ES480850A1 - Procedimiento para preparar hidantoinas. - Google Patents
Procedimiento para preparar hidantoinas.Info
- Publication number
- ES480850A1 ES480850A1 ES480850A ES480850A ES480850A1 ES 480850 A1 ES480850 A1 ES 480850A1 ES 480850 A ES480850 A ES 480850A ES 480850 A ES480850 A ES 480850A ES 480850 A1 ES480850 A1 ES 480850A1
- Authority
- ES
- Spain
- Prior art keywords
- phenyl
- alkyl
- alkoxy
- optionally substituted
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/96—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/74—Two oxygen atoms, e.g. hydantoin with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to other ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/72—Two oxygen atoms, e.g. hydantoin
- C07D233/76—Two oxygen atoms, e.g. hydantoin with substituted hydrocarbon radicals attached to the third ring carbon atom
- C07D233/78—Radicals substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Procedimiento para preparar hidantoinas, de fórmula: **(Fórmula 01)** en la que Ar es fenilo opcionalmente sustituido por hasta 3 radiales elegidos entre alcoxi C1-6, halógeno, 1,3-dioxol¿2- ilo, hidroxialcoxi C1-4-alquilo C1-4, fenilo, hidroxilo, nitrilo, haloalquilo C1-4, alquilo C1-4, alquiniloxi C2-4, alcoxicarbonilo C1-4 o fenoxi opcionalmente sustituido por haloalquilo C1-4, alcoxi C1-4 ó halógeno; o es tiofeno opcionalmente sustituido por fenilo o por 1 ó 2 grupos alquilo C1-4; R1 y R2 son independientemente hidrógeno o juntos representan un enlace químico; R3 es hidrógeno, alquilo C1-6 ó alquenilo C2-4; y R4 es alquilo C1-6, alquinilo C2-4, fenilo o bencilo; a condición de que R3 no puede ser hidrógeno cuando Ar es fenilo insustituido y R4 es n-butilo; caracterizado porque comprende: (a) reaccionar un compuesto de fórmula: **(Fórmula 02)** con un aldehido de fórmula ArCHO para dar un compuesto de fórmula I en donde R1 y R2 representan un enlace químico; o (b) reducir un compuesto de fórmula I en donde R1 y R2 representan un enlace químico para dar un compuesto de fórmula I en donde R1 y R2 son hidrógeno; o (c) reaccionar un compuesto de fórmula: **(Fórmula 03)** con un isocianato de fórmula R4NCO para dar un compuesto de fórmula I en donde R1 y R2 son hidrógeno.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB21352/78A GB1601310A (en) | 1978-05-23 | 1978-05-23 | Aryl hydantoins |
Publications (1)
Publication Number | Publication Date |
---|---|
ES480850A1 true ES480850A1 (es) | 1980-02-01 |
Family
ID=10161451
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES480850A Expired ES480850A1 (es) | 1978-05-23 | 1979-05-23 | Procedimiento para preparar hidantoinas. |
Country Status (31)
Country | Link |
---|---|
US (2) | US4241073A (es) |
EP (1) | EP0005647B1 (es) |
JP (1) | JPS54160373A (es) |
KR (1) | KR830000635B1 (es) |
AR (2) | AR225143A1 (es) |
AT (1) | AT366034B (es) |
AU (1) | AU530968B2 (es) |
BE (1) | BE876435A (es) |
BG (2) | BG31799A3 (es) |
CA (1) | CA1120481A (es) |
CH (2) | CH639650A5 (es) |
CS (2) | CS208654B2 (es) |
DD (1) | DD143769A5 (es) |
DE (1) | DE2963061D1 (es) |
DK (1) | DK207579A (es) |
ES (1) | ES480850A1 (es) |
FI (1) | FI791614A (es) |
FR (1) | FR2426681A1 (es) |
GB (1) | GB1601310A (es) |
GR (1) | GR68363B (es) |
HU (1) | HU184648B (es) |
IL (1) | IL57343A (es) |
LU (1) | LU81300A1 (es) |
MX (1) | MX5604E (es) |
NZ (1) | NZ190512A (es) |
PL (2) | PL125075B1 (es) |
PT (1) | PT69648A (es) |
RO (2) | RO79703A (es) |
SU (2) | SU873878A3 (es) |
YU (1) | YU120179A (es) |
ZA (1) | ZA792501B (es) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3013647C2 (de) * | 1980-04-09 | 1985-07-11 | Degussa Ag, 6000 Frankfurt | Verfahren zur Herstellung von 5-Arylidenhydantoinen (B) |
US4431656A (en) * | 1981-02-05 | 1984-02-14 | Kanegafuchi Chemical Industry Company Limited | 3,5-di-Tert-butylstyrene derivatives, salts thereof, and pharmaceutical compositions containing the same as an active ingredient |
US4684735A (en) * | 1985-07-01 | 1987-08-04 | Stauffer Chemical Company | Promotion of raney nickel hydrogenation catalyst |
JPS6317864A (ja) * | 1986-07-11 | 1988-01-25 | Mitsui Toatsu Chem Inc | ヒダントイン類の製造方法 |
HU204047B (en) * | 1987-01-31 | 1991-11-28 | Sandoz Ag | Process for producing pilocarpine derivatives and pharmaceutical compositions comprising such compounds |
IE62214B1 (en) * | 1988-05-25 | 1995-01-11 | Warner Lambert Co | Arylmethylenyl derivatives of thiazolidinones, imidazolidinones and oxazolidinones useful as antiallergy agents and antiinflammatory agents |
US5143928A (en) * | 1990-03-27 | 1992-09-01 | Warner-Lambert Company | 3,5-di-tertiarybutyl-4-hydroxyphenylmethylene derivatives of 2-substituted thiazolidinones, oxazolidinones, and imidazolidinones as antiinflammatory agents |
US5362733A (en) * | 1990-04-27 | 1994-11-08 | Orion-Yhtyma Oy | Pharmacologically active catechol derivatives |
FR2687153B1 (fr) * | 1992-02-07 | 1994-05-13 | Hoechst Ste Francaise | Procede de preparation de la (thenyl-2)-5 hydantouine. |
WO1995029910A1 (en) * | 1994-04-28 | 1995-11-09 | Yamanouchi Pharmaceutical Co., Ltd. | Imidazolidinedione derivative |
SE0100903D0 (sv) * | 2001-03-15 | 2001-03-15 | Astrazeneca Ab | Compounds |
SE0100902D0 (sv) * | 2001-03-15 | 2001-03-15 | Astrazeneca Ab | Compounds |
SE0103710D0 (sv) * | 2001-11-07 | 2001-11-07 | Astrazeneca Ab | Compounds |
CN1582279A (zh) * | 2001-11-30 | 2005-02-16 | 伊莱利利公司 | 过氧化物酶体激活的受体激动剂 |
SE0202539D0 (sv) * | 2002-08-27 | 2002-08-27 | Astrazeneca Ab | Compounds |
GB0221246D0 (en) * | 2002-09-13 | 2002-10-23 | Astrazeneca Ab | Compounds |
FR2845000B1 (fr) * | 2002-09-27 | 2005-05-27 | Oreal | Utilisation d'un compose heterocyclique ou de l'un de ses sels pour stimuler ou induire la pousse des cheveux et/ou freiner leur chute |
SE0401762D0 (sv) * | 2004-07-05 | 2004-07-05 | Astrazeneca Ab | Novel compounds |
US7648992B2 (en) | 2004-07-05 | 2010-01-19 | Astrazeneca Ab | Hydantoin derivatives for the treatment of obstructive airway diseases |
SE0403086D0 (sv) * | 2004-12-17 | 2004-12-17 | Astrazeneca Ab | Compounds |
SE0403085D0 (sv) * | 2004-12-17 | 2004-12-17 | Astrazeneca Ab | Novel componds |
TW200831488A (en) * | 2006-11-29 | 2008-08-01 | Astrazeneca Ab | Novel compounds |
KR101542629B1 (ko) * | 2007-05-30 | 2015-08-06 | 에프. 호프만-라 로슈 아게 | 비-뉴클레오사이드 역전사효소 억제제 |
WO2009059243A1 (en) * | 2007-11-01 | 2009-05-07 | The Uab Research Foundation | Treating and preventing viral infections |
GB2463514C (en) * | 2008-09-11 | 2018-09-26 | Galapagos Nv | Imidazolidine compounds and uses therefor |
ITBO20090078A1 (it) * | 2009-02-13 | 2010-08-14 | Consiglio Nazionale Ricerche | Composti per il trattamento del tumore alla prostata e procedimenti per la loro sintesi |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR910275A (fr) * | 1944-11-14 | 1946-06-03 | Nouvelles hydantoïnes et leur procédé de préparation | |
US2479065A (en) * | 1945-09-06 | 1949-08-16 | Du Pont | Preparation of 5-benzylhydantoin |
US2861079A (en) * | 1956-06-04 | 1958-11-18 | Dow Chemical Co | Process for making unsaturated hydantoins |
GB846601A (en) * | 1958-01-13 | 1960-08-31 | British Oxygen Res And Dev Ltd | Vinyl hydantoins |
NL131665C (es) * | 1964-05-18 | |||
US3395153A (en) * | 1964-12-16 | 1968-07-30 | United States Borax Chem | 3, 5-dialkylhydantoins |
JPS5136332B1 (es) * | 1970-12-09 | 1976-10-07 | ||
US3847933A (en) * | 1970-12-09 | 1974-11-12 | Exxon Research Engineering Co | Acid catalyzed alkylation of hydantoin |
US3932449A (en) * | 1973-10-09 | 1976-01-13 | Morton-Norwich Products, Inc. | 5-(P-dimethylaminobenzyl) hydantoin |
GB1575904A (en) * | 1976-04-23 | 1980-10-01 | Lilly Industries Ltd | Phenyl piperazines |
JPS54122276A (en) * | 1978-03-15 | 1979-09-21 | Kanegafuchi Chem Ind Co Ltd | Preparation of 5-(2-thienyl) hydantion |
-
1978
- 1978-05-23 GB GB21352/78A patent/GB1601310A/en not_active Expired
-
1979
- 1979-05-14 US US06/039,075 patent/US4241073A/en not_active Expired - Lifetime
- 1979-05-21 AT AT0373379A patent/AT366034B/de not_active IP Right Cessation
- 1979-05-21 RO RO79101095A patent/RO79703A/ro unknown
- 1979-05-21 CS CS793513A patent/CS208654B2/cs unknown
- 1979-05-21 DD DD79213034A patent/DD143769A5/de unknown
- 1979-05-21 CH CH473179A patent/CH639650A5/fr not_active IP Right Cessation
- 1979-05-21 RO RO7997601A patent/RO76807A/ro unknown
- 1979-05-21 IL IL57343A patent/IL57343A/xx unknown
- 1979-05-21 BE BE6/46839A patent/BE876435A/xx not_active IP Right Cessation
- 1979-05-21 GR GR59139A patent/GR68363B/el unknown
- 1979-05-21 CS CS793513A patent/CS208653B2/cs unknown
- 1979-05-21 DK DK207579A patent/DK207579A/da unknown
- 1979-05-21 AR AR276599A patent/AR225143A1/es active
- 1979-05-22 ZA ZA792501A patent/ZA792501B/xx unknown
- 1979-05-22 NZ NZ190512A patent/NZ190512A/en unknown
- 1979-05-22 EP EP79300907A patent/EP0005647B1/en not_active Expired
- 1979-05-22 DE DE7979300907T patent/DE2963061D1/de not_active Expired
- 1979-05-22 BG BG7944820A patent/BG31799A3/xx unknown
- 1979-05-22 AU AU47289/79A patent/AU530968B2/en not_active Ceased
- 1979-05-22 PL PL1979222701A patent/PL125075B1/pl unknown
- 1979-05-22 LU LU81300A patent/LU81300A1/fr unknown
- 1979-05-22 PL PL1979215773A patent/PL119612B1/pl unknown
- 1979-05-22 SU SU792765804A patent/SU873878A3/ru active
- 1979-05-22 YU YU01201/79A patent/YU120179A/xx unknown
- 1979-05-22 PT PT69648A patent/PT69648A/pt unknown
- 1979-05-22 FI FI791614A patent/FI791614A/fi not_active Application Discontinuation
- 1979-05-22 BG BG7943691A patent/BG32115A4/xx unknown
- 1979-05-22 HU HU79LI341A patent/HU184648B/hu unknown
- 1979-05-22 CA CA000327985A patent/CA1120481A/en not_active Expired
- 1979-05-22 FR FR7912962A patent/FR2426681A1/fr active Granted
- 1979-05-22 JP JP6317379A patent/JPS54160373A/ja active Pending
- 1979-05-22 MX MX797992U patent/MX5604E/es unknown
- 1979-05-23 KR KR1019790001672A patent/KR830000635B1/ko active
- 1979-05-23 ES ES480850A patent/ES480850A1/es not_active Expired
-
1980
- 1980-05-12 US US06/148,633 patent/US4293563A/en not_active Expired - Lifetime
- 1980-08-13 SU SU802955865A patent/SU988190A3/ru active
-
1981
- 1981-02-26 AR AR284450A patent/AR224186A1/es active
-
1983
- 1983-06-30 CH CH360783A patent/CH643546A5/fr not_active IP Right Cessation
Also Published As
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