ZA985017B - 4"-substituted-9-deoxo-9A-aza-9a-homoerythromycin a derivatives. - Google Patents

4"-substituted-9-deoxo-9A-aza-9a-homoerythromycin a derivatives.

Info

Publication number
ZA985017B
ZA985017B ZA9805017A ZA985017A ZA985017B ZA 985017 B ZA985017 B ZA 985017B ZA 9805017 A ZA9805017 A ZA 9805017A ZA 985017 A ZA985017 A ZA 985017A ZA 985017 B ZA985017 B ZA 985017B
Authority
ZA
South Africa
Prior art keywords
homoerythromycin
deoxo
aza
derivatives
substituted
Prior art date
Application number
ZA9805017A
Other languages
English (en)
Inventor
Brian Scott Bronk
Michael Anthony Letavic
Takushi Kaneko
Bingwei Vera Yang
Edward Alan Glazer
Hengmiao Cheng
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21959336&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA985017(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of ZA985017B publication Critical patent/ZA985017B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ZA9805017A 1997-06-11 1998-06-10 4"-substituted-9-deoxo-9A-aza-9a-homoerythromycin a derivatives. ZA985017B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4934897P 1997-06-11 1997-06-11

Publications (1)

Publication Number Publication Date
ZA985017B true ZA985017B (en) 1999-12-17

Family

ID=21959336

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9805017A ZA985017B (en) 1997-06-11 1998-06-10 4"-substituted-9-deoxo-9A-aza-9a-homoerythromycin a derivatives.

Country Status (49)

Country Link
US (4) US6420536B1 (2)
EP (1) EP0988310B9 (2)
JP (2) JP3315704B2 (2)
KR (1) KR100396168B1 (2)
CN (4) CN1793155B (2)
AP (1) AP1231A (2)
AR (1) AR013086A1 (2)
AT (1) ATE251173T1 (2)
AU (1) AU749816B2 (2)
BG (1) BG64391B1 (2)
BR (1) BRPI9810519B8 (2)
CA (1) CA2293823C (2)
CO (1) CO4950611A1 (2)
CZ (1) CZ298556B6 (2)
DE (2) DE69818665T2 (2)
DK (1) DK0988310T3 (2)
DZ (1) DZ2514A1 (2)
EA (1) EA002441B1 (2)
EG (1) EG24081A (2)
ES (1) ES2205487T3 (2)
FR (1) FR04C0013I2 (2)
GT (1) GT199800077A (2)
HN (1) HN1998000086A (2)
HR (1) HRP980314B1 (2)
HU (2) HU228005B1 (2)
ID (1) ID22992A (2)
IL (1) IL132809A0 (2)
IS (1) IS1998B (2)
LU (1) LU91076I9 (2)
MA (1) MA24564A1 (2)
ME (1) ME00876B (2)
MY (1) MY123354A (2)
NL (1) NL300150I2 (2)
NO (1) NO316911B1 (2)
NZ (2) NZ500660A (2)
OA (1) OA11224A (2)
PA (1) PA8452201A1 (2)
PE (1) PE79699A1 (2)
PL (1) PL191601B1 (2)
PT (1) PT988310E (2)
RS (1) RS49675B (2)
SI (1) SI0988310T1 (2)
SK (1) SK284171B9 (2)
TN (1) TNSN98082A1 (2)
TW (1) TW472060B (2)
UA (1) UA67744C2 (2)
UY (1) UY25040A1 (2)
WO (1) WO1998056802A1 (2)
ZA (1) ZA985017B (2)

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US6100240A (en) * 1998-10-09 2000-08-08 Pfizer Inc Macrolide derivatives
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US6764996B1 (en) 1999-08-24 2004-07-20 Abbott Laboratories 9a-azalides with antibacterial activity
US6608033B1 (en) 1999-08-27 2003-08-19 Pfizer Inc. Treatment or prevention of coccidiosis
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US20070141086A1 (en) * 2003-11-21 2007-06-21 Ohara Michael K Use of antibiotics as vaccine adjuvants
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US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7402568B2 (en) 2004-09-29 2008-07-22 Enanta Pharmaceuticals, Inc. Bicyclic 9a-azalide derivatives
US7767797B1 (en) * 2004-09-30 2010-08-03 Synovo Gmbh Macrocyclic compounds and methods of use thereof
US7271155B2 (en) 2005-01-07 2007-09-18 Enanta Pharmaceuticals, Inc. 9A, 11-2C-bicyclic 9a-azalide derivatives
EP1841437B1 (en) * 2005-01-14 2009-04-29 GlaxoSmithKline istrazivacki centar Zagreb d.o.o. 9a-carbamoyl and thiocarbamoyl azalides with antimalarial activity
CN105732745A (zh) 2007-10-25 2016-07-06 森普拉制药公司 大环内酯类抗菌剂的制备方法
AU2009308182B2 (en) * 2008-10-24 2016-05-19 Cempra Pharmaceuticals, Inc. Biodefenses using triazole-containing macrolides
US9937194B1 (en) * 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
US9480679B2 (en) 2009-09-10 2016-11-01 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and MAC diseases
DK2550286T3 (en) 2010-03-22 2016-02-29 Cempra Pharmaceuticals Inc CRYSTALLINE FORMS OF A MACROLID AND APPLICATIONS THEREOF
CN105198944B (zh) 2010-05-20 2018-06-01 森普拉制药公司 制备大环内酯和酮内酯及其中间体的方法
EP2613630A4 (en) 2010-09-10 2014-01-15 Cempra Pharmaceuticals Inc HYDROGEN BOND FOR THE PREPARATION OF FLUOROCHETOLIDES FOR THE TREATMENT OF DISEASES
CN103080121B (zh) * 2010-09-20 2015-11-25 瑞士诺华动物保健有限公司 用于制备在二脱氧甲基己糖环的C-4”处被环氧基团修饰的9-脱氧-9a-氮杂-9a-高红霉素A的新方法
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CN102260306B (zh) * 2011-07-22 2012-07-18 山东鲁抗舍里乐药业有限公司 一种制备泰拉霉素的方法
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MX2014011537A (es) 2012-03-27 2015-02-10 Cempra Pharmaceuticals Inc Formulaciones parenterales para la administracion de antibioticos macrolidos.
CN102786569B (zh) * 2012-09-07 2016-12-07 安徽中升药业有限公司 泰拉霉素中间体及其制备方法与泰拉霉素的制备方法
HK1217665A1 (zh) 2013-03-14 2017-01-20 森普拉制药公司 用於治療呼吸道疾病的方法及其製劑
RU2015138797A (ru) 2013-03-15 2017-04-24 Семпра Фармасьютикалс, Инк. Конвергентные способы получения макролидных антибактериальных агентов
WO2015014907A1 (en) * 2013-07-31 2015-02-05 Farma Grs, D.O.O. Process for preparation of tulathromycin
CN103497227B (zh) * 2013-09-13 2015-09-30 青岛科技大学 一种泰拉菌素中间体的制备方法
CN104725446B (zh) * 2015-03-26 2017-10-27 宁夏泰瑞制药股份有限公司 一种从泰拉霉素粗品中分离泰拉霉素a和泰拉霉素b的方法
CN104861018A (zh) * 2015-06-17 2015-08-26 瑞普（天津）生物药业有限公司 一种泰拉菌素的制备方法
CN105646617A (zh) * 2016-01-21 2016-06-08 杭州海尔希畜牧科技有限公司 一种制备泰拉霉素的方法
FR3048612B1 (fr) * 2016-03-14 2020-10-02 Septeos Tulathromycine potentialisee
CN106046077B (zh) * 2016-08-04 2019-07-26 湖北美天生物科技股份有限公司 一种泰拉霉素a的合成方法
CN108003207B (zh) * 2017-12-19 2019-05-10 海门慧聚药业有限公司 制备泰拉霉素的方法
CN111087433B (zh) * 2018-10-23 2023-03-21 湖北美天生物科技股份有限公司 一种泰拉霉素中间体的制备方法

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Also Published As

Publication number Publication date
CA2293823A1 (en) 1998-12-17
EG24081A (en) 2008-05-11
LU91076I9 (en) 2018-07-02
US20040023896A1 (en) 2004-02-05
CZ442199A3 (cs) 2000-07-12
CN1172947C (zh) 2004-10-27
AU7347598A (en) 1998-12-30
ME00876B (me) 2012-06-20
BRPI9810519B1 (pt) 2012-02-22
CN1243766C (zh) 2006-03-01
HU228005B1 (en) 2012-08-28
HN1998000086A (es) 1999-03-08
NO996106D0 (no) 1999-12-10
SI0988310T1 (en) 2004-02-29
MA24564A1 (fr) 1998-12-31
CN1566129A (zh) 2005-01-19
IS5252A (is) 1999-11-16
EP0988310B1 (en) 2003-10-01
OA11224A (en) 2003-07-16
AU749816B2 (en) 2002-07-04
JP3315704B2 (ja) 2002-08-19
PT988310E (pt) 2003-12-31
RS49675B (sr) 2007-11-15
UA67744C2 (uk) 2004-07-15
CZ298556B6 (cs) 2007-11-07
KR100396168B1 (ko) 2003-08-27
NO316911B1 (no) 2004-06-21
CN1793155A (zh) 2006-06-28
US20040180842A1 (en) 2004-09-16
US6777393B2 (en) 2004-08-17
BRPI9810519B8 (pt) 2022-11-16
BG103945A (bg) 2000-07-31
FR04C0013I2 (2) 2005-10-21
SK284171B9 (sk) 2005-03-04
JP2000514098A (ja) 2000-10-24
HK1028048A1 (en) 2001-02-02
AP9801255A0 (en) 1998-06-30
CN1793155B (zh) 2010-05-12
PA8452201A1 (es) 2000-05-24
TNSN98082A1 (fr) 2005-03-15
PE79699A1 (es) 1999-08-25
NZ500660A (en) 2002-03-01
ID22992A (id) 1999-12-23
HK1068893A1 (en) 2005-07-29
UY25040A1 (es) 2000-09-29
US6936592B2 (en) 2005-08-30
HUS1200028I1 (hu) 2016-08-29
DE122004000018I2 (de) 2011-01-13
GT199800077A (es) 1999-12-02
CO4950611A1 (es) 2000-09-01
IS1998B (is) 2005-03-15
MY123354A (en) 2006-05-31
NO996106L (no) 2000-02-10
NL300150I2 (nl) 2004-09-01
HUP0002209A3 (en) 2003-05-28
HUP0002209A2 (hu) 2000-12-28
YU58699A (2) 2002-08-12
CA2293823C (en) 2004-02-17
WO1998056802A1 (en) 1998-12-17
HK1088014A1 (zh) 2006-10-27
LU91076I2 (fr) 2004-07-05
HRP980314A2 (en) 1999-04-30
IL132809A0 (en) 2001-03-19
DE69818665T2 (de) 2004-04-29
DE69818665D1 (de) 2003-11-06
JP2002316933A (ja) 2002-10-31
EA002441B1 (ru) 2002-04-25
PL337505A1 (en) 2000-08-28
DK0988310T3 (da) 2003-12-15
ATE251173T1 (de) 2003-10-15
BG64391B1 (bg) 2004-12-30
EP0988310A1 (en) 2000-03-29
EA199901015A1 (ru) 2000-06-26
ES2205487T3 (es) 2004-05-01
HRP980314B1 (en) 2004-04-30
FR04C0013I1 (2) 2004-06-11
CN1259136A (zh) 2000-07-05
NL300150I1 (nl) 2004-08-02
DZ2514A1 (fr) 2003-02-01
SK284171B6 (sk) 2004-10-05
CN101691390A (zh) 2010-04-07
NZ514871A (en) 2003-08-29
DE122004000018I1 (de) 2004-09-30
SK168399A3 (en) 2000-11-07
BRPI9810519A (pt) 2000-09-19
US20020061858A1 (en) 2002-05-23
KR20010013632A (ko) 2001-02-26
TW472060B (en) 2002-01-11
AP1231A (en) 2003-12-11
US6420536B1 (en) 2002-07-16
AR013086A1 (es) 2000-12-13
EP0988310B9 (en) 2006-03-08
PL191601B1 (pl) 2006-06-30

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