CS207387A2 - Method of phenoxyalkylcarboxyl acid's derivatives production - Google Patents
Method of phenoxyalkylcarboxyl acid's derivatives productionInfo
- Publication number
- CS207387A2 CS207387A2 CS872073A CS207387A CS207387A2 CS 207387 A2 CS207387 A2 CS 207387A2 CS 872073 A CS872073 A CS 872073A CS 207387 A CS207387 A CS 207387A CS 207387 A2 CS207387 A2 CS 207387A2
- Authority
- CS
- Czechoslovakia
- Prior art keywords
- group
- alkyl
- trifluoromethyl
- cyano
- alkoxy
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000005840 aryl radicals Chemical class 0.000 abstract 1
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 230000000055 hyoplipidemic effect Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- -1 nitro, amino Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000010110 spontaneous platelet aggregation Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C307/00—Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C307/02—Monoamides of sulfuric acids or esters thereof, e.g. sulfamic acids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Professional, Industrial, Or Sporting Protective Garments (AREA)
- Detergent Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Phenoxyalkylcarboxylic acid derivatives of the formula I <IMAGE> in which the sulfonylaminoalkyl group is in the ortho- or the meta-position to the phenoxyalkylcarboxylic acid group and in which R1 denotes an aryl group, aralkyl group or an aralkenyl group whose aryl radical can in each case be optionally mono- or polysubstituted by halogen, cyano, alkyl, trifluoromethyl, alkoxy, hydroxyl, nitro, amino, alkylamino, dialkylamino, acylamino, acyl, azido or can be substituted by phenyl which is optionally substituted by halogen, cyano, alkyl, trifluoromethyl or alkoxy, R2 represents hydrogen, an alkyl group, aralkyl group or an acyl group, R3 and R4, which can be identical or different, denote hydrogen or a lower alkyl group and n denotes the numbers 1-3, and their physiologically acceptable salts, esters and amides have platelet aggregation-inhibiting and/or hypolipidaemic action.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19863610643 DE3610643A1 (en) | 1986-03-29 | 1986-03-29 | NEW PHENOXYALKYL CARBONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CS207387A2 true CS207387A2 (en) | 1990-02-12 |
| CS271469B2 CS271469B2 (en) | 1990-10-12 |
Family
ID=6297529
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CS872073A CS271469B2 (en) | 1986-03-29 | 1987-03-26 | Method of phenoxyalkylcarboxyl acid's derivatives production |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0239907B1 (en) |
| JP (1) | JPS62238259A (en) |
| AT (1) | ATE67483T1 (en) |
| AU (1) | AU582043B2 (en) |
| CS (1) | CS271469B2 (en) |
| DD (1) | DD263287A5 (en) |
| DE (2) | DE3610643A1 (en) |
| DK (1) | DK155387A (en) |
| ES (1) | ES2037676T3 (en) |
| FI (1) | FI871360A7 (en) |
| GR (1) | GR3003100T3 (en) |
| HU (1) | HU197879B (en) |
| IL (1) | IL82039A0 (en) |
| PT (1) | PT84572B (en) |
| ZA (1) | ZA872254B (en) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8528398D0 (en) * | 1985-11-19 | 1985-12-24 | Glaxo Group Ltd | Chemical compounds |
| JPS62277347A (en) * | 1986-02-25 | 1987-12-02 | Microbial Chem Res Found | Novel physiologically active substance arbutatin related compounds |
| IL83230A (en) * | 1986-08-06 | 1992-06-21 | Tanabe Seiyaku Co | Phenoxyacetic acid derivatives,their preparation and pharmaceutical compositions containing them |
| AT396235B (en) * | 1987-02-06 | 1993-07-26 | Tanabe Seiyaku Co | New sulphonyl amino phenoxy acetic acid cpds. - are platelet agglutination inhibitors useful for treating e.g. cerebral thrombosis and pulmonary embolism |
| GB8708233D0 (en) * | 1987-04-07 | 1987-05-13 | Smith Kline French Lab | Pharmaceutically active compounds |
| JPH068274B2 (en) * | 1988-01-19 | 1994-02-02 | 田辺製薬株式会社 | Phenoxyacetic acid derivative |
| JPH068275B2 (en) * | 1988-02-04 | 1994-02-02 | 田辺製薬株式会社 | Phenoxyacetic acid derivative |
| EP0325245B1 (en) * | 1988-01-19 | 1993-10-20 | Tanabe Seiyaku Co., Ltd. | Phenoxyacetic acid derivatives, preparation thereof, pharmaceutical compositions comprising them and use |
| US5173500A (en) * | 1988-08-31 | 1992-12-22 | Boehringer Mannheim Gmbh | Pharmaceutical compositions and methods of sulphonamides containing a tetrazolyl radical |
| DE3829431A1 (en) * | 1988-08-31 | 1990-03-01 | Boehringer Mannheim Gmbh | SULPHONAMID WITH TETRAZOLYL RESIDUE, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS |
| DE3829455A1 (en) * | 1988-08-31 | 1990-03-15 | Boehringer Mannheim Gmbh | SULFONAMIDOALKYL-CYCLOHEXAN COMPOUNDS, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS |
| US5280043A (en) * | 1988-10-10 | 1994-01-18 | Smith Kline & French Laboratories Ltd. | Sulphonamido containing phenylalkanoic acids as thromboxane A2 antagonists |
| US5256812A (en) * | 1989-01-31 | 1993-10-26 | Hoffmann-La Roche Inc. | Carboxamides and sulfonamides |
| US5084466A (en) * | 1989-01-31 | 1992-01-28 | Hoffmann-La Roche Inc. | Novel carboxamide pyridine compounds which have useful pharmaceutical utility |
| DE3942923A1 (en) * | 1989-12-23 | 1991-06-27 | Boehringer Mannheim Gmbh | NEW PHENOXYALKYL CARBONIC ACID AMIDES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
| JPH05125038A (en) * | 1991-03-07 | 1993-05-21 | Tanabe Seiyaku Co Ltd | Phenyloxyalkanoic acid derivative and process for producing the same |
| US5360909A (en) * | 1992-03-23 | 1994-11-01 | Terumo Kabushiki Kaisha | Phenoxyacetic acid compounds and medical preparations containing them |
| IL110172A (en) * | 1993-07-22 | 2001-10-31 | Lilly Co Eli | Bicyclic compounds and pharmaceutical compositions containing them |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2809377A1 (en) * | 1978-03-04 | 1979-09-13 | Boehringer Mannheim Gmbh | PHENOXYALKYL CARBONIC ACID DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF, AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS |
| GB8528398D0 (en) * | 1985-11-19 | 1985-12-24 | Glaxo Group Ltd | Chemical compounds |
-
1986
- 1986-03-29 DE DE19863610643 patent/DE3610643A1/en not_active Withdrawn
-
1987
- 1987-03-24 EP EP87104281A patent/EP0239907B1/en not_active Expired - Lifetime
- 1987-03-24 AT AT87104281T patent/ATE67483T1/en not_active IP Right Cessation
- 1987-03-24 DE DE8787104281T patent/DE3773026D1/en not_active Expired - Lifetime
- 1987-03-24 ES ES198787104281T patent/ES2037676T3/en not_active Expired - Lifetime
- 1987-03-25 DD DD87301115A patent/DD263287A5/en not_active IP Right Cessation
- 1987-03-26 PT PT84572A patent/PT84572B/en not_active IP Right Cessation
- 1987-03-26 CS CS872073A patent/CS271469B2/en unknown
- 1987-03-26 DK DK155387A patent/DK155387A/en not_active Application Discontinuation
- 1987-03-27 HU HU871347A patent/HU197879B/en not_active IP Right Cessation
- 1987-03-27 JP JP62071957A patent/JPS62238259A/en active Pending
- 1987-03-27 AU AU70723/87A patent/AU582043B2/en not_active Ceased
- 1987-03-27 FI FI871360A patent/FI871360A7/en not_active Application Discontinuation
- 1987-03-27 ZA ZA872254A patent/ZA872254B/en unknown
- 1987-03-29 IL IL82039A patent/IL82039A0/en unknown
-
1991
- 1991-11-11 GR GR91401329T patent/GR3003100T3/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUT43559A (en) | 1987-11-30 |
| PT84572B (en) | 1989-11-30 |
| FI871360A0 (en) | 1987-03-27 |
| FI871360A7 (en) | 1987-09-30 |
| DE3610643A1 (en) | 1987-10-01 |
| EP0239907A1 (en) | 1987-10-07 |
| HU197879B (en) | 1989-06-28 |
| PT84572A (en) | 1987-04-01 |
| IL82039A0 (en) | 1987-10-20 |
| JPS62238259A (en) | 1987-10-19 |
| GR3003100T3 (en) | 1993-02-17 |
| DE3773026D1 (en) | 1991-10-24 |
| DD263287A5 (en) | 1988-12-28 |
| CS271469B2 (en) | 1990-10-12 |
| ES2037676T3 (en) | 1993-07-01 |
| DK155387D0 (en) | 1987-03-26 |
| DK155387A (en) | 1987-09-30 |
| EP0239907B1 (en) | 1991-09-18 |
| ATE67483T1 (en) | 1991-10-15 |
| ZA872254B (en) | 1987-11-25 |
| AU7072387A (en) | 1987-10-15 |
| AU582043B2 (en) | 1989-03-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CS207387A2 (en) | Method of phenoxyalkylcarboxyl acid's derivatives production | |
| HUT45489A (en) | Process for producing substituted amino-5,6,7,8-tetrahydronaphthyl-oxy-acetic acid derivatives and pharmaceutics comprising the same | |
| DE3675087D1 (en) | PYRIDONE CARBONIC DERIVATIVES AND METHOD FOR THE PRODUCTION THEREOF. | |
| ATE47138T1 (en) | PROCESS FOR THE PREPARATION OF 1,2-DITHIOLANE-3PENTANS|URE (THIOCTAID). | |
| IE861810L (en) | Eicosatriynoic acid esters and amides | |
| ES8602716A1 (en) | Thiazolidine derivatives, their preparation and intermediates therefor, and pharmaceutical preparations. | |
| PT87160A (en) | VERFAHREN ZUR HERSTELLUNG VON 3H-1,2,3-TRIAZOLO] 4,5-D "PYRIMIDINEN | |
| DE3572808D1 (en) | 4-(nitrophenyl)-tetrahydropyridines, process for their preparation and their application as pharmaceutical compounds | |
| ATE36853T1 (en) | BETA-CARBOLINE-3-CARBONIC ACID DERIVATIVES AND METHOD FOR THEIR PRODUCTION. | |
| ATE37368T1 (en) | BENZOTHIAZOLONE DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. | |
| DE3688161D1 (en) | If necessary, etherified or esterified in position 2 substituted 4-OH-CHINOLINE CARBONIC ACID DERIVATIVES, METHODS AND INTERMEDIATE PRODUCTS FOR THEIR PRODUCTION, THEIR USE AS A MEDICINAL PRODUCT, AND THE EQUIPMENT THEREOF. | |
| ES8707523A1 (en) | 8-Thiotetrahydroquinoleine derivatives and their salts. | |
| ATE33139T1 (en) | OXIMINOPHOSPHORIC ACID DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND USE TO COMBAT PESTS. | |
| ATE46340T1 (en) | OXIMINOPHOSPHORIC ACID DERIVATIVES, PROCESS FOR THEIR PRODUCTION AND USE TO COMBAT PESTS. | |
| DE3772852D1 (en) | THIADIAZOLYL ACETAMIDE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE. | |
| ES8504688A1 (en) | Halogenoalkylcarbamic-acid esters, their preparation and their use as pesticides. | |
| ATE59651T1 (en) | SODIUM SALT OF ETODOL ACID AND METHOD OF PRODUCTION. |