ZA200501846B - PyrazoloÄ1,5-aÜpyrimidines compounds as cyclin dependent kinase inhibitors. - Google Patents
PyrazoloÄ1,5-aÜpyrimidines compounds as cyclin dependent kinase inhibitors. Download PDFInfo
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- ZA200501846B ZA200501846B ZA200501846A ZA200501846A ZA200501846B ZA 200501846 B ZA200501846 B ZA 200501846B ZA 200501846 A ZA200501846 A ZA 200501846A ZA 200501846 A ZA200501846 A ZA 200501846A ZA 200501846 B ZA200501846 B ZA 200501846B
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- South Africa
- Prior art keywords
- compound
- aryl
- group
- alkyl
- cycloalkyl
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- 150000001875 compounds Chemical class 0.000 title claims description 73
- 229940043378 cyclin-dependent kinase inhibitor Drugs 0.000 title description 6
- 239000002875 cyclin dependent kinase inhibitor Substances 0.000 title description 2
- 125000000217 alkyl group Chemical group 0.000 claims description 51
- 125000003118 aryl group Chemical group 0.000 claims description 48
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 39
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- 229910052736 halogen Inorganic materials 0.000 claims description 24
- 150000002367 halogens Chemical class 0.000 claims description 24
- 239000000203 mixture Substances 0.000 claims description 24
- 125000001072 heteroaryl group Chemical group 0.000 claims description 23
- 238000000034 method Methods 0.000 claims description 20
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- 125000003710 aryl alkyl group Chemical group 0.000 claims description 18
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims description 17
- 238000011282 treatment Methods 0.000 claims description 17
- -1 -C(O2)R® Chemical group 0.000 claims description 16
- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims description 15
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Landscapes
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Applications Claiming Priority (1)
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| WO1999001124A1 (en) | 1996-12-03 | 1999-01-14 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
| EP1388541A1 (en) * | 2002-08-09 | 2004-02-11 | Centre National De La Recherche Scientifique (Cnrs) | Pyrrolopyrazines as kinase inhibitors |
| US6921769B2 (en) | 2002-08-23 | 2005-07-26 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
| ATE350383T1 (de) | 2002-08-23 | 2007-01-15 | Sloan Kettering Inst Cancer | Synthese von epothilonen, zwischenprodukte dafür, analoga und deren verwendungen |
| US7601724B2 (en) * | 2002-09-04 | 2009-10-13 | Schering Corporation | Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors |
| US7205308B2 (en) * | 2002-09-04 | 2007-04-17 | Schering Corporation | Trisubstituted 7-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors |
| MY145332A (en) * | 2002-09-04 | 2012-01-31 | Schering Corp | Trisubstituted 4-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors |
| BRPI0407834A (pt) * | 2003-02-28 | 2006-02-14 | Teijin Pharma Ltd | composto, processo para a manufatura do mesmo, composição, processo para a manufatura da mesma, método de tratamento ou prevenção de um distúrbio mediado por proteìna quinase em um indivìduo, uso de um composto, ensaio para determinar a atividade dos compostos, e, método de inibição da atividade ou função de uma proteìna quinase |
| WO2004087707A1 (en) * | 2003-03-31 | 2004-10-14 | Vernalis (Cambridge) Limited | Pyrazolopyrimidine compounds and their use in medicine |
| WO2005035516A1 (ja) * | 2003-10-10 | 2005-04-21 | Ono Pharmaceutical Co., Ltd. | 新規縮合複素環化合物およびその用途 |
| US20080287405A1 (en) * | 2004-05-14 | 2008-11-20 | Thannickal Victor J | Compositions and Methods Relating to Protein Kinase Inhibitors |
| EP1797096B1 (en) | 2004-09-06 | 2011-07-27 | Bayer Schering Pharma Aktiengesellschaft | Pyrazolopyrimidines as inhibitors of protein kinase b (akt) |
| FR2876582B1 (fr) * | 2004-10-15 | 2007-01-05 | Centre Nat Rech Scient Cnrse | Utilisation de derives de pyrrolo-pyrazines pour la fabrication de medicaments pour le traitement de la mucoviscidose et de maladies liees a un defaut d'adressage des proteines dans les cellules |
| MX2007007604A (es) * | 2004-12-21 | 2007-08-02 | Schering Corp | Antagonistas del receptor de pirazolo[1,5-a]pirimidina adenosina a2a. |
| US7678363B2 (en) | 2005-08-26 | 2010-03-16 | Braincells Inc | Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs |
| EP2258358A3 (en) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenesis with acetylcholinesterase inhibitor |
| ES2349476T3 (es) | 2005-09-09 | 2011-01-03 | Schering Corporation | Nuevos derivados de 4-ciano, 4-amino y 4-aminometilo de compuestos de pirazolo[1,5-a]piridinas, pirazolo[1,5-c]pirimidinas y 2h-indazol y derivados de 5-ciano, 5-amino y 5-aminometilo de compuestos de imidazo[1,2-a]piridinas e imidazo[1,5-a]pirazinas, como inhibidores de cinasa dependiente de ciclina. |
| EP2377530A3 (en) | 2005-10-21 | 2012-06-20 | Braincells, Inc. | Modulation of neurogenesis by PDE inhibition |
| EP1942879A1 (en) | 2005-10-31 | 2008-07-16 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| WO2007118844A1 (de) * | 2006-04-13 | 2007-10-25 | Basf Se | Substituierte pyrazolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel |
| WO2007134136A2 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| AU2007268083A1 (en) * | 2006-05-22 | 2007-12-06 | Schering Corporation | Pyrazolo [1, 5-A] pyrimidines as CDK inhibitors |
| US8008307B2 (en) | 2006-08-08 | 2011-08-30 | Millennium Pharmaceuticals, Inc. | Heteroaryl compounds useful as inhibitors of E1 activating enzymes |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| US8299241B2 (en) * | 2006-12-05 | 2012-10-30 | Arena Pharmaceuticals, Inc. | Processes for preparing (R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine and intermediates thereof |
| AU2009233963B2 (en) * | 2008-04-07 | 2011-10-06 | Irm Llc | Compounds and compositions as kinase inhibitors |
| US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| US8993535B2 (en) | 2009-09-04 | 2015-03-31 | Merck Sharp & Dohme Corp. | Modulators of cell cycle checkpoints and their use in combination with checkpoint kinase inhibitors |
| SG181507A1 (en) * | 2009-12-04 | 2012-07-30 | Cylene Pharmaceuticals Inc | Pyrazolopyrimidines and related heterocycles as ck2 inhibitors |
| AU2010343102B2 (en) | 2009-12-29 | 2016-03-24 | Dana-Farber Cancer Institute, Inc. | Type II Raf kinase inhibitors |
| US10953012B2 (en) | 2011-04-26 | 2021-03-23 | Bioenergenix Llc | Heterocyclic compounds for the inhibition of pask |
| US9309250B2 (en) | 2011-06-22 | 2016-04-12 | Vertex Pharmaceuticals Incorporated | Substituted pyrrolo[2,3-b]pyrazines as ATR kinase inhibitors |
| JP6106685B2 (ja) | 2011-11-17 | 2017-04-05 | ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド | Ｃ−ｊｕｎ−ｎ−末端キナーゼ（ｊｎｋ）の阻害剤 |
| UA116534C2 (uk) | 2012-02-17 | 2018-04-10 | Мілленніум Фармасьютікалз, Інк. | Піразолопіримідинілові інгібітори убіквітинактивуючого ферменту |
| CN102633803A (zh) * | 2012-05-03 | 2012-08-15 | 盛世泰科生物医药技术(苏州)有限公司 | 一种5,7-二氯吡唑并[1,5-a]嘧啶的合成方法 |
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| US9278973B2 (en) | 2012-10-25 | 2016-03-08 | Bioenergenix Llc | Heterocyclic compounds for the inhibition of PASK |
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2003
- 2003-09-03 MY MYPI20071385A patent/MY145332A/en unknown
- 2003-09-03 AT AT03796321T patent/ATE362474T1/de not_active IP Right Cessation
- 2003-09-03 US US10/653,776 patent/US7067661B2/en not_active Expired - Lifetime
- 2003-09-03 EP EP03796321A patent/EP1534712B1/en not_active Expired - Lifetime
- 2003-09-03 CN CN038247011A patent/CN1701073B/zh not_active Expired - Fee Related
- 2003-09-03 ES ES03796321T patent/ES2283868T3/es not_active Expired - Lifetime
- 2003-09-03 MX MXPA05002572A patent/MXPA05002572A/es active IP Right Grant
- 2003-09-03 JP JP2004537708A patent/JP4790265B2/ja not_active Expired - Fee Related
- 2003-09-03 WO PCT/US2003/027491 patent/WO2004026229A2/en not_active Ceased
- 2003-09-03 MY MYPI20033315A patent/MY137843A/en unknown
- 2003-09-03 NZ NZ539161A patent/NZ539161A/en not_active IP Right Cessation
- 2003-09-03 CA CA2497544A patent/CA2497544C/en not_active Expired - Fee Related
- 2003-09-03 AR ARP030103188A patent/AR041133A1/es unknown
- 2003-09-03 TW TW092124336A patent/TWI329645B/zh active
- 2003-09-03 KR KR1020057003527A patent/KR20050033659A/ko not_active Ceased
- 2003-09-03 AU AU2003298571A patent/AU2003298571B2/en not_active Ceased
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- 2003-09-04 PE PE2003000900A patent/PE20041000A1/es not_active Application Discontinuation
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2005
- 2005-03-03 ZA ZA200501846A patent/ZA200501846B/en unknown
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| MY137843A (en) | 2009-03-31 |
| NZ539161A (en) | 2006-05-26 |
| JP2006502184A (ja) | 2006-01-19 |
| DE60313872D1 (de) | 2007-06-28 |
| ATE362474T1 (de) | 2007-06-15 |
| JP2010180235A (ja) | 2010-08-19 |
| CN1701073A (zh) | 2005-11-23 |
| TW200413376A (en) | 2004-08-01 |
| WO2004026229A2 (en) | 2004-04-01 |
| CA2497544C (en) | 2010-11-02 |
| PE20041000A1 (es) | 2004-12-29 |
| US20060178371A1 (en) | 2006-08-10 |
| KR20050033659A (ko) | 2005-04-12 |
| TWI329645B (en) | 2010-09-01 |
| CN1701073B (zh) | 2011-06-22 |
| DE60313872T2 (de) | 2008-01-17 |
| MY145332A (en) | 2012-01-31 |
| EP1534712A2 (en) | 2005-06-01 |
| US20040106624A1 (en) | 2004-06-03 |
| JP4790265B2 (ja) | 2011-10-12 |
| EP1534712B1 (en) | 2007-05-16 |
| WO2004026229A3 (en) | 2004-06-17 |
| US7514442B2 (en) | 2009-04-07 |
| AR041133A1 (es) | 2005-05-04 |
| US7067661B2 (en) | 2006-06-27 |
| HK1071572A1 (en) | 2005-07-22 |
| CA2497544A1 (en) | 2004-04-01 |
| MXPA05002572A (es) | 2005-09-08 |
| AU2003298571A1 (en) | 2004-04-08 |
| AU2003298571B2 (en) | 2006-10-19 |
| ES2283868T3 (es) | 2007-11-01 |
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