YU47019B - Postupak za dobijanje antineoplastičnih, aromatičnih i heterocikličnih karboksamidnih derivata - Google Patents

Postupak za dobijanje antineoplastičnih, aromatičnih i heterocikličnih karboksamidnih derivata

Info

Publication number
YU47019B
YU47019B YU105989A YU105989A YU47019B YU 47019 B YU47019 B YU 47019B YU 105989 A YU105989 A YU 105989A YU 105989 A YU105989 A YU 105989A YU 47019 B YU47019 B YU 47019B
Authority
YU
Yugoslavia
Prior art keywords
hydrogen
alkyl
fluoro
chloro
bromo
Prior art date
Application number
YU105989A
Other languages
English (en)
Serbo-Croatian (sh)
Other versions
YU105989A (en
Inventor
A.F.J. Fliri
R.C. Schnur
Original Assignee
Pfiyer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfiyer Inc. filed Critical Pfiyer Inc.
Publication of YU105989A publication Critical patent/YU105989A/xx
Publication of YU47019B publication Critical patent/YU47019B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Graft Or Block Polymers (AREA)
YU105989A 1988-05-24 1989-05-24 Postupak za dobijanje antineoplastičnih, aromatičnih i heterocikličnih karboksamidnih derivata YU47019B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19803488A 1988-05-24 1988-05-24

Publications (2)

Publication Number Publication Date
YU105989A YU105989A (en) 1990-08-31
YU47019B true YU47019B (sh) 1994-11-15

Family

ID=22731735

Family Applications (1)

Application Number Title Priority Date Filing Date
YU105989A YU47019B (sh) 1988-05-24 1989-05-24 Postupak za dobijanje antineoplastičnih, aromatičnih i heterocikličnih karboksamidnih derivata

Country Status (25)

Country Link
EP (1) EP0343893B1 (enExample)
JP (1) JPH0678331B2 (enExample)
KR (1) KR910006864B1 (enExample)
CN (1) CN1023700C (enExample)
AT (1) ATE79114T1 (enExample)
AU (1) AU601905B2 (enExample)
CA (1) CA1328871C (enExample)
DD (1) DD283815A5 (enExample)
DE (1) DE68902358T2 (enExample)
DK (1) DK249389A (enExample)
ES (1) ES2043012T3 (enExample)
FI (1) FI892498A7 (enExample)
GR (1) GR3005844T3 (enExample)
HU (1) HU202507B (enExample)
IE (1) IE891667L (enExample)
IL (1) IL90337A0 (enExample)
MX (1) MX173140B (enExample)
MY (1) MY106035A (enExample)
NO (1) NO172389C (enExample)
NZ (1) NZ229234A (enExample)
PL (1) PL154875B1 (enExample)
PT (1) PT90622B (enExample)
SU (1) SU1681728A3 (enExample)
YU (1) YU47019B (enExample)
ZA (1) ZA893862B (enExample)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2790299B2 (ja) * 1989-02-01 1998-08-27 保土谷化学工業株式会社 ペンゾチアゾール誘導体
US5262400A (en) * 1991-06-20 1993-11-16 Merck & Co., Inc. 4α-substituted avermectin derivatives
MX9801716A (es) 1995-08-30 1998-05-31 Searle & Co Derivados de meta-guanidina, urea, tiourea o acido aminobenzoico azaciclico, como antagonistas de integrina.
US6100423A (en) * 1995-08-30 2000-08-08 G. D. Searle & Co. Amino benzenepropanoic acid compounds and derivatives thereof
US5716281A (en) * 1995-11-27 1998-02-10 Sega Enterprises, Ltd. Game apparatus using a vehicle with an optical image synthesizing system
TW513418B (en) * 1996-07-31 2002-12-11 Otsuka Pharma Co Ltd Thiazole derivatives, their production and use
NZ503491A (en) 1997-11-10 2002-08-28 Bristol Myers Squibb Co 2-substituted amino-1,3-benzothiazole derivatives useful as protein tyrosine kinase inhibitors
SI0928793T1 (en) * 1998-01-02 2002-10-31 F. Hoffmann-La Roche Ag Thiazole derivatives
AU3406599A (en) * 1998-04-09 1999-11-01 Institut Fur Diagnostikforschung Gmbh An Der Freien Universitat Berlin Novel benzyl guanidine derivatives for therapy and (in-vivo) and (in-vitro) diagnosis
RU2251419C2 (ru) * 2000-06-21 2005-05-10 Ф. Хоффманн-Ля Рош Аг Производные бензотиазола
US6599901B1 (en) * 2001-11-19 2003-07-29 Hoffman-La Roche Inc. Pyridone substituted benzothiazole derivatives
US6620811B2 (en) * 2001-11-19 2003-09-16 Hoffmann-La Roche Inc. Isonicotin- and nicotinamide derivatives of benzothiazoles
US6624163B2 (en) 2001-11-29 2003-09-23 Hoffman-La Roche Inc. Benzothiazole derivatives
GB0130868D0 (en) * 2001-12-24 2002-02-06 Univ Strathclyde New compounds
CN100357283C (zh) * 2002-04-02 2007-12-26 中国科学院上海药物研究所 一类甲硫氨酰氨肽酶抑制剂
US7087761B2 (en) 2003-01-07 2006-08-08 Hoffmann-La Roche Inc. Cyclization process for substituted benzothiazole derivatives
WO2004101558A1 (en) * 2003-05-13 2004-11-25 F. Hoffmann-La Roche Ag 2-imidazo-benzothiazoles as adenosine receptor ligands
ATE389652T1 (de) * 2003-05-19 2008-04-15 Hoffmann La Roche Benzothiazol-derivate als liganden des adenosinrezeptors
EP1628662B1 (en) * 2003-05-21 2007-02-14 F. Hoffmann-La Roche Ag Benzothiazole derivatives and use thereof in the treatment of diseases related to the adenosine a2a receptor
RU2348629C2 (ru) * 2003-05-30 2009-03-10 Ф.Хоффманн-Ля Рош Аг Производные бензотиазола и их применение при лечении заболеваний, связанных с аденозиновыми a2a-рецепторами
WO2005012296A1 (en) * 2003-07-28 2005-02-10 Janssen Pharmaceutica N.V. Benzimidazole, benzthiazole and benzoxazole derivatives and their use as lta4h modulators
AU2005247567B2 (en) 2004-05-24 2010-09-02 F. Hoffmann-La Roche Ag 4-hydroxy-4-methyl-piperidine-1-carboxylic acid (4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-amide
AU2005263500B2 (en) * 2004-07-22 2011-02-24 F. Hoffmann-La Roche Ag Benzothiazole derivatives
RU2381227C2 (ru) * 2004-07-22 2010-02-10 Ф. Хоффманн-Ля Рош Аг Замещенные бензотиазолы
EP1812392B1 (en) 2004-11-05 2008-07-09 F.Hoffmann-La Roche Ag Process for preparation of isonicotinic acid derivatives
PT1863818E (pt) 2005-03-23 2010-04-09 Hoffmann La Roche Derivados de acetilenil-pirazolo-pirimidina como antagonistas de mglur2
ATE463495T1 (de) 2005-09-27 2010-04-15 Hoffmann La Roche Oxadiazolylpyrazolopyrimidine als mglur2- antagonisten
EP1994017A2 (en) * 2006-03-15 2008-11-26 4Sc Ag Novel heterocyclic nf-kb inhibitors
GB0619325D0 (en) 2006-09-30 2006-11-08 Univ Strathclyde New compounds
EP2311842A3 (en) * 2008-06-24 2011-07-13 Takeda Pharmaceutical Company Limited PI3K/M TOR inhibitors
US9499790B2 (en) 2010-08-26 2016-11-22 Kyoto University Method for promoting differentiation of pluripotent stem cells into cardiac muscle cells
AU2012315953A1 (en) * 2011-09-30 2014-04-03 Kineta, Inc. Anti-viral compounds
JP6274510B2 (ja) 2012-01-27 2018-02-07 国立大学法人京都大学 多能性幹細胞の心筋分化誘導法
JP6351567B2 (ja) 2013-03-08 2018-07-04 国立大学法人京都大学 Ｅｇｆ受容体阻害剤を含む多能性幹細胞の心筋分化促進剤
EP3045451B1 (en) * 2013-09-13 2018-03-28 Kyoto University Compound promoting differentiation of pluripotent stem cells into cardiomyocytes
WO2015182765A1 (ja) 2014-05-30 2015-12-03 国立大学法人京都大学 低分子化合物を用いた多能性幹細胞の心筋分化誘導法
CN109776486A (zh) * 2019-02-26 2019-05-21 武汉松石科技股份有限公司 一种硫酸亚丙酯的制备方法
CN110590735B (zh) * 2019-09-30 2021-07-23 江苏国泰超威新材料有限公司 一种环状硫酸酯的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61225168A (ja) * 1985-03-30 1986-10-06 Nippon Tokushu Noyaku Seizo Kk 新規ベンズアミド、その製法及び殺虫剤
KR930005004B1 (ko) * 1985-04-15 1993-06-11 쟈안센 파아마슈우티카 엔. 부이. 치환된 n-[(4-피페리디닐)알킬]이환 축합 옥사졸아민 및 티아졸아민의 제조방법
GB8611606D0 (en) * 1986-05-13 1986-06-18 Fbc Ltd Fungicides

Also Published As

Publication number Publication date
PT90622A (pt) 1989-11-30
JPH0678331B2 (ja) 1994-10-05
YU105989A (en) 1990-08-31
MY106035A (en) 1995-03-31
FI892498A7 (fi) 1989-11-25
NO172389C (no) 1993-07-14
DE68902358D1 (de) 1992-09-10
NO892059D0 (no) 1989-05-23
DD283815A5 (de) 1990-10-24
ES2043012T3 (es) 1993-12-16
HUT51606A (en) 1990-05-28
DK249389A (da) 1989-11-27
HU202507B (en) 1991-03-28
NZ229234A (en) 1990-09-26
SU1681728A3 (ru) 1991-09-30
AU601905B2 (en) 1990-09-20
CN1023700C (zh) 1994-02-09
ATE79114T1 (de) 1992-08-15
DK249389D0 (da) 1989-05-23
GR3005844T3 (enExample) 1993-06-07
IL90337A0 (en) 1989-12-15
EP0343893A1 (en) 1989-11-29
PT90622B (pt) 1994-10-31
PL154875B1 (en) 1991-09-30
JPH0217181A (ja) 1990-01-22
PL279613A1 (en) 1989-11-27
AU3509889A (en) 1989-11-30
KR910006864B1 (ko) 1991-09-09
EP0343893B1 (en) 1992-08-05
KR890017248A (ko) 1989-12-15
CA1328871C (en) 1994-04-26
NO892059L (no) 1989-11-27
CN1037898A (zh) 1989-12-13
ZA893862B (en) 1991-01-30
MX173140B (es) 1994-02-02
FI892498A0 (fi) 1989-05-23
DE68902358T2 (de) 1992-12-10
MX16158A (es) 1993-06-01
IE891667L (en) 1989-11-24
NO172389B (no) 1993-04-05

Similar Documents

Publication Publication Date Title
NO902214D0 (no) Fremgangsmaate for fremstilling av n-(aryloksyalkyl)-heteroarylpiperidiner og -heteroarylpiperaziner og deres anvendelse som medikamenter.
NO800034L (no) Nye (piperidinylalkyl)kinazolinderivater samt fremgangsmaate til deres fremstilling
IS1360B6 (is) Ný tegund af lyfjablöndu
PT83310A (de) Heterocyclish substitutierte indole zwischenprodukte verfahren zu ihrer herstellung und arzneimittel
YU79893A (sh) Farmaceutska formulacija na bazi benzotiofena
MY102084A (en) Cyclohexandionecarboxylic acid derivatives having a herbicidal and plant growth-regulating action.
BR9202525A (pt) Composto,composicao farmaceutica,uso,metodo de tratamento ou prevencao de angina,processo para a preparacao de um composto
PL346345A1 (en) Heterocyclic compounds and methods to treat cardiac failure and other disorders
YU48133B (sh) 4-benzoil izoksazol derivati i postupak za njihovo dobivanje
SE9703377D0 (sv) New compounds
YU47728B (sh) Azaoksindol derivati
SE9703378D0 (sv) New compounds
ES8503213A1 (es) "procedimiento para la preparacion de un ester basico de acido 1, 4-dihidropiridin-3,5-dicarboxilico"
DK290688A (da) Dihydropyridin-forbindelser og deres anvendelse som antiallergiske og antiinflammatoriske midler samt farmaceutiske praeparater indeholdende disse forbindelser
SE7703068L (sv) Nya sulfonamido-bensoesyraderivat jemte sett for deras framstellning
EP0324521A3 (en) Method of treating haematologic diseases and pharmaceutical compositions to be used therefor
HUT54464A (en) Herbicidal and plant grwoth regulating compositions comprising carboxylic acid derivatives as active ingredient and process for producing the active ingredients
ES478485A1 (es) Procedimiento para la preparacion de 1-oxo-1h-pirimido (6-1-b) benzotiazoles.
ATE42546T1 (de) 1-acylimidazolinone, verfahren zu ihrer herstellung und ihre verwendung in der landwirtschaft.
DK1161424T3 (da) Hidtil ukendte diazolderivater som serotonerge midler
DE3688161D1 (de) Gegebenenfalls etherifizierte oder esterifizierte in stellung 2 substituierte 4-oh-chinolincarbonsaeurederivate, verfahren und zwischenprodukte zu ihrer herstellung, ihre anwendung als arzneimittel und diese enthaltende zubereitungen.
KR950702533A (ko) 리폭시게나제 억제제로서의 인돌리닐 n-하이드록시우레아 및 n-하이드록삼산 유도체(indolinyl n-hydroxyurea and n-hydroxamic acid derivatives as lipoxygenase inhibitors)
HRP20120329T1 (hr) 9-supstituirani derivati b-karboksioksadiazinokinolona, njihovo dobivanje i njihova upotreba kao antibakterijskih sredstava
DE69707504D1 (de) Diphenylalkyl-tetrahydropyridine, verfahren zu ihren herstellung und diese enthaltende arzneimittel
YU46886B (sh) Postupak za dobijanje haloalkil tiazola