CN1023700C - 芳族及杂环甲酰胺衍生物抗肿瘤剂的制备 - Google Patents

芳族及杂环甲酰胺衍生物抗肿瘤剂的制备 Download PDF

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Publication number
CN1023700C
CN1023700C CN89103540A CN89103540A CN1023700C CN 1023700 C CN1023700 C CN 1023700C CN 89103540 A CN89103540 A CN 89103540A CN 89103540 A CN89103540 A CN 89103540A CN 1023700 C CN1023700 C CN 1023700C
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China
Prior art keywords
hydrogen
alkyl
product
methyl
acid
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Expired - Fee Related
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CN89103540A
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Chinese (zh)
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CN1037898A (zh
Inventor
安东·弗朗兹·约瑟夫·弗里利
罗德尼·考伦·斯纽尔
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Pfizer Inc
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Pfizer Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Steroid Compounds (AREA)
  • Graft Or Block Polymers (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN89103540A 1988-05-24 1989-05-24 芳族及杂环甲酰胺衍生物抗肿瘤剂的制备 Expired - Fee Related CN1023700C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19803488A 1988-05-24 1988-05-24
US198,034 1988-05-24

Publications (2)

Publication Number Publication Date
CN1037898A CN1037898A (zh) 1989-12-13
CN1023700C true CN1023700C (zh) 1994-02-09

Family

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CN89103540A Expired - Fee Related CN1023700C (zh) 1988-05-24 1989-05-24 芳族及杂环甲酰胺衍生物抗肿瘤剂的制备

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EP (1) EP0343893B1 (enExample)
JP (1) JPH0678331B2 (enExample)
KR (1) KR910006864B1 (enExample)
CN (1) CN1023700C (enExample)
AT (1) ATE79114T1 (enExample)
AU (1) AU601905B2 (enExample)
CA (1) CA1328871C (enExample)
DD (1) DD283815A5 (enExample)
DE (1) DE68902358T2 (enExample)
DK (1) DK249389A (enExample)
ES (1) ES2043012T3 (enExample)
FI (1) FI892498A7 (enExample)
GR (1) GR3005844T3 (enExample)
HU (1) HU202507B (enExample)
IE (1) IE891667L (enExample)
IL (1) IL90337A0 (enExample)
MX (1) MX173140B (enExample)
MY (1) MY106035A (enExample)
NO (1) NO172389C (enExample)
NZ (1) NZ229234A (enExample)
PL (1) PL154875B1 (enExample)
PT (1) PT90622B (enExample)
SU (1) SU1681728A3 (enExample)
YU (1) YU47019B (enExample)
ZA (1) ZA893862B (enExample)

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JP2790299B2 (ja) * 1989-02-01 1998-08-27 保土谷化学工業株式会社 ペンゾチアゾール誘導体
US5262400A (en) * 1991-06-20 1993-11-16 Merck & Co., Inc. 4α-substituted avermectin derivatives
US6100423A (en) * 1995-08-30 2000-08-08 G. D. Searle & Co. Amino benzenepropanoic acid compounds and derivatives thereof
CZ293323B6 (cs) * 1995-08-30 2004-04-14 G. D. Searle & Co. Meta-guanidinové, močovinové, thiomočovinové nebo azacyklické deriváty aminobenzoové kyseliny jako antagonisty integrinů
US5716281A (en) * 1995-11-27 1998-02-10 Sega Enterprises, Ltd. Game apparatus using a vehicle with an optical image synthesizing system
TW513418B (en) * 1996-07-31 2002-12-11 Otsuka Pharma Co Ltd Thiazole derivatives, their production and use
CA2309319A1 (en) 1997-11-10 1999-05-20 Bristol-Myers Squibb Company Benzothiazole protein tyrosine kinase inhibitors
EP0928793B1 (en) * 1998-01-02 2002-05-15 F. Hoffmann-La Roche Ag Thiazole derivatives
AU3406599A (en) * 1998-04-09 1999-11-01 Institut Fur Diagnostikforschung Gmbh An Der Freien Universitat Berlin Novel benzyl guanidine derivatives for therapy and (in-vivo) and (in-vitro) diagnosis
NZ522928A (en) 2000-06-21 2005-05-27 F Benzothiazole derivatives
US6620811B2 (en) * 2001-11-19 2003-09-16 Hoffmann-La Roche Inc. Isonicotin- and nicotinamide derivatives of benzothiazoles
US6599901B1 (en) * 2001-11-19 2003-07-29 Hoffman-La Roche Inc. Pyridone substituted benzothiazole derivatives
US6624163B2 (en) * 2001-11-29 2003-09-23 Hoffman-La Roche Inc. Benzothiazole derivatives
GB0130868D0 (en) 2001-12-24 2002-02-06 Univ Strathclyde New compounds
CN100357283C (zh) * 2002-04-02 2007-12-26 中国科学院上海药物研究所 一类甲硫氨酰氨肽酶抑制剂
US7087761B2 (en) 2003-01-07 2006-08-08 Hoffmann-La Roche Inc. Cyclization process for substituted benzothiazole derivatives
DE602004016328D1 (de) * 2003-05-13 2008-10-16 Hoffmann La Roche 2-imidazo-benzothiazole als adenosin-rezeptor liganden
AU2004251814B2 (en) * 2003-05-19 2009-07-23 F. Hoffmann-La Roche Ag Benzothiazole derivatives as adenosine receptor ligands
EP1628662B1 (en) * 2003-05-21 2007-02-14 F. Hoffmann-La Roche Ag Benzothiazole derivatives and use thereof in the treatment of diseases related to the adenosine a2a receptor
MXPA05012772A (es) * 2003-05-30 2006-02-13 Hoffmann La Roche Derivados de benzotiazol y uso de los mismos en el tratamiento de enfermedades relacionadas con el receptor a2a de adenosina.
PT1660491E (pt) * 2003-07-28 2008-10-10 Janssen Pharmaceutica Nv Derivados de benzimidazole, benzotiazole e benzoxazole e a sua utilização como moduladores de lta4h
CN1956983B (zh) 2004-05-24 2010-05-26 弗·哈夫曼-拉罗切有限公司 4-羟基-4-甲基-哌啶-1-甲酸(4-甲氧基-7-吗啉-4-基-苯并噻唑-2-基)-酰胺
EP1773827B1 (en) * 2004-07-22 2010-02-17 F.Hoffmann-La Roche Ag Benzothiazole derivatives
KR100818028B1 (ko) * 2004-07-22 2008-03-31 에프. 호프만-라 로슈 아게 치환된 벤조티아졸
CA2586931C (en) 2004-11-05 2013-08-06 Paul Spurr Process for preparation of isonicotinic acid derivatives
RU2412943C2 (ru) 2005-03-23 2011-02-27 Ф. Хоффманн-Ля Рош Аг ПРОИЗВОДНЫЕ АЦЕТИЛЕНИЛ-ПИРАЗОЛО-ПИРИМИДИНА В КАЧЕСТВЕ АНТАГОНИСТОВ mGluR2
ES2340321T3 (es) 2005-09-27 2010-06-01 F.Hoffmann-La Roche Ag Oxadiazolilpirazolo-pirimidinas, como antagonistas de mglur2.
WO2007104557A2 (en) * 2006-03-15 2007-09-20 4Sc Ag Novel heterocyclic nf-kb inhibitors
GB0619325D0 (en) 2006-09-30 2006-11-08 Univ Strathclyde New compounds
EP2311842A3 (en) * 2008-06-24 2011-07-13 Takeda Pharmaceutical Company Limited PI3K/M TOR inhibitors
US9499790B2 (en) 2010-08-26 2016-11-22 Kyoto University Method for promoting differentiation of pluripotent stem cells into cardiac muscle cells
AP2014007595A0 (en) * 2011-09-30 2014-04-30 Kineta Inc Anti-viral compounds
WO2013111875A1 (ja) 2012-01-27 2013-08-01 国立大学法人京都大学 多能性幹細胞の心筋分化誘導法
US10196609B2 (en) 2013-03-08 2019-02-05 Kyoto University Composition for promoting cardiac differentiation of pluripotent stem cell comprising EGFR inhibitor
EP3045451B1 (en) * 2013-09-13 2018-03-28 Kyoto University Compound promoting differentiation of pluripotent stem cells into cardiomyocytes
WO2015182765A1 (ja) 2014-05-30 2015-12-03 国立大学法人京都大学 低分子化合物を用いた多能性幹細胞の心筋分化誘導法
CN109776486A (zh) * 2019-02-26 2019-05-21 武汉松石科技股份有限公司 一种硫酸亚丙酯的制备方法
CN110590735B (zh) * 2019-09-30 2021-07-23 江苏国泰超威新材料有限公司 一种环状硫酸酯的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61225168A (ja) * 1985-03-30 1986-10-06 Nippon Tokushu Noyaku Seizo Kk 新規ベンズアミド、その製法及び殺虫剤
KR930005004B1 (ko) * 1985-04-15 1993-06-11 쟈안센 파아마슈우티카 엔. 부이. 치환된 n-[(4-피페리디닐)알킬]이환 축합 옥사졸아민 및 티아졸아민의 제조방법
GB8611606D0 (en) * 1986-05-13 1986-06-18 Fbc Ltd Fungicides

Also Published As

Publication number Publication date
ZA893862B (en) 1991-01-30
CN1037898A (zh) 1989-12-13
PL154875B1 (en) 1991-09-30
NO892059D0 (no) 1989-05-23
YU47019B (sh) 1994-11-15
NO172389C (no) 1993-07-14
DD283815A5 (de) 1990-10-24
NZ229234A (en) 1990-09-26
IL90337A0 (en) 1989-12-15
FI892498A0 (fi) 1989-05-23
KR890017248A (ko) 1989-12-15
FI892498A7 (fi) 1989-11-25
DE68902358T2 (de) 1992-12-10
JPH0217181A (ja) 1990-01-22
PL279613A1 (en) 1989-11-27
MY106035A (en) 1995-03-31
JPH0678331B2 (ja) 1994-10-05
NO172389B (no) 1993-04-05
PT90622B (pt) 1994-10-31
MX173140B (es) 1994-02-02
ES2043012T3 (es) 1993-12-16
DE68902358D1 (de) 1992-09-10
NO892059L (no) 1989-11-27
IE891667L (en) 1989-11-24
YU105989A (en) 1990-08-31
HU202507B (en) 1991-03-28
ATE79114T1 (de) 1992-08-15
KR910006864B1 (ko) 1991-09-09
MX16158A (es) 1993-06-01
GR3005844T3 (enExample) 1993-06-07
EP0343893A1 (en) 1989-11-29
DK249389A (da) 1989-11-27
EP0343893B1 (en) 1992-08-05
SU1681728A3 (ru) 1991-09-30
HUT51606A (en) 1990-05-28
CA1328871C (en) 1994-04-26
AU601905B2 (en) 1990-09-20
PT90622A (pt) 1989-11-30
DK249389D0 (da) 1989-05-23
AU3509889A (en) 1989-11-30

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