ES8503213A1 - "procedimiento para la preparacion de un ester basico de acido 1, 4-dihidropiridin-3,5-dicarboxilico" - Google Patents

"procedimiento para la preparacion de un ester basico de acido 1, 4-dihidropiridin-3,5-dicarboxilico"

Info

Publication number
ES8503213A1
ES8503213A1 ES522883A ES522883A ES8503213A1 ES 8503213 A1 ES8503213 A1 ES 8503213A1 ES 522883 A ES522883 A ES 522883A ES 522883 A ES522883 A ES 522883A ES 8503213 A1 ES8503213 A1 ES 8503213A1
Authority
ES
Spain
Prior art keywords
alkyl
substituted
phenyl
mono
carbon atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES522883A
Other languages
English (en)
Other versions
ES522883A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierrel SpA
Original Assignee
Pierrel SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26327745&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES8503213(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from IT21678/82A external-priority patent/IT1198377B/it
Priority claimed from IT8321043A external-priority patent/IT1206451B/it
Application filed by Pierrel SpA filed Critical Pierrel SpA
Publication of ES522883A0 publication Critical patent/ES522883A0/es
Publication of ES8503213A1 publication Critical patent/ES8503213A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE UN ESTER BASICO DE ACIDO 1,4-DIHIDROPIRIDIN-3,5-DICARBOXILICO.PROCEDIMIENTO PARA LA PREPARACION DE UN ESTER BASICO DE ACIDO 1,4-DIHIDROPIRIDIN-3,5-DICARBOXILICO, DE FORMULA GENERAL (I), Y SUS RACEMATOS, ENANTIOMEROS Y DIASTEREOISOMEROS Y SUS SALES DE ADICION CON UN ACIDO FARMACEUTICAMENTE ACEPTABLE.CONSISTE EN HACER REACCIONAR COMPUESTOS DE FORMULA GENERAL (II) CON COMPUESTOS DE FORMULA GENERAL (III) O CON COMPUESTOS DE CONDENSACION DE FORMULA GENERAL (IV).DE APLICACION EN EL TRATAMIENTO Y PROFILAXIS DE HIPERTENSION, DE LAS DIVERSAS FORMAS DE ANGINA Y EN OTRAS PATOLOGIAS CARDIOVASCULARES.
ES522883A 1982-06-03 1983-06-01 "procedimiento para la preparacion de un ester basico de acido 1, 4-dihidropiridin-3,5-dicarboxilico" Expired ES8503213A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT21678/82A IT1198377B (it) 1982-06-03 1982-06-03 Esteri basici ad attivita' calcioanatagonista,procedimenti per la loro preparazione e relative composizioni farmaceutiche
IT8321043A IT1206451B (it) 1983-05-11 1983-05-11 Esteri basici ad attivita'calcioantagonista, procedimenti per la loro preparazione e relative composizioni farmaceutiche.

Publications (2)

Publication Number Publication Date
ES522883A0 ES522883A0 (es) 1985-02-16
ES8503213A1 true ES8503213A1 (es) 1985-02-16

Family

ID=26327745

Family Applications (1)

Application Number Title Priority Date Filing Date
ES522883A Expired ES8503213A1 (es) 1982-06-03 1983-06-01 "procedimiento para la preparacion de un ester basico de acido 1, 4-dihidropiridin-3,5-dicarboxilico"

Country Status (5)

Country Link
US (1) US4894460A (es)
EP (1) EP0097821B1 (es)
AU (1) AU541067B2 (es)
DE (1) DE3377352D1 (es)
ES (1) ES8503213A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4603135A (en) * 1983-10-17 1986-07-29 Takeda Chemical Industries, Ltd. Substituted piperazinyl alkyl esters of 2-amino-4-aryl-1,4-dihydro-6-alkyl-3,5-pyridinedicarboxylates
US4755512A (en) * 1984-04-11 1988-07-05 Bristol-Myers Company Pharmaceutically useful dihydropyridinyldicarboxylate amides and esters incorporating arylpiperazinylalkyl moities
US4895846A (en) * 1984-04-11 1990-01-23 Bristol-Myers Company Pharmaceutically useful dihydropyridinyldicarboxylate amides and esters incorporating arylpiperazinylalkyl moieties
GB8413385D0 (en) * 1984-05-24 1984-06-27 Recordati Chem Pharm Carboxylic acid derivatives
WO1986003748A1 (en) * 1984-12-21 1986-07-03 Byk Gulden Lomberg Chemische Fabrik Gesellschaft M New piperazine derivatives
DE3601397A1 (de) * 1986-01-18 1987-07-23 Bayer Ag Substituierte 1,4-dihydropyridin-3-carbonsaeurepiperazide, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
DE3607821A1 (de) * 1986-03-08 1987-09-10 Bayer Ag Aminoester-dihydropyridine, verfahren zur herstellung und ihre verwendung
US4814455A (en) * 1986-04-16 1989-03-21 Bristol-Myers Company Dihydro-3,5-dicarboxylates
US4868181A (en) * 1986-08-04 1989-09-19 E. I. Du Pont De Nemours And Company 1,4-dihydropyridine derivatives with calcium agonist and alpha1 -antagonist activity
JPH0686429B2 (ja) * 1986-08-27 1994-11-02 株式会社ミドリ十字 ジヒドロピリジン誘導体
US4886819A (en) * 1986-08-27 1989-12-12 The Green Cross Corporation Dihydropyridine derivatives and pharmaceutical composition thereof
JPH0725750B2 (ja) * 1987-12-18 1995-03-22 富士レビオ株式会社 １，４‐ジヒドロピリジン誘導体
JPH02149563A (ja) * 1988-11-30 1990-06-08 Nisshin Flour Milling Co Ltd ２−ハロエトキシカルボニル基を含有する１，４−ジヒドロピリジン誘導体の製造法
US5286869A (en) * 1988-12-15 1994-02-15 Fujirebio Kabushiki Kaisha 1,4-dihydropyridine derivatives
US5166147A (en) * 1990-07-09 1992-11-24 The Du Pont Merck Pharmaceutical Company 4-heteroaryl-and 4-aryl-1,4-dihydropyridine, derivatives with calcium agonist and alpha1 -antagonist activity
CN101215258A (zh) * 2008-01-21 2008-07-09 中国药科大学 二氢吡啶类钙拮抗剂化合物及其制备方法与医药用途
CN103408483A (zh) * 2013-07-17 2013-11-27 张家港威胜生物医药有限公司 钙离子通道拮抗剂马尼地平的制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2218644C3 (de) * 1972-04-18 1982-08-19 Bayer Ag, 5090 Leverkusen Basische Ester von 1,4-Dihydropyridinen, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
US4267328A (en) * 1978-08-01 1981-05-12 Synthelabo 1-Phenylpiperazines
EP0094159B1 (en) * 1982-05-10 1990-03-14 Takeda Chemical Industries, Ltd. Dihydropyridine derivatives, their production and use
US4755512A (en) * 1984-04-11 1988-07-05 Bristol-Myers Company Pharmaceutically useful dihydropyridinyldicarboxylate amides and esters incorporating arylpiperazinylalkyl moities

Also Published As

Publication number Publication date
ES522883A0 (es) 1985-02-16
AU541067B2 (en) 1984-12-13
EP0097821A2 (en) 1984-01-11
AU1528483A (en) 1983-12-08
EP0097821A3 (en) 1984-09-12
EP0097821B1 (en) 1988-07-13
DE3377352D1 (en) 1988-08-18
US4894460A (en) 1990-01-16

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19970303