ES8401065A1 - Procedimiento para preparar derivados de benzotiadiazol-amina. - Google Patents

Procedimiento para preparar derivados de benzotiadiazol-amina.

Info

Publication number
ES8401065A1
ES8401065A1 ES509734A ES509734A ES8401065A1 ES 8401065 A1 ES8401065 A1 ES 8401065A1 ES 509734 A ES509734 A ES 509734A ES 509734 A ES509734 A ES 509734A ES 8401065 A1 ES8401065 A1 ES 8401065A1
Authority
ES
Spain
Prior art keywords
benzothiadiazol
benzoxadiazol
derivatives
amino
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES509734A
Other languages
English (en)
Other versions
ES509734A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES8401065A1 publication Critical patent/ES8401065A1/es
Publication of ES509734A0 publication Critical patent/ES509734A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE BENZOTIADIAZOLAMINA Y DE SUS SALES, DE FORMULA A-B-C, EN LA QUE A ES 2,1,3-BENZOTIADIAZOL O 2,1,3-BENZOXADIAZOL; B ES AMINO TRISUSTITUIDO; Y C ES 4,5-DIHIDRO-1-H-IMIDAZOL-2-ILO, O 3,4,5,6-TETRAHIDROPIRIMIDIN-2-ILO, EVENTUALMENTE SUSTITUIDO.CONSISTE EN LA REACCION DE SUSTITUCION NUCLEOFILA EN UN COMPUESTO DE FORMULA (I), EN LA QUE N VALE 2 O 3, X ES OXIGENO O AZUFRE, R5 ES HIDROGENO O ALQUILO C1-4, Y R1, R2 Y R3 PUEDEN SER VARIOS TIPOS DE RADICALES. LA N-ALQUILACION SE EFECTUA POR TRATAMIENTO CON UN COMPUESTO DE FORMULA Z-R4 EN LAQUE R4 PUEDE SER VARIOS RADICALES Y Z ES UN GRUPO FACILMENTE ELIMINABLE, EN UN DISOLVENTE INERTE, A TEMPERATURAS ENTRE LA AMBIENTE Y 100JC.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE LA ANGINA DE PECHO Y DE TRASTORNOS DEL RITMO CARDIACO COMO LA SINUS-TAQUICARDIA.
ES509734A 1981-02-19 1982-02-18 Procedimiento para preparar derivados de benzotiadiazol-amina. Granted ES509734A0 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CH111181 1981-02-19
CH111081 1981-02-19
CH648081 1981-10-09

Publications (2)

Publication Number Publication Date
ES8401065A1 true ES8401065A1 (es) 1983-12-01
ES509734A0 ES509734A0 (es) 1983-12-01

Family

ID=27172704

Family Applications (1)

Application Number Title Priority Date Filing Date
ES509734A Granted ES509734A0 (es) 1981-02-19 1982-02-18 Procedimiento para preparar derivados de benzotiadiazol-amina.

Country Status (17)

Country Link
US (1) US4476135A (es)
AU (1) AU555173B2 (es)
CA (1) CA1199636A (es)
CH (1) CH652401A5 (es)
DE (1) DE3204623A1 (es)
DK (1) DK70482A (es)
ES (1) ES509734A0 (es)
FI (1) FI820477L (es)
FR (1) FR2499991A1 (es)
GB (1) GB2093450B (es)
HU (1) HU189562B (es)
IL (1) IL65040A (es)
IT (1) IT1186667B (es)
NL (1) NL8200565A (es)
PT (1) PT74448B (es)
SE (1) SE8201019L (es)
WO (1) WO1982002891A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5032604A (en) * 1989-12-08 1991-07-16 Merck & Co., Inc. Class III antiarrhythmic agents
US6110935A (en) * 1997-02-13 2000-08-29 The Regents Of The University Of California Benzofurazan compounds for enhancing glutamatergic synaptic responses
GB9802251D0 (en) * 1998-02-03 1998-04-01 Ciba Geigy Ag Organic compounds
US6756367B2 (en) 1998-02-03 2004-06-29 Novartis Ag Benzo-oxadiazoles, -thiadiazoles and -1,4-diazines, pharmaceutical compositions containing them and a process for preparing them
ATE529293T1 (de) 2001-08-09 2011-11-15 Virgin Atlantic Airways Ltd Eine sitzanordnung und eine passagier-sitzeinheit für ein flugzeug
GB0224198D0 (en) * 2002-10-17 2002-11-27 Novartis Ag Organic compounds

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3636219A (en) * 1964-03-02 1972-01-18 Du Pont Anticholinergic compositions containing certain thiazolines or imidazolines
BE759125A (fr) * 1969-11-19 1971-05-18 Boehringer Sohn Ingelheim Nouvelles n-allyl-2-arylamino-imidazolines-(2) substituees et procedes pour les fabriquer
CH570401A5 (es) * 1972-05-09 1975-12-15 Wander Ag Dr A
CH579565A5 (en) * 1973-03-15 1976-09-15 Wander Ag Dr A Imidazolin-2-ylamino-2,1,3-benzothiadiazoles prodn. - by cyclising corresp. beta aminoethyl (thio) ureas, active against muscle tremors and rigor
US4217356A (en) * 1975-08-22 1980-08-12 Sandoz Ltd. 2-Imidazolinylamino-2,1,3-benzothiadiazoles
CH625238A5 (en) * 1976-12-02 1981-09-15 Sandoz Ag Process for the preparation of (2-imidazolin-2-ylamino)-2,1,3-benzoxadiazoles
DE2831671A1 (de) * 1978-07-19 1980-02-07 Boehringer Sohn Ingelheim Neue substituierte 2-phenylamino-imidazoline-(2), deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben
AU534451B2 (en) * 1979-02-16 1984-02-02 Sandoz Ltd. Organic compounds and method of treatment
DE3012837A1 (de) * 1979-04-10 1980-10-30 Sandoz Ag Analgetische und myotonolytische praeparate
DE2947563A1 (de) * 1979-11-26 1981-06-04 C.H. Boehringer Sohn, 6507 Ingelheim Neue substituierte 2-phenylamino-imidazoline-(2), deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben
DE2950345A1 (de) * 1979-12-14 1981-07-02 C.H. Boehringer Sohn, 6507 Ingelheim Neue substituierte 2-phenylaminoimidazoline-(2), deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zur herstellung derselben

Also Published As

Publication number Publication date
CA1199636A (en) 1986-01-21
AU8056082A (en) 1982-08-26
IT8247807A0 (it) 1982-02-17
PT74448A (en) 1982-03-01
SE8201019L (sv) 1982-08-20
US4476135A (en) 1984-10-09
CH652401A5 (de) 1985-11-15
IL65040A (en) 1986-03-31
FR2499991A1 (fr) 1982-08-20
WO1982002891A1 (en) 1982-09-02
DK70482A (da) 1982-08-20
IL65040A0 (en) 1984-04-30
AU555173B2 (en) 1986-09-18
GB2093450B (en) 1984-10-31
DE3204623A1 (de) 1982-09-16
IT1186667B (it) 1987-12-04
ES509734A0 (es) 1983-12-01
FI820477L (fi) 1982-08-20
HU189562B (en) 1986-07-28
FR2499991B1 (es) 1984-12-21
GB2093450A (en) 1982-09-02
PT74448B (en) 1984-08-01
NL8200565A (nl) 1982-09-16

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