DE60233874D1 - Pharmazeutische zusammensetzungen enthaltend dispersionen aus arzneistoffen und neutralen polymeren - Google Patents
Pharmazeutische zusammensetzungen enthaltend dispersionen aus arzneistoffen und neutralen polymerenInfo
- Publication number
- DE60233874D1 DE60233874D1 DE60233874T DE60233874T DE60233874D1 DE 60233874 D1 DE60233874 D1 DE 60233874D1 DE 60233874 T DE60233874 T DE 60233874T DE 60233874 T DE60233874 T DE 60233874T DE 60233874 D1 DE60233874 D1 DE 60233874D1
- Authority
- DE
- Germany
- Prior art keywords
- pharmaceutical compositions
- medicaments
- dispersions
- compositions contain
- neutral polymers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30025501P | 2001-06-22 | 2001-06-22 | |
PCT/IB2002/001783 WO2003000235A1 (en) | 2001-06-22 | 2002-05-10 | Pharmaceutical compositions of dispersions of drugs and neutral polymers |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60233874D1 true DE60233874D1 (de) | 2009-11-12 |
Family
ID=23158329
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60233874T Expired - Lifetime DE60233874D1 (de) | 2001-06-22 | 2002-05-10 | Pharmazeutische zusammensetzungen enthaltend dispersionen aus arzneistoffen und neutralen polymeren |
Country Status (11)
Country | Link |
---|---|
US (4) | US20030091643A1 (de) |
EP (1) | EP1404300B1 (de) |
JP (1) | JP2004534812A (de) |
AT (1) | ATE444060T1 (de) |
BR (1) | BR0210518A (de) |
CA (1) | CA2450957A1 (de) |
DE (1) | DE60233874D1 (de) |
ES (1) | ES2333645T3 (de) |
MX (1) | MXPA03011784A (de) |
PT (1) | PT1404300E (de) |
WO (1) | WO2003000235A1 (de) |
Families Citing this family (63)
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IL130602A0 (en) * | 1999-06-22 | 2000-06-01 | Dexcel Ltd | Stable benzimidazole formulation |
EP1175205B1 (de) * | 1999-11-12 | 2006-06-14 | Abbott Laboratories | Feste dispersion mit ritonavir, fenofibrat oder griseofulvin |
US7364752B1 (en) | 1999-11-12 | 2008-04-29 | Abbott Laboratories | Solid dispersion pharamaceutical formulations |
US7115279B2 (en) * | 2000-08-03 | 2006-10-03 | Curatolo William J | Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors |
BR0210505A (pt) * | 2001-06-21 | 2004-05-18 | Pfizer Prod Inc | Formulações auto-emulsionantes de inibidores da proteìna de transferência de ésteres de colesterilo |
EP1269994A3 (de) | 2001-06-22 | 2003-02-12 | Pfizer Products Inc. | Pharmazeutische Zusammensetzungen die ein Arzneimittel und die Konzentration verbesserende Polymere enthalten |
MY169670A (en) | 2003-09-03 | 2019-05-08 | Tibotec Pharm Ltd | Combinations of a pyrimidine containing nnrti with rt inhibitors |
AR038375A1 (es) | 2002-02-01 | 2005-01-12 | Pfizer Prod Inc | Composiciones farmaceuticas de inhibidores de la proteina de transferencia de esteres de colesterilo |
JP2006518751A (ja) * | 2003-02-20 | 2006-08-17 | サンタラス インコーポレイティッド | 胃酸の急速かつ持続的な抑制のための新規製剤、オメプラゾール制酸剤複合体−即時放出物 |
US20050220870A1 (en) * | 2003-02-20 | 2005-10-06 | Bonnie Hepburn | Novel formulation, omeprazole antacid complex-immediate release for rapid and sustained suppression of gastric acid |
CA2519432C (en) * | 2003-03-17 | 2009-06-09 | Japan Tobacco Inc. | Pharmaceutical compositions comprising cetp inhibitors and a water-insoluble concentration-enhancing additive for the treatment of cardiovascular disease |
CN1761463A (zh) * | 2003-03-17 | 2006-04-19 | 日本烟草产业株式会社 | 提高s-[2-([[1-(2-乙基丁基)环己基]羰基]氨基)苯基]-2-甲基丙硫代酸酯口服生物利用度的方法 |
CA2531116A1 (en) * | 2003-07-01 | 2005-01-20 | Michael Hawley | Diffusion layer modulated solids |
MXPA06000529A (es) * | 2003-07-18 | 2006-08-11 | Santarus Inc | Formulaciones farmaceuticas utiles para inhibir la secrecion de acido y metodos para elaborarlas y utilizarlas. |
US8993599B2 (en) * | 2003-07-18 | 2015-03-31 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
EP1648417A4 (de) * | 2003-07-18 | 2010-01-20 | Santarus Inc | Pharmazeutische formulierung und verfahren zur behandlung von säurebedingten gastrointestinalen erkrankungen |
MXPA06001506A (es) * | 2003-08-04 | 2006-05-15 | Pfizer Prod Inc | Formas de dosificacion de inhibidores de la proteina de transferencia de colesteril ester e inhibidores de la hmg-coa reductasa. |
US8377952B2 (en) * | 2003-08-28 | 2013-02-19 | Abbott Laboratories | Solid pharmaceutical dosage formulation |
US8025899B2 (en) * | 2003-08-28 | 2011-09-27 | Abbott Laboratories | Solid pharmaceutical dosage form |
US20070292498A1 (en) * | 2003-11-05 | 2007-12-20 | Warren Hall | Combinations of proton pump inhibitors, sleep aids, buffers and pain relievers |
US20090191274A1 (en) * | 2004-01-16 | 2009-07-30 | Sang-Joon Lee | Pharmaceutical composition of amlodipine maleate having enhanced stability |
AU2005213472A1 (en) * | 2004-02-10 | 2005-08-25 | Santarus, Inc. | Combination of proton pump inhibitor, buffering agent, and nonsteroidal anti-inflammatory agent |
WO2005117870A2 (en) * | 2004-04-16 | 2005-12-15 | Santarus, Inc. | Combination of proton pump inhibitor, buffering agent, and prokinetic agent |
US8906940B2 (en) * | 2004-05-25 | 2014-12-09 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
US8815916B2 (en) * | 2004-05-25 | 2014-08-26 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
CA2586760A1 (en) * | 2004-11-05 | 2006-05-18 | Edward S. Wilson | Stabilized ramipril compositions and methods of making |
WO2006069159A2 (en) * | 2004-12-20 | 2006-06-29 | Dr. Reddy's Laboratories Ltd. | Pharmaceutical compositions comprising amorphous benzimidazole compounds |
AU2005320547B2 (en) * | 2004-12-27 | 2009-02-05 | Eisai R & D Management Co., Ltd. | Method for stabilizing anti-dementia drug |
US20090208579A1 (en) * | 2004-12-27 | 2009-08-20 | Eisai R & D Management Co., Ltd. | Matrix Type Sustained-Release Preparation Containing Basic Drug or Salt Thereof, and Method for Manufacturing the Same |
US20070129402A1 (en) * | 2004-12-27 | 2007-06-07 | Eisai Research Institute | Sustained release formulations |
KR100760430B1 (ko) * | 2004-12-31 | 2007-10-04 | 한미약품 주식회사 | 당뇨병 치료제의 경구 투여용 서방성 복합 제제 및 이의제조 방법 |
WO2006118265A1 (ja) * | 2005-04-28 | 2006-11-09 | Eisai R & D Management Co., Ltd. | 抗痴呆薬を含有する組成物 |
US10532028B2 (en) * | 2005-07-28 | 2020-01-14 | Isp Investments Llc | Method to improve characteristics of spray dried powders and granulated materials, and the products thereby produced |
EP1942872A2 (de) * | 2005-11-04 | 2008-07-16 | Eastman Chemical Company | Carboxyalkylcelluloseester zur verabreichung von schwer löslichen pharmazeutischen wirkstoffen |
EP2004150A1 (de) * | 2006-03-27 | 2008-12-24 | Panacea Biotec Ltd. | Pharmazeutische zusammensetzung mit verzögerter freisetzung auf basis eines freisetzungssystems mit einem säurelöslichen polymer und einem ph-abhängigen polymer |
US20090092658A1 (en) * | 2007-10-05 | 2009-04-09 | Santarus, Inc. | Novel formulations of proton pump inhibitors and methods of using these formulations |
US20080085315A1 (en) * | 2006-10-10 | 2008-04-10 | John Alfred Doney | Amorphous ezetimibe and the production thereof |
ATE476966T1 (de) * | 2006-10-17 | 2010-08-15 | Bend Res Inc | Feste dispersion mit schwer wasserlöslichem wirkstoff |
WO2008076780A2 (en) * | 2006-12-14 | 2008-06-26 | Isp Investments Inc. | Amorphous valsartan and the production thereof |
WO2008080037A2 (en) | 2006-12-21 | 2008-07-03 | Isp Investments Inc. | Carotenoids of enhanced bioavailability |
WO2008092046A2 (en) * | 2007-01-26 | 2008-07-31 | Isp Investments Inc. | Amorphous oxcarbazepine and the production thereof |
WO2008092057A2 (en) * | 2007-01-26 | 2008-07-31 | Isp Investments Inc. | Formulation process method to produce spray dried products |
AR065720A1 (es) | 2007-03-14 | 2009-06-24 | Tibotec Pharm Ltd | Polvos para reconstitucion que comprenden rilpivirina dispersos en ciertos polimeros. uso. proceso. |
EP2105130A1 (de) | 2008-03-25 | 2009-09-30 | Ratiopharm GmbH | Pharmazeutische Formulierung und Verfahren zu deren Herstellung |
WO2009136398A2 (en) * | 2008-05-06 | 2009-11-12 | Dexcel Ltd | Stable benzimidazole formulation |
KR101004205B1 (ko) * | 2008-12-17 | 2010-12-24 | 동아제약주식회사 | 유데나필 함유 서방성 제제를 제조하기 위한 제어방출 조성물 |
JP2012527491A (ja) * | 2009-05-27 | 2012-11-08 | サムヤン バイオファーマシューティカルズ コーポレイション | 生体利用率が向上した難溶性薬物含有微粒球およびその製造方法 |
CN103271884B (zh) * | 2013-06-28 | 2015-12-09 | 悦康药业集团有限公司 | 一种兰索拉唑组合物及其制备方法 |
US11311519B2 (en) | 2014-05-01 | 2022-04-26 | Eiger Biopharmaceuticals, Inc. | Treatment of hepatitis delta virus infection |
US10076512B2 (en) | 2014-05-01 | 2018-09-18 | Eiger Biopharmaceuticals, Inc. | Treatment of hepatitis delta virus infection |
US10245238B2 (en) | 2014-05-15 | 2019-04-02 | Theravalues Corporation | Composition for oral intake |
CA2962719A1 (en) | 2014-10-31 | 2016-05-06 | Bend Research Inc. | Process for forming active domains dispersed in a matrix |
KR102514971B1 (ko) | 2015-04-21 | 2023-03-27 | 아이거 바이오파마슈티컬스 인코포레이티드 | 로나파르닙 및 리토나버를 포함하는 약제 조성물 |
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US11331316B2 (en) | 2016-10-12 | 2022-05-17 | Intra-Cellular Therapies, Inc. | Amorphous solid dispersions |
RU2767410C2 (ru) | 2017-03-24 | 2022-03-17 | Интра-Селлулар Терапиз, Инк. | Новые композиции и способы |
US11708463B2 (en) | 2018-04-06 | 2023-07-25 | Capsugel Belgium Nv | Spray drying process for low aspect ratio particles comprising poly[(methyl methacrylate)-co-(methacrylic acid)] |
EP3843739A4 (de) | 2018-08-31 | 2022-06-01 | Intra-Cellular Therapies, Inc. | Neuartige verfahren |
JP2021536453A (ja) | 2018-08-31 | 2021-12-27 | イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. | 新規方法 |
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-
2002
- 2002-05-10 AT AT02727944T patent/ATE444060T1/de not_active IP Right Cessation
- 2002-05-10 WO PCT/IB2002/001783 patent/WO2003000235A1/en active Application Filing
- 2002-05-10 MX MXPA03011784A patent/MXPA03011784A/es not_active Application Discontinuation
- 2002-05-10 JP JP2003506882A patent/JP2004534812A/ja active Pending
- 2002-05-10 BR BR0210518-7A patent/BR0210518A/pt not_active IP Right Cessation
- 2002-05-10 CA CA002450957A patent/CA2450957A1/en not_active Abandoned
- 2002-05-10 ES ES02727944T patent/ES2333645T3/es not_active Expired - Lifetime
- 2002-05-10 PT PT02727944T patent/PT1404300E/pt unknown
- 2002-05-10 DE DE60233874T patent/DE60233874D1/de not_active Expired - Lifetime
- 2002-05-10 EP EP02727944A patent/EP1404300B1/de not_active Revoked
- 2002-06-18 US US10/175,132 patent/US20030091643A1/en not_active Abandoned
-
2006
- 2006-05-16 US US11/383,520 patent/US20060216351A1/en not_active Abandoned
-
2014
- 2014-04-01 US US14/242,141 patent/US9468604B2/en not_active Expired - Lifetime
-
2016
- 2016-09-07 US US15/258,477 patent/US20160374945A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
ATE444060T1 (de) | 2009-10-15 |
WO2003000235A9 (en) | 2003-12-24 |
WO2003000235A1 (en) | 2003-01-03 |
EP1404300A1 (de) | 2004-04-07 |
US20030091643A1 (en) | 2003-05-15 |
ES2333645T3 (es) | 2010-02-25 |
JP2004534812A (ja) | 2004-11-18 |
BR0210518A (pt) | 2004-06-22 |
US20140210117A1 (en) | 2014-07-31 |
CA2450957A1 (en) | 2003-01-03 |
US9468604B2 (en) | 2016-10-18 |
US20060216351A1 (en) | 2006-09-28 |
EP1404300B1 (de) | 2009-09-30 |
PT1404300E (pt) | 2009-11-09 |
US20160374945A1 (en) | 2016-12-29 |
MXPA03011784A (es) | 2004-04-02 |
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