HUP9903744A2 - Eljárás omeprazol előállítására - Google Patents

Eljárás omeprazol előállítására

Info

Publication number
HUP9903744A2
HUP9903744A2 HU9903744A HUP9903744A HUP9903744A2 HU P9903744 A2 HUP9903744 A2 HU P9903744A2 HU 9903744 A HU9903744 A HU 9903744A HU P9903744 A HUP9903744 A HU P9903744A HU P9903744 A2 HUP9903744 A2 HU P9903744A2
Authority
HU
Hungary
Prior art keywords
methoxy
reaction
omeprazole
organic solvent
water
Prior art date
Application number
HU9903744A
Other languages
English (en)
Inventor
Ondrej Gattnar
Katarína Heleyová
Ladislav Jezek
Vladimír Oremus
Vendel Smahovsky
Valdemar Stalmach
Ivan Varga
Pavol Zlatoidsky
Original Assignee
Slovakofarma, A.S.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Slovakofarma, A.S. filed Critical Slovakofarma, A.S.
Publication of HUP9903744A2 publication Critical patent/HUP9903744A2/hu
Publication of HUP9903744A3 publication Critical patent/HUP9903744A3/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Eljárás őmeprazől előállítására azzal jellemezve, hőgy 5-metőxi-2[4-metőxi-3,5-dimetil-2-piridinil)-metil-tiő]-1H-benzimidazőlt perőxi-ecetsavval reagáltatnak két-fázisú víz és klórőzőtt szerves őldószerközegben, alkálikűs pH-nál, ezt követően a vizet és a szervesőldószert elválasztják, a reakció űtán a szerves fázist izőlálják. Azőmeprazőlt fekélyellenes szerként használják. ŕ
HU9903744A 1996-09-09 1997-09-08 Method of omeprazole preparation HUP9903744A3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SK1155-96A SK283805B6 (sk) 1996-09-09 1996-09-09 Spôsob prípravy omeprazolu

Publications (2)

Publication Number Publication Date
HUP9903744A2 true HUP9903744A2 (hu) 2000-05-28
HUP9903744A3 HUP9903744A3 (en) 2002-04-29

Family

ID=20434314

Family Applications (1)

Application Number Title Priority Date Filing Date
HU9903744A HUP9903744A3 (en) 1996-09-09 1997-09-08 Method of omeprazole preparation

Country Status (12)

Country Link
US (1) US6229021B1 (hu)
EP (1) EP0931076A1 (hu)
KR (1) KR19990046151A (hu)
AU (1) AU4325397A (hu)
CA (1) CA2265538A1 (hu)
CZ (1) CZ293946B6 (hu)
HU (1) HUP9903744A3 (hu)
PL (1) PL332077A1 (hu)
SK (1) SK283805B6 (hu)
TR (1) TR199900509T2 (hu)
UA (1) UA56179C2 (hu)
WO (1) WO1998009962A1 (hu)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6191148B1 (en) 1998-08-11 2001-02-20 Merck & Co., Inc. Omerazole process and compositions thereof
US6166213A (en) * 1998-08-11 2000-12-26 Merck & Co., Inc. Omeprazole process and compositions thereof
DE19951960C2 (de) 1999-10-28 2002-06-27 Gruenenthal Gmbh Verfahren zur Herstellung als Ulkustherapeutika geeigneter Benzimidazol-Derivate
CN1876647A (zh) * 2001-02-02 2006-12-13 特瓦制药工业有限公司 苯并咪唑化合物产品
IL159854A0 (en) * 2001-07-16 2004-06-20 Janssen Pharmaceutica Nv Improved process for preparing benzimidazole-type compounds
SI1802584T1 (sl) * 2004-10-11 2010-01-29 Ranbaxy Lab Ltd Postopki za pripravo substituiranih sulfoksidov
DE112005003147T5 (de) * 2004-12-16 2008-01-17 Cipla Ltd. Verfahren
WO2007066202A1 (en) * 2005-12-06 2007-06-14 Inogent Laboratories Private Limited Process for the preparation of 2-(2-pyridylmethyl)-sulfinyl-1h-benzimidazoles

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3722810A1 (de) * 1987-07-10 1989-01-19 Hoechst Ag Substituierte benzimidazole, verfahren zu deren herstellung, diese enthaltende pharmazeutische zubereitungen und deren verwendung
SE9002043D0 (sv) 1990-06-07 1990-06-07 Astra Ab Improved method for synthesis
NZ244301A (en) * 1991-09-20 1994-08-26 Merck & Co Inc Preparation of 2-pyridylmethylsulphinylbenzimidazole and pyridoimidazole derivatives from the corresponding sulphenyl compounds
SE521100C2 (sv) 1995-12-15 2003-09-30 Astra Ab Förfarande för framställning av en bensimidazolförening

Also Published As

Publication number Publication date
WO1998009962A1 (en) 1998-03-12
SK283805B6 (sk) 2004-02-03
SK115596A3 (en) 1999-02-11
AU4325397A (en) 1998-03-26
CZ79299A3 (cs) 1999-06-16
EP0931076A1 (en) 1999-07-28
US6229021B1 (en) 2001-05-08
CA2265538A1 (en) 1998-03-12
CZ293946B6 (cs) 2004-08-18
TR199900509T2 (xx) 1999-06-21
HUP9903744A3 (en) 2002-04-29
UA56179C2 (uk) 2003-05-15
KR19990046151A (ko) 1999-06-25
PL332077A1 (en) 1999-08-30

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