MX351818B - Compuestos antivirales. - Google Patents

Compuestos antivirales.

Info

Publication number
MX351818B
MX351818B MX2014003887A MX2014003887A MX351818B MX 351818 B MX351818 B MX 351818B MX 2014003887 A MX2014003887 A MX 2014003887A MX 2014003887 A MX2014003887 A MX 2014003887A MX 351818 B MX351818 B MX 351818B
Authority
MX
Mexico
Prior art keywords
compounds
viral compounds
rig
pathway
viral infection
Prior art date
Application number
MX2014003887A
Other languages
English (en)
Other versions
MX2014003887A (es
Inventor
P Iadonato Shawn
Bedard Kristin
Wang Imanaka Myra
W Fowler Kerry
Original Assignee
Kineta Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kineta Inc filed Critical Kineta Inc
Publication of MX2014003887A publication Critical patent/MX2014003887A/es
Publication of MX351818B publication Critical patent/MX351818B/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

En la presente se describen los compuestos y las composiciones relacionadas para el tratamiento de una infección viral, que incluye la infección viral de ARN, y los compuestos que pueden modular la ruta de RIG-l en las células de vertebrados, que incluyen los compuestos que pueden activar la ruta de RIG-l.
MX2014003887A 2011-09-30 2012-09-27 Compuestos antivirales. MX351818B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161542049P 2011-09-30 2011-09-30
PCT/US2012/057646 WO2013049407A2 (en) 2011-09-30 2012-09-27 Anti-viral compounds

Publications (2)

Publication Number Publication Date
MX2014003887A MX2014003887A (es) 2014-11-21
MX351818B true MX351818B (es) 2017-10-30

Family

ID=47996748

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014003887A MX351818B (es) 2011-09-30 2012-09-27 Compuestos antivirales.

Country Status (16)

Country Link
US (2) US9555106B2 (es)
EP (1) EP2748172B1 (es)
JP (2) JP2014528412A (es)
KR (1) KR20140070631A (es)
CN (1) CN103857683B (es)
AP (1) AP2014007595A0 (es)
AU (3) AU2012315953A1 (es)
BR (1) BR112014007599A2 (es)
CA (1) CA2859946C (es)
HK (1) HK1199029A1 (es)
IL (1) IL231780A (es)
MX (1) MX351818B (es)
SG (1) SG11201401084TA (es)
TW (1) TW201326163A (es)
WO (1) WO2013049407A2 (es)
ZA (1) ZA201401825B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112014007599A2 (pt) 2011-09-30 2017-04-11 Kineta Inc compostos anti-virais
US9073946B2 (en) 2013-01-15 2015-07-07 Kineta, Inc. Anti-viral compounds
US9884876B2 (en) * 2014-05-09 2018-02-06 Kineta, Inc. Anti-viral compounds, pharmaceutical compositions, and methods of use thereof
AU2018252193A1 (en) 2017-04-14 2019-10-17 Tallac Therapeutics, Inc. Immunomodulating polynucleotides, antibody conjugates thereof, and methods of their use
AU2019291488B2 (en) 2018-06-19 2022-02-24 Novartis Ag N-substituted tetrahydrothienopyridine derivatives and uses thereof
WO2020036574A1 (en) * 2018-08-17 2020-02-20 Kineta, Inc. Activators of the retinoic acid inducible gene "rig-i' pathway and methods of use thereof
AU2021226023A1 (en) 2020-02-28 2022-09-15 Tallac Therapeutics, Inc. Transglutaminase-mediated conjugation
JP2024508817A (ja) * 2021-02-24 2024-02-28 エフ． ホフマン－ラ ロシュ アーゲー Ｂ型肝炎ウイルス感染症の処置および予防のためのベンゾチアゾリルビシクロ［１．１．１］ペンタン誘導体

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3489558A (en) * 1967-09-18 1970-01-13 Ibm Photoconductive benzobisthiazoles and their use in electrophotographic processes
JPS60205454A (ja) * 1984-03-29 1985-10-17 Mitsubishi Paper Mills Ltd 電子写真感光体
JPS63190880A (ja) * 1986-09-09 1988-08-08 Nippon Tokushu Noyaku Seizo Kk 新規ｎ−ベンゾチアゾリル−アミド類及び殺虫剤
US4940722A (en) * 1986-12-10 1990-07-10 Sumitomo Chemical Companmy, Limited Seed disinfectant composition
JPS63270608A (ja) * 1986-12-10 1988-11-08 Sumitomo Chem Co Ltd 種子消毒剤
IL90337A0 (en) * 1988-05-24 1989-12-15 Pfizer Aromatic and heterocyclic carboxamide derivatives as antineoplastic agents
NZ273741A (en) * 1993-08-24 2000-06-23 Medivir Ab Heterocyclically-substituted guanidine, urea and thiourea derivatives
AU4172197A (en) * 1996-09-10 1998-04-02 Pharmacia & Upjohn Company 8-hydroxy-7-substituted quinolines as anti-viral agents
AU763356C (en) * 1999-12-27 2004-08-26 Japan Tobacco Inc. Fused-ring compounds and use thereof as drugs
JP3972167B2 (ja) * 2000-01-26 2007-09-05 株式会社大塚製薬工場 ホスホン酸ジエステル誘導体
KR20020084116A (ko) * 2000-02-07 2002-11-04 애보트 게엠베하 운트 콤파니 카게 2-벤조티아졸릴 우레아 유도체 및 이의 단백질 키나제억제제로서의 용도
AU2001219185A1 (en) * 2000-03-17 2001-10-03 Alcon, Inc. 2-acylaminobenzimidazole derivatives for treating glaucoma
US7122544B2 (en) * 2000-12-06 2006-10-17 Signal Pharmaceuticals, Llc Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto
JP4038665B2 (ja) * 2002-06-19 2008-01-30 株式会社大塚製薬工場 ホスホン酸ジエステル誘導体
WO2004078115A2 (en) * 2003-02-28 2004-09-16 Viropharma, Incorporated Benzothiazole compounds, compositions and methods for treatment and prophylaxis of rotavirus infections and associated diseases
EP2258365B1 (en) * 2003-03-28 2013-05-29 Novartis Vaccines and Diagnostics, Inc. Use of organic compounds for immunopotentiation
EP1680431A1 (en) * 2003-10-17 2006-07-19 Rigel Pharmaceuticals, Inc. Benzothiazole and thiazole'5,5-b!pyridine compositions and their use as ubiquitin ligase inhibitors
MX2007003115A (es) * 2004-09-20 2007-07-16 4Sc Ag Novedosos inhibidores heterociclicos del nf-kb.
US20100267717A1 (en) * 2005-07-29 2010-10-21 4Sc Ag Novel Heterocyclic NF-kB Inhibitors
GB0421908D0 (en) * 2004-10-01 2004-11-03 Angeletti P Ist Richerche Bio New uses
EP1879575A2 (en) * 2005-05-09 2008-01-23 Achillion Pharmaceuticals, Inc. Thiazole compounds and methods of use
EP1945208A4 (en) * 2005-10-06 2011-08-03 Univ Massachusetts COMPOSITION AND SYNTHESIS OF NEW REAGENTS TO INHIBIT HIV REPLICATION
KR20080075909A (ko) * 2005-12-12 2008-08-19 제네랩스 테크놀로지스, 인코포레이티드 Ｎ-(6-원 방향족 환)-아미도 항-바이러스 화합물
JP2009529555A (ja) * 2006-03-15 2009-08-20 ４エスツェー アクチェンゲゼルシャフト 新規複素環式ＮＦ−κＢ阻害薬
CN101528744A (zh) * 2006-10-20 2009-09-09 Irm责任有限公司 用于调节c-kit和pdgfr受体的组合物和方法
WO2008141385A1 (en) * 2007-05-21 2008-11-27 Biota Scientific Management Pty Ltd Viral polymerase inhibitors
JP2010535708A (ja) * 2007-08-03 2010-11-25 ビオマリン アイジーエー リミテッド デュシェンヌ型筋ジストロフィーの治療のための薬物併用
UA100527C2 (en) * 2007-10-10 2013-01-10 Астразенека Аб Benzothiazoles as ghrelin receptor modulators
US20110178070A1 (en) * 2008-06-24 2011-07-21 Takeda Pharmaceutical Company Limited PI3K/mTOR INHIBITORS
WO2010024903A1 (en) 2008-08-29 2010-03-04 Yangbo Feng BENZO[d]OXAZOLES AND BENZO[d]THIAZOLES AS KINASE INHIBITORS
GB0820856D0 (en) * 2008-11-14 2008-12-24 Univ Leuven Kath Novel inhibitors of flavivirus replication
PA8854001A1 (es) * 2008-12-16 2010-07-27 Abbott Lab Compuestos novedosos como ligandos de receptores de canabinoides
CN104856991A (zh) * 2009-02-27 2015-08-26 西佳技术公司 用于治疗和预防登革热病毒感染的噻吩并吡啶衍生物
WO2010100144A1 (en) * 2009-03-04 2010-09-10 Merck Serono S.A. Fused bicyclic compounds as inhibitors for pi3 kinase
US8338441B2 (en) * 2009-05-15 2012-12-25 Gilead Sciences, Inc. Inhibitors of human immunodeficiency virus replication
US8765747B2 (en) * 2009-06-12 2014-07-01 Dana-Farber Cancer Institute, Inc. Fused 2-aminothiazole compounds
JP2012532102A (ja) 2009-06-30 2012-12-13 シガ・テクノロジーズ・インコーポレーテッド デングウイルス感染の治療法および予防法
WO2011006158A2 (en) * 2009-07-10 2011-01-13 University Of Maryland, Baltimore Targeting nad biosynthesis in bacterial pathogens
WO2011022721A1 (en) * 2009-08-21 2011-02-24 Microbiotix, Inc Inhibitors of botulinum neurotoxins
BR112014007599A2 (pt) 2011-09-30 2017-04-11 Kineta Inc compostos anti-virais

Also Published As

Publication number Publication date
CA2859946C (en) 2019-11-05
US20140227320A1 (en) 2014-08-14
JP2014528412A (ja) 2014-10-27
CN103857683B (zh) 2016-10-12
AP2014007595A0 (en) 2014-04-30
TW201326163A (zh) 2013-07-01
HK1199029A1 (en) 2015-06-19
AU2017254812B2 (en) 2018-07-19
IL231780A (en) 2017-08-31
CA2859946A1 (en) 2013-04-04
AU2017254812A1 (en) 2017-11-16
SG11201401084TA (en) 2014-04-28
WO2013049407A2 (en) 2013-04-04
EP2748172A4 (en) 2015-10-14
US20170258897A1 (en) 2017-09-14
CN103857683A (zh) 2014-06-11
EP2748172A2 (en) 2014-07-02
JP2017222656A (ja) 2017-12-21
ZA201401825B (en) 2017-08-30
BR112014007599A2 (pt) 2017-04-11
US9555106B2 (en) 2017-01-31
EP2748172B1 (en) 2017-12-06
AU2017210483A1 (en) 2017-08-17
MX2014003887A (es) 2014-11-21
AU2012315953A1 (en) 2014-04-03
WO2013049407A3 (en) 2013-05-30
NZ622636A (en) 2016-07-29
KR20140070631A (ko) 2014-06-10
IL231780A0 (en) 2014-05-28
US9956285B2 (en) 2018-05-01

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