IL98274A - Synthesis method for the preparation of omeprazole - Google Patents

Synthesis method for the preparation of omeprazole

Info

Publication number
IL98274A
IL98274A IL9827491A IL9827491A IL98274A IL 98274 A IL98274 A IL 98274A IL 9827491 A IL9827491 A IL 9827491A IL 9827491 A IL9827491 A IL 9827491A IL 98274 A IL98274 A IL 98274A
Authority
IL
Israel
Prior art keywords
omeprazole
aqueous
reaction mixture
phase
synthesis
Prior art date
Application number
IL9827491A
Other languages
English (en)
Hebrew (he)
Other versions
IL98274A0 (en
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of IL98274A0 publication Critical patent/IL98274A0/xx
Publication of IL98274A publication Critical patent/IL98274A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
IL9827491A 1990-06-07 1991-05-27 Synthesis method for the preparation of omeprazole IL98274A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9002043A SE9002043D0 (sv) 1990-06-07 1990-06-07 Improved method for synthesis

Publications (2)

Publication Number Publication Date
IL98274A0 IL98274A0 (en) 1992-06-21
IL98274A true IL98274A (en) 1995-03-30

Family

ID=20379708

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9827491A IL98274A (en) 1990-06-07 1991-05-27 Synthesis method for the preparation of omeprazole

Country Status (42)

Country Link
US (1) US5386032A (fr)
EP (1) EP0533752B1 (fr)
JP (1) JP2993122B2 (fr)
KR (1) KR0178045B1 (fr)
CN (1) CN1040536C (fr)
AP (1) AP216A (fr)
AT (1) ATE162790T1 (fr)
AU (1) AU640246B2 (fr)
BG (1) BG61265B1 (fr)
CA (1) CA2083605C (fr)
CZ (1) CZ279928B6 (fr)
DE (1) DE69128832T2 (fr)
DK (1) DK0533752T3 (fr)
DZ (1) DZ1504A1 (fr)
EG (1) EG19392A (fr)
ES (1) ES2113378T3 (fr)
FI (1) FI102967B (fr)
GR (1) GR3026642T3 (fr)
HK (1) HK1003831A1 (fr)
HR (1) HRP920770B1 (fr)
HU (1) HU214323B (fr)
IE (1) IE911845A1 (fr)
IL (1) IL98274A (fr)
IS (1) IS1752B (fr)
LT (1) LT3584B (fr)
LV (1) LV10271B (fr)
MA (1) MA22171A1 (fr)
NO (1) NO300541B1 (fr)
NZ (1) NZ238224A (fr)
PL (1) PL165433B1 (fr)
PT (1) PT97873B (fr)
RO (1) RO111366B1 (fr)
RU (1) RU2061693C1 (fr)
SA (1) SA91120027B1 (fr)
SE (1) SE9002043D0 (fr)
SG (1) SG48053A1 (fr)
SK (1) SK278505B6 (fr)
TN (1) TNSN91042A1 (fr)
UA (1) UA32524C2 (fr)
WO (1) WO1991018895A1 (fr)
YU (1) YU47570B (fr)
ZA (1) ZA913779B (fr)

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SE521100C2 (sv) * 1995-12-15 2003-09-30 Astra Ab Förfarande för framställning av en bensimidazolförening
US6699885B2 (en) 1996-01-04 2004-03-02 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and methods of using same
US6489346B1 (en) 1996-01-04 2002-12-03 The Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US6645988B2 (en) * 1996-01-04 2003-11-11 Curators Of The University Of Missouri Substituted benzimidazole dosage forms and method of using same
US5840737A (en) 1996-01-04 1998-11-24 The Curators Of The University Of Missouri Omeprazole solution and method for using same
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CA2204580A1 (fr) * 1997-05-06 1998-11-06 Michel Zoghbi Synthese de derives de la pyridine utiles en pharmacie
US6437139B1 (en) 1997-05-06 2002-08-20 Pdi-Research Laboratories, Inc. Synthesis of pharmaceutically useful pyridine derivatives
KR100463031B1 (ko) * 1997-05-26 2005-04-06 동아제약주식회사 5-메톡시-2-[3,5-디메틸-4-메톡시피리딜메틸)설피닐]-1h-벤즈이미다졸의신규제조방법
SE9704183D0 (sv) 1997-11-14 1997-11-14 Astra Ab New process
US6096340A (en) * 1997-11-14 2000-08-01 Andrx Pharmaceuticals, Inc. Omeprazole formulation
US6174548B1 (en) 1998-08-28 2001-01-16 Andrx Pharmaceuticals, Inc. Omeprazole formulation
SI20019A (sl) * 1998-07-13 2000-02-29 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Izboljšan postopek sinteze 5-metoksi -2-/(4-metoksi-3,5-dimetil-2-piridil)metil/ sulfinil-1H-benzimidazola
US6166213A (en) * 1998-08-11 2000-12-26 Merck & Co., Inc. Omeprazole process and compositions thereof
US6191148B1 (en) 1998-08-11 2001-02-20 Merck & Co., Inc. Omerazole process and compositions thereof
US6733778B1 (en) 1999-08-27 2004-05-11 Andrx Pharmaceuticals, Inc. Omeprazole formulation
UA72748C2 (en) * 1998-11-10 2005-04-15 Astrazeneca Ab A novel crystalline form of omeprazole
IL142703A (en) 1998-11-10 2006-04-10 Astrazeneca Ab Crystalline form of omeprazole
US6362202B1 (en) 1999-03-02 2002-03-26 Sepracor Inc. Methods and compositions using (−) norcisapride in combination with proton pump inhibitors or H2 receptor antagonists
US6353005B1 (en) 1999-03-02 2002-03-05 Sepracor, Inc. Method and compositions using (+) norcisapride in combination with proton pump inhibitors or H2 receptor antagonist
US6268385B1 (en) 1999-08-26 2001-07-31 Robert R. Whittle Dry blend pharmaceutical formulations
US6326384B1 (en) 1999-08-26 2001-12-04 Robert R. Whittle Dry blend pharmaceutical unit dosage form
US6262085B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Alkoxy substituted Benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6369087B1 (en) * 1999-08-26 2002-04-09 Robert R. Whittle Alkoxy substituted benzimidazole compounds, pharmaceutical preparations containing the same, and methods of using the same
US6316020B1 (en) 1999-08-26 2001-11-13 Robert R. Whittle Pharmaceutical formulations
US6780880B1 (en) 1999-08-26 2004-08-24 Robert R. Whittle FT-Raman spectroscopic measurement
US6312712B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Method of improving bioavailability
US6312723B1 (en) 1999-08-26 2001-11-06 Robert R. Whittle Pharmaceutical unit dosage form
US6262086B1 (en) 1999-08-26 2001-07-17 Robert R. Whittle Pharmaceutical unit dosage form
DE19951960C2 (de) 1999-10-28 2002-06-27 Gruenenthal Gmbh Verfahren zur Herstellung als Ulkustherapeutika geeigneter Benzimidazol-Derivate
MXPA03006904A (es) 2001-02-02 2004-12-06 Teva Pharma Procesos para la produccion de 2-(2-piridilmetil) sulfinil - 1h - bencimidazoles sustituidos.
KR100783020B1 (ko) * 2001-03-23 2007-12-07 동아제약주식회사 2-메틸클로라이드 피리딘 유도체 및 이를 이용한 벤즈이미다졸 유도체의 제조 방법
EP1409478B1 (fr) 2001-07-16 2006-03-29 Janssen Pharmaceutica N.V. Procede ameliore de preparation de composes de type benzimidazole
MXPA04007169A (es) * 2002-01-25 2004-10-29 Santarus Inc Suministro transmucosal de inhibidores de bomba de protones.
SE0203092D0 (en) 2002-10-18 2002-10-18 Astrazeneca Ab Method for the synthesis of a benzimidazole compound
CA2517005A1 (fr) * 2003-02-20 2004-09-02 Santarus, Inc. Liberation immediate d'un complexe antacide d'omeprazole presentant une nouvelle formulation pour une elimination rapide et prolongee d'acide gastrique
US8993599B2 (en) * 2003-07-18 2015-03-31 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
JP2006528182A (ja) * 2003-07-18 2006-12-14 サンタラス インコーポレイティッド 薬学的製剤および酸に起因する消化器疾患の治療法
EP1648416A4 (fr) * 2003-07-18 2012-03-28 Santarus Inc Formulations pharmaceutiques utilisees pour inhiber une secretion acide et procede de fabrication associe
US20070292498A1 (en) * 2003-11-05 2007-12-20 Warren Hall Combinations of proton pump inhibitors, sleep aids, buffers and pain relievers
US8815916B2 (en) * 2004-05-25 2014-08-26 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
US8906940B2 (en) * 2004-05-25 2014-12-09 Santarus, Inc. Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them
EP1790647B1 (fr) 2004-09-13 2013-05-08 Takeda Pharmaceutical Company Limited Procede destines a produire un compose oxyde
PL1802584T3 (pl) * 2004-10-11 2010-03-31 Ranbaxy Laboratories Ltd Sposób wytwarzania podstawionych sulfotlenków
KR100641534B1 (ko) 2005-07-28 2006-11-01 한미약품 주식회사 에스오메프라졸 및 그의 염의 제조방법
KR101068180B1 (ko) 2005-12-01 2011-09-28 오스펙스 파마슈티칼스, 인코포레이티드 세로토닌성 및/또는 노르에피네프린성 활성을 갖는 치환된펜에틸아민
EP1801110A1 (fr) 2005-12-22 2007-06-27 KRKA, tovarna zdravil, d.d., Novo mesto Sel d'arginine d'ésoméprazole
WO2007129328A2 (fr) * 2006-05-09 2007-11-15 Cadila Healthcare Limited Méthode de préparation de benzimidazones substitués 2-[pyridinyl]sulfinyle
US20090092658A1 (en) * 2007-10-05 2009-04-09 Santarus, Inc. Novel formulations of proton pump inhibitors and methods of using these formulations
EP2114919A2 (fr) 2007-01-31 2009-11-11 Krka Tovarna Zdravil, D.D., Novo Mesto Procédé de préparation d'oméprazole optiquement pur
ES2693948T3 (es) 2007-03-15 2018-12-14 Auspex Pharmaceuticals, Inc. Fenetilamina sustituida con actividad serotoninérgica y/o norepinefrinérgica
US8513226B2 (en) * 2008-03-31 2013-08-20 Council Of Scientific And Industrial Research Simultaneous method for the preparation of a mixture of 3-acetoxy-17-acetamido-16-formyl-androst-5,17-diene and 3-acetoxy-2'-chloro-5-androsteno[17,16-b]pyridine
WO2010134099A1 (fr) 2009-05-21 2010-11-25 Cadila Healthcare Limited Procédé de préparation dans un récipient unique d'oméprazole
CN102786513A (zh) * 2011-05-18 2012-11-21 中国医学科学院药物研究所 奥美拉唑晶e型物质及制备方法与在药品和保健品中应用
CN104203938A (zh) 2012-01-21 2014-12-10 朱比兰特生命科学有限公司 用于制备2-吡啶基甲基亚硫酰基苯并咪唑、它们的类似物和光学活性对映体的方法
AU2020354581A1 (en) 2019-09-24 2022-03-03 Prolacta Bioscience, Inc. Compositions and methods for treatment of inflammatory and immune diseases

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IN148930B (fr) * 1977-09-19 1981-07-25 Hoffmann La Roche
SE7804231L (sv) * 1978-04-14 1979-10-15 Haessle Ab Magsyrasekretionsmedel
US4307102A (en) * 1981-02-19 1981-12-22 Sterling Drug Inc. Phenanthro[2,3-c]pyrazole
SE8300736D0 (sv) * 1983-02-11 1983-02-11 Haessle Ab Novel pharmacologically active compounds
ZW4585A1 (en) * 1984-04-19 1985-11-20 Hoffmann La Roche Imidazole derivatives
IL76839A (en) * 1984-10-31 1988-08-31 Byk Gulden Lomberg Chem Fab Picoline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
SE8500996D0 (sv) * 1985-03-01 1985-03-01 Haessle Ab Method of treatment
SE8600658D0 (sv) * 1986-02-14 1986-02-14 Haessle Ab Novel composition of matter
FI91754C (fi) * 1986-12-02 1994-08-10 Tanabe Seiyaku Co Analogiamenetelmä lääkeaineena käyttökelpoisen imidatsolijohdannaisen valmistamiseksi
DE3722810A1 (de) * 1987-07-10 1989-01-19 Hoechst Ag Substituierte benzimidazole, verfahren zu deren herstellung, diese enthaltende pharmazeutische zubereitungen und deren verwendung
SE9002206D0 (sv) * 1990-06-20 1990-06-20 Haessle Ab New compounds
NZ244301A (en) * 1991-09-20 1994-08-26 Merck & Co Inc Preparation of 2-pyridylmethylsulphinylbenzimidazole and pyridoimidazole derivatives from the corresponding sulphenyl compounds

Also Published As

Publication number Publication date
MA22171A1 (fr) 1991-12-31
FI925529A0 (fi) 1992-12-04
DK0533752T3 (da) 1998-06-02
NO924682D0 (no) 1992-12-04
CZ279928B6 (cs) 1995-08-16
LTIP1711A (en) 1995-07-25
PT97873A (pt) 1992-04-30
YU47570B (sh) 1995-10-03
YU99291A (sh) 1993-11-16
EP0533752B1 (fr) 1998-01-28
HRP920770A2 (en) 1995-12-31
SE9002043D0 (sv) 1990-06-07
IL98274A0 (en) 1992-06-21
PL165433B1 (pl) 1994-12-30
LV10271A (lv) 1994-10-20
WO1991018895A1 (fr) 1991-12-12
SA91120027B1 (ar) 2002-06-03
ES2113378T3 (es) 1998-05-01
HU9203855D0 (en) 1993-03-29
HRP920770B1 (en) 2000-06-30
HUT63408A (en) 1993-08-30
CS172691A3 (en) 1992-01-15
TNSN91042A1 (fr) 1992-10-25
CN1058211A (zh) 1992-01-29
GR3026642T3 (en) 1998-07-31
BG97146A (bg) 1993-12-24
NO924682L (no) 1992-12-04
UA32524C2 (uk) 2001-02-15
AU8080791A (en) 1991-12-31
HK1003831A1 (en) 1998-11-06
BG61265B1 (en) 1997-04-30
US5386032A (en) 1995-01-31
LV10271B (en) 1995-04-20
RU2061693C1 (ru) 1996-06-10
FI102967B1 (fi) 1999-03-31
IS3711A7 (is) 1991-12-08
AP216A (en) 1992-09-02
HU214323B (hu) 1998-03-02
IS1752B (is) 2000-07-21
JPH05507699A (ja) 1993-11-04
DE69128832D1 (de) 1998-03-05
KR0178045B1 (en) 1999-03-20
RO111366B1 (ro) 1996-09-30
DE69128832T2 (de) 1998-05-28
PT97873B (pt) 1998-10-30
CA2083605A1 (fr) 1991-12-08
SG48053A1 (en) 1998-04-17
FI925529A (fi) 1992-12-04
DZ1504A1 (fr) 2004-09-13
EG19392A (en) 1995-06-29
NO300541B1 (no) 1997-06-16
LT3584B (en) 1995-12-27
CN1040536C (zh) 1998-11-04
IE911845A1 (en) 1991-12-18
CA2083605C (fr) 1998-12-08
ATE162790T1 (de) 1998-02-15
EP0533752A1 (fr) 1993-03-31
ZA913779B (en) 1992-02-26
NZ238224A (en) 1993-11-25
AU640246B2 (en) 1993-08-19
JP2993122B2 (ja) 1999-12-20
SK278505B6 (en) 1997-08-06
AP9100274A0 (en) 1991-07-31
FI102967B (fi) 1999-03-31

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Legal Events

Date Code Title Description
KB Patent renewed
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KB Patent renewed
MM9K Patent not in force due to non-payment of renewal fees