ZA200209364B - Inhibitors of 11-Beta-hydroxy steroid dehydrogenase type 1. - Google Patents

Inhibitors of 11-Beta-hydroxy steroid dehydrogenase type 1. Download PDF

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Publication number
ZA200209364B
ZA200209364B ZA200209364A ZA200209364A ZA200209364B ZA 200209364 B ZA200209364 B ZA 200209364B ZA 200209364 A ZA200209364 A ZA 200209364A ZA 200209364 A ZA200209364 A ZA 200209364A ZA 200209364 B ZA200209364 B ZA 200209364B
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ZA
South Africa
Prior art keywords
thiazol
chloro
phenyl
dichloro
benzenesulfonamide
Prior art date
Application number
ZA200209364A
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English (en)
Inventor
Guido Kurz
Marianne Nilsson
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Biovitrum Ab
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Publication of ZA200209364B publication Critical patent/ZA200209364B/en

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    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/50—Nitrogen atoms bound to hetero atoms
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    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Cardiology (AREA)
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ZA200209364A 2000-05-22 2002-11-18 Inhibitors of 11-Beta-hydroxy steroid dehydrogenase type 1. ZA200209364B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0001899A SE0001899D0 (sv) 2000-05-22 2000-05-22 New compounds

Publications (1)

Publication Number Publication Date
ZA200209364B true ZA200209364B (en) 2004-02-18

Family

ID=20279781

Family Applications (4)

Application Number Title Priority Date Filing Date
ZA200209362A ZA200209362B (en) 2000-05-22 2002-11-18 Inhibitors of 11-Beta-hydroxy steroid dehydrogenase type 1.
ZA200209360A ZA200209360B (en) 2000-05-22 2002-11-18 Inhibitors of 11-Beta-hydroxy steroid dehydrogenase type 1.
ZA200209359A ZA200209359B (en) 2000-05-22 2002-11-18 Inhibitors of 11-Beta-hydroxy steroid dehydrogenase type 1.
ZA200209364A ZA200209364B (en) 2000-05-22 2002-11-18 Inhibitors of 11-Beta-hydroxy steroid dehydrogenase type 1.

Family Applications Before (3)

Application Number Title Priority Date Filing Date
ZA200209362A ZA200209362B (en) 2000-05-22 2002-11-18 Inhibitors of 11-Beta-hydroxy steroid dehydrogenase type 1.
ZA200209360A ZA200209360B (en) 2000-05-22 2002-11-18 Inhibitors of 11-Beta-hydroxy steroid dehydrogenase type 1.
ZA200209359A ZA200209359B (en) 2000-05-22 2002-11-18 Inhibitors of 11-Beta-hydroxy steroid dehydrogenase type 1.

Country Status (24)

Country Link
US (7) US7618961B2 (ru)
EP (4) EP1283831A1 (ru)
JP (4) JP2003534337A (ru)
KR (4) KR20030016272A (ru)
CN (4) CN1437588A (ru)
AR (1) AR033534A1 (ru)
AT (2) ATE485283T1 (ru)
AU (6) AU6093101A (ru)
BR (1) BR0111099A (ru)
CA (4) CA2408144C (ru)
DE (3) DE60139931D1 (ru)
EA (1) EA005274B1 (ru)
ES (1) ES2333846T3 (ru)
HK (1) HK1056878A1 (ru)
HU (1) HUP0302435A3 (ru)
IL (4) IL152753A0 (ru)
MX (1) MXPA02011632A (ru)
NO (4) NO20025588L (ru)
NZ (4) NZ522538A (ru)
PE (1) PE20020100A1 (ru)
PL (1) PL360137A1 (ru)
SE (1) SE0001899D0 (ru)
WO (5) WO2001090090A1 (ru)
ZA (4) ZA200209362B (ru)

Families Citing this family (185)

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SE0001899D0 (sv) 2000-05-22 2000-05-22 Pharmacia & Upjohn Ab New compounds
JP2004502432A (ja) * 2000-07-05 2004-01-29 バイエル　アクチェンゲゼルシャフト ヒト１１β−ヒドロキシステロイドデヒドロゲナーゼ１様酵素の調節
GB0107383D0 (en) * 2001-03-23 2001-05-16 Univ Edinburgh Lipid profile modulation
AU2007205749B2 (en) * 2001-11-22 2009-04-23 Biovitrum Ab Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
US7094792B2 (en) * 2001-11-22 2006-08-22 Biovitrum Ab Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
EA200400708A1 (ru) * 2001-11-22 2004-10-28 Биовитрум Аб Ингибиторы 11-бета-гидроксистероиддегидрогеназы типа 1
US20030130279A1 (en) * 2001-11-22 2003-07-10 Guido Kurz Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
BR0214342A (pt) * 2001-11-22 2004-09-14 Biovitrum Ab Inibidores de 11 - beta - hidroxi esteróide desidrogenase tipo 1
PL370111A1 (en) 2001-11-22 2005-05-16 Biovitrum Ab Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1
US7485655B2 (en) 2002-01-16 2009-02-03 University Of Virginia Patent Foundation 2-Aminothiazole allosteric enhancers of A1 adenosine receptors
EP1474139B1 (en) * 2002-02-01 2007-11-21 Merck & Co., Inc. 11-beta-hydroxysteroid dehydrogenase 1 inhibitors useful for the treatment of diabetes, obesity and dyslipidemia
US7338969B2 (en) * 2002-03-08 2008-03-04 Quonova, Llc Modulation of pathogenicity
CN100343240C (zh) * 2002-03-29 2007-10-17 先灵公司 手性2－甲基－4－保护的哌嗪的立体选择性烷基化
SE0201194D0 (sv) * 2002-04-19 2002-04-19 Astrazeneca Ab New compounds
US20030198965A1 (en) 2002-04-19 2003-10-23 Isis Pharmaceuticals Inc. Antisense modulation of hydroxysteroid 11-beta dehydrogenase 1 expression
AR040241A1 (es) * 2002-06-10 2005-03-23 Merck & Co Inc Inhibidores de la 11-beta-hidroxiesteroide deshidrogrenasa 1 para el tratamiento de la diabetes obesidad y dislipidemia
US7105526B2 (en) 2002-06-28 2006-09-12 Banyu Pharmaceuticals Co., Ltd. Benzimidazole derivatives
AU2003275195A1 (en) * 2002-09-18 2004-04-08 Hartmut M. Hanauske-Abel INHIBITORS OF 11Beta-HYDROXYSTEROID DEHYDROGENASE AND USES THEREFOR
JP2006506451A (ja) * 2002-10-11 2006-02-23 アストラゼネカ アクチボラグ １，４−ジ置換ピペリジン誘導体および１１−βＨＳＤ１阻害薬としてのそれらの使用
CA2501228A1 (en) * 2002-10-24 2004-05-06 Sterix Limited Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 and type 2
GB0224830D0 (en) 2002-10-24 2002-12-04 Sterix Ltd Compound
US20060058315A1 (en) * 2002-11-07 2006-03-16 Astrazeneca Ab 2-Oxo-ethanesulfonamide derivates
PE20040693A1 (es) * 2002-11-14 2004-11-23 Novartis Ag N-sulfonilaminotiazol como mediadores de la sulfatasa de esteroides
GB0226602D0 (en) * 2002-11-14 2002-12-24 Novartis Ag Organic compounds
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