KR910006864B1 - 종양억제제인 방향족 및 헤테로사이클릭 카복스아미드 유도체 - Google Patents

종양억제제인 방향족 및 헤테로사이클릭 카복스아미드 유도체 Download PDF

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Publication number
KR910006864B1
KR910006864B1 KR1019890006889A KR890006889A KR910006864B1 KR 910006864 B1 KR910006864 B1 KR 910006864B1 KR 1019890006889 A KR1019890006889 A KR 1019890006889A KR 890006889 A KR890006889 A KR 890006889A KR 910006864 B1 KR910006864 B1 KR 910006864B1
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KR
South Korea
Prior art keywords
hydrogen
compound
fluoro
methyl
chloro
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Expired
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KR1019890006889A
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English (en)
Korean (ko)
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KR890017248A (ko
Inventor
프라츠 조세프 플리리 안톤
카우렌 슈너 로드니
Original Assignee
화이자 인코포레이티드
윌리암 데이비스 헌
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Publication of KR890017248A publication Critical patent/KR890017248A/ko
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Publication of KR910006864B1 publication Critical patent/KR910006864B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Graft Or Block Polymers (AREA)
KR1019890006889A 1988-05-24 1989-05-23 종양억제제인 방향족 및 헤테로사이클릭 카복스아미드 유도체 Expired KR910006864B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19803488A 1988-05-24 1988-05-24
US198034 1988-05-24

Publications (2)

Publication Number Publication Date
KR890017248A KR890017248A (ko) 1989-12-15
KR910006864B1 true KR910006864B1 (ko) 1991-09-09

Family

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KR1019890006889A Expired KR910006864B1 (ko) 1988-05-24 1989-05-23 종양억제제인 방향족 및 헤테로사이클릭 카복스아미드 유도체

Country Status (25)

Country Link
EP (1) EP0343893B1 (enExample)
JP (1) JPH0678331B2 (enExample)
KR (1) KR910006864B1 (enExample)
CN (1) CN1023700C (enExample)
AT (1) ATE79114T1 (enExample)
AU (1) AU601905B2 (enExample)
CA (1) CA1328871C (enExample)
DD (1) DD283815A5 (enExample)
DE (1) DE68902358T2 (enExample)
DK (1) DK249389A (enExample)
ES (1) ES2043012T3 (enExample)
FI (1) FI892498A7 (enExample)
GR (1) GR3005844T3 (enExample)
HU (1) HU202507B (enExample)
IE (1) IE891667L (enExample)
IL (1) IL90337A0 (enExample)
MX (1) MX173140B (enExample)
MY (1) MY106035A (enExample)
NO (1) NO172389C (enExample)
NZ (1) NZ229234A (enExample)
PL (1) PL154875B1 (enExample)
PT (1) PT90622B (enExample)
SU (1) SU1681728A3 (enExample)
YU (1) YU47019B (enExample)
ZA (1) ZA893862B (enExample)

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JP2790299B2 (ja) * 1989-02-01 1998-08-27 保土谷化学工業株式会社 ペンゾチアゾール誘導体
US5262400A (en) * 1991-06-20 1993-11-16 Merck & Co., Inc. 4α-substituted avermectin derivatives
ATE203234T1 (de) 1995-08-30 2001-08-15 Searle & Co Meta-guanidine, harnstoff, thioharnstoff oder azacyklische aminobenzoesäure-derivate als integrin antagonisten
US6100423A (en) * 1995-08-30 2000-08-08 G. D. Searle & Co. Amino benzenepropanoic acid compounds and derivatives thereof
US5716281A (en) * 1995-11-27 1998-02-10 Sega Enterprises, Ltd. Game apparatus using a vehicle with an optical image synthesizing system
TW513418B (en) * 1996-07-31 2002-12-11 Otsuka Pharma Co Ltd Thiazole derivatives, their production and use
ID24289A (id) 1997-11-10 2000-07-13 Bristol Myers Squibb Co Benzotiazol inhibitor-inhibitor protein terosin kinase
SI0928793T1 (en) * 1998-01-02 2002-10-31 F. Hoffmann-La Roche Ag Thiazole derivatives
AU3406599A (en) * 1998-04-09 1999-11-01 Institut Fur Diagnostikforschung Gmbh An Der Freien Universitat Berlin Novel benzyl guanidine derivatives for therapy and (in-vivo) and (in-vitro) diagnosis
JP3886897B2 (ja) 2000-06-21 2007-02-28 エフ．ホフマン−ラ ロシュ アーゲー ベンゾチアゾール誘導体
US6620811B2 (en) * 2001-11-19 2003-09-16 Hoffmann-La Roche Inc. Isonicotin- and nicotinamide derivatives of benzothiazoles
US6599901B1 (en) * 2001-11-19 2003-07-29 Hoffman-La Roche Inc. Pyridone substituted benzothiazole derivatives
US6624163B2 (en) * 2001-11-29 2003-09-23 Hoffman-La Roche Inc. Benzothiazole derivatives
GB0130868D0 (en) * 2001-12-24 2002-02-06 Univ Strathclyde New compounds
CN100357283C (zh) * 2002-04-02 2007-12-26 中国科学院上海药物研究所 一类甲硫氨酰氨肽酶抑制剂
US7087761B2 (en) 2003-01-07 2006-08-08 Hoffmann-La Roche Inc. Cyclization process for substituted benzothiazole derivatives
PL1636217T3 (pl) * 2003-05-13 2009-02-27 Hoffmann La Roche 1-Imidazobenzotiazole jako ligandy receptora adenozynowego
SI1636223T1 (sl) * 2003-05-19 2008-06-30 Hoffmann La Roche Derivati benzotiazola kot ligandi receptorja adenozina
KR100765565B1 (ko) * 2003-05-21 2007-10-09 에프. 호프만-라 로슈 아게 벤조티아졸 유도체 및 그의 아데노신 에이2에이 수용체에관련된 질병의 치료에서의 용도
ATE396726T1 (de) * 2003-05-30 2008-06-15 Hoffmann La Roche Benzothiazole derivate und ihre anwendung in der behandlung von adenosine a2a rezeptor vermittelte krankheiten
KR20060054408A (ko) * 2003-07-28 2006-05-22 얀센 파마슈티카 엔.브이. 벤즈이미다졸, 벤즈티아졸 및 벤즈옥사졸 유도체 및ｌｔａ4 ｈ 조정자로서의 그의 용도
PT1753760E (pt) 2004-05-24 2008-02-12 Hoffmann La Roche '' - metoxi - 7 - morfolin - 4 - il - benzotiazol - 2 - il) - amida do ácido 4 - hidroxi - 4 - metil - piperidina - 1 - carboxílico''
JP2008506735A (ja) * 2004-07-22 2008-03-06 エフ．ホフマン−ラ　ロシュ　アーゲー 置換されているベンゾチアゾール類
JP5202946B2 (ja) * 2004-07-22 2013-06-05 エフ．ホフマン−ラ ロシュ アーゲー ベンゾチアゾール誘導体
US7459563B2 (en) 2004-11-05 2008-12-02 Hoffmann-La Roche Inc. Process for the preparation of isonicotinic acid derivatives
DK1863818T3 (da) 2005-03-23 2010-05-10 Hoffmann La Roche Acetylenyl-pyrazolo-pyrimidinderivater som mglur2-antagonister
KR101121292B1 (ko) 2005-09-27 2012-04-13 에프. 호프만-라 로슈 아게 Ｍｇｌｕｒ2 길항제로서 옥사다이아졸일 피라졸로-피리미딘
WO2007104557A2 (en) * 2006-03-15 2007-09-20 4Sc Ag Novel heterocyclic nf-kb inhibitors
GB0619325D0 (en) 2006-09-30 2006-11-08 Univ Strathclyde New compounds
EP2303886A2 (en) * 2008-06-24 2011-04-06 Takeda Pharmaceutical Company Limited Pi3k/m tor inhibitors
US9499790B2 (en) 2010-08-26 2016-11-22 Kyoto University Method for promoting differentiation of pluripotent stem cells into cardiac muscle cells
AU2012315953A1 (en) * 2011-09-30 2014-04-03 Kineta, Inc. Anti-viral compounds
EP2808383B1 (en) 2012-01-27 2018-07-25 Kyoto University Method for inducing cardiac differentiation of pluripotent stem cell
JP6351567B2 (ja) 2013-03-08 2018-07-04 国立大学法人京都大学 Ｅｇｆ受容体阻害剤を含む多能性幹細胞の心筋分化促進剤
WO2015037706A1 (ja) * 2013-09-13 2015-03-19 国立大学法人京都大学 多能性幹細胞の心筋分化を促進する化合物
WO2015182765A1 (ja) 2014-05-30 2015-12-03 国立大学法人京都大学 低分子化合物を用いた多能性幹細胞の心筋分化誘導法
CN109776486A (zh) * 2019-02-26 2019-05-21 武汉松石科技股份有限公司 一种硫酸亚丙酯的制备方法
CN110590735B (zh) * 2019-09-30 2021-07-23 江苏国泰超威新材料有限公司 一种环状硫酸酯的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61225168A (ja) * 1985-03-30 1986-10-06 Nippon Tokushu Noyaku Seizo Kk 新規ベンズアミド、その製法及び殺虫剤
KR930005004B1 (ko) * 1985-04-15 1993-06-11 쟈안센 파아마슈우티카 엔. 부이. 치환된 n-[(4-피페리디닐)알킬]이환 축합 옥사졸아민 및 티아졸아민의 제조방법
GB8611606D0 (en) * 1986-05-13 1986-06-18 Fbc Ltd Fungicides

Also Published As

Publication number Publication date
MX16158A (es) 1993-06-01
CN1023700C (zh) 1994-02-09
PT90622B (pt) 1994-10-31
IL90337A0 (en) 1989-12-15
KR890017248A (ko) 1989-12-15
DK249389A (da) 1989-11-27
HU202507B (en) 1991-03-28
NO172389B (no) 1993-04-05
DK249389D0 (da) 1989-05-23
DE68902358T2 (de) 1992-12-10
ES2043012T3 (es) 1993-12-16
NO892059L (no) 1989-11-27
PL154875B1 (en) 1991-09-30
JPH0678331B2 (ja) 1994-10-05
JPH0217181A (ja) 1990-01-22
SU1681728A3 (ru) 1991-09-30
NZ229234A (en) 1990-09-26
ZA893862B (en) 1991-01-30
EP0343893B1 (en) 1992-08-05
FI892498A0 (fi) 1989-05-23
CA1328871C (en) 1994-04-26
EP0343893A1 (en) 1989-11-29
IE891667L (en) 1989-11-24
YU105989A (en) 1990-08-31
NO892059D0 (no) 1989-05-23
ATE79114T1 (de) 1992-08-15
CN1037898A (zh) 1989-12-13
MY106035A (en) 1995-03-31
PT90622A (pt) 1989-11-30
AU601905B2 (en) 1990-09-20
DE68902358D1 (de) 1992-09-10
DD283815A5 (de) 1990-10-24
GR3005844T3 (enExample) 1993-06-07
FI892498A7 (fi) 1989-11-25
YU47019B (sh) 1994-11-15
HUT51606A (en) 1990-05-28
NO172389C (no) 1993-07-14
MX173140B (es) 1994-02-02
AU3509889A (en) 1989-11-30
PL279613A1 (en) 1989-11-27

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