ZA200108331B - Benzimidazole compound crystal. - Google Patents
Benzimidazole compound crystal. Download PDFInfo
- Publication number
- ZA200108331B ZA200108331B ZA200108331A ZA200108331A ZA200108331B ZA 200108331 B ZA200108331 B ZA 200108331B ZA 200108331 A ZA200108331 A ZA 200108331A ZA 200108331 A ZA200108331 A ZA 200108331A ZA 200108331 B ZA200108331 B ZA 200108331B
- Authority
- ZA
- South Africa
- Prior art keywords
- crystal
- benzimidazole
- methyl
- cellulose
- trifluoroethoxy
- Prior art date
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- 239000013078 crystal Substances 0.000 title claims description 51
- -1 Benzimidazole compound Chemical class 0.000 title description 26
- 150000003839 salts Chemical class 0.000 claims description 32
- 239000008194 pharmaceutical composition Substances 0.000 claims description 10
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- 231100000397 ulcer Toxicity 0.000 claims description 9
- 230000001079 digestive effect Effects 0.000 claims description 7
- 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims description 6
- 238000004458 analytical method Methods 0.000 claims description 3
- 238000000634 powder X-ray diffraction Methods 0.000 claims description 3
- HYZJCKYKOHLVJF-UHFFFAOYSA-N 1H-benzimidazole Chemical compound C1=CC=C2NC=NC2=C1 HYZJCKYKOHLVJF-UHFFFAOYSA-N 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 238000000034 method Methods 0.000 description 44
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- 230000003287 optical effect Effects 0.000 description 18
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17150999 | 1999-06-17 |
Publications (1)
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| ZA200108331B true ZA200108331B (en) | 2002-10-10 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200108331A ZA200108331B (en) | 1999-06-17 | 2001-10-10 | Benzimidazole compound crystal. |
Country Status (26)
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| EP (3) | EP2343289A1 (forum.php) |
| KR (3) | KR100407847B1 (forum.php) |
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| AR (5) | AR031069A1 (forum.php) |
| AT (1) | ATE391126T1 (forum.php) |
| AU (1) | AU778820B2 (forum.php) |
| BE (1) | BE2014C017I2 (forum.php) |
| BR (1) | BRPI0011674B8 (forum.php) |
| CA (1) | CA2375201C (forum.php) |
| CY (2) | CY1110384T1 (forum.php) |
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| HU (1) | HU229067B1 (forum.php) |
| IL (2) | IL145996A0 (forum.php) |
| MX (1) | MXPA01012642A (forum.php) |
| MY (1) | MY125399A (forum.php) |
| NO (1) | NO321168B1 (forum.php) |
| NZ (1) | NZ515702A (forum.php) |
| PL (1) | PL201068B1 (forum.php) |
| PT (2) | PT1977751E (forum.php) |
| SI (1) | SI1129088T1 (forum.php) |
| TW (2) | TWI289557B (forum.php) |
| WO (2) | WO2000078745A2 (forum.php) |
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Families Citing this family (95)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5840737A (en) | 1996-01-04 | 1998-11-24 | The Curators Of The University Of Missouri | Omeprazole solution and method for using same |
| US6489346B1 (en) * | 1996-01-04 | 2002-12-03 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
| US20040224989A1 (en) * | 1999-01-29 | 2004-11-11 | Barberich Timothy J. | S-lansoprazole compositions and methods |
| TWI289557B (en) * | 1999-06-17 | 2007-11-11 | Takeda Chemical Industries Ltd | A crystal of a hydrate of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole |
| WO2001002389A1 (fr) * | 1999-06-30 | 2001-01-11 | Takeda Chemical Industries, Ltd. | Cristaux de composes benzimidazole |
| AU2001252595A1 (en) | 2000-04-28 | 2001-11-12 | Takeda Chemical Industries Ltd. | Process for producing optically active sulfoxide derivative |
| CA2701704C (en) * | 2000-05-15 | 2011-09-06 | Takeda Pharmaceutical Company Limited | Process for producing crystal |
| CA2775616C (en) | 2000-08-04 | 2013-09-17 | Takeda Pharmaceutical Company Limited | Salts of benzimidazole compound and application thereof |
| CA2436825C (en) * | 2000-12-01 | 2011-01-18 | Takeda Chemical Industries, Ltd. | Process for the crystallization of (r)- or (s)-lansoprazole |
| DK1459737T3 (da) | 2001-10-17 | 2013-01-02 | Takeda Pharmaceutical | Granulat indeholdende syreustabilt kemisk middel i stor mængde |
| KR100467100B1 (ko) * | 2002-03-20 | 2005-01-24 | 일양약품주식회사 | 2-[(4-메톡시-3-메틸)-2-피리디닐]메틸설피닐-5-(1Ｈ-피롤-1-릴)-1Ｈ-벤즈이미다졸 또는 이의 Ｎа염을 함유하는주사제의 제조방법 |
| PL373539A1 (en) * | 2002-03-27 | 2005-09-05 | Teva Pharmaceutical Industries Ltd. | Lansoprazole polymorphs and processes for preparation thereof |
| MY148805A (en) | 2002-10-16 | 2013-05-31 | Takeda Pharmaceutical | Controlled release preparation |
| EP2596792A1 (en) * | 2002-10-16 | 2013-05-29 | Takeda Pharmaceutical Company Limited | Stable solid preparations |
| US20050220870A1 (en) * | 2003-02-20 | 2005-10-06 | Bonnie Hepburn | Novel formulation, omeprazole antacid complex-immediate release for rapid and sustained suppression of gastric acid |
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