AU582043B2 - Phenoxyalkylcarboxylic acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing them - Google Patents
Phenoxyalkylcarboxylic acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing themInfo
- Publication number
- AU582043B2 AU582043B2 AU70723/87A AU7072387A AU582043B2 AU 582043 B2 AU582043 B2 AU 582043B2 AU 70723/87 A AU70723/87 A AU 70723/87A AU 7072387 A AU7072387 A AU 7072387A AU 582043 B2 AU582043 B2 AU 582043B2
- Authority
- AU
- Australia
- Prior art keywords
- group
- alkyl
- acid derivatives
- phenoxyalkylcarboxylic acid
- processes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C307/02—Monoamides of sulfuric acids or esters thereof, e.g. sulfamic acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Professional, Industrial, Or Sporting Protective Garments (AREA)
- Detergent Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Phenoxyalkylcarboxylic acid derivatives of the formula I <IMAGE> in which the sulfonylaminoalkyl group is in the ortho- or the meta-position to the phenoxyalkylcarboxylic acid group and in which R1 denotes an aryl group, aralkyl group or an aralkenyl group whose aryl radical can in each case be optionally mono- or polysubstituted by halogen, cyano, alkyl, trifluoromethyl, alkoxy, hydroxyl, nitro, amino, alkylamino, dialkylamino, acylamino, acyl, azido or can be substituted by phenyl which is optionally substituted by halogen, cyano, alkyl, trifluoromethyl or alkoxy, R2 represents hydrogen, an alkyl group, aralkyl group or an acyl group, R3 and R4, which can be identical or different, denote hydrogen or a lower alkyl group and n denotes the numbers 1-3, and their physiologically acceptable salts, esters and amides have platelet aggregation-inhibiting and/or hypolipidaemic action.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19863610643 DE3610643A1 (en) | 1986-03-29 | 1986-03-29 | NEW PHENOXYALKYL CARBONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
DE3610643 | 1986-03-29 |
Publications (2)
Publication Number | Publication Date |
---|---|
AU7072387A AU7072387A (en) | 1987-10-15 |
AU582043B2 true AU582043B2 (en) | 1989-03-09 |
Family
ID=6297529
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU70723/87A Ceased AU582043B2 (en) | 1986-03-29 | 1987-03-27 | Phenoxyalkylcarboxylic acid derivatives, processes for the preparation thereof and pharmaceutical compositions containing them |
Country Status (15)
Country | Link |
---|---|
EP (1) | EP0239907B1 (en) |
JP (1) | JPS62238259A (en) |
AT (1) | ATE67483T1 (en) |
AU (1) | AU582043B2 (en) |
CS (1) | CS271469B2 (en) |
DD (1) | DD263287A5 (en) |
DE (2) | DE3610643A1 (en) |
DK (1) | DK155387A (en) |
ES (1) | ES2037676T3 (en) |
FI (1) | FI871360A (en) |
GR (1) | GR3003100T3 (en) |
HU (1) | HU197879B (en) |
IL (1) | IL82039A0 (en) |
PT (1) | PT84572B (en) |
ZA (1) | ZA872254B (en) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8528398D0 (en) * | 1985-11-19 | 1985-12-24 | Glaxo Group Ltd | Chemical compounds |
JPS62277347A (en) * | 1986-02-25 | 1987-12-02 | Microbial Chem Res Found | Novel performed chemical mediator aabustatin analog compound |
IL83230A (en) * | 1986-08-06 | 1992-06-21 | Tanabe Seiyaku Co | Phenoxyacetic acid derivatives,their preparation and pharmaceutical compositions containing them |
AT396235B (en) * | 1987-02-06 | 1993-07-26 | Tanabe Seiyaku Co | New sulphonyl amino phenoxy acetic acid cpds. - are platelet agglutination inhibitors useful for treating e.g. cerebral thrombosis and pulmonary embolism |
GB8708233D0 (en) * | 1987-04-07 | 1987-05-13 | Smith Kline French Lab | Pharmaceutically active compounds |
JPH068274B2 (en) * | 1988-01-19 | 1994-02-02 | 田辺製薬株式会社 | Phenoxyacetic acid derivative |
JPH068275B2 (en) * | 1988-02-04 | 1994-02-02 | 田辺製薬株式会社 | Phenoxyacetic acid derivative |
DE68909958D1 (en) * | 1988-01-19 | 1993-11-25 | Tanabe Seiyaku Co | Phenoxyacetic acid derivatives, their preparation, pharmaceutical compositions containing them and their use. |
DE3829455A1 (en) * | 1988-08-31 | 1990-03-15 | Boehringer Mannheim Gmbh | SULFONAMIDOALKYL-CYCLOHEXAN COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS |
US5173500A (en) * | 1988-08-31 | 1992-12-22 | Boehringer Mannheim Gmbh | Pharmaceutical compositions and methods of sulphonamides containing a tetrazolyl radical |
DE3829431A1 (en) * | 1988-08-31 | 1990-03-01 | Boehringer Mannheim Gmbh | SULPHONAMID WITH TETRAZOLYL RESIDUE, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS |
US5280043A (en) * | 1988-10-10 | 1994-01-18 | Smith Kline & French Laboratories Ltd. | Sulphonamido containing phenylalkanoic acids as thromboxane A2 antagonists |
US5084466A (en) * | 1989-01-31 | 1992-01-28 | Hoffmann-La Roche Inc. | Novel carboxamide pyridine compounds which have useful pharmaceutical utility |
US5256812A (en) * | 1989-01-31 | 1993-10-26 | Hoffmann-La Roche Inc. | Carboxamides and sulfonamides |
DE3942923A1 (en) * | 1989-12-23 | 1991-06-27 | Boehringer Mannheim Gmbh | NEW PHENOXYALKYL CARBONIC ACID AMIDES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
JPH05125038A (en) * | 1991-03-07 | 1993-05-21 | Tanabe Seiyaku Co Ltd | Phenoxyalkanoic acid derivative and its production |
EP0562796A1 (en) * | 1992-03-23 | 1993-09-29 | Terumo Kabushiki Kaisha | Phenoxyacetic acid compounds and medical preparations containing them |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU6550586A (en) * | 1985-11-19 | 1987-05-21 | Glaxo Group Limited | Phenoxyalkylcarboxylic acids and esters and their preparation and pharmaceutical formulation |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2809377A1 (en) * | 1978-03-04 | 1979-09-13 | Boehringer Mannheim Gmbh | PHENOXYALKYL CARBONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
-
1986
- 1986-03-29 DE DE19863610643 patent/DE3610643A1/en not_active Withdrawn
-
1987
- 1987-03-24 EP EP87104281A patent/EP0239907B1/en not_active Expired - Lifetime
- 1987-03-24 ES ES198787104281T patent/ES2037676T3/en not_active Expired - Lifetime
- 1987-03-24 DE DE8787104281T patent/DE3773026D1/en not_active Expired - Lifetime
- 1987-03-24 AT AT87104281T patent/ATE67483T1/en not_active IP Right Cessation
- 1987-03-25 DD DD87301115A patent/DD263287A5/en not_active IP Right Cessation
- 1987-03-26 DK DK155387A patent/DK155387A/en not_active Application Discontinuation
- 1987-03-26 CS CS872073A patent/CS271469B2/en unknown
- 1987-03-26 PT PT84572A patent/PT84572B/en not_active IP Right Cessation
- 1987-03-27 JP JP62071957A patent/JPS62238259A/en active Pending
- 1987-03-27 FI FI871360A patent/FI871360A/en not_active Application Discontinuation
- 1987-03-27 HU HU871347A patent/HU197879B/en not_active IP Right Cessation
- 1987-03-27 AU AU70723/87A patent/AU582043B2/en not_active Ceased
- 1987-03-27 ZA ZA872254A patent/ZA872254B/en unknown
- 1987-03-29 IL IL82039A patent/IL82039A0/en unknown
-
1991
- 1991-11-11 GR GR91401329T patent/GR3003100T3/en unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU6550586A (en) * | 1985-11-19 | 1987-05-21 | Glaxo Group Limited | Phenoxyalkylcarboxylic acids and esters and their preparation and pharmaceutical formulation |
Also Published As
Publication number | Publication date |
---|---|
DK155387A (en) | 1987-09-30 |
CS271469B2 (en) | 1990-10-12 |
GR3003100T3 (en) | 1993-02-17 |
HUT43559A (en) | 1987-11-30 |
EP0239907B1 (en) | 1991-09-18 |
HU197879B (en) | 1989-06-28 |
IL82039A0 (en) | 1987-10-20 |
ES2037676T3 (en) | 1993-07-01 |
DE3773026D1 (en) | 1991-10-24 |
ATE67483T1 (en) | 1991-10-15 |
JPS62238259A (en) | 1987-10-19 |
AU7072387A (en) | 1987-10-15 |
FI871360A (en) | 1987-09-30 |
PT84572B (en) | 1989-11-30 |
ZA872254B (en) | 1987-11-25 |
DE3610643A1 (en) | 1987-10-01 |
EP0239907A1 (en) | 1987-10-07 |
CS207387A2 (en) | 1990-02-12 |
FI871360A0 (en) | 1987-03-27 |
DK155387D0 (en) | 1987-03-26 |
DD263287A5 (en) | 1988-12-28 |
PT84572A (en) | 1987-04-01 |
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