ES8204720A1 - Procedimiento para preparar derivados de dihidropiridina - Google Patents
Procedimiento para preparar derivados de dihidropiridinaInfo
- Publication number
- ES8204720A1 ES8204720A1 ES497927A ES497927A ES8204720A1 ES 8204720 A1 ES8204720 A1 ES 8204720A1 ES 497927 A ES497927 A ES 497927A ES 497927 A ES497927 A ES 497927A ES 8204720 A1 ES8204720 A1 ES 8204720A1
- Authority
- ES
- Spain
- Prior art keywords
- preparation
- pharmaceutical preparations
- dihydropyridine
- dichlorophenyl
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
- C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE DIHIDROPIRIDINA DE FORMULA (I), EN LA QUE R1, R2 Y R3 PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II) EN LA QUE RA ES METILO O R3 Y RB ES R1 O R2, CON UN COMPUESTO DE FORMULA (III), EN LA QUE R''A ES METILO CUANDO RA ES R3, Y VICEVERSA, Y R''B ES R1 CUANDO RB ES R2, Y VICEVERSA. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE O DISOLVENTES ORGANICOS INERTES, A LA TEMPERATURA AMBIENTE. LA SEPARACION Y PURIFICACION DEL PRODUCTO OBTENIDO SE EFECTUA POR METODOS CONVENCIONALES. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO AGENTES ANTIHIPERTENSORES.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE7910521A SE7910521L (sv) | 1979-12-20 | 1979-12-20 | Nya 2-metyl-6-substituerade-4-(2,3-disubstituerad fenyl)-1,4-dihydropyridin-3,5-diestrar med hypotesiva egenskaper, samt forfarande for deras framstellning, och farmaceutiska beredningar innehallande desamma |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8204720A1 true ES8204720A1 (es) | 1982-05-01 |
| ES497927A0 ES497927A0 (es) | 1982-05-01 |
Family
ID=20339605
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES497927A Granted ES497927A0 (es) | 1979-12-20 | 1980-12-19 | Procedimiento para preparar derivados de dihidropiridina |
| ES508024A Expired ES8307220A1 (es) | 1979-12-20 | 1981-12-16 | "procedimiento para preparar derivados de dihidropiridina". |
| ES508031A Granted ES508031A0 (es) | 1979-12-20 | 1981-12-16 | Procedimiento para preparar derivados de dihidropiridina. |
| ES508025A Expired ES8307221A1 (es) | 1979-12-20 | 1981-12-16 | "procedimiento para preparar derivados de dihidropiridina". |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES508024A Expired ES8307220A1 (es) | 1979-12-20 | 1981-12-16 | "procedimiento para preparar derivados de dihidropiridina". |
| ES508031A Granted ES508031A0 (es) | 1979-12-20 | 1981-12-16 | Procedimiento para preparar derivados de dihidropiridina. |
| ES508025A Expired ES8307221A1 (es) | 1979-12-20 | 1981-12-16 | "procedimiento para preparar derivados de dihidropiridina". |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP0031801A3 (es) |
| JP (1) | JPS56127356A (es) |
| AU (1) | AU6542380A (es) |
| DD (1) | DD155519A5 (es) |
| DK (1) | DK539980A (es) |
| ES (4) | ES497927A0 (es) |
| FI (1) | FI803984L (es) |
| MY (1) | MY8500404A (es) |
| NO (1) | NO803856L (es) |
| SE (1) | SE7910521L (es) |
| ZA (1) | ZA807634B (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3018259A1 (de) * | 1980-05-13 | 1981-11-19 | Bayer Ag, 5090 Leverkusen | 1,4-dihydropyridine mit unterschiedlichen substituenten in 2- und 6-position, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln |
| DK161312C (da) * | 1982-03-11 | 1991-12-09 | Pfizer | Analogifremgangsmaade til fremstilling af 2-aminoalkoxymethyl-4-phenyl-6-methyl-1,4-dihydropyridin-3,5-dicarboxylsyreestere eller syreadditionssalte deraf samt phthalimidoderivater til anvendelse som udgangsmateriale ved fremgangsmaaden |
| IL68604A0 (en) * | 1982-05-21 | 1983-09-30 | Haessle Ab | Processes for preparing therapeutically active dihydropyridines and intermediates for the processes |
| ATE20064T1 (de) * | 1982-07-22 | 1986-06-15 | Pfizer | Anti-ischaemische und antihypertensive dihydropyridin-derivate. |
| HU197881B (en) * | 1982-08-06 | 1989-06-28 | Banyu Pharma Co Ltd | Process for producing new carbamoyl-oxy-alkyl-carboxy-lic acid derivatives |
| PH19166A (en) * | 1982-09-04 | 1986-01-16 | Pfizer | Dihydropyridined,pharmaceutical compositions and method of use |
| EP0107293A3 (en) * | 1982-09-04 | 1984-06-06 | Pfizer Limited | Dihydropyridines |
| PT77842B (en) * | 1982-12-21 | 1986-05-05 | Pfizer | Process for preparing dihydropyridines |
| US4515799A (en) * | 1983-02-02 | 1985-05-07 | Pfizer Inc. | Dihydropyridine anti-ischaemic and antihypertensive agents |
| GB8306666D0 (en) * | 1983-03-10 | 1983-04-13 | Pfizer Ltd | Therapeutic agents |
| GB8412208D0 (en) * | 1984-05-12 | 1984-06-20 | Pfizer Ltd | Quinolone inotropic agents |
| GB8415386D0 (en) * | 1984-06-15 | 1984-07-18 | Pfizer Ltd | Therapeutic agents |
| GB8526411D0 (en) * | 1985-10-25 | 1985-11-27 | Pfizer Ltd | Dihydropyridines |
| GB8527698D0 (en) * | 1985-11-09 | 1985-12-11 | Pfizer Ltd | Dihydropyridine antiischaemic & antihypertensive agents |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2117572C3 (de) * | 1971-04-10 | 1980-03-20 | Bayer Ag, 5090 Leverkusen | Unsymmetrische 1,4-Dihydropyridin ^-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel |
| SE429652B (sv) * | 1978-06-30 | 1983-09-19 | Haessle Ab | 2.6-dimetyl-4-(2.3-diklorfenyl)-1.4-dihydropyridin-3.5-dikarboxylsyra-3-metylester-5-etylester |
| CA1117117A (en) * | 1978-10-10 | 1982-01-26 | Fujisawa Pharmaceutical Co., Ltd. | 2-methyl-dihydropyridine compound, processes for preparation thereof and pharmaceutical composition comprising the same |
-
1979
- 1979-12-20 SE SE7910521A patent/SE7910521L/xx not_active Application Discontinuation
-
1980
- 1980-12-05 ZA ZA00807634A patent/ZA807634B/xx unknown
- 1980-12-16 AU AU65423/80A patent/AU6542380A/en not_active Abandoned
- 1980-12-16 EP EP80850190A patent/EP0031801A3/en not_active Withdrawn
- 1980-12-18 NO NO803856A patent/NO803856L/no unknown
- 1980-12-18 DK DK539980A patent/DK539980A/da unknown
- 1980-12-19 DD DD80226363A patent/DD155519A5/de unknown
- 1980-12-19 FI FI803984A patent/FI803984L/fi not_active Application Discontinuation
- 1980-12-19 ES ES497927A patent/ES497927A0/es active Granted
- 1980-12-20 JP JP18180980A patent/JPS56127356A/ja active Pending
-
1981
- 1981-12-16 ES ES508024A patent/ES8307220A1/es not_active Expired
- 1981-12-16 ES ES508031A patent/ES508031A0/es active Granted
- 1981-12-16 ES ES508025A patent/ES8307221A1/es not_active Expired
-
1985
- 1985-12-30 MY MY404/85A patent/MY8500404A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU6542380A (en) | 1981-06-25 |
| DK539980A (da) | 1981-06-21 |
| NO803856L (no) | 1981-06-22 |
| FI803984L (fi) | 1981-06-21 |
| ES8306109A1 (es) | 1982-10-01 |
| EP0031801A2 (en) | 1981-07-08 |
| MY8500404A (en) | 1985-12-31 |
| ES497927A0 (es) | 1982-05-01 |
| ZA807634B (en) | 1981-11-25 |
| JPS56127356A (en) | 1981-10-06 |
| ES508024A0 (es) | 1982-11-16 |
| DD155519A5 (de) | 1982-06-16 |
| ES508025A0 (es) | 1982-11-01 |
| SE7910521L (sv) | 1981-06-21 |
| ES8307220A1 (es) | 1982-11-16 |
| EP0031801A3 (en) | 1981-09-16 |
| ES508031A0 (es) | 1982-10-01 |
| ES8307221A1 (es) | 1982-11-01 |
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