ES8406193A1 - Procedimiento para la preparacion de nuevas 1,4-dihidropiridinas sustituidas - Google Patents
Procedimiento para la preparacion de nuevas 1,4-dihidropiridinas sustituidasInfo
- Publication number
- ES8406193A1 ES8406193A1 ES528175A ES528175A ES8406193A1 ES 8406193 A1 ES8406193 A1 ES 8406193A1 ES 528175 A ES528175 A ES 528175A ES 528175 A ES528175 A ES 528175A ES 8406193 A1 ES8406193 A1 ES 8406193A1
- Authority
- ES
- Spain
- Prior art keywords
- denotes
- dihydropyridines
- pharmaceuticals
- substituted
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyridine Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Protection Of Plants (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Storage Of Fruits Or Vegetables (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE 1,4-DIHIDROPIRIDINAS SUSTITUIDAS Y DE SUS SALES DE ADICION DE ACIDO, DE FORMULA (I), EN LA QUE R, R Y R PUEDEN SER VARIOS TIPOS DE RADICALES.CONSISTE EN LA REACCION DE 2 MOLES DE UN COMPUESTO DE FORMULA H3C-CO-CH2-R1 CON UN MOL DE UN COMPUESTO DE FORMULA RCHO, EN LAS QUE R Y R SON LOS MISMOS QUE EN LA FORMULA (I), Y UN MOL DE AMONIACO, EN UN DISOLVENTE INERTE, A UNA TEMPERATURA ENTRE LA AMBIENTE Y LA DE REFLUJO DEL DISOLVENTE.TAMBIEN SE PUEDE PARTIR DE OTROS COMPUESTOS COMO PRODUCTOS DE PARTIDA, EFECTUANDO LA REACCION EN LAS MISMAS CONDICIONES.ESTOS COMPUESTOSTIENEN APLICACIONES FARMACOLOGICAS POR SUS ACTIVIDADES CARDIOVASCULARES.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19823247118 DE3247118A1 (de) | 1982-12-20 | 1982-12-20 | Neue substituierte 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8406193A1 true ES8406193A1 (es) | 1984-08-01 |
ES528175A0 ES528175A0 (es) | 1984-08-01 |
Family
ID=6181182
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES528175A Granted ES528175A0 (es) | 1982-12-20 | 1983-12-19 | Procedimiento para la preparacion de nuevas 1,4-dihidropiridinas sustituidas |
Country Status (20)
Country | Link |
---|---|
US (1) | US4558058A (es) |
EP (1) | EP0116708B1 (es) |
JP (1) | JPS59118783A (es) |
KR (1) | KR840006969A (es) |
AT (1) | ATE19776T1 (es) |
AU (1) | AU562583B2 (es) |
CA (1) | CA1194480A (es) |
CS (1) | CS241144B2 (es) |
DD (1) | DD215548A5 (es) |
DE (2) | DE3247118A1 (es) |
DK (1) | DK562683A (es) |
ES (1) | ES528175A0 (es) |
FI (1) | FI834451A (es) |
GR (1) | GR79484B (es) |
HU (1) | HU194556B (es) |
NO (1) | NO834480L (es) |
PH (1) | PH20327A (es) |
PL (1) | PL140526B1 (es) |
SU (1) | SU1360585A3 (es) |
ZA (1) | ZA839382B (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4414213A (en) * | 1982-03-22 | 1983-11-08 | Mead Johnson & Company | Dihydropyridyl cyclic imidate esters and their pharmaceutical use |
DE3431152A1 (de) * | 1984-08-24 | 1986-03-06 | Cassella Ag, 6000 Frankfurt | Verfahren zur herstellung optisch aktiver, substituierter 1,4-dihydropyridine und ihre verwendung als arzneimittel |
DE3431862A1 (de) * | 1984-08-30 | 1986-03-13 | Bayer Ag, 5090 Leverkusen | Neue 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln |
US5326772A (en) * | 1984-09-28 | 1994-07-05 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Diaryl compounds for their use |
JPS6191185A (ja) * | 1984-10-11 | 1986-05-09 | Sumitomo Seiyaku Kk | 新規なオキサジアゾリル−1,4−ジヒドロピリジン誘導体 |
DE3443179A1 (de) * | 1984-11-27 | 1986-05-28 | Cassella Ag, 6000 Frankfurt | 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung |
US4650805A (en) * | 1985-12-02 | 1987-03-17 | Warner-Lambert Company | 4-(1,2,5,6-Tetrahydro-1-alkyl-3-pyridinyl)-2-thiazolamines and 4-(hexahydro-1-alkyl-3-pyridinyl)-2-thiazolamines having anti-psychotic activity |
US4920225A (en) * | 1986-12-22 | 1990-04-24 | Laboratoires Syntex S.A. | Resolution of 1,4-dihydropyridine derivatives |
JP2625190B2 (ja) * | 1987-03-27 | 1997-07-02 | ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | 1,4―ジヒドロピリジン―エナンチオマーおよびその製法 |
SE8703881D0 (sv) * | 1987-10-08 | 1987-10-08 | Haessle Ab | New pharmaceutical preparation |
FR2627696B1 (fr) * | 1988-02-26 | 1991-09-13 | Fournier Innovation Synergie | Nouvelle forme galenique du fenofibrate |
DE3807895A1 (de) * | 1988-03-10 | 1989-09-21 | Knoll Ag | Erzeugnisse, enthaltend einen calciumantagonisten und einen lipidsenker |
US5276150A (en) * | 1989-05-31 | 1994-01-04 | Fujirebio Inc. | 1,4-dihydropyridine derivatives |
FR2758459B1 (fr) | 1997-01-17 | 1999-05-07 | Pharma Pass | Composition pharmaceutique de fenofibrate presentant une biodisponibilite elevee et son procede de preparation |
US6531158B1 (en) | 2000-08-09 | 2003-03-11 | Impax Laboratories, Inc. | Drug delivery system for enhanced bioavailability of hydrophobic active ingredients |
US7312337B2 (en) * | 2004-09-30 | 2007-12-25 | Eastman Kodak Company | Oxadiazoles and their manufacture |
DE102006044696A1 (de) * | 2006-09-22 | 2008-03-27 | Bayer Healthcare Ag | 3-Cyano-5-thiazaheteroaryl-dihydropyridine und ihre Verwendung |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3647809A (en) * | 1968-04-26 | 1972-03-07 | Chinoin Gyogyszer Es Vegyeszet | Certain pyridyl-1 2 4-oxadiazole derivatives |
DE1963186C3 (de) * | 1969-12-17 | 1979-02-15 | Bayer Ag, 5090 Leverkusen | Schwefelhaltige 1,4-Dihydropyridin-33-dicarbonsäureester |
DE2005116C3 (de) * | 1970-02-05 | 1980-02-14 | Bayer Ag, 5090 Leverkusen | Symmetrische 1,4-Dihydropyridin-3,5-dicarbonsäureester |
CA962269A (en) * | 1971-05-05 | 1975-02-04 | Robert E. Grahame (Jr.) | Thiazoles, and their use as insecticides |
GB1552911A (en) * | 1975-07-02 | 1979-09-19 | Fujisawa Pharmaceutical Co | 1,4 dihydropyridine derivatives and the preparation thereof |
DE2747513A1 (de) * | 1977-10-22 | 1979-05-03 | Bayer Ag | Dihydropyridine mit schwefelhaltigen estergruppierungen |
US4144343A (en) * | 1978-01-04 | 1979-03-13 | Merck & Co., Inc. | Heterocycle substituted (3-loweralkylamino-2-R1 O-propoxy)pyridines |
DE2847236A1 (de) * | 1978-10-31 | 1980-05-14 | Bayer Ag | Neue dihydropyridine mit substituierten estergruppierungen, mehrer verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel |
DE3022030A1 (de) * | 1980-06-12 | 1981-12-17 | Bayer Ag, 5090 Leverkusen | 4-thiazol- bzw. 4-imidazol-substituierte, 1,4-dihydropyridine, verfahren zu deren herstellung sowie diese enthaltende arzneimittel |
US4414213A (en) * | 1982-03-22 | 1983-11-08 | Mead Johnson & Company | Dihydropyridyl cyclic imidate esters and their pharmaceutical use |
-
1982
- 1982-12-20 DE DE19823247118 patent/DE3247118A1/de not_active Withdrawn
-
1983
- 1983-12-05 FI FI834451A patent/FI834451A/fi not_active Application Discontinuation
- 1983-12-06 NO NO834480A patent/NO834480L/no unknown
- 1983-12-06 DK DK562683A patent/DK562683A/da not_active Application Discontinuation
- 1983-12-09 US US06/560,197 patent/US4558058A/en not_active Expired - Fee Related
- 1983-12-14 EP EP83112562A patent/EP0116708B1/de not_active Expired
- 1983-12-14 AT AT83112562T patent/ATE19776T1/de active
- 1983-12-14 DE DE8383112562T patent/DE3363545D1/de not_active Expired
- 1983-12-19 GR GR73283A patent/GR79484B/el unknown
- 1983-12-19 CS CS839613A patent/CS241144B2/cs unknown
- 1983-12-19 SU SU833675005A patent/SU1360585A3/ru active
- 1983-12-19 AU AU22533/83A patent/AU562583B2/en not_active Expired - Fee Related
- 1983-12-19 PL PL1983245200A patent/PL140526B1/pl unknown
- 1983-12-19 ZA ZA839382A patent/ZA839382B/xx unknown
- 1983-12-19 ES ES528175A patent/ES528175A0/es active Granted
- 1983-12-19 JP JP58238045A patent/JPS59118783A/ja active Pending
- 1983-12-19 CA CA000443586A patent/CA1194480A/en not_active Expired
- 1983-12-19 HU HU834330A patent/HU194556B/hu not_active IP Right Cessation
- 1983-12-19 DD DD83258173A patent/DD215548A5/de unknown
- 1983-12-20 KR KR1019830006046A patent/KR840006969A/ko not_active Application Discontinuation
-
1986
- 1986-12-02 PH PH29994A patent/PH20327A/en unknown
Also Published As
Publication number | Publication date |
---|---|
NO834480L (no) | 1984-06-21 |
SU1360585A3 (ru) | 1987-12-15 |
PL140526B1 (en) | 1987-05-30 |
DE3247118A1 (de) | 1984-06-20 |
GR79484B (es) | 1984-10-30 |
DD215548A5 (de) | 1984-11-14 |
ES528175A0 (es) | 1984-08-01 |
DK562683A (da) | 1984-06-21 |
DE3363545D1 (en) | 1986-06-19 |
US4558058A (en) | 1985-12-10 |
KR840006969A (ko) | 1984-12-04 |
PL245200A1 (en) | 1985-02-27 |
EP0116708B1 (de) | 1986-05-14 |
ZA839382B (en) | 1984-08-29 |
DK562683D0 (da) | 1983-12-06 |
FI834451A (fi) | 1984-06-21 |
EP0116708A1 (de) | 1984-08-29 |
JPS59118783A (ja) | 1984-07-09 |
CS961383A2 (en) | 1985-07-16 |
AU562583B2 (en) | 1987-06-11 |
ATE19776T1 (de) | 1986-05-15 |
CA1194480A (en) | 1985-10-01 |
FI834451A0 (fi) | 1983-12-05 |
PH20327A (en) | 1986-12-02 |
HU194556B (en) | 1988-02-29 |
CS241144B2 (en) | 1986-03-13 |
AU2253383A (en) | 1984-06-28 |
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