AU601905B2 - Substituted benzthiazol-2-yl compounds as antitumor agents - Google Patents

Substituted benzthiazol-2-yl compounds as antitumor agents Download PDF

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Publication number
AU601905B2
AU601905B2 AU35098/89A AU3509889A AU601905B2 AU 601905 B2 AU601905 B2 AU 601905B2 AU 35098/89 A AU35098/89 A AU 35098/89A AU 3509889 A AU3509889 A AU 3509889A AU 601905 B2 AU601905 B2 AU 601905B2
Authority
AU
Australia
Prior art keywords
hydrogen
compound
fluoro
methyl
ethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU35098/89A
Other languages
English (en)
Other versions
AU3509889A (en
Inventor
Anton Franz Josef Fliri
Rodney Caughren Schnur
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
PFIZER
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PFIZER, Pfizer Inc filed Critical PFIZER
Publication of AU3509889A publication Critical patent/AU3509889A/en
Application granted granted Critical
Publication of AU601905B2 publication Critical patent/AU601905B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Graft Or Block Polymers (AREA)
AU35098/89A 1988-05-24 1989-05-23 Substituted benzthiazol-2-yl compounds as antitumor agents Ceased AU601905B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19803488A 1988-05-24 1988-05-24
US198034 1988-05-24

Publications (2)

Publication Number Publication Date
AU3509889A AU3509889A (en) 1989-11-30
AU601905B2 true AU601905B2 (en) 1990-09-20

Family

ID=22731735

Family Applications (1)

Application Number Title Priority Date Filing Date
AU35098/89A Ceased AU601905B2 (en) 1988-05-24 1989-05-23 Substituted benzthiazol-2-yl compounds as antitumor agents

Country Status (25)

Country Link
EP (1) EP0343893B1 (enExample)
JP (1) JPH0678331B2 (enExample)
KR (1) KR910006864B1 (enExample)
CN (1) CN1023700C (enExample)
AT (1) ATE79114T1 (enExample)
AU (1) AU601905B2 (enExample)
CA (1) CA1328871C (enExample)
DD (1) DD283815A5 (enExample)
DE (1) DE68902358T2 (enExample)
DK (1) DK249389A (enExample)
ES (1) ES2043012T3 (enExample)
FI (1) FI892498A7 (enExample)
GR (1) GR3005844T3 (enExample)
HU (1) HU202507B (enExample)
IE (1) IE891667L (enExample)
IL (1) IL90337A0 (enExample)
MX (1) MX173140B (enExample)
MY (1) MY106035A (enExample)
NO (1) NO172389C (enExample)
NZ (1) NZ229234A (enExample)
PL (1) PL154875B1 (enExample)
PT (1) PT90622B (enExample)
SU (1) SU1681728A3 (enExample)
YU (1) YU47019B (enExample)
ZA (1) ZA893862B (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU623500B2 (en) * 1989-02-01 1992-05-14 Hodogaya Chemical Co., Ltd. Carboxylimino benzothiazole derivatives

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5262400A (en) * 1991-06-20 1993-11-16 Merck & Co., Inc. 4α-substituted avermectin derivatives
MX9801716A (es) 1995-08-30 1998-05-31 Searle & Co Derivados de meta-guanidina, urea, tiourea o acido aminobenzoico azaciclico, como antagonistas de integrina.
US6100423A (en) * 1995-08-30 2000-08-08 G. D. Searle & Co. Amino benzenepropanoic acid compounds and derivatives thereof
US5716281A (en) * 1995-11-27 1998-02-10 Sega Enterprises, Ltd. Game apparatus using a vehicle with an optical image synthesizing system
TW513418B (en) * 1996-07-31 2002-12-11 Otsuka Pharma Co Ltd Thiazole derivatives, their production and use
NZ503491A (en) 1997-11-10 2002-08-28 Bristol Myers Squibb Co 2-substituted amino-1,3-benzothiazole derivatives useful as protein tyrosine kinase inhibitors
SI0928793T1 (en) * 1998-01-02 2002-10-31 F. Hoffmann-La Roche Ag Thiazole derivatives
AU3406599A (en) * 1998-04-09 1999-11-01 Institut Fur Diagnostikforschung Gmbh An Der Freien Universitat Berlin Novel benzyl guanidine derivatives for therapy and (in-vivo) and (in-vitro) diagnosis
RU2251419C2 (ru) * 2000-06-21 2005-05-10 Ф. Хоффманн-Ля Рош Аг Производные бензотиазола
US6599901B1 (en) * 2001-11-19 2003-07-29 Hoffman-La Roche Inc. Pyridone substituted benzothiazole derivatives
US6620811B2 (en) * 2001-11-19 2003-09-16 Hoffmann-La Roche Inc. Isonicotin- and nicotinamide derivatives of benzothiazoles
US6624163B2 (en) 2001-11-29 2003-09-23 Hoffman-La Roche Inc. Benzothiazole derivatives
GB0130868D0 (en) * 2001-12-24 2002-02-06 Univ Strathclyde New compounds
CN100357283C (zh) * 2002-04-02 2007-12-26 中国科学院上海药物研究所 一类甲硫氨酰氨肽酶抑制剂
US7087761B2 (en) 2003-01-07 2006-08-08 Hoffmann-La Roche Inc. Cyclization process for substituted benzothiazole derivatives
WO2004101558A1 (en) * 2003-05-13 2004-11-25 F. Hoffmann-La Roche Ag 2-imidazo-benzothiazoles as adenosine receptor ligands
ATE389652T1 (de) * 2003-05-19 2008-04-15 Hoffmann La Roche Benzothiazol-derivate als liganden des adenosinrezeptors
EP1628662B1 (en) * 2003-05-21 2007-02-14 F. Hoffmann-La Roche Ag Benzothiazole derivatives and use thereof in the treatment of diseases related to the adenosine a2a receptor
RU2348629C2 (ru) * 2003-05-30 2009-03-10 Ф.Хоффманн-Ля Рош Аг Производные бензотиазола и их применение при лечении заболеваний, связанных с аденозиновыми a2a-рецепторами
WO2005012296A1 (en) * 2003-07-28 2005-02-10 Janssen Pharmaceutica N.V. Benzimidazole, benzthiazole and benzoxazole derivatives and their use as lta4h modulators
AU2005247567B2 (en) 2004-05-24 2010-09-02 F. Hoffmann-La Roche Ag 4-hydroxy-4-methyl-piperidine-1-carboxylic acid (4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-amide
AU2005263500B2 (en) * 2004-07-22 2011-02-24 F. Hoffmann-La Roche Ag Benzothiazole derivatives
RU2381227C2 (ru) * 2004-07-22 2010-02-10 Ф. Хоффманн-Ля Рош Аг Замещенные бензотиазолы
EP1812392B1 (en) 2004-11-05 2008-07-09 F.Hoffmann-La Roche Ag Process for preparation of isonicotinic acid derivatives
PT1863818E (pt) 2005-03-23 2010-04-09 Hoffmann La Roche Derivados de acetilenil-pirazolo-pirimidina como antagonistas de mglur2
ATE463495T1 (de) 2005-09-27 2010-04-15 Hoffmann La Roche Oxadiazolylpyrazolopyrimidine als mglur2- antagonisten
EP1994017A2 (en) * 2006-03-15 2008-11-26 4Sc Ag Novel heterocyclic nf-kb inhibitors
GB0619325D0 (en) 2006-09-30 2006-11-08 Univ Strathclyde New compounds
EP2311842A3 (en) * 2008-06-24 2011-07-13 Takeda Pharmaceutical Company Limited PI3K/M TOR inhibitors
US9499790B2 (en) 2010-08-26 2016-11-22 Kyoto University Method for promoting differentiation of pluripotent stem cells into cardiac muscle cells
AU2012315953A1 (en) * 2011-09-30 2014-04-03 Kineta, Inc. Anti-viral compounds
JP6274510B2 (ja) 2012-01-27 2018-02-07 国立大学法人京都大学 多能性幹細胞の心筋分化誘導法
JP6351567B2 (ja) 2013-03-08 2018-07-04 国立大学法人京都大学 Ｅｇｆ受容体阻害剤を含む多能性幹細胞の心筋分化促進剤
EP3045451B1 (en) * 2013-09-13 2018-03-28 Kyoto University Compound promoting differentiation of pluripotent stem cells into cardiomyocytes
WO2015182765A1 (ja) 2014-05-30 2015-12-03 国立大学法人京都大学 低分子化合物を用いた多能性幹細胞の心筋分化誘導法
CN109776486A (zh) * 2019-02-26 2019-05-21 武汉松石科技股份有限公司 一种硫酸亚丙酯的制备方法
CN110590735B (zh) * 2019-09-30 2021-07-23 江苏国泰超威新材料有限公司 一种环状硫酸酯的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5533186A (en) * 1985-03-30 1986-10-02 Nihon Tokushu Noyaku Seizo K.K. Benzthiazole and benzoxazole substituted benzamides
AU7279787A (en) * 1986-05-13 1987-12-17 Schering Agrochemicals Limited Benzothiazoline fungicides

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR930005004B1 (ko) * 1985-04-15 1993-06-11 쟈안센 파아마슈우티카 엔. 부이. 치환된 n-[(4-피페리디닐)알킬]이환 축합 옥사졸아민 및 티아졸아민의 제조방법

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5533186A (en) * 1985-03-30 1986-10-02 Nihon Tokushu Noyaku Seizo K.K. Benzthiazole and benzoxazole substituted benzamides
AU7279787A (en) * 1986-05-13 1987-12-17 Schering Agrochemicals Limited Benzothiazoline fungicides

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU623500B2 (en) * 1989-02-01 1992-05-14 Hodogaya Chemical Co., Ltd. Carboxylimino benzothiazole derivatives

Also Published As

Publication number Publication date
PT90622A (pt) 1989-11-30
JPH0678331B2 (ja) 1994-10-05
YU105989A (en) 1990-08-31
MY106035A (en) 1995-03-31
FI892498A7 (fi) 1989-11-25
NO172389C (no) 1993-07-14
DE68902358D1 (de) 1992-09-10
NO892059D0 (no) 1989-05-23
DD283815A5 (de) 1990-10-24
ES2043012T3 (es) 1993-12-16
HUT51606A (en) 1990-05-28
DK249389A (da) 1989-11-27
HU202507B (en) 1991-03-28
NZ229234A (en) 1990-09-26
SU1681728A3 (ru) 1991-09-30
CN1023700C (zh) 1994-02-09
ATE79114T1 (de) 1992-08-15
DK249389D0 (da) 1989-05-23
GR3005844T3 (enExample) 1993-06-07
IL90337A0 (en) 1989-12-15
EP0343893A1 (en) 1989-11-29
PT90622B (pt) 1994-10-31
PL154875B1 (en) 1991-09-30
JPH0217181A (ja) 1990-01-22
PL279613A1 (en) 1989-11-27
AU3509889A (en) 1989-11-30
KR910006864B1 (ko) 1991-09-09
EP0343893B1 (en) 1992-08-05
YU47019B (sh) 1994-11-15
KR890017248A (ko) 1989-12-15
CA1328871C (en) 1994-04-26
NO892059L (no) 1989-11-27
CN1037898A (zh) 1989-12-13
ZA893862B (en) 1991-01-30
MX173140B (es) 1994-02-02
FI892498A0 (fi) 1989-05-23
DE68902358T2 (de) 1992-12-10
MX16158A (es) 1993-06-01
IE891667L (en) 1989-11-24
NO172389B (no) 1993-04-05

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