DE68902358T2 - Aromatische und heterocyclische carboxamide als antineoplastische mittel. - Google Patents

Aromatische und heterocyclische carboxamide als antineoplastische mittel.

Info

Publication number
DE68902358T2
DE68902358T2 DE8989305141T DE68902358T DE68902358T2 DE 68902358 T2 DE68902358 T2 DE 68902358T2 DE 8989305141 T DE8989305141 T DE 8989305141T DE 68902358 T DE68902358 T DE 68902358T DE 68902358 T2 DE68902358 T2 DE 68902358T2
Authority
DE
Germany
Prior art keywords
hydrogen
compound
fluoro
alkyl
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8989305141T
Other languages
German (de)
English (en)
Other versions
DE68902358D1 (de
Inventor
Anton Franz Josef Fliri
Rodney Caughren Schnur
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Original Assignee
Pfizer Corp Belgium
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium filed Critical Pfizer Corp Belgium
Publication of DE68902358D1 publication Critical patent/DE68902358D1/de
Application granted granted Critical
Publication of DE68902358T2 publication Critical patent/DE68902358T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Graft Or Block Polymers (AREA)
DE8989305141T 1988-05-24 1989-05-22 Aromatische und heterocyclische carboxamide als antineoplastische mittel. Expired - Lifetime DE68902358T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19803488A 1988-05-24 1988-05-24

Publications (2)

Publication Number Publication Date
DE68902358D1 DE68902358D1 (de) 1992-09-10
DE68902358T2 true DE68902358T2 (de) 1992-12-10

Family

ID=22731735

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8989305141T Expired - Lifetime DE68902358T2 (de) 1988-05-24 1989-05-22 Aromatische und heterocyclische carboxamide als antineoplastische mittel.

Country Status (25)

Country Link
EP (1) EP0343893B1 (enExample)
JP (1) JPH0678331B2 (enExample)
KR (1) KR910006864B1 (enExample)
CN (1) CN1023700C (enExample)
AT (1) ATE79114T1 (enExample)
AU (1) AU601905B2 (enExample)
CA (1) CA1328871C (enExample)
DD (1) DD283815A5 (enExample)
DE (1) DE68902358T2 (enExample)
DK (1) DK249389A (enExample)
ES (1) ES2043012T3 (enExample)
FI (1) FI892498A7 (enExample)
GR (1) GR3005844T3 (enExample)
HU (1) HU202507B (enExample)
IE (1) IE891667L (enExample)
IL (1) IL90337A0 (enExample)
MX (1) MX173140B (enExample)
MY (1) MY106035A (enExample)
NO (1) NO172389C (enExample)
NZ (1) NZ229234A (enExample)
PL (1) PL154875B1 (enExample)
PT (1) PT90622B (enExample)
SU (1) SU1681728A3 (enExample)
YU (1) YU47019B (enExample)
ZA (1) ZA893862B (enExample)

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JP2790299B2 (ja) * 1989-02-01 1998-08-27 保土谷化学工業株式会社 ペンゾチアゾール誘導体
US5262400A (en) * 1991-06-20 1993-11-16 Merck & Co., Inc. 4α-substituted avermectin derivatives
US6100423A (en) * 1995-08-30 2000-08-08 G. D. Searle & Co. Amino benzenepropanoic acid compounds and derivatives thereof
NZ318926A (en) * 1995-08-30 1999-04-29 Searle & Co Alpha v beta 3 integrin (vitronectin) inhibitors or anatagonists derived from benzoic acid for treating diseases of cell adhesion
US5716281A (en) * 1995-11-27 1998-02-10 Sega Enterprises, Ltd. Game apparatus using a vehicle with an optical image synthesizing system
TW513418B (en) * 1996-07-31 2002-12-11 Otsuka Pharma Co Ltd Thiazole derivatives, their production and use
IL135176A0 (en) 1997-11-10 2001-05-20 Bristol Myers Squibb Co Benzothiazole derivatives and pharmaceutical compositions containing the same
SI0928793T1 (en) * 1998-01-02 2002-10-31 F. Hoffmann-La Roche Ag Thiazole derivatives
AU3406599A (en) * 1998-04-09 1999-11-01 Institut Fur Diagnostikforschung Gmbh An Der Freien Universitat Berlin Novel benzyl guanidine derivatives for therapy and (in-vivo) and (in-vitro) diagnosis
CN1234358C (zh) 2000-06-21 2006-01-04 弗·哈夫曼-拉罗切有限公司 苯并噻唑衍生物
US6599901B1 (en) * 2001-11-19 2003-07-29 Hoffman-La Roche Inc. Pyridone substituted benzothiazole derivatives
US6620811B2 (en) * 2001-11-19 2003-09-16 Hoffmann-La Roche Inc. Isonicotin- and nicotinamide derivatives of benzothiazoles
US6624163B2 (en) * 2001-11-29 2003-09-23 Hoffman-La Roche Inc. Benzothiazole derivatives
GB0130868D0 (en) * 2001-12-24 2002-02-06 Univ Strathclyde New compounds
CN100357283C (zh) * 2002-04-02 2007-12-26 中国科学院上海药物研究所 一类甲硫氨酰氨肽酶抑制剂
US7087761B2 (en) 2003-01-07 2006-08-08 Hoffmann-La Roche Inc. Cyclization process for substituted benzothiazole derivatives
RU2340612C2 (ru) * 2003-05-13 2008-12-10 Ф.Хоффманн-Ля Рош Аг 2-имидазобензотиазолы как лиганды аденозинового рецептора
AU2004251814B2 (en) * 2003-05-19 2009-07-23 F. Hoffmann-La Roche Ag Benzothiazole derivatives as adenosine receptor ligands
ES2280964T3 (es) * 2003-05-21 2007-09-16 F. Hoffmann-La Roche Ag Derivados de benzotiazol y uso de los mismos en el tratamiento de enfermedades relacionadas con el receptor a2a de adenosina.
DK1633355T3 (da) * 2003-05-30 2008-08-04 Hoffmann La Roche Benzothiazol-derivater og anvendelse deraf i behandlingen af sygdomme der er relateret til adenosin A2A-receptoren
AU2004261610B2 (en) * 2003-07-28 2010-05-20 Janssen Pharmaceutica N.V. Benzimidazole, benzthiazole and benzoxazole derivatives and their use as LTA4H modulators
EP1753760B1 (en) 2004-05-24 2008-01-02 F.Hoffmann-La Roche Ag 4-hydroxy-4-methyl-piperidine-1-carboxylic acid (4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-amide
EP1773795A1 (en) * 2004-07-22 2007-04-18 F.Hoffmann-La Roche Ag Substituted benzothiazoles
CN1989139B (zh) * 2004-07-22 2010-05-12 弗·哈夫曼-拉罗切有限公司 苯并噻唑衍生物
CN101056857B (zh) 2004-11-05 2010-12-01 弗·哈夫曼-拉罗切有限公司 异烟酸衍生物的制备方法
KR100973609B1 (ko) 2005-03-23 2010-08-03 에프. 호프만-라 로슈 아게 ｍＧｌｕＲ2 길항제로서 아세틸렌일-피라졸로-피리미딘유도체
CA2623721C (en) 2005-09-27 2014-05-13 F. Hoffmann-La Roche Ag Oxadiazolyl pyrazolo-pyrimidines as mglur2 antagonists
CN101405278A (zh) * 2006-03-15 2009-04-08 4Sc股份公司 新颖的杂环NF-κB抑制剂
GB0619325D0 (en) 2006-09-30 2006-11-08 Univ Strathclyde New compounds
JP2011525535A (ja) * 2008-06-24 2011-09-22 武田薬品工業株式会社 ＰＩ３Ｋ／ｍＴＯＲ阻害剤
US9499790B2 (en) 2010-08-26 2016-11-22 Kyoto University Method for promoting differentiation of pluripotent stem cells into cardiac muscle cells
AP2014007595A0 (en) * 2011-09-30 2014-04-30 Kineta Inc Anti-viral compounds
JP6274510B2 (ja) 2012-01-27 2018-02-07 国立大学法人京都大学 多能性幹細胞の心筋分化誘導法
WO2014136519A1 (ja) 2013-03-08 2014-09-12 国立大学法人京都大学 Ｅｇｆ受容体阻害剤を含む多能性幹細胞の心筋分化促進剤
EP3045451B1 (en) * 2013-09-13 2018-03-28 Kyoto University Compound promoting differentiation of pluripotent stem cells into cardiomyocytes
EP3150705B1 (en) 2014-05-30 2019-05-15 Kyoto University Method for inducing myocardial differentiation of pluripotent stem cells using low-molecular compound
CN109776486A (zh) * 2019-02-26 2019-05-21 武汉松石科技股份有限公司 一种硫酸亚丙酯的制备方法
CN110590735B (zh) * 2019-09-30 2021-07-23 江苏国泰超威新材料有限公司 一种环状硫酸酯的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61225168A (ja) * 1985-03-30 1986-10-06 Nippon Tokushu Noyaku Seizo Kk 新規ベンズアミド、その製法及び殺虫剤
KR930005004B1 (ko) * 1985-04-15 1993-06-11 쟈안센 파아마슈우티카 엔. 부이. 치환된 n-[(4-피페리디닐)알킬]이환 축합 옥사졸아민 및 티아졸아민의 제조방법
GB8611606D0 (en) * 1986-05-13 1986-06-18 Fbc Ltd Fungicides

Also Published As

Publication number Publication date
PL279613A1 (en) 1989-11-27
PL154875B1 (en) 1991-09-30
AU601905B2 (en) 1990-09-20
JPH0678331B2 (ja) 1994-10-05
MY106035A (en) 1995-03-31
ZA893862B (en) 1991-01-30
NO172389C (no) 1993-07-14
CA1328871C (en) 1994-04-26
PT90622B (pt) 1994-10-31
FI892498A7 (fi) 1989-11-25
NO892059D0 (no) 1989-05-23
ES2043012T3 (es) 1993-12-16
MX16158A (es) 1993-06-01
YU105989A (en) 1990-08-31
EP0343893A1 (en) 1989-11-29
IL90337A0 (en) 1989-12-15
ATE79114T1 (de) 1992-08-15
CN1023700C (zh) 1994-02-09
DE68902358D1 (de) 1992-09-10
EP0343893B1 (en) 1992-08-05
CN1037898A (zh) 1989-12-13
MX173140B (es) 1994-02-02
FI892498A0 (fi) 1989-05-23
NO172389B (no) 1993-04-05
YU47019B (sh) 1994-11-15
IE891667L (en) 1989-11-24
KR910006864B1 (ko) 1991-09-09
DK249389D0 (da) 1989-05-23
NO892059L (no) 1989-11-27
KR890017248A (ko) 1989-12-15
PT90622A (pt) 1989-11-30
DD283815A5 (de) 1990-10-24
NZ229234A (en) 1990-09-26
SU1681728A3 (ru) 1991-09-30
AU3509889A (en) 1989-11-30
HUT51606A (en) 1990-05-28
GR3005844T3 (enExample) 1993-06-07
JPH0217181A (ja) 1990-01-22
DK249389A (da) 1989-11-27
HU202507B (en) 1991-03-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee