ES8401056A1 - "procedimiento para la fabricacion de derivados de la quinolina". - Google Patents

"procedimiento para la fabricacion de derivados de la quinolina".

Info

Publication number
ES8401056A1
ES8401056A1 ES513385A ES513385A ES8401056A1 ES 8401056 A1 ES8401056 A1 ES 8401056A1 ES 513385 A ES513385 A ES 513385A ES 513385 A ES513385 A ES 513385A ES 8401056 A1 ES8401056 A1 ES 8401056A1
Authority
ES
Spain
Prior art keywords
alkyl
pharmaceutical compositions
compounds
hydroxy
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES513385A
Other languages
English (en)
Other versions
ES513385A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ACF Chemiefarma NV
Original Assignee
ACF Chemiefarma NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from NL8001369A external-priority patent/NL8001369A/nl
Application filed by ACF Chemiefarma NV filed Critical ACF Chemiefarma NV
Publication of ES513385A0 publication Critical patent/ES513385A0/es
Publication of ES8401056A1 publication Critical patent/ES8401056A1/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE LA QUINOLINA DE FORMULA (I), EN LA QUE A-B ES -CH2-CH2-CHOH-CH2-,-CH2-CHOH-,-C(O)-CH2-,-CH2- C(O)-,-C(NOR5)-CH2-, O -CH2-C- (NOR5)-; R1 ES HIDROGENO, HIDROXO O ALCOXI INFERIOR; R2 ES ALQUILO INFERIOR, HIDROXI, ALCOXI INFERIOR O CF3; R3 ES ETILO O VINILO; R4 PUEDE SER VARIOS RADICALES; Y R5 ES ALQUILO INFERIOR.CONSISTE EN LA REACCION DE REDUCCION DE UN COMPUESTO DE FORMULA (II), EN LA QUE A-B, R1, R2 Y R3 TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), PARA DAR UN COMPUESTO EN EL CUAL R4 CONTIENE UN GRUPO 1-METILENO O UNCOMPUESTO DE FORMULA (I) EN EL CUAL AFB ES -C(O)-CH2- O -CH2-C(O)- ESTA PARCIAL O TOTALMENTE REDUCIDO A -CHOH-CH2- O -CH2-CH2-, RESPECTIVAMENTE. EN EL PRIMER CASO LA REDUCCION ES LLEVADA A CABO PREFERENTEMENTE UTILIZANDO DIBORANO O UN HIDRURO COMPLEJO TAL COMO HIDRURO DE ALUMINIO Y LITIO, AÑADIDO EN CANTIDADES EQUIVALENTES O EN CANTIDADES HASTA EL TRIPLE DE LAS EQUIVALENTES, EN UN DISOLVENTE INERTE, PARTICULARMENTE TETRAHIDROFURANO, A UNA TEMPERATURA DE REACCION COMPRENDIDA ENTRE 0JC Y EL PUNTO DE EBULLICION DEL DISOLVENTE. DE APLICACION FARMACOLOGICA POR SUS EFECTOS UNANTI-HIPERTENSIVOS, ANTI-TROMBOTICOS, VASODILATATORIOS Y ANTIARRITMICOS.
ES513385A 1980-03-06 1982-06-23 "procedimiento para la fabricacion de derivados de la quinolina". Expired ES8401056A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL8001369A NL8001369A (nl) 1980-03-06 1980-03-06 Nieuwe chinolinederivaten en farmaceutische preparaten die een dergelijke verbinding bevatten, alsmede werkwijze voor het bereiden van deze verbindingen.

Publications (2)

Publication Number Publication Date
ES513385A0 ES513385A0 (es) 1983-12-16
ES8401056A1 true ES8401056A1 (es) 1983-12-16

Family

ID=19834945

Family Applications (3)

Application Number Title Priority Date Filing Date
ES500761A Granted ES500761A0 (es) 1980-03-06 1981-03-05 Procedimiento perfeccionado para la fabricacion de derivadosde la quinolina
ES513385A Expired ES8401056A1 (es) 1980-03-06 1982-06-23 "procedimiento para la fabricacion de derivados de la quinolina".
ES513384A Expired ES8401055A1 (es) 1980-03-06 1982-06-23 "metodo para la fabricacion de derivados de la quinolina".

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES500761A Granted ES500761A0 (es) 1980-03-06 1981-03-05 Procedimiento perfeccionado para la fabricacion de derivadosde la quinolina

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES513384A Expired ES8401055A1 (es) 1980-03-06 1982-06-23 "metodo para la fabricacion de derivados de la quinolina".

Country Status (8)

Country Link
US (1) US4442106A (es)
DE (1) DE3166538D1 (es)
DK (1) DK100081A (es)
ES (3) ES500761A0 (es)
GR (1) GR74836B (es)
IL (1) IL62240A0 (es)
PT (1) PT72619B (es)
ZA (3) ZA811480B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2495470A1 (fr) * 1980-12-05 1982-06-11 Pharmindustrie Nouveaux medicaments a base de derives de (quinolyl-4)-1 (piperidyl-4)-2 ethanol ou (quinolyl-4)-1 (piperidyl-4)-3 propanol
US4792561A (en) * 1986-05-29 1988-12-20 Syntex (U.S.A.) Inc. Carbostyril derivatives as combined thromboxane synthetase and cyclic-AMP phosphodiesterase inhibitors
US4921862A (en) * 1986-05-29 1990-05-01 Syntex (U.S.A.) Inc. Carbostyril derivatives as combined thromboxane synthetase and cyclic-amp phosphodiesterase inhibitors
US6376514B1 (en) * 2000-10-17 2002-04-23 The Procter & Gamble Co. Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof
US6693099B2 (en) * 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
WO2011060036A1 (en) * 2009-11-16 2011-05-19 Schering Corporation Bicyclic compounds and methods of use thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3914235A (en) * 1968-07-02 1975-10-21 Hoffmann La Roche Processes and intermediates for quinine, quinidine, isomers and derivatives thereof
FR2177511A1 (en) * 1972-03-28 1973-11-09 Omnium Chimique Sa Quinolyl pipiridylethyl ketones - with vasodilatory and antispasmodic activity
GB1441244A (en) * 1972-11-17 1976-06-30 Rech Et Dapplications Scient S Derivatives of quinoline and method of preparing the same
US3953453A (en) * 1973-12-07 1976-04-27 Hoffmann-La Roche Inc. Trifluoromethyl substituted analogs of quinine and quinidine
PT66682B (pt) * 1976-06-18 1978-11-15 Ind Biolog Francaise /(quinolyl-4)-propyl-1/-4 piperidines leur preparation et leur utilisation comme medicaments /(quinolyl-4)-propyl/-4 piperidines leur preparation et leur utilisation comme medicaments
GR69926B (es) * 1978-03-23 1982-07-21 Pharmindustrie
FR2485014A1 (fr) * 1980-06-20 1981-12-24 Pharmindustrie Nouveaux derives de (quinolyl-2, -3 ou -4)-1 (piperidyl ou pyrrolidinyl-2 ou -3)-2 ou -3 ethanone ou propanone, procedes pour leur preparation, et leur utilisation comme medicaments

Also Published As

Publication number Publication date
DK100081A (da) 1981-09-07
ES513384A0 (es) 1983-12-01
PT72619B (en) 1982-03-26
ZA811479B (en) 1982-03-31
ZA811478B (en) 1982-03-31
IL62240A0 (en) 1981-05-20
ES8401055A1 (es) 1983-12-01
ES513385A0 (es) 1983-12-16
ES8307788A1 (es) 1983-08-01
US4442106A (en) 1984-04-10
ZA811480B (en) 1982-03-31
GR74836B (es) 1984-07-12
PT72619A (en) 1981-04-01
DE3166538D1 (en) 1984-11-15
ES500761A0 (es) 1983-08-01

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