ES8307788A1 - Procedimiento perfeccionado para la fabricacion de derivadosde la quinolina - Google Patents

Procedimiento perfeccionado para la fabricacion de derivadosde la quinolina

Info

Publication number
ES8307788A1
ES8307788A1 ES500761A ES500761A ES8307788A1 ES 8307788 A1 ES8307788 A1 ES 8307788A1 ES 500761 A ES500761 A ES 500761A ES 500761 A ES500761 A ES 500761A ES 8307788 A1 ES8307788 A1 ES 8307788A1
Authority
ES
Spain
Prior art keywords
alkyl
pharmaceutical compositions
compounds
hydroxy
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES500761A
Other languages
English (en)
Other versions
ES500761A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ACF Chemiefarma NV
Original Assignee
ACF Chemiefarma NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from NL8001369A external-priority patent/NL8001369A/nl
Application filed by ACF Chemiefarma NV filed Critical ACF Chemiefarma NV
Publication of ES8307788A1 publication Critical patent/ES8307788A1/es
Publication of ES500761A0 publication Critical patent/ES500761A0/es
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines

Abstract

PROCEDIMIENTO PARA LA FABRICACION DE DERIVADOS DE LA QUINOLINA, DE FORMULA GENERAL (I), EN LA QUE A-B ES -CH<2-CH<2- O -CH<2-CHOH; R>1 ES HIDROGENO, HIDROXI O ALCOXI; R>2 ES ALQUILO INFERIOR, HIDROXI O ALCOXI; R>3 ES ETILO O VINILO; Y R>4 ES ALQUILO INFERIOR, Y LAS SALES FARMACEUTICAMENTE ACEPTABLES. CONSISTE EN HACER REACCIONAR UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO R>4Y, EN DONDE Y ES UN GRUPO NUCLEOFILO, EN PARTICULAR CLORO, BROMO, YODO O TOSILOXI; Y A-B, R>1, R>2, R>3 Y R>4 TIENEN LOS SIGNIFICADOS YA MENCIONADOS. DE APLICACION EN EL TRATAMIENTO Y PROFILAXIS DE AFECCIONES CARDIOVASCULARES.
ES500761A 1980-03-06 1981-03-05 Procedimiento perfeccionado para la fabricacion de derivadosde la quinolina Granted ES500761A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL8001369A NL8001369A (nl) 1980-03-06 1980-03-06 Nieuwe chinolinederivaten en farmaceutische preparaten die een dergelijke verbinding bevatten, alsmede werkwijze voor het bereiden van deze verbindingen.

Publications (2)

Publication Number Publication Date
ES8307788A1 true ES8307788A1 (es) 1983-08-01
ES500761A0 ES500761A0 (es) 1983-08-01

Family

ID=19834945

Family Applications (3)

Application Number Title Priority Date Filing Date
ES500761A Granted ES500761A0 (es) 1980-03-06 1981-03-05 Procedimiento perfeccionado para la fabricacion de derivadosde la quinolina
ES513385A Expired ES8401056A1 (es) 1980-03-06 1982-06-23 "procedimiento para la fabricacion de derivados de la quinolina".
ES513384A Granted ES513384A0 (es) 1980-03-06 1982-06-23 "metodo para la fabricacion de derivados de la quinolina".

Family Applications After (2)

Application Number Title Priority Date Filing Date
ES513385A Expired ES8401056A1 (es) 1980-03-06 1982-06-23 "procedimiento para la fabricacion de derivados de la quinolina".
ES513384A Granted ES513384A0 (es) 1980-03-06 1982-06-23 "metodo para la fabricacion de derivados de la quinolina".

Country Status (8)

Country Link
US (1) US4442106A (es)
DE (1) DE3166538D1 (es)
DK (1) DK100081A (es)
ES (3) ES500761A0 (es)
GR (1) GR74836B (es)
IL (1) IL62240A0 (es)
PT (1) PT72619B (es)
ZA (3) ZA811478B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2495470A1 (fr) * 1980-12-05 1982-06-11 Pharmindustrie Nouveaux medicaments a base de derives de (quinolyl-4)-1 (piperidyl-4)-2 ethanol ou (quinolyl-4)-1 (piperidyl-4)-3 propanol
US4921862A (en) * 1986-05-29 1990-05-01 Syntex (U.S.A.) Inc. Carbostyril derivatives as combined thromboxane synthetase and cyclic-amp phosphodiesterase inhibitors
US4792561A (en) * 1986-05-29 1988-12-20 Syntex (U.S.A.) Inc. Carbostyril derivatives as combined thromboxane synthetase and cyclic-AMP phosphodiesterase inhibitors
US6693099B2 (en) * 2000-10-17 2004-02-17 The Procter & Gamble Company Substituted piperazine compounds optionally containing a quinolyl moiety for treating multidrug resistance
US6376514B1 (en) * 2000-10-17 2002-04-23 The Procter & Gamble Co. Substituted six-membered heterocyclic compounds useful for treating multidrug resistance and compositions and methods thereof
WO2011060036A1 (en) * 2009-11-16 2011-05-19 Schering Corporation Bicyclic compounds and methods of use thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3914235A (en) * 1968-07-02 1975-10-21 Hoffmann La Roche Processes and intermediates for quinine, quinidine, isomers and derivatives thereof
FR2177511A1 (en) * 1972-03-28 1973-11-09 Omnium Chimique Sa Quinolyl pipiridylethyl ketones - with vasodilatory and antispasmodic activity
GB1441244A (en) * 1972-11-17 1976-06-30 Rech Et Dapplications Scient S Derivatives of quinoline and method of preparing the same
US3953453A (en) * 1973-12-07 1976-04-27 Hoffmann-La Roche Inc. Trifluoromethyl substituted analogs of quinine and quinidine
PT66682B (pt) * 1976-06-18 1978-11-15 Ind Biolog Francaise /(quinolyl-4)-propyl-1/-4 piperidines leur preparation et leur utilisation comme medicaments /(quinolyl-4)-propyl/-4 piperidines leur preparation et leur utilisation comme medicaments
GR69926B (es) * 1978-03-23 1982-07-21 Pharmindustrie
FR2485014A1 (fr) * 1980-06-20 1981-12-24 Pharmindustrie Nouveaux derives de (quinolyl-2, -3 ou -4)-1 (piperidyl ou pyrrolidinyl-2 ou -3)-2 ou -3 ethanone ou propanone, procedes pour leur preparation, et leur utilisation comme medicaments

Also Published As

Publication number Publication date
ZA811480B (en) 1982-03-31
ZA811479B (en) 1982-03-31
ES8401055A1 (es) 1983-12-01
IL62240A0 (en) 1981-05-20
GR74836B (es) 1984-07-12
ES513385A0 (es) 1983-12-16
PT72619B (en) 1982-03-26
ES500761A0 (es) 1983-08-01
US4442106A (en) 1984-04-10
ES8401056A1 (es) 1983-12-16
DK100081A (da) 1981-09-07
ES513384A0 (es) 1983-12-01
DE3166538D1 (en) 1984-11-15
PT72619A (en) 1981-04-01
ZA811478B (en) 1982-03-31

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