CO4410177A1 - Granulos entericos de duloxetina - Google Patents
Granulos entericos de duloxetinaInfo
- Publication number
- CO4410177A1 CO4410177A1 CO95031237A CO95031237A CO4410177A1 CO 4410177 A1 CO4410177 A1 CO 4410177A1 CO 95031237 A CO95031237 A CO 95031237A CO 95031237 A CO95031237 A CO 95031237A CO 4410177 A1 CO4410177 A1 CO 4410177A1
- Authority
- CO
- Colombia
- Prior art keywords
- duloxetine
- hpmcas
- granule
- layer
- approximately
- Prior art date
Links
- ZEUITGRIYCTCEM-KRWDZBQOSA-N (S)-duloxetine Chemical compound C1([C@@H](OC=2C3=CC=CC=C3C=CC=2)CCNC)=CC=CS1 ZEUITGRIYCTCEM-KRWDZBQOSA-N 0.000 title abstract 4
- 229960002866 duloxetine Drugs 0.000 title abstract 4
- 239000008187 granular material Substances 0.000 title abstract 3
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 2
- -1 AMMONIUM IONS Chemical class 0.000 abstract 1
- IYKJEILNJZQJPU-UHFFFAOYSA-N acetic acid;butanedioic acid Chemical compound CC(O)=O.OC(=O)CCC(O)=O IYKJEILNJZQJPU-UHFFFAOYSA-N 0.000 abstract 1
- 238000000926 separation method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Organic Chemistry (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
Abstract
REIVINDICACION NUMERO UN GRANULO DE DULOXETINA ENTERICO QUE COMPRENDE A) UN NUCLEO QUE CONSTA DE DULOXETINA Y UN EXCIPIENTE ACEPTABLE FARMACEUTICAMENTE; B) UNA CAPA DE SEPA- RACION OPCIONAL; C) UNA CAPA ENTERICA QUE COMPREN- DE HIDROXIPROPPILMETILCELULOSA ACETATO SUCCINATO (HPMCAS) Y UN EXIPIENTE ACEPTABLE FARMACEUTICAMEN- TE; D) UNA CAPA DE ACABADO OPCIONAL. REIVINDICACION NUMERO UN GRANULO DE ACUERDO CON LA REIVINDICACION 1, EN EL QUE EL HPMCAS ES NEUTRALIZADO PARCIALMENTE CON IONES DE AMONIO HASTA EL GRADO DE QUE SE NEUTRALI- ZAN DESDE APROXIMADAMENTE 0% HASTA APROXIMADAMENTE 25% DE GRUPOS DE ACIDO SUCCINICO. REIVINDICACION NUMERO UN GRANULO DE ACUERDO CON LA REIVINDICACION 5, EN EL QUE EL NUCLEO COMPRENDE UNA PERLA INERTE SOBRE LA QUE SE DEPOSITA LA DULOXETINA COMO UNA CAPA QUE COMPRENDE ADICIONALMENTE UN EXCIPIENTE ACEPTABLE FARMACEUTICAMENTE.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/276,232 US5508276A (en) | 1994-07-18 | 1994-07-18 | Duloxetine enteric pellets |
Publications (1)
Publication Number | Publication Date |
---|---|
CO4410177A1 true CO4410177A1 (es) | 1997-01-09 |
Family
ID=23055767
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO95031237A CO4410177A1 (es) | 1994-07-18 | 1995-07-14 | Granulos entericos de duloxetina |
Country Status (30)
Country | Link |
---|---|
US (1) | US5508276A (es) |
EP (1) | EP0693282B1 (es) |
JP (1) | JP3707831B2 (es) |
KR (1) | KR100356240B1 (es) |
CN (1) | CN1106191C (es) |
AT (1) | ATE200620T1 (es) |
AU (1) | AU686384B2 (es) |
BR (1) | BR9503346A (es) |
CA (1) | CA2153856C (es) |
CO (1) | CO4410177A1 (es) |
CZ (1) | CZ288095B6 (es) |
DE (1) | DE69520711T2 (es) |
DK (1) | DK0693282T3 (es) |
ES (1) | ES2157297T3 (es) |
GE (1) | GEP20063944B (es) |
GR (1) | GR3036185T3 (es) |
HU (1) | HU221502B (es) |
IL (1) | IL114584A (es) |
MY (1) | MY116361A (es) |
NO (2) | NO312397B1 (es) |
NZ (1) | NZ272554A (es) |
PE (1) | PE32196A1 (es) |
PL (1) | PL181296B1 (es) |
PT (1) | PT693282E (es) |
RU (1) | RU2147231C1 (es) |
SI (1) | SI0693282T1 (es) |
TW (1) | TW382596B (es) |
UA (1) | UA41344C2 (es) |
YU (1) | YU49445B (es) |
ZA (1) | ZA955799B (es) |
Families Citing this family (98)
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EP1565182A1 (en) * | 2002-11-19 | 2005-08-24 | Eli Lilly And Company | Treatment of gastrointestinal disorders with duloxetine |
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US5019302A (en) | 1986-03-12 | 1991-05-28 | Washington University Technology Associates, Inc. | Method for granulation |
US5100592A (en) | 1986-03-12 | 1992-03-31 | Washington University Technology Associated, Inc. | Method and apparatus for granulation and granulated product |
GB2189699A (en) * | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated acid-labile medicaments |
JP2773959B2 (ja) * | 1990-07-10 | 1998-07-09 | 信越化学工業株式会社 | 大腸内放出性固形製剤 |
JPH04346930A (ja) * | 1991-05-25 | 1992-12-02 | Sumitomo Pharmaceut Co Ltd | 安定なアスピリン腸溶錠 |
ZA93694B (en) * | 1993-02-01 | 1993-06-03 | Lilly Co Eli | Pharmaceutical treatments. |
US5362886A (en) * | 1993-10-12 | 1994-11-08 | Eli Lilly And Company | Asymmetric synthesis |
-
1994
- 1994-07-18 US US08/276,232 patent/US5508276A/en not_active Expired - Lifetime
-
1995
- 1995-07-12 NZ NZ272554A patent/NZ272554A/en not_active IP Right Cessation
- 1995-07-12 PL PL95309588A patent/PL181296B1/pl unknown
- 1995-07-12 TW TW084107228A patent/TW382596B/zh not_active IP Right Cessation
- 1995-07-12 CZ CZ19951805A patent/CZ288095B6/cs not_active IP Right Cessation
- 1995-07-12 PE PE1995273613A patent/PE32196A1/es not_active IP Right Cessation
- 1995-07-12 ZA ZA955799A patent/ZA955799B/xx unknown
- 1995-07-13 UA UA95073317A patent/UA41344C2/uk unknown
- 1995-07-13 NO NO19952786A patent/NO312397B1/no not_active IP Right Cessation
- 1995-07-13 MY MYPI95001986A patent/MY116361A/en unknown
- 1995-07-13 IL IL11458495A patent/IL114584A/xx not_active IP Right Cessation
- 1995-07-13 CA CA002153856A patent/CA2153856C/en not_active Expired - Lifetime
- 1995-07-14 HU HU9502134A patent/HU221502B/hu unknown
- 1995-07-14 CO CO95031237A patent/CO4410177A1/es unknown
- 1995-07-15 KR KR1019950020885A patent/KR100356240B1/ko not_active IP Right Cessation
- 1995-07-17 ES ES95304977T patent/ES2157297T3/es not_active Expired - Lifetime
- 1995-07-17 AU AU25051/95A patent/AU686384B2/en not_active Expired
- 1995-07-17 SI SI9530506T patent/SI0693282T1/xx unknown
- 1995-07-17 BR BR9503346A patent/BR9503346A/pt not_active IP Right Cessation
- 1995-07-17 PT PT95304977T patent/PT693282E/pt unknown
- 1995-07-17 DK DK95304977T patent/DK0693282T3/da active
- 1995-07-17 AT AT95304977T patent/ATE200620T1/de active
- 1995-07-17 CN CN95108414A patent/CN1106191C/zh not_active Expired - Lifetime
- 1995-07-17 RU RU95113118A patent/RU2147231C1/ru active
- 1995-07-17 JP JP18002695A patent/JP3707831B2/ja not_active Expired - Lifetime
- 1995-07-17 EP EP95304977A patent/EP0693282B1/en not_active Expired - Lifetime
- 1995-07-17 DE DE69520711T patent/DE69520711T2/de not_active Expired - Lifetime
- 1995-07-17 YU YU48095A patent/YU49445B/sh unknown
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2001
- 2001-07-06 GR GR20010401033T patent/GR3036185T3/el unknown
-
2005
- 2005-02-01 NO NO2005002C patent/NO2005002I2/no unknown
-
2006
- 2006-03-23 GE GEAP20069310A patent/GEP20063944B/en unknown
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