SI0693282T1 - Duloxetine enteric pellets - Google Patents

Duloxetine enteric pellets

Info

Publication number
SI0693282T1
SI0693282T1 SI9530506T SI9530506T SI0693282T1 SI 0693282 T1 SI0693282 T1 SI 0693282T1 SI 9530506 T SI9530506 T SI 9530506T SI 9530506 T SI9530506 T SI 9530506T SI 0693282 T1 SI0693282 T1 SI 0693282T1
Authority
SI
Slovenia
Prior art keywords
enteric pellets
duloxetine
duloxetine enteric
enteric
pellets
Prior art date
Application number
SI9530506T
Other languages
English (en)
Slovenian (sl)
Inventor
Neil Robert Anderson
Peter Lloyd Oren
Toshihiro Ogura
Toshiro Fujii
Original Assignee
Eli Lilly And Company
Shionogi & Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23055767&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI0693282(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Eli Lilly And Company, Shionogi & Co., Ltd. filed Critical Eli Lilly And Company
Publication of SI0693282T1 publication Critical patent/SI0693282T1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SI9530506T 1994-07-18 1995-07-17 Duloxetine enteric pellets SI0693282T1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/276,232 US5508276A (en) 1994-07-18 1994-07-18 Duloxetine enteric pellets

Publications (1)

Publication Number Publication Date
SI0693282T1 true SI0693282T1 (en) 2002-02-28

Family

ID=23055767

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9530506T SI0693282T1 (en) 1994-07-18 1995-07-17 Duloxetine enteric pellets

Country Status (30)

Country Link
US (1) US5508276A (xx)
EP (1) EP0693282B1 (xx)
JP (1) JP3707831B2 (xx)
KR (1) KR100356240B1 (xx)
CN (1) CN1106191C (xx)
AT (1) ATE200620T1 (xx)
AU (1) AU686384B2 (xx)
BR (1) BR9503346A (xx)
CA (1) CA2153856C (xx)
CO (1) CO4410177A1 (xx)
CZ (1) CZ288095B6 (xx)
DE (1) DE69520711T2 (xx)
DK (1) DK0693282T3 (xx)
ES (1) ES2157297T3 (xx)
GE (1) GEP20063944B (xx)
GR (1) GR3036185T3 (xx)
HU (1) HU221502B (xx)
IL (1) IL114584A (xx)
MY (1) MY116361A (xx)
NO (2) NO312397B1 (xx)
NZ (1) NZ272554A (xx)
PE (1) PE32196A1 (xx)
PL (1) PL181296B1 (xx)
PT (1) PT693282E (xx)
RU (1) RU2147231C1 (xx)
SI (1) SI0693282T1 (xx)
TW (1) TW382596B (xx)
UA (1) UA41344C2 (xx)
YU (1) YU49445B (xx)
ZA (1) ZA955799B (xx)

Families Citing this family (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA000856B1 (ru) * 1995-07-24 2000-06-26 Эли Лилли Энд Компани Способ лечения синдрома дефицита внимания/гиперактивности
US5910319A (en) * 1997-05-29 1999-06-08 Eli Lilly And Company Fluoxetine enteric pellets and methods for their preparation and use
ES2335067T3 (es) 1998-09-15 2010-03-18 Eli Lilly And Company Uso de duloxetina en el tratamiento de la fibromialgia.
EP1027885B1 (en) * 1999-02-09 2008-07-09 Pfizer Products Inc. Basic drug compositions with enhanced bioavailability
IL130602A0 (en) * 1999-06-22 2000-06-01 Dexcel Ltd Stable benzimidazole formulation
BR0108980A (pt) * 2000-03-07 2003-06-03 Lilly Co Eli Aplicação e formulação farmacêuticas compreendendo inibidor de reabsorção de norepinefrina
CA2442410A1 (en) * 2001-03-29 2002-10-10 Owen Brendan Wallace Duloxetine for treatment of hot flashes
DE60233874D1 (de) * 2001-06-22 2009-11-12 Pfizer Prod Inc Pharmazeutische zusammensetzungen enthaltend dispersionen aus arzneistoffen und neutralen polymeren
SK15732003A3 (sk) * 2001-06-22 2005-01-03 Pfizer Products Inc. Farmaceutické kompozície zahrnujúce liečivá s nízkou rozpustnosťou a/alebo liečivá citlivé na kyselinu a neutralizované kyslé polyméry
JP2006508978A (ja) * 2002-11-19 2006-03-16 イーライ・リリー・アンド・カンパニー デュロキセチンを用いる胃腸障害の処置
AU2004259006B2 (en) * 2003-07-24 2010-10-07 Glaxosmithkline Llc Orally dissolving films
WO2005097070A1 (ja) * 2004-04-08 2005-10-20 Kyowa Hakko Kogyo Co., Ltd. 安定性の向上した固形製剤およびその製造方法
GB0410470D0 (en) * 2004-05-11 2004-06-16 Cipla Ltd Pharmaceutical compound and polymorphs thereof
JP2007523213A (ja) * 2004-12-23 2007-08-16 テバ ファーマシューティカル インダストリーズ リミティド 医薬的に許容できるデュロキセチンの塩及びその中間体の調製方法
MX2007010931A (es) * 2005-03-08 2007-10-16 Teva Pharma Formas cristalinas de (s)-(+)-n,n-dimetil-3-(1-naftaleniloxi)-3-(2 -tienil)propanamina oxalato y la preparacion ellas.
WO2006099433A1 (en) * 2005-03-14 2006-09-21 Teva Pharmaceutical Industries Ltd. Pure duloxetine hydrochloride
EP1904039A2 (en) * 2005-06-20 2008-04-02 Cadila Healthcare Ltd. Controlled release dosage formulation of duloxetine
US8153824B2 (en) * 2005-06-22 2012-04-10 The Wockhardt Company Antidepressant oral liquid compositions
US11311490B2 (en) 2005-08-10 2022-04-26 Add Advanced Drug Delivery Technologies Ltd. Oral preparation with controlled release
US20060165776A1 (en) * 2005-08-31 2006-07-27 Ramesh Sesha Antidepressant oral pharmaceutical compositions
US20080207923A1 (en) * 2005-09-22 2008-08-28 Santiago Ini Pure DNT-maleate and methods of preparation thereof
WO2007038253A2 (en) * 2005-09-22 2007-04-05 Teva Pharmaceutical Industries Ltd. Dnt-maleate and methods of preparation thereof
CA2629800A1 (en) * 2005-11-23 2007-05-31 Thomas G. Gant Substituted aryloxypropylamines with serotoninergic and/or norepinephrinergic activity
US7759500B2 (en) * 2005-12-05 2010-07-20 Teva Pharmaceutical Industries Ltd. 2-(N-methyl-propanamine)-3-(2-naphthol)thiophene, an impurity of duloxetine hydrochloride
DE102005060393A1 (de) * 2005-12-16 2007-06-21 Add Advanced Drug Delivery Technologies Ltd. Orales Präparat mit kontrollierter Freisetzung
MX2007011611A (es) * 2006-01-23 2007-10-18 Teva Pharma Fumarato de dnt y metodos de preparacion de ellos.
EP1820800A1 (en) * 2006-02-17 2007-08-22 KRKA, tovarna zdravil, d.d., Novo mesto Crystalline forms of duloxetine hydrochloride and processes for their preparation
KR200416582Y1 (ko) 2006-03-07 2006-05-19 김정배 건강신발
BRPI0711606A2 (pt) * 2006-05-22 2012-02-14 Teva Pharma formulações de hidrocloreto de duloxetina de liberação retardada
MX2008001079A (es) * 2006-05-23 2008-03-19 Teva Pharma Polimorfos de hidrocloruro de duloxetina.
JP5052051B2 (ja) * 2006-06-16 2012-10-17 トーアエイヨー株式会社 腸溶性顆粒剤及びその製造方法
US20090175935A1 (en) * 2006-08-14 2009-07-09 Torrent Research Ltd. Pharmaceutical compositions of duloxetine
CN101190208B (zh) * 2006-11-30 2011-11-02 石药集团中奇制药技术（石家庄）有限公司 一种含有盐酸度洛西汀的药物制剂及其制备方法
ATE552250T1 (de) 2006-12-22 2012-04-15 Synthon Bv Verfahren zur herstellung von duloxetin und verwandten verbindungen
EP1938840A1 (en) * 2006-12-27 2008-07-02 LEK Pharmaceuticals D.D. Duloxetine composition
EP2018860A1 (en) * 2007-07-16 2009-01-28 LEK Pharmaceuticals D.D. Duloxetine composition
BRPI0720958A2 (pt) * 2006-12-27 2014-03-18 Lek Pharmaceuticals Omposição de duloxetina
US20080226711A1 (en) * 2007-03-12 2008-09-18 Torrent Pharmaceuticals Ltd. Pharmaceutical compositions of duloxetine
US9358213B2 (en) * 2007-04-20 2016-06-07 Wockhardt Limited Pharmaceutical compositions of duloxetine
WO2009004649A2 (en) * 2007-05-21 2009-01-08 Sun Pharmaceutical Industries Limited Enteric coated pharmaceutical compositions
GB0712220D0 (en) * 2007-06-23 2007-08-01 Arrow Int Ltd Duloxetine formulation
WO2009066181A2 (en) * 2007-07-09 2009-05-28 Combino Pharm, S.L. Oral delayed-release duloxentine hydrochloride pellets
US20090017113A1 (en) * 2007-07-13 2009-01-15 Osinga Niels J Duloxetine formulations
WO2009087657A2 (en) * 2007-11-03 2009-07-16 Alkem Laboratories Ltd. Stable pharmaceutical composition of duloxetine and process for its preparation
US9233078B2 (en) 2007-12-06 2016-01-12 Bend Research, Inc. Nanoparticles comprising a non-ionizable polymer and an Amine-functionalized methacrylate copolymer
EP2231169B1 (en) * 2007-12-06 2016-05-04 Bend Research, Inc. Pharmaceutical compositions comprising nanoparticles and a resuspending material
EP2240173A4 (en) * 2008-01-25 2013-07-17 Alphapharm Pty Ltd PHARMACEUTICAL COMPOSITION OF DULOXETINE WITH DELAYED RELEASE
US20090226517A1 (en) * 2008-02-06 2009-09-10 Vinita Umashankar Vyas Pharmaceutical formulations comprising duloxetine
AU2009230676A1 (en) * 2008-03-24 2009-10-01 Lupin Limited Delayed release compositions of duloxetine
US20110038933A1 (en) * 2008-05-06 2011-02-17 Dexcell Ltd. Stable benzimidazole formulation
EP2133072A1 (en) 2008-06-13 2009-12-16 KRKA, D.D., Novo Mesto Gastro-resistant pharmaceutical oral compositions comprising duloxetine or its pharmaceutically acceptable derivatives
US20100040680A1 (en) * 2008-08-15 2010-02-18 Felix Lai Multiparticulate selective serotonin and norepinephrine reuptake inhibitor formulation
WO2010037849A1 (en) * 2008-10-02 2010-04-08 Laboratorios Del Dr. Esteve, S.A. Duloxetine enteric pellets
CN101756960B (zh) 2008-12-26 2012-06-27 上海中西制药有限公司 一种度洛西汀肠溶制剂及其芯材和制备方法
WO2010078878A1 (en) * 2009-01-12 2010-07-15 Synthon B.V. Duloxetine formulations
US8758779B2 (en) * 2009-06-25 2014-06-24 Wockhardt Ltd. Pharmaceutical composition of duloxetine
DE102009033621A1 (de) 2009-07-17 2011-01-20 Add Technologies Ltd. Trennschichten für pharmazeutische Zubereitungen zur Verhinderung von Wechselwirkungen zwischen Arzneistoffen und pharmazeutisch-technologischen Hilfsstoffen
US20120207825A1 (en) * 2009-09-17 2012-08-16 Sunilendu Bhushan Roy Pharmaceutical compositions for reducing alcohol-induced dose dumping
WO2011074961A1 (en) * 2009-12-18 2011-06-23 Frieslandcampina Nederland Holding B.V. Co-processed tablet excipient composition its preparation and use
EA029077B1 (ru) * 2010-03-09 2018-02-28 Алкермес Фарма Айэленд Лимитед Устойчивая к спирту фармацевтическая лекарственная форма
EP2377525A1 (en) 2010-03-26 2011-10-19 Laboratorios del Dr. Esteve S.A. Duloxetine enteric pellets
US20130224290A1 (en) * 2010-05-25 2013-08-29 Hetero Research Foundation Oral Pharmaceutical Composition of Duloxetine
CN102908331A (zh) * 2011-08-01 2013-02-06 浙江九洲药物科技有限公司 一种盐酸度洛西汀肠溶胶囊及其制备方法
RS56839B1 (sr) 2012-04-30 2018-04-30 Tillotts Pharma Ag Formulacija leka sa odloženim otpuštanjem
ES2728850T3 (es) * 2012-05-02 2019-10-29 Capsugel Belgium Nv Dispersiones acuosas de acetato acetato succinato de hidroxipropilmetilcelulosa (HPMCAS)
CN103505421B (zh) * 2012-06-29 2018-04-27 石药集团中奇制药技术（石家庄）有限公司 一种盐酸度洛西汀的肠溶微丸制剂
CN103211777A (zh) * 2013-03-31 2013-07-24 北京万全阳光医学技术有限公司 一种盐酸度洛西汀的药物制剂及其制备的方法
GR1008228B (el) * 2013-04-23 2014-06-16 "Φαρματεν Α.Β.Ε.Ε.", Φαρμακευτικο σκευασμα περιεχον ενα διπλο αναστολεα επαναπροσληψης και μεθοδος για την παρασκευη αυτου
EP2813218B1 (en) * 2013-06-14 2022-08-24 Shin-Etsu Chemical Co., Ltd. Method for producing aqueous enteric coating liquid, solid preparation, and method for producing same
CN103393615B (zh) * 2013-07-24 2015-07-15 海南华益泰康药业有限公司 一种度洛西汀肠溶小丸及其制备方法
PL224543B1 (pl) 2013-08-21 2017-01-31 Pabianickie Zakłady Farm Polfa Spółka Akcyjna Dojelitowa tabletka duloksetyny
US10799515B2 (en) 2013-10-29 2020-10-13 Tillotts Pharma Ag Delayed release drug formulation
EP3065720A1 (en) 2013-11-04 2016-09-14 Capsugel Belgium NV Methods and systems for improved bioavailability of active pharmaceutical ingredients including esomeprazole
WO2015179073A1 (en) * 2014-05-20 2015-11-26 Dow Global Technologies Llc Capsule shells comprising an esterified cellulose ether
EP3182970A4 (en) * 2014-08-22 2018-03-21 Medipath Inc. Compositions and methods for cannabinoid coatings for use in drug delivery
US10471152B2 (en) * 2014-08-29 2019-11-12 Capsugel Belgium Nv Colloidal dispersion comprising HPMCAS
US20170182070A1 (en) 2014-10-08 2017-06-29 Mayne Pharma International Pty Ltd. Controlled Release Doxycycline
US9668975B2 (en) 2014-10-14 2017-06-06 PharmaDax Inc. Method of preparing drug agglomerate
CN105726488B (zh) * 2014-12-08 2020-10-20 上海爱科百发生物医药技术有限公司 含有呼吸道合胞病毒抑制剂的肠溶微丸及其制备方法
KR101625344B1 (ko) 2015-12-21 2016-06-08 주식회사 유영제약 세레콕시브 및 둘록세틴을 함유하는 약제학적 조성물
CN105534949A (zh) * 2016-01-06 2016-05-04 北京修正创新药物研究院有限公司 一种盐酸度洛西汀的肠溶微丸制剂
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions
JP6815109B2 (ja) * 2016-06-23 2021-01-20 キョーリンリメディオ株式会社 デュロキセチンまたは薬学的に許容されるその塩を有効成分とする医薬組成物
JP6856326B2 (ja) * 2016-07-15 2021-04-07 富士化学工業株式会社 腸放出粒子組成物
CN106166144A (zh) * 2016-08-12 2016-11-30 海南合瑞制药股份有限公司 一种盐酸度洛西汀肠溶胶囊药物组合物
JP2018172361A (ja) * 2016-10-14 2018-11-08 大原薬品工業株式会社 光安定性を改善した、デュロキセチンを含有する固形製剤
US9839626B1 (en) 2016-12-14 2017-12-12 Sun Pharmaceutical Industries Limited Duloxetine sprinkles
JP7072431B2 (ja) * 2017-04-14 2022-05-20 富士化学工業株式会社 錠剤及びその製造方法
JP6972674B2 (ja) * 2017-06-06 2021-11-24 ニプロ株式会社 経口医薬製剤
JP2020029447A (ja) * 2018-06-25 2020-02-27 大原薬品工業株式会社 腸溶性高分子及び抗付着剤を含有する顆粒
CN115844846A (zh) * 2018-10-25 2023-03-28 上海上药中西制药有限公司 盐酸度洛西汀肠溶制剂、其主药层及其混悬液、其隔离层及其包衣液、及其制备方法
JP7050714B2 (ja) * 2019-04-04 2022-04-08 信越化学工業株式会社 腸溶性コーティング用組成物及び固形製剤の製造方法
JP2020189815A (ja) * 2019-05-23 2020-11-26 東和薬品株式会社 デュロキセチン製剤およびその安定化方法
EP4025206A1 (en) 2019-09-02 2022-07-13 Institut National de la Santé et de la Recherche Médicale (INSERM) Methods and compositions for treating pax6- deficiency related disease
WO2021126098A1 (en) * 2019-12-18 2021-06-24 Santa Farma İlaç Sanayi̇ A.Ş. Gastro-resistant pellet comprising duloxetine
WO2021126099A1 (en) * 2019-12-18 2021-06-24 Santa Farma İlaç Sanayi̇ A.Ş. An enteric coated pellet comprising duloxetine hydrochloride with optimized degrees of neutralization
WO2022115054A1 (en) * 2020-11-27 2022-06-02 Santa Farma Ilac Sanayii A.S. Enteric coated duloxetine compositions
WO2024117996A1 (en) * 2022-11-30 2024-06-06 Santa Farma Ilac Sanayii A.S. Bioequivalent oral pharmaceutical composition comprising duloxetine hydrochloride

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS517116A (en) * 1974-06-11 1976-01-21 Shinetsu Chemical Co Choyoseihifukuyakuzaino seizohoho
CH649216A5 (de) * 1979-08-16 1985-05-15 Sandoz Ag Verfahren zur auftragung eines magensaftresistenten filmes auf einen heilmittelkern und feste einheitsdosierungsform mit magensaftresistentem film.
US5019302A (en) 1986-03-12 1991-05-28 Washington University Technology Associates, Inc. Method for granulation
US5100592A (en) 1986-03-12 1992-03-31 Washington University Technology Associated, Inc. Method and apparatus for granulation and granulated product
GB2189699A (en) * 1986-04-30 1987-11-04 Haessle Ab Coated acid-labile medicaments
JP2773959B2 (ja) * 1990-07-10 1998-07-09 信越化学工業株式会社 大腸内放出性固形製剤
JPH04346930A (ja) * 1991-05-25 1992-12-02 Sumitomo Pharmaceut Co Ltd 安定なアスピリン腸溶錠
ZA93694B (en) * 1993-02-01 1993-06-03 Lilly Co Eli Pharmaceutical treatments.
US5362886A (en) * 1993-10-12 1994-11-08 Eli Lilly And Company Asymmetric synthesis

Also Published As

Publication number Publication date
IL114584A (en) 1999-09-22
CZ288095B6 (cs) 2001-04-11
AU2505195A (en) 1996-02-01
DE69520711D1 (de) 2001-05-23
RU2147231C1 (ru) 2000-04-10
PL181296B1 (pl) 2001-07-31
ES2157297T3 (es) 2001-08-16
KR960003722A (ko) 1996-02-23
YU48095A (sh) 1998-07-10
YU49445B (sh) 2006-03-03
HU221502B (en) 2002-10-28
CN1128141A (zh) 1996-08-07
NO2005002I1 (no) 2005-02-28
ATE200620T1 (de) 2001-05-15
HU9502134D0 (en) 1995-09-28
NO2005002I2 (no) 2009-10-05
GEP20063944B (en) 2006-10-10
JP3707831B2 (ja) 2005-10-19
NO952786D0 (no) 1995-07-13
US5508276A (en) 1996-04-16
BR9503346A (pt) 1996-02-27
KR100356240B1 (ko) 2002-12-26
PL309588A1 (en) 1996-01-22
IL114584A0 (en) 1995-11-27
HUT72466A (en) 1996-04-29
ZA955799B (en) 1997-01-13
EP0693282A3 (en) 1996-12-18
EP0693282B1 (en) 2001-04-18
CA2153856C (en) 2005-05-10
AU686384B2 (en) 1998-02-05
UA41344C2 (uk) 2001-09-17
NO952786L (no) 1996-01-19
NZ272554A (en) 1996-11-26
EP0693282A2 (en) 1996-01-24
DK0693282T3 (da) 2001-05-07
CA2153856A1 (en) 1996-01-19
DE69520711T2 (de) 2001-09-20
GR3036185T3 (en) 2001-10-31
TW382596B (en) 2000-02-21
MY116361A (en) 2004-01-31
PT693282E (pt) 2001-07-31
CZ180595A3 (en) 1996-03-13
CO4410177A1 (es) 1997-01-09
PE32196A1 (es) 1996-08-07
JPH0840895A (ja) 1996-02-13
NO312397B1 (no) 2002-05-06
CN1106191C (zh) 2003-04-23

Similar Documents

Publication Publication Date Title
HUT72466A (en) Duloxetine enteric pellets
MY118139A (en) Fluoxetine enteric pellets
ID21115A (id) Isokuinolin-3-karboksamida tersubstitusi, pembuatannya serta penggunaannya sebagai obat
ATE238776T1 (de) Geschmacksmaskierte pharmazeutische dosisform mit schneller freisetzung
EP0676707A3 (en) Promoting expressions for hierarchical netlist.
IL135520A0 (en) 8-azabicyclo [3.2.1.] octane-3-methanamine derivatives, their preparation and their therapeutic application
IL122655A0 (en) Resolution of 1-azabicyclo[2.2.2]octan-3-amine, 2-(diphenylmethyl)-N-[[2-methoxy-5-(1-methylethyl)phenyl]methyl]
ZA9710874B (en) New therapeutic application of a derivative of thienylcyclohexylamine.
AU1361601A (en) 18892, a novel human lipase
NO952426D0 (no) Nytt legemiddel som inneholder 3,7-diazabisyklo[3,3,1Ånonan forbindelser
AU6164898A (en) Use of thymosin alpha 1 for the manufacture of a medicament for promoting stem cell development
MA23288A1 (fr) Implant intra-oculaire a auses modifiees .
AU6218598A (en) Alpha-azacyclomethyl benzothiophene and alpha-azacyclomethyl benzofurane derivatives, preparation and therapeutic application
ITBO930154A1 (it) Composti a struttura benzammidica attivi nelle patologie gastro-intestinali.
ITFI930055A1 (it) Procedimento per la decorazione di un manufatto agugliato, e manufatto cosi' costituito.
AUPM747994A0 (en) Circle exercise no.1
ITTO930252U1 (it) Procedimento e macchina per la fabbricazione di copertine per libri e simili, e copertine cosi' realizzate.
TW336443U (en) A turntable walking chair
IT1274202B (it) Procedimento per la realizzazione di un soffietto, e soffietto