FI102967B1 - Parannettu synteesimenetelmä - Google Patents

Parannettu synteesimenetelmä

Info

Publication number
FI102967B1
FI102967B1 FI925529A FI925529A FI102967B1 FI 102967 B1 FI102967 B1 FI 102967B1 FI 925529 A FI925529 A FI 925529A FI 925529 A FI925529 A FI 925529A FI 102967 B1 FI102967 B1 FI 102967B1
Authority
FI
Finland
Prior art keywords
synthesis method
improved synthesis
improved
synthesis
Prior art date
Application number
FI925529A
Other languages
English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI925529A0 (fi
FI102967B (fi
FI925529A (fi
Inventor
Arne Elof Braendstroem
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of FI925529A0 publication Critical patent/FI925529A0/fi
Publication of FI925529A publication Critical patent/FI925529A/fi
Application granted granted Critical
Publication of FI102967B publication Critical patent/FI102967B/fi
Publication of FI102967B1 publication Critical patent/FI102967B1/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
FI925529A 1990-06-07 1992-12-04 Parannettu synteesimenetelmä FI102967B1 (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
SE9002043A SE9002043D0 (sv) 1990-06-07 1990-06-07 Improved method for synthesis
SE9002043 1990-06-07
SE9100402 1991-06-05
PCT/SE1991/000402 WO1991018895A1 (en) 1990-06-07 1991-06-05 Improved method for synthesis

Publications (4)

Publication Number Publication Date
FI925529A0 FI925529A0 (fi) 1992-12-04
FI925529A FI925529A (fi) 1992-12-04
FI102967B FI102967B (fi) 1999-03-31
FI102967B1 true FI102967B1 (fi) 1999-03-31

Family

ID=20379708

Family Applications (1)

Application Number Title Priority Date Filing Date
FI925529A FI102967B1 (fi) 1990-06-07 1992-12-04 Parannettu synteesimenetelmä

Country Status (42)

Country Link
US (1) US5386032A (ru)
EP (1) EP0533752B1 (ru)
JP (1) JP2993122B2 (ru)
KR (1) KR0178045B1 (ru)
CN (1) CN1040536C (ru)
AP (1) AP216A (ru)
AT (1) ATE162790T1 (ru)
AU (1) AU640246B2 (ru)
BG (1) BG61265B1 (ru)
CA (1) CA2083605C (ru)
CZ (1) CZ279928B6 (ru)
DE (1) DE69128832T2 (ru)
DK (1) DK0533752T3 (ru)
DZ (1) DZ1504A1 (ru)
EG (1) EG19392A (ru)
ES (1) ES2113378T3 (ru)
FI (1) FI102967B1 (ru)
GR (1) GR3026642T3 (ru)
HK (1) HK1003831A1 (ru)
HR (1) HRP920770B1 (ru)
HU (1) HU214323B (ru)
IE (1) IE911845A1 (ru)
IL (1) IL98274A (ru)
IS (1) IS1752B (ru)
LT (1) LT3584B (ru)
LV (1) LV10271B (ru)
MA (1) MA22171A1 (ru)
NO (1) NO300541B1 (ru)
NZ (1) NZ238224A (ru)
PL (1) PL165433B1 (ru)
PT (1) PT97873B (ru)
RO (1) RO111366B1 (ru)
RU (1) RU2061693C1 (ru)
SA (1) SA91120027B1 (ru)
SE (1) SE9002043D0 (ru)
SG (1) SG48053A1 (ru)
SK (1) SK278505B6 (ru)
TN (1) TNSN91042A1 (ru)
UA (1) UA32524C2 (ru)
WO (1) WO1991018895A1 (ru)
YU (1) YU47570B (ru)
ZA (1) ZA913779B (ru)

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SE521100C2 (sv) * 1995-12-15 2003-09-30 Astra Ab Förfarande för framställning av en bensimidazolförening
US6645988B2 (en) * 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
US6489346B1 (en) 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US6699885B2 (en) 1996-01-04 2004-03-02 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and methods of using same
SK283805B6 (sk) 1996-09-09 2004-02-03 Slovakofarma, A. S. Spôsob prípravy omeprazolu
CA2204580A1 (en) * 1997-05-06 1998-11-06 Michel Zoghbi Synthesis of pharmaceutically useful pyridine derivatives
US6437139B1 (en) 1997-05-06 2002-08-20 Pdi-Research Laboratories, Inc. Synthesis of pharmaceutically useful pyridine derivatives
KR100463031B1 (ko) * 1997-05-26 2005-04-06 동아제약주식회사 5-메톡시-2-[3,5-디메틸-4-메톡시피리딜메틸)설피닐]-1h-벤즈이미다졸의신규제조방법
SE9704183D0 (sv) 1997-11-14 1997-11-14 Astra Ab New process
US6174548B1 (en) 1998-08-28 2001-01-16 Andrx Pharmaceuticals, Inc. Omeprazole formulation
US6096340A (en) * 1997-11-14 2000-08-01 Andrx Pharmaceuticals, Inc. Omeprazole formulation
SI20019A (sl) 1998-07-13 2000-02-29 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Izboljšan postopek sinteze 5-metoksi -2-/(4-metoksi-3,5-dimetil-2-piridil)metil/ sulfinil-1H-benzimidazola
US6191148B1 (en) 1998-08-11 2001-02-20 Merck & Co., Inc. Omerazole process and compositions thereof
US6166213A (en) * 1998-08-11 2000-12-26 Merck & Co., Inc. Omeprazole process and compositions thereof
US6733778B1 (en) 1999-08-27 2004-05-11 Andrx Pharmaceuticals, Inc. Omeprazole formulation
IL142703A (en) 1998-11-10 2006-04-10 Astrazeneca Ab Crystalline form of omeprazole
UA72748C2 (en) * 1998-11-10 2005-04-15 Astrazeneca Ab A novel crystalline form of omeprazole
US6362202B1 (en) 1999-03-02 2002-03-26 Sepracor Inc. Methods and compositions using (−) norcisapride in combination with proton pump inhibitors or H2 receptor antagonists
US6353005B1 (en) 1999-03-02 2002-03-05 Sepracor, Inc. Method and compositions using (+) norcisapride in combination with proton pump inhibitors or H2 receptor antagonist
US6312712B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Method of improving bioavailability
US6780880B1 (en) 1999-08-26 2004-08-24 Robert R. Whittle FT-Raman spectroscopic measurement
US6268385B1 (en) 1999-08-26 2001-07-31 Robert R. Whittle Dry blend pharmaceutical formulations
US6312723B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Pharmaceutical unit dosage form
US6326384B1 (en) 1999-08-26 2001-12-04 Robert R. Whittle Dry blend pharmaceutical unit dosage form
US6262086B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Pharmaceutical unit dosage form
US6262085B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6316020B1 (en) 1999-08-26 2001-11-13 Robert R. Whittle Pharmaceutical formulations
US6369087B1 (en) 1999-08-26 2002-04-09 Robert R. Whittle Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
DE19951960C2 (de) * 1999-10-28 2002-06-27 Gruenenthal Gmbh Verfahren zur Herstellung als Ulkustherapeutika geeigneter Benzimidazol-Derivate
CN100347167C (zh) * 2001-02-02 2007-11-07 特瓦制药工业有限公司 取代的2－(2－吡啶基甲基)亚磺酰基－1h－苯并咪唑化合物的生产方法
KR100783020B1 (ko) * 2001-03-23 2007-12-07 동아제약주식회사 2-메틸클로라이드 피리딘 유도체 및 이를 이용한 벤즈이미다졸 유도체의 제조 방법
AU2002321204B2 (en) * 2001-07-16 2008-05-08 Janssen Pharmaceutica N.V. Improved process for preparing benzimidazole-type compounds
US20040006111A1 (en) * 2002-01-25 2004-01-08 Kenneth Widder Transmucosal delivery of proton pump inhibitors
SE0203092D0 (en) 2002-10-18 2002-10-18 Astrazeneca Ab Method for the synthesis of a benzimidazole compound
EP1603537A4 (en) * 2003-02-20 2009-11-04 Santarus Inc IMMEDIATE RELEASE OF OMEPRAZOLE ANTACIDAL COMPLEX WITH NEW FORMULATION FOR RAPID AND PROLONGED ELIMINATION OF GASTRIC ACID
US8993599B2 (en) * 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
TWI337877B (en) * 2003-07-18 2011-03-01 Santarus Inc Pharmaceutical formulation and method for treating acid-caused gastrointestinal disorders
EP1648416A4 (en) * 2003-07-18 2012-03-28 Santarus Inc PHARMACEUTICAL FORMULATIONS FOR INHIBITING THE ACIDIC ACIDIFICATION AND MANUFACTURING AND USE METHOD
US20070292498A1 (en) * 2003-11-05 2007-12-20 Warren Hall Combinations of proton pump inhibitors, sleep aids, buffers and pain relievers
US8906940B2 (en) * 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8815916B2 (en) * 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
CA2579665C (en) 2004-09-13 2014-03-18 Takeda Pharmaceutical Company Limited Method and apparatus for producing oxidized compound
DE602005016705D1 (de) * 2004-10-11 2009-10-29 Ranbaxy Lab Ltd Verfahren zur herstellung substituierter sulfoxide
KR100641534B1 (ko) 2005-07-28 2006-11-01 한미약품 주식회사 에스오메프라졸 및 그의 염의 제조방법
DK1954669T3 (en) 2005-12-01 2015-10-12 Auspex Pharmaceuticals Inc SUBSTITUTED phenethylamines a serotonergic AND / OR NOREPINEPHRINERG ACTIVITY
EP1801110A1 (en) 2005-12-22 2007-06-27 KRKA, tovarna zdravil, d.d., Novo mesto Esomeprazole arginine salt
WO2007129328A2 (en) * 2006-05-09 2007-11-15 Cadila Healthcare Limited Process for preparing 2-[pyridinyl]sulfinyl-substituted benzimidazoles
US20090092658A1 (en) * 2007-10-05 2009-04-09 Santarus, Inc. Novel formulations of proton pump inhibitors and methods of using these formulations
EA200900985A1 (ru) 2007-01-31 2009-12-30 Крка, Товарна Здравил, Д. Д., Ново Место Способ получения оптически чистого омепразола
TW200846305A (en) 2007-03-15 2008-12-01 Auspex Pharmaceuticals Inc Substituted phenethylamines with serotoninergic and/or norepinephrinergic activity
GB2471619B (en) * 2008-03-31 2012-10-31 Council Scient Ind Res Method for the simultaneous preparation of 3-acetoxy-17-acetamdo-16-formyl-androst-5,16-diene and 3-acetoxy-2'-chloro-5-androsteno[17,6-B]pyridine
WO2010134099A1 (en) 2009-05-21 2010-11-25 Cadila Healthcare Limited One pot process for preparing omeprazole and related compounds
CN102786513A (zh) * 2011-05-18 2012-11-21 中国医学科学院药物研究所 奥美拉唑晶e型物质及制备方法与在药品和保健品中应用
CN104203938A (zh) 2012-01-21 2014-12-10 朱比兰特生命科学有限公司 用于制备2-吡啶基甲基亚硫酰基苯并咪唑、它们的类似物和光学活性对映体的方法
BR112022005578A2 (pt) 2019-09-24 2022-09-20 Prolacta Bioscience Inc Composições e métodos para tratamento de doenças inflamatórias e imunes

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IN148930B (ru) * 1977-09-19 1981-07-25 Hoffmann La Roche
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US4307102A (en) * 1981-02-19 1981-12-22 Sterling Drug Inc. Phenanthro[2,3-c]pyrazole
SE8300736D0 (sv) * 1983-02-11 1983-02-11 Haessle Ab Novel pharmacologically active compounds
ZW4585A1 (en) * 1984-04-19 1985-11-20 Hoffmann La Roche Imidazole derivatives
IL76839A (en) * 1984-10-31 1988-08-31 Byk Gulden Lomberg Chem Fab Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
SE8500996D0 (sv) * 1985-03-01 1985-03-01 Haessle Ab Method of treatment
SE8600658D0 (sv) * 1986-02-14 1986-02-14 Haessle Ab Novel composition of matter
FI91754C (fi) * 1986-12-02 1994-08-10 Tanabe Seiyaku Co Analogiamenetelmä lääkeaineena käyttökelpoisen imidatsolijohdannaisen valmistamiseksi
DE3722810A1 (de) * 1987-07-10 1989-01-19 Hoechst Ag Substituierte benzimidazole, verfahren zu deren herstellung, diese enthaltende pharmazeutische zubereitungen und deren verwendung
SE9002206D0 (sv) * 1990-06-20 1990-06-20 Haessle Ab New compounds
WO1993006097A1 (en) * 1991-09-20 1993-04-01 Merck & Co., Inc. Novel process for the preparation of anti-ulcer agents

Also Published As

Publication number Publication date
SE9002043D0 (sv) 1990-06-07
HRP920770B1 (en) 2000-06-30
WO1991018895A1 (en) 1991-12-12
AP9100274A0 (en) 1991-07-31
NO924682L (no) 1992-12-04
NZ238224A (en) 1993-11-25
LV10271B (en) 1995-04-20
RU2061693C1 (ru) 1996-06-10
IL98274A0 (en) 1992-06-21
MA22171A1 (fr) 1991-12-31
CN1040536C (zh) 1998-11-04
EP0533752A1 (en) 1993-03-31
RO111366B1 (ro) 1996-09-30
NO300541B1 (no) 1997-06-16
AU8080791A (en) 1991-12-31
GR3026642T3 (en) 1998-07-31
PT97873A (pt) 1992-04-30
IL98274A (en) 1995-03-30
JPH05507699A (ja) 1993-11-04
AU640246B2 (en) 1993-08-19
EP0533752B1 (en) 1998-01-28
PL165433B1 (pl) 1994-12-30
HU9203855D0 (en) 1993-03-29
AP216A (en) 1992-09-02
KR0178045B1 (en) 1999-03-20
EG19392A (en) 1995-06-29
ES2113378T3 (es) 1998-05-01
FI925529A0 (fi) 1992-12-04
SK278505B6 (en) 1997-08-06
CS172691A3 (en) 1992-01-15
NO924682D0 (no) 1992-12-04
SA91120027B1 (ar) 2002-06-03
IE911845A1 (en) 1991-12-18
BG97146A (bg) 1993-12-24
LT3584B (en) 1995-12-27
DE69128832D1 (de) 1998-03-05
HU214323B (hu) 1998-03-02
CA2083605A1 (en) 1991-12-08
HRP920770A2 (en) 1995-12-31
HUT63408A (en) 1993-08-30
CZ279928B6 (cs) 1995-08-16
PT97873B (pt) 1998-10-30
CA2083605C (en) 1998-12-08
FI102967B (fi) 1999-03-31
DK0533752T3 (da) 1998-06-02
FI925529A (fi) 1992-12-04
UA32524C2 (ru) 2001-02-15
ZA913779B (en) 1992-02-26
US5386032A (en) 1995-01-31
JP2993122B2 (ja) 1999-12-20
CN1058211A (zh) 1992-01-29
IS3711A7 (is) 1991-12-08
LTIP1711A (en) 1995-07-25
BG61265B1 (en) 1997-04-30
IS1752B (is) 2000-07-21
ATE162790T1 (de) 1998-02-15
HK1003831A1 (en) 1998-11-06
TNSN91042A1 (fr) 1992-10-25
SG48053A1 (en) 1998-04-17
LV10271A (lv) 1994-10-20
DE69128832T2 (de) 1998-05-28
DZ1504A1 (fr) 2004-09-13
YU47570B (sh) 1995-10-03
YU99291A (sh) 1993-11-16

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