JP4790265B2 - サイクリン依存性キナーゼインヒビターとしての新規ピラゾロピリミジン - Google Patents

サイクリン依存性キナーゼインヒビターとしての新規ピラゾロピリミジン Download PDF

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JP4790265B2
JP4790265B2 JP2004537708A JP2004537708A JP4790265B2 JP 4790265 B2 JP4790265 B2 JP 4790265B2 JP 2004537708 A JP2004537708 A JP 2004537708A JP 2004537708 A JP2004537708 A JP 2004537708A JP 4790265 B2 JP4790265 B2 JP 4790265B2
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cancer
alkyl
group
compound
aryl
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JP2006502184A (ja
JP2006502184A5 (enExample
Inventor
ティモシー ジェイ． グジ，
カミル パルク，
マイケル ピー． ドワイヤー，
ロナルド ジェイ． ドール，
ビッヨール ムーピル ギリジャヴァラバーン，
カルメン エス． アルバレツ，
ティン−ヤウ チャン，
チャド ナットソン，
ヴィンセント マディソン，
シェリー オー． フィッシュマン，
ローレンス ダブリュー． ディラード，
ヴィン ディー． トラン，
ゼン ミン ヘー，
レイ アンソニー ジェームス，
ヘンスーン パーク，
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Merck Sharp and Dohme LLC
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Schering Corp
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Diabetes (AREA)
  • Psychology (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Psychiatry (AREA)
JP2004537708A 2002-09-04 2003-09-03 サイクリン依存性キナーゼインヒビターとしての新規ピラゾロピリミジン Expired - Fee Related JP4790265B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40802902P 2002-09-04 2002-09-04
US60/408,029 2002-09-04
PCT/US2003/027491 WO2004026229A2 (en) 2002-09-04 2003-09-03 Pyrazolo[1,5-a]pyrimidines compounds as cyclin dependent kinase inhibitors

Related Child Applications (1)

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JP2010088212A Division JP2010180235A (ja) 2002-09-04 2010-04-06 サイクリン依存性キナーゼインヒビターとしての新規ピラゾロピリミジン

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JP2006502184A JP2006502184A (ja) 2006-01-19
JP2006502184A5 JP2006502184A5 (enExample) 2006-09-21
JP4790265B2 true JP4790265B2 (ja) 2011-10-12

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JP2010088212A Withdrawn JP2010180235A (ja) 2002-09-04 2010-04-06 サイクリン依存性キナーゼインヒビターとしての新規ピラゾロピリミジン

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Country Status (18)

Country Link
US (2) US7067661B2 (enExample)
EP (1) EP1534712B1 (enExample)
JP (2) JP4790265B2 (enExample)
KR (1) KR20050033659A (enExample)
CN (1) CN1701073B (enExample)
AR (1) AR041133A1 (enExample)
AT (1) ATE362474T1 (enExample)
AU (1) AU2003298571B2 (enExample)
CA (1) CA2497544C (enExample)
DE (1) DE60313872T2 (enExample)
ES (1) ES2283868T3 (enExample)
MX (1) MXPA05002572A (enExample)
MY (2) MY145332A (enExample)
NZ (1) NZ539161A (enExample)
PE (1) PE20041000A1 (enExample)
TW (1) TWI329645B (enExample)
WO (1) WO2004026229A2 (enExample)
ZA (1) ZA200501846B (enExample)

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