YU47019B - Postupak za dobijanje antineoplastičnih, aromatičnih i heterocikličnih karboksamidnih derivata - Google Patents

Postupak za dobijanje antineoplastičnih, aromatičnih i heterocikličnih karboksamidnih derivata

Info

Publication number
YU47019B
YU47019B YU105989A YU105989A YU47019B YU 47019 B YU47019 B YU 47019B YU 105989 A YU105989 A YU 105989A YU 105989 A YU105989 A YU 105989A YU 47019 B YU47019 B YU 47019B
Authority
YU
Yugoslavia
Prior art keywords
antineoplastic
aromatic
preparation
carboxamide derivatives
heterocyclic carboxamide
Prior art date
Application number
YU105989A
Other languages
English (en)
Other versions
YU105989A (en
Inventor
A.F.J. Fliri
R.C. Schnur
Original Assignee
Pfiyer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfiyer Inc. filed Critical Pfiyer Inc.
Publication of YU105989A publication Critical patent/YU105989A/xx
Publication of YU47019B publication Critical patent/YU47019B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Abstract

POSTUPAK ZA DOBIJANJE ANTINEOPLASTIČNIH, AROMATIČNIH I HETEROCIKLIČNIH KARBOKSAMIDNIH DERIVATA formule: kojoj M je gde X je (C1-C5)alkil, vodonik, (C1C5)alkoksi, (C1-C5)alkiltio, (C1-C5)alkilsulfinil, (C1-C5)alkilsulfoil, fluoro, hloro, bromo, nitro, tri-fluorometil, karbamil, N,N-di(C1-C3)alkilkarbamil, fenil, fluorofenil, metoksifenil, hidroksifenil, cijano, cikloheksil ili hidroksi (C1-C5)alkil, Y je vodonik, (C1-C5)alkil, (C1-C5)alkoksi, fluoro ili hloro; W je vodonik, (C1-C5)alkoksi, (C1-C5)alkil, cijano, fluoro, hloro ili bromo; X i Y kada se uzmu zajedno obrazuju benzo prsten ili tetrahidrobenzo prsten; Z je vodonik, fluoro, hloro bromo ili (C1-C3)alkil; R je supstituent formule gde m je ceo broj od 0 do 1; n je ceo broj od 0 do 2; R3, R4 i R5 su svaki vodonik ili (C1-C3)alkil; Q je CH2,O,NR4 ili S; p je ceo broj od 0 do 3; R4 i R5 kada se uzmu zajedno sa azotom za koji su vezani su piperidino, pirolidino, morfolino, tiomorfolino, piperazino ili 4-(C1-C5)alkilpiperayino; R1 je vodonik ili metil; i R2 je vodonik, (C1-C4)alkil, nitro, cijano, triluorometil, fluoro, hloro ili bromo, pod uslovom što kod jedinjenja gde M je fenil, R je u m ili p-položaju u odnosu na karbonil i kada Q je O,NR4 ili S, p je 2 do 3, naznače n time, što obuhvata reakciju derivata kiseline formule M-CO2H gde M ima napred navedeno značenje, sa 2-aminobenzotiazolom formula u kojoj X,Y,W i R1 imaju napred navedena značenja ili njegove soli sa alkalnim metalom u reakciono inertnom rastvaraču do u suštini završetka reakcije, i opciono, alkilovanje proizvoda u kome R1 je vodonik. Prijava sadrži 3 zavisna zahteva.
YU105989A 1988-05-24 1989-05-24 Postupak za dobijanje antineoplastičnih, aromatičnih i heterocikličnih karboksamidnih derivata YU47019B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19803488A 1988-05-24 1988-05-24

Publications (2)

Publication Number Publication Date
YU105989A YU105989A (en) 1990-08-31
YU47019B true YU47019B (sh) 1994-11-15

Family

ID=22731735

Family Applications (1)

Application Number Title Priority Date Filing Date
YU105989A YU47019B (sh) 1988-05-24 1989-05-24 Postupak za dobijanje antineoplastičnih, aromatičnih i heterocikličnih karboksamidnih derivata

Country Status (25)

Country Link
EP (1) EP0343893B1 (sh)
JP (1) JPH0678331B2 (sh)
KR (1) KR910006864B1 (sh)
CN (1) CN1023700C (sh)
AT (1) ATE79114T1 (sh)
AU (1) AU601905B2 (sh)
CA (1) CA1328871C (sh)
DD (1) DD283815A5 (sh)
DE (1) DE68902358T2 (sh)
DK (1) DK249389A (sh)
ES (1) ES2043012T3 (sh)
FI (1) FI892498A (sh)
GR (1) GR3005844T3 (sh)
HU (1) HU202507B (sh)
IE (1) IE891667L (sh)
IL (1) IL90337A0 (sh)
MX (1) MX173140B (sh)
MY (1) MY106035A (sh)
NO (1) NO172389C (sh)
NZ (1) NZ229234A (sh)
PL (1) PL154875B1 (sh)
PT (1) PT90622B (sh)
SU (1) SU1681728A3 (sh)
YU (1) YU47019B (sh)
ZA (1) ZA893862B (sh)

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JP2790299B2 (ja) * 1989-02-01 1998-08-27 保土谷化学工業株式会社 ペンゾチアゾール誘導体
US5262400A (en) * 1991-06-20 1993-11-16 Merck & Co., Inc. 4α-substituted avermectin derivatives
CZ293323B6 (cs) * 1995-08-30 2004-04-14 G. D. Searle & Co. Meta-guanidinové, močovinové, thiomočovinové nebo azacyklické deriváty aminobenzoové kyseliny jako antagonisty integrinů
US6100423A (en) * 1995-08-30 2000-08-08 G. D. Searle & Co. Amino benzenepropanoic acid compounds and derivatives thereof
US5716281A (en) * 1995-11-27 1998-02-10 Sega Enterprises, Ltd. Game apparatus using a vehicle with an optical image synthesizing system
TW513418B (en) * 1996-07-31 2002-12-11 Otsuka Pharma Co Ltd Thiazole derivatives, their production and use
IL135176A0 (en) 1997-11-10 2001-05-20 Bristol Myers Squibb Co Benzothiazole derivatives and pharmaceutical compositions containing the same
SI0928793T1 (en) * 1998-01-02 2002-10-31 F. Hoffmann-La Roche Ag Thiazole derivatives
AU3406599A (en) * 1998-04-09 1999-11-01 Institut Fur Diagnostikforschung Gmbh An Der Freien Universitat Berlin Novel benzyl guanidine derivatives for therapy and (in-vivo) and (in-vitro) diagnosis
MXPA02012596A (es) 2000-06-21 2003-04-10 Hoffmann La Roche Derivados de benzotiazol.
US6624163B2 (en) * 2001-11-29 2003-09-23 Hoffman-La Roche Inc. Benzothiazole derivatives
GB0130868D0 (en) * 2001-12-24 2002-02-06 Univ Strathclyde New compounds
CN100357283C (zh) * 2002-04-02 2007-12-26 中国科学院上海药物研究所 一类甲硫氨酰氨肽酶抑制剂
US7087761B2 (en) 2003-01-07 2006-08-08 Hoffmann-La Roche Inc. Cyclization process for substituted benzothiazole derivatives
PT1753760E (pt) 2004-05-24 2008-02-12 Hoffmann La Roche '' - metoxi - 7 - morfolin - 4 - il - benzotiazol - 2 - il) - amida do ácido 4 - hidroxi - 4 - metil - piperidina - 1 - carboxílico''
DE602005008095D1 (de) 2004-11-05 2008-08-21 Hoffmann La Roche Verfahren zur herstellung von isonikotinsäurederivaten
RU2412943C2 (ru) 2005-03-23 2011-02-27 Ф. Хоффманн-Ля Рош Аг ПРОИЗВОДНЫЕ АЦЕТИЛЕНИЛ-ПИРАЗОЛО-ПИРИМИДИНА В КАЧЕСТВЕ АНТАГОНИСТОВ mGluR2
ATE463495T1 (de) 2005-09-27 2010-04-15 Hoffmann La Roche Oxadiazolylpyrazolopyrimidine als mglur2- antagonisten
EP1994017A2 (en) * 2006-03-15 2008-11-26 4Sc Ag Novel heterocyclic nf-kb inhibitors
GB0619325D0 (en) 2006-09-30 2006-11-08 Univ Strathclyde New compounds
US20110178070A1 (en) * 2008-06-24 2011-07-21 Takeda Pharmaceutical Company Limited PI3K/mTOR INHIBITORS
US9499790B2 (en) 2010-08-26 2016-11-22 Kyoto University Method for promoting differentiation of pluripotent stem cells into cardiac muscle cells
EP2748172B1 (en) * 2011-09-30 2017-12-06 Kineta, Inc. Anti-viral compounds
KR101996343B1 (ko) 2012-01-27 2019-07-05 고쿠리츠 다이가쿠 호진 교토 다이가쿠 전능성 줄기세포의 심근분화 유도방법
WO2014136519A1 (ja) 2013-03-08 2014-09-12 国立大学法人京都大学 Ｅｇｆ受容体阻害剤を含む多能性幹細胞の心筋分化促進剤
WO2015037706A1 (ja) * 2013-09-13 2015-03-19 国立大学法人京都大学 多能性幹細胞の心筋分化を促進する化合物
JP6651218B2 (ja) 2014-05-30 2020-02-19 国立大学法人京都大学 低分子化合物を用いた多能性幹細胞の心筋分化誘導法
CN109776486A (zh) * 2019-02-26 2019-05-21 武汉松石科技股份有限公司 一种硫酸亚丙酯的制备方法
CN110590735B (zh) * 2019-09-30 2021-07-23 江苏国泰超威新材料有限公司 一种环状硫酸酯的制备方法

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JPS61225168A (ja) * 1985-03-30 1986-10-06 Nippon Tokushu Noyaku Seizo Kk 新規ベンズアミド、その製法及び殺虫剤
KR930005004B1 (ko) * 1985-04-15 1993-06-11 쟈안센 파아마슈우티카 엔. 부이. 치환된 n-[(4-피페리디닐)알킬]이환 축합 옥사졸아민 및 티아졸아민의 제조방법
GB8611606D0 (en) * 1986-05-13 1986-06-18 Fbc Ltd Fungicides

Also Published As

Publication number Publication date
PT90622A (pt) 1989-11-30
CN1037898A (zh) 1989-12-13
ATE79114T1 (de) 1992-08-15
NO892059L (no) 1989-11-27
YU105989A (en) 1990-08-31
DE68902358D1 (de) 1992-09-10
SU1681728A3 (ru) 1991-09-30
DK249389D0 (da) 1989-05-23
NO172389C (no) 1993-07-14
MX173140B (es) 1994-02-02
MX16158A (es) 1993-06-01
AU601905B2 (en) 1990-09-20
EP0343893B1 (en) 1992-08-05
ES2043012T3 (es) 1993-12-16
GR3005844T3 (sh) 1993-06-07
DK249389A (da) 1989-11-27
IL90337A0 (en) 1989-12-15
NZ229234A (en) 1990-09-26
HU202507B (en) 1991-03-28
EP0343893A1 (en) 1989-11-29
DD283815A5 (de) 1990-10-24
JPH0678331B2 (ja) 1994-10-05
MY106035A (en) 1995-03-31
PL279613A1 (en) 1989-11-27
CN1023700C (zh) 1994-02-09
NO892059D0 (no) 1989-05-23
PL154875B1 (en) 1991-09-30
AU3509889A (en) 1989-11-30
DE68902358T2 (de) 1992-12-10
CA1328871C (en) 1994-04-26
HUT51606A (en) 1990-05-28
KR890017248A (ko) 1989-12-15
FI892498A (fi) 1989-11-25
JPH0217181A (ja) 1990-01-22
ZA893862B (en) 1991-01-30
FI892498A0 (fi) 1989-05-23
PT90622B (pt) 1994-10-31
IE891667L (en) 1989-11-24
KR910006864B1 (ko) 1991-09-09
NO172389B (no) 1993-04-05

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