YU49445B - Enteričke granule duloksetina - Google Patents
Enteričke granule duloksetinaInfo
- Publication number
- YU49445B YU49445B YU48095A YU48095A YU49445B YU 49445 B YU49445 B YU 49445B YU 48095 A YU48095 A YU 48095A YU 48095 A YU48095 A YU 48095A YU 49445 B YU49445 B YU 49445B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- duloxetine
- enteric pellets
- duloxetine enteric
- pharmaceutically acceptable
- acceptable excipient
- Prior art date
Links
- ZEUITGRIYCTCEM-KRWDZBQOSA-N (S)-duloxetine Chemical compound C1([C@@H](OC=2C3=CC=CC=C3C=CC=2)CCNC)=CC=CS1 ZEUITGRIYCTCEM-KRWDZBQOSA-N 0.000 title abstract 3
- 229960002866 duloxetine Drugs 0.000 title abstract 3
- 239000008188 pellet Substances 0.000 title 1
- 229920000639 hydroxypropylmethylcellulose acetate succinate Polymers 0.000 abstract 2
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 2
- ZUAAPNNKRHMPKG-UHFFFAOYSA-N acetic acid;butanedioic acid;methanol;propane-1,2-diol Chemical compound OC.CC(O)=O.CC(O)CO.OC(=O)CCC(O)=O ZUAAPNNKRHMPKG-UHFFFAOYSA-N 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 239000012055 enteric layer Substances 0.000 abstract 1
- 239000008187 granular material Substances 0.000 abstract 1
- 239000010410 layer Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Enterička granula duloksetina, naznačena time, što obuhvata: a) jezgro koje se sastoji od duloksetina i farmaceutski prihvatljivog ekscipijenta; b) opciono razdvajajući sloj; c) enterički sloj koji obuhvata acetat sukcinat hidroksipropilmetilceluloze (HPMCAS) i farmaceutski prihvatljiv ekscipijent; d) opciono završni sloj. Prijava sadrži još 9 zavisnih patentnih zahteva.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/276,232 US5508276A (en) | 1994-07-18 | 1994-07-18 | Duloxetine enteric pellets |
Publications (2)
Publication Number | Publication Date |
---|---|
YU48095A YU48095A (sh) | 1998-07-10 |
YU49445B true YU49445B (sh) | 2006-03-03 |
Family
ID=23055767
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU48095A YU49445B (sh) | 1994-07-18 | 1995-07-17 | Enteričke granule duloksetina |
Country Status (30)
Country | Link |
---|---|
US (1) | US5508276A (sh) |
EP (1) | EP0693282B1 (sh) |
JP (1) | JP3707831B2 (sh) |
KR (1) | KR100356240B1 (sh) |
CN (1) | CN1106191C (sh) |
AT (1) | ATE200620T1 (sh) |
AU (1) | AU686384B2 (sh) |
BR (1) | BR9503346A (sh) |
CA (1) | CA2153856C (sh) |
CO (1) | CO4410177A1 (sh) |
CZ (1) | CZ288095B6 (sh) |
DE (1) | DE69520711T2 (sh) |
DK (1) | DK0693282T3 (sh) |
ES (1) | ES2157297T3 (sh) |
GE (1) | GEP20063944B (sh) |
GR (1) | GR3036185T3 (sh) |
HU (1) | HU221502B (sh) |
IL (1) | IL114584A (sh) |
MY (1) | MY116361A (sh) |
NO (2) | NO312397B1 (sh) |
NZ (1) | NZ272554A (sh) |
PE (1) | PE32196A1 (sh) |
PL (1) | PL181296B1 (sh) |
PT (1) | PT693282E (sh) |
RU (1) | RU2147231C1 (sh) |
SI (1) | SI0693282T1 (sh) |
TW (1) | TW382596B (sh) |
UA (1) | UA41344C2 (sh) |
YU (1) | YU49445B (sh) |
ZA (1) | ZA955799B (sh) |
Families Citing this family (98)
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EA000856B1 (ru) * | 1995-07-24 | 2000-06-26 | Эли Лилли Энд Компани | Способ лечения синдрома дефицита внимания/гиперактивности |
US5910319A (en) * | 1997-05-29 | 1999-06-08 | Eli Lilly And Company | Fluoxetine enteric pellets and methods for their preparation and use |
ES2335067T3 (es) | 1998-09-15 | 2010-03-18 | Eli Lilly And Company | Uso de duloxetina en el tratamiento de la fibromialgia. |
EP1027885B1 (en) * | 1999-02-09 | 2008-07-09 | Pfizer Products Inc. | Basic drug compositions with enhanced bioavailability |
IL130602A0 (en) * | 1999-06-22 | 2000-06-01 | Dexcel Ltd | Stable benzimidazole formulation |
BR0108980A (pt) * | 2000-03-07 | 2003-06-03 | Lilly Co Eli | Aplicação e formulação farmacêuticas compreendendo inibidor de reabsorção de norepinefrina |
CA2442410A1 (en) * | 2001-03-29 | 2002-10-10 | Owen Brendan Wallace | Duloxetine for treatment of hot flashes |
DE60233874D1 (de) * | 2001-06-22 | 2009-11-12 | Pfizer Prod Inc | Pharmazeutische zusammensetzungen enthaltend dispersionen aus arzneistoffen und neutralen polymeren |
SK15732003A3 (sk) * | 2001-06-22 | 2005-01-03 | Pfizer Products Inc. | Farmaceutické kompozície zahrnujúce liečivá s nízkou rozpustnosťou a/alebo liečivá citlivé na kyselinu a neutralizované kyslé polyméry |
JP2006508978A (ja) * | 2002-11-19 | 2006-03-16 | イーライ・リリー・アンド・カンパニー | デュロキセチンを用いる胃腸障害の処置 |
AU2004259006B2 (en) * | 2003-07-24 | 2010-10-07 | Glaxosmithkline Llc | Orally dissolving films |
WO2005097070A1 (ja) * | 2004-04-08 | 2005-10-20 | Kyowa Hakko Kogyo Co., Ltd. | 安定性の向上した固形製剤およびその製造方法 |
GB0410470D0 (en) * | 2004-05-11 | 2004-06-16 | Cipla Ltd | Pharmaceutical compound and polymorphs thereof |
JP2007523213A (ja) * | 2004-12-23 | 2007-08-16 | テバ ファーマシューティカル インダストリーズ リミティド | 医薬的に許容できるデュロキセチンの塩及びその中間体の調製方法 |
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WO2006099433A1 (en) * | 2005-03-14 | 2006-09-21 | Teva Pharmaceutical Industries Ltd. | Pure duloxetine hydrochloride |
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US20080207923A1 (en) * | 2005-09-22 | 2008-08-28 | Santiago Ini | Pure DNT-maleate and methods of preparation thereof |
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CA2629800A1 (en) * | 2005-11-23 | 2007-05-31 | Thomas G. Gant | Substituted aryloxypropylamines with serotoninergic and/or norepinephrinergic activity |
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DE102005060393A1 (de) * | 2005-12-16 | 2007-06-21 | Add Advanced Drug Delivery Technologies Ltd. | Orales Präparat mit kontrollierter Freisetzung |
MX2007011611A (es) * | 2006-01-23 | 2007-10-18 | Teva Pharma | Fumarato de dnt y metodos de preparacion de ellos. |
EP1820800A1 (en) * | 2006-02-17 | 2007-08-22 | KRKA, tovarna zdravil, d.d., Novo mesto | Crystalline forms of duloxetine hydrochloride and processes for their preparation |
KR200416582Y1 (ko) | 2006-03-07 | 2006-05-19 | 김정배 | 건강신발 |
BRPI0711606A2 (pt) * | 2006-05-22 | 2012-02-14 | Teva Pharma | formulações de hidrocloreto de duloxetina de liberação retardada |
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JP5052051B2 (ja) * | 2006-06-16 | 2012-10-17 | トーアエイヨー株式会社 | 腸溶性顆粒剤及びその製造方法 |
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CN101190208B (zh) * | 2006-11-30 | 2011-11-02 | 石药集团中奇制药技术(石家庄)有限公司 | 一种含有盐酸度洛西汀的药物制剂及其制备方法 |
ATE552250T1 (de) | 2006-12-22 | 2012-04-15 | Synthon Bv | Verfahren zur herstellung von duloxetin und verwandten verbindungen |
EP1938840A1 (en) * | 2006-12-27 | 2008-07-02 | LEK Pharmaceuticals D.D. | Duloxetine composition |
EP2018860A1 (en) * | 2007-07-16 | 2009-01-28 | LEK Pharmaceuticals D.D. | Duloxetine composition |
BRPI0720958A2 (pt) * | 2006-12-27 | 2014-03-18 | Lek Pharmaceuticals | Omposição de duloxetina |
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US20090226517A1 (en) * | 2008-02-06 | 2009-09-10 | Vinita Umashankar Vyas | Pharmaceutical formulations comprising duloxetine |
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US20110038933A1 (en) * | 2008-05-06 | 2011-02-17 | Dexcell Ltd. | Stable benzimidazole formulation |
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US20100040680A1 (en) * | 2008-08-15 | 2010-02-18 | Felix Lai | Multiparticulate selective serotonin and norepinephrine reuptake inhibitor formulation |
WO2010037849A1 (en) * | 2008-10-02 | 2010-04-08 | Laboratorios Del Dr. Esteve, S.A. | Duloxetine enteric pellets |
CN101756960B (zh) | 2008-12-26 | 2012-06-27 | 上海中西制药有限公司 | 一种度洛西汀肠溶制剂及其芯材和制备方法 |
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GB2189699A (en) * | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated acid-labile medicaments |
JP2773959B2 (ja) * | 1990-07-10 | 1998-07-09 | 信越化学工業株式会社 | 大腸内放出性固形製剤 |
JPH04346930A (ja) * | 1991-05-25 | 1992-12-02 | Sumitomo Pharmaceut Co Ltd | 安定なアスピリン腸溶錠 |
ZA93694B (en) * | 1993-02-01 | 1993-06-03 | Lilly Co Eli | Pharmaceutical treatments. |
US5362886A (en) * | 1993-10-12 | 1994-11-08 | Eli Lilly And Company | Asymmetric synthesis |
-
1994
- 1994-07-18 US US08/276,232 patent/US5508276A/en not_active Expired - Lifetime
-
1995
- 1995-07-12 PE PE1995273613A patent/PE32196A1/es not_active IP Right Cessation
- 1995-07-12 ZA ZA955799A patent/ZA955799B/xx unknown
- 1995-07-12 CZ CZ19951805A patent/CZ288095B6/cs not_active IP Right Cessation
- 1995-07-12 PL PL95309588A patent/PL181296B1/pl unknown
- 1995-07-12 TW TW084107228A patent/TW382596B/zh not_active IP Right Cessation
- 1995-07-12 NZ NZ272554A patent/NZ272554A/en not_active IP Right Cessation
- 1995-07-13 UA UA95073317A patent/UA41344C2/uk unknown
- 1995-07-13 IL IL11458495A patent/IL114584A/xx not_active IP Right Cessation
- 1995-07-13 CA CA002153856A patent/CA2153856C/en not_active Expired - Lifetime
- 1995-07-13 NO NO19952786A patent/NO312397B1/no not_active IP Right Cessation
- 1995-07-13 MY MYPI95001986A patent/MY116361A/en unknown
- 1995-07-14 HU HU9502134A patent/HU221502B/hu unknown
- 1995-07-14 CO CO95031237A patent/CO4410177A1/es unknown
- 1995-07-15 KR KR1019950020885A patent/KR100356240B1/ko not_active IP Right Cessation
- 1995-07-17 DK DK95304977T patent/DK0693282T3/da active
- 1995-07-17 ES ES95304977T patent/ES2157297T3/es not_active Expired - Lifetime
- 1995-07-17 SI SI9530506T patent/SI0693282T1/xx unknown
- 1995-07-17 DE DE69520711T patent/DE69520711T2/de not_active Expired - Lifetime
- 1995-07-17 YU YU48095A patent/YU49445B/sh unknown
- 1995-07-17 RU RU95113118A patent/RU2147231C1/ru active
- 1995-07-17 AU AU25051/95A patent/AU686384B2/en not_active Expired
- 1995-07-17 EP EP95304977A patent/EP0693282B1/en not_active Expired - Lifetime
- 1995-07-17 BR BR9503346A patent/BR9503346A/pt not_active IP Right Cessation
- 1995-07-17 AT AT95304977T patent/ATE200620T1/de active
- 1995-07-17 PT PT95304977T patent/PT693282E/pt unknown
- 1995-07-17 CN CN95108414A patent/CN1106191C/zh not_active Expired - Lifetime
- 1995-07-17 JP JP18002695A patent/JP3707831B2/ja not_active Expired - Lifetime
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2001
- 2001-07-06 GR GR20010401033T patent/GR3036185T3/el unknown
-
2005
- 2005-02-01 NO NO2005002C patent/NO2005002I2/no unknown
-
2006
- 2006-03-23 GE GEAP20069310A patent/GEP20063944B/en unknown
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