Crystalline form of omeprazole
US6362202B1 (en) 1999-03-02 2002-03-26 Sepracor Inc. Methods and compositions using (−) norcisapride in combination with proton pump inhibitors or H2 receptor antagonists
US6353005B1 (en) 1999-03-02 2002-03-05 Sepracor, Inc. Method and compositions using (+) norcisapride in combination with proton pump inhibitors or H2 receptor antagonist
US6262085B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6312712B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Method of improving bioavailability
US6369087B1 (en) 1999-08-26 2002-04-09 Robert R. Whittle Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6316020B1 (en) 1999-08-26 2001-11-13 Robert R. Whittle Pharmaceutical formulations
US6312723B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Pharmaceutical unit dosage form
US6262086B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Pharmaceutical unit dosage form
US6268385B1 (en) 1999-08-26 2001-07-31 Robert R. Whittle Dry blend pharmaceutical formulations
US6780880B1 (en) * 1999-08-26 2004-08-24 Robert R. Whittle FT-Raman spectroscopic measurement
US6326384B1 (en) 1999-08-26 2001-12-04 Robert R. Whittle Dry blend pharmaceutical unit dosage form
DE19951960C2 (de) 1999-10-28 2002-06-27 Gruenenthal Gmbh Verfahren zur Herstellung als Ulkustherapeutika geeigneter Benzimidazol-Derivate
WO2002062786A1 (en) 2001-02-02 2002-08-15 Teva Pharmaceutical Industries Ltd. Processes for the production of substituted 2-(2-pyridylmethyl) sulfinyl-1h-benzimidazoles
KR100783020B1 (ko) * 2001-03-23 2007-12-07 동아제약주식회사 2-메틸클로라이드 피리딘 유도체 및 이를 이용한 벤즈이미다졸 유도체의 제조 방법
IL159854A0 (en) * 2001-07-16 2004-06-20 Janssen Pharmaceutica Nv Improved process for preparing benzimidazole-type compounds
CA2472103A1 (en) * 2002-01-25 2003-08-07 Santarus, Inc. Transmucosal delivery of proton pump inhibitors
SE0203092D0 (en) 2002-10-18 2002-10-18 Astrazeneca Ab Method for the synthesis of a benzimidazole compound
EP1603537A4 (en) * 2003-02-20 2009-11-04 Santarus Inc IMMEDIATE RELEASE OF OMEPRAZOLE ANTACIDAL COMPLEX WITH NEW FORMULATION FOR RAPID AND PROLONGED ELIMINATION OF GASTRIC ACID
JP2006528181A (ja) * 2003-07-18 2006-12-14 サンタラス インコーポレイティッド 酸分泌を阻害するために有用な薬学的製剤ならびにそれらを作製および使用する方法
AU2004257864A1 (en) * 2003-07-18 2005-01-27 Santarus, Inc. Pharmaceutical formulation and method for treating acid-caused gastrointestinal disorders
US8993599B2 (en) * 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US20070292498A1 (en) * 2003-11-05 2007-12-20 Warren Hall Combinations of proton pump inhibitors, sleep aids, buffers and pain relievers
US8815916B2 (en) * 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8906940B2 (en) * 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
JP5173191B2 (ja) 2004-09-13 2013-03-27 武田薬品工業株式会社 酸化化合物の製造方法及び製造装置
SI1802584T1 (sl) * 2004-10-11 2010-01-29 Ranbaxy Lab Ltd Postopki za pripravo substituiranih sulfoksidov
KR100641534B1 (ko) 2005-07-28 2006-11-01 한미약품 주식회사 에스오메프라졸 및 그의 염의 제조방법
CA2631581C (en) 2005-12-01 2011-05-03 Auspex Pharmaceuticals, Inc. Substituted phenethylamines with serotoninergic and/or norepinephrinergic activity
EP1801110A1 (en) 2005-12-22 2007-06-27 KRKA, tovarna zdravil, d.d., Novo mesto Esomeprazole arginine salt
WO2007129328A2 (en) * 2006-05-09 2007-11-15 Cadila Healthcare Limited Process for preparing 2-[pyridinyl]sulfinyl-substituted benzimidazoles
US20090092658A1 (en) * 2007-10-05 2009-04-09 Santarus, Inc. Novel formulations of proton pump inhibitors and methods of using these formulations
EA200900985A1 (ru) 2007-01-31 2009-12-30 Крка, Товарна Здравил, Д. Д., Ново Место Способ получения оптически чистого омепразола
WO2008140859A1 (en) 2007-03-15 2008-11-20 Auspex Pharmaceuticals, Inc. Deuterated venlafaxines and 0-desmetylvenlafaxines with serotoninergic and / or norepinephrinergic activity
WO2009122435A2 (en) * 2008-03-31 2009-10-08 Council Of Scientific & Industrial Research A simultaneous method for the preparation of a mixture of 3- acetoxy-17-acetamido-16-formyl-androst-5,17-diene and 3- acetoxy-2'-chloro-5-androsteno[17,16-b]pyridine
WO2010134099A1 (en) 2009-05-21 2010-11-25 Cadila Healthcare Limited One pot process for preparing omeprazole and related compounds
CN102786513A (zh) * 2011-05-18 2012-11-21 中国医学科学院药物研究所 奥美拉唑晶e型物质及制备方法与在药品和保健品中应用
CN104203938A (zh) 2012-01-21 2014-12-10 朱比兰特生命科学有限公司 用于制备2-吡啶基甲基亚硫酰基苯并咪唑、它们的类似物和光学活性对映体的方法
TW202126317A (zh) 2019-09-24 2021-07-16 美商普拉塔生技公司 用於治療發炎和免疫疾病之組成物和方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IN148930B (ru) * 1977-09-19 1981-07-25 Hoffmann La Roche
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US4307102A (en) * 1981-02-19 1981-12-22 Sterling Drug Inc. Phenanthro[2,3-c]pyrazole
SE8300736D0 (sv) * 1983-02-11 1983-02-11 Haessle Ab Novel pharmacologically active compounds
ZW4585A1 (en) * 1984-04-19 1985-11-20 Hoffmann La Roche Imidazole derivatives
IL76839A (en) * 1984-10-31 1988-08-31 Byk Gulden Lomberg Chem Fab Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
SE8500996D0 (sv) * 1985-03-01 1985-03-01 Haessle Ab Method of treatment
SE8600658D0 (sv) * 1986-02-14 1986-02-14 Haessle Ab Novel composition of matter
FI91754C (fi) * 1986-12-02 1994-08-10 Tanabe Seiyaku Co Analogiamenetelmä lääkeaineena käyttökelpoisen imidatsolijohdannaisen valmistamiseksi
DE3722810A1 (de) * 1987-07-10 1989-01-19 Hoechst Ag Substituierte benzimidazole, verfahren zu deren herstellung, diese enthaltende pharmazeutische zubereitungen und deren verwendung
SE9002206D0 (sv) * 1990-06-20 1990-06-20 Haessle Ab New compounds
WO1993006097A1 (en) * 1991-09-20 1993-04-01 Merck & Co., Inc. Novel process for the preparation of anti-ulcer agents

Similar Documents

Publication Publication Date Title
RU92016535A (ru) Способ получения омепразола
SE9002043D0 (sv) Improved method for synthesis
BR9912883A (pt) Processo para a preparação de omeprazol, 5-metóxi-2- [ [4-metóxi-3, 5-dimetil-2-piridinil) -metil] -sulfinil] 1h-benzimidazol (omeprazol), composição, e, composição farmacêutica
EP1897877A3 (en) Process for producing crystal
YU60999A (sh) Novi oblik s-omeprazola
NO20016087D0 (no) Benzimidazolforbindelsekrystall
TR200102138T2 (tr) (S)-Omeprazolün potasyum tuzu.
CO4750654A1 (es) Proceso para la sintesis de un compuesto omeprazol
HUP0102523A2 (hu) Javított eljárás 5-metoxi-2-[(4-metoxi-3,5-dimetil-2-piridil)-metil]-szulfinil-1H-benzimidazol előállítására
DE60316791D1 (de) Verfahren zur aufreinigung von lanzoprazol
ATE212349T1 (de) Neues verfahren zur herstellung von nucleosiden
HUP9903744A2 (hu) Eljárás omeprazol előállítására
JO1707B1 (en) An improved method of construction
TH26860EX (th) วิธีที่ได้ปรับปรุงให้ดีขึ้นสำหรับการสังเคราะห์
TH26736A (th) วิธีสำหรับการสังเคราะห์สารประกอบเบมซิมิดาโซล
TH26860A (th) วิธีที่ได้ปรับปรุงให้ดีขึ้นสำหรับการสังเคราะห์
TH16348B (th) วิธีที่ได้ปรับปรุงให้ดีขึ้นสำหรับการสังเคราะห์
TH26736B (th) วิธีสำหรับการสังเคราะห์สารประกอบเบมซิมิดาโซล
MY118724A (en) New crystalline form of omeprazole
KR880001623A (ko) 질소 함유 헤테로 사이클릭 화합물의 제조 방법