WO2019234148A1 - Implantierbares, ventrikuläres unterstützungssystem sowie verfahren zu dessen betrieb - Google Patents

Implantierbares, ventrikuläres unterstützungssystem sowie verfahren zu dessen betrieb Download PDF

Info

Publication number
WO2019234148A1
WO2019234148A1 PCT/EP2019/064779 EP2019064779W WO2019234148A1 WO 2019234148 A1 WO2019234148 A1 WO 2019234148A1 EP 2019064779 W EP2019064779 W EP 2019064779W WO 2019234148 A1 WO2019234148 A1 WO 2019234148A1
Authority
WO
WIPO (PCT)
Prior art keywords
volume
support system
impedance
ventricular
impedance parameter
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2019/064779
Other languages
German (de)
English (en)
French (fr)
Inventor
Thomas Alexander SCHLEBUSCH
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kardion GmbH
Original Assignee
Kardion GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kardion GmbH filed Critical Kardion GmbH
Priority to CN201980051744.7A priority Critical patent/CN112584890B/zh
Priority to JP2020567819A priority patent/JP7626431B2/ja
Priority to US15/734,342 priority patent/US12257424B2/en
Priority to EP19729720.3A priority patent/EP3801674B1/de
Publication of WO2019234148A1 publication Critical patent/WO2019234148A1/de
Anticipated expiration legal-status Critical
Priority to US19/088,678 priority patent/US20250222247A1/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/10—Location thereof with respect to the patient's body
    • A61M60/122—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
    • A61M60/126—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel
    • A61M60/13—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel by means of a catheter allowing explantation, e.g. catheter pumps temporarily introduced via the vascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/10—Location thereof with respect to the patient's body
    • A61M60/122—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
    • A61M60/165—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable in, on, or around the heart
    • A61M60/178—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable in, on, or around the heart drawing blood from a ventricle and returning the blood to the arterial system via a cannula external to the ventricle, e.g. left or right ventricular assist devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/20—Type thereof
    • A61M60/205—Non-positive displacement blood pumps
    • A61M60/216—Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/50—Details relating to control
    • A61M60/508—Electronic control means, e.g. for feedback regulation
    • A61M60/515—Regulation using real-time patient data
    • A61M60/523—Regulation using real-time patient data using blood flow data, e.g. from blood flow transducers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/80—Constructional details other than related to driving
    • A61M60/802—Constructional details other than related to driving of non-positive displacement blood pumps
    • A61M60/81—Pump housings
    • A61M60/816—Sensors arranged on or in the housing, e.g. ultrasonic flow sensors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3317—Electromagnetic, inductive or dielectric measuring means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3375—Acoustical, e.g. ultrasonic, measuring means

Definitions

  • the invention relates to a method for operating an implanted ventricular support system, a processing unit and an implantable, ventricular support system.
  • the invention finds particular application in (fully) implanted left heart assist systems (LVAD).
  • LVAD left heart assist systems
  • Implanted left heart assist systems exist mainly in two variants. On the one hand there are (percutaneous) minimally invasive left heart support systems. The second variant is under the thorax opening invasively implanted left heart support systems. The first variant delivers blood directly from the left ventricle into the aorta because the (percutaneous) minimally invasive left ventricular assist system is positioned centrally in the aortic valve. The second variant promotes the blood of apically from the left ventricle via a bypass tube into the aorta.
  • the task of a cardiac support system is the promotion of blood.
  • the so-called heart-time volume (CO, usually expressed in liters per minute) has a high clinical relevance.
  • the heart-time volume relates here to the total volume flow of blood from a ventricle, in particular from the left ventricle to the aorta.
  • the effort to use this parameter as a measured value during the operation of a cardiac support system is correspondingly common.
  • the heart-time volume or the total volume flow (QHZV) from the ventricle to the aorta is therefore usually the sum of the pump volume flow (Q p ) and the aortic valve volume flow
  • An established method for determining the heart-time volume (QHZV) in the clinical setting is the use of dilution methods, all of which rely on a transcutaneously inserted catheter and therefore can only provide heart-time-volume measurement data during cardiac surgery.
  • An established method for measuring the pump volume flow (Q p ) is the correlation of the operating parameters of the support system, in particular the electrical power consumption, possibly supplemented by other physiological parameters such as blood pressure.
  • the integration of dedicated ultrasonic measurement technology into a support system has also been proposed.
  • fully implanted means that the resources required for the detection are located completely in the body of the patient and remain there. This makes it possible to detect the heart-time volume even outside a heart operation.
  • Impedance cardiography is a method for determining cardiac output by means of extracorporeal impedance measurements.
  • Four electrodes are used. A small alternating current is fed in via two electrodes, and the resulting voltage drop is measured via two further electrodes. Since blood has a higher conductivity than surrounding tissue, especially as the air-filled lung, the blood volume change in the thorax over a cardiac cycle is detectable as an impedance change.
  • Impem- patic cardiography is extracorporeal, usually with ring or adhesive electrodes around the neck and abdomen.
  • the use of left ventricular impedance along with the electrocardiogram to detect abnormal mechanical contraction of the heart muscle in LVAD patients.
  • an intracardiac ECG is combined with a left ventricular impedance measurement to detect abnor- mal contractions of the ventricle. The measurement is synchronized via the ECG. The measurement is qualitative, a volume determination does not take place.
  • the object of the invention is to further improve a method for operating an implanted, ventricular support system for the detection of special parameters and to specify a corresponding advantageous system.
  • a method for operating an implanted, ventricular assist system comprising the following steps:
  • the support system preferably serves to convey fluid.
  • the ventricular assist system is preferably a cardiac assist system.
  • the method for determining a total fluid flow is from a ventricle of a vein, especially from a ventricle of a vertex to the aorta in the area of a (fully) implanted (left) ventricular (Flerz) support system, and / or to determine an aortic valve or bypass flow rate that flows past the support system.
  • the fluid is usually blood.
  • the support system is preferably arranged at the outlet of the left ventricle of the heart or the left ventricular chamber. Particularly preferably, the support system is arranged in aortic valve position.
  • the total volume flow means the entire volume flow through a blood vessel or through a cross section of the blood vessel.
  • the blood vessel is, for example, the aorta, in particular in the case of a left heart support system, or the common trunk (trunk pulmonalis) in the two pulmonary arteries, in particular in a right heart support system.
  • the method is particularly suitable for determining the total heart-time volume (CO, QZM) of a patient, in particular with (fully) implanted left ventricular heart support system (LVAD) in aortic valve position and / or by the support system itself ,
  • the method is based in particular on the integration of a ventricular impedance measurement, in particular impedance spectroscopy into a (left-handed ) ventricular (cardiac) support system (LVAD), preferably for determining the heart-time volume (CO) and / or the aortic valve or bypass volume flow.
  • LVAD ventricular ventricular
  • the method can help to determine the level of support.
  • the method advantageously makes it possible to provide the heart-time volume and / or the bypass volume flow outside of the surgical scenario with comparable quality as when using a dilution catheter. This is of particular benefit because the heart-time-volume (QHZV) has a greater clinical relevance than the most commonly used pump volume flow (Q p ), which only quantifies the flow through the support system itself.
  • QHZV heart-time-volume
  • Q p most commonly used pump volume flow
  • the solution proposed here is characterized in particular by the use of sensors integrated purely in the LVAD; for example, no separate ultrasound cuff around the a
  • a determination (at least) of a first impedance parameter takes place at a first time by means of the support system.
  • a first ventricular volume is determined at a first time by means of an impedance measurement by means of the support system or by means of the first impedance parameter.
  • a determination (at least) of a second impedance parameter takes place at a second point in time by means of the assistance system.
  • a determination of a second ventricular volume at a second time takes place by means of an impedance measurement by means of the assistance system.
  • the ventricular volume is limited, in particular, by the ventricular wall or the ventricular wall formed in the manner of a bag and by two cardiac valves, one of which is also referred to as the aortic valve.
  • the ventricular volume is essentially determined by the volume of fluid (here in particular blood volume) in the ventricle. The differences in the ventricular volume arise, in particular, due to the contraction of the heart muscle and usually contribute to the promotion of blood through the circulation of a human, possibly patients.
  • the impedance parameter can be, for example, a (bi) immunity, in particular of fluid and / or tissue in the area of the support system.
  • an impedance parameter raw data of an analog-to-digital converter (unitless values) of an impedance measuring device can also be used.
  • the impedance parameter is a ventricular impedance. In other words, this means in particular that in each case a ventricular impedance is determined in steps a) and b).
  • the ventricular impedance is regularly dependent on the ventricular volume, in particular the volume of fluid in the ventricle and the fluid conductivity (in particular blood conductivity).
  • the musculature surrounding the ventricle can also provide an impedance component.
  • the influence of the blood conductivity can be determined by separate impedance measurement in a known sample volume.
  • a measurement in the defined volume of the (inflow) cannula offers.
  • the impedance measurement serves in particular for the determination of the pulsatile volume change of the ventricle during systole.
  • the impedance data can be plausibilized in an advantageous embodiment by pressure sensor data.
  • the determination of the impedance of the ventricle takes place via electrodes which are integrated on and / or in the support system.
  • the electrodes for Ventrikelim- impedance measurement
  • the electrodes are arranged on or in the outer surface of a (inlet) cannula of the support system (revolving).
  • a determination of a (temporal) change of the impedance parameter takes place using the first impedance parameter and the second impedance parameter.
  • a comparison of at least the first or second impedance parameter with a threshold value can be performed.
  • a determination of a (temporal) change in a ventricular impedance takes place using the first impedance parameter and the second impedance parameter.
  • the threshold value is preferably a (pre-) defined and / or constant threshold value.
  • the threshold value can be determined, in particular determined, by a calibration (in vivo) as a particularly lower threshold for the impedance parameter or corresponding raw data values.
  • the lower threshold is dimensioned such that a collapse of the ventricle and / or a suction effect, which leads to a fixed eye of the support system on the ventricle inner wall, can be avoided.
  • step c) it is preferable to determine a (temporal) change in the ventricular volume using the first impedance parameter and / or the first ventricular volume and the second impedance parameter and / or the second ventricular volume.
  • the first and / or second impedance parameter and / or ventricular volume can be compared with a minimum ventricle volume.
  • the determination of the change in the impedance parameter or ventricular volume takes place, in particular, when the support system is implanted in a patient with a partial support (low to high degree of support).
  • that can Determining the change and comparing cumulative, in particular at the same time or at least partially performed in parallel, example, in a convalescent short-term (full) support patients.
  • an upper threshold or ventricular maximum volume may be provided for comparison.
  • the upper threshold value or the minimum ventricular volume is in particular dimensioned such that excessive loading, in particular stretching of the ventricular wall, can be avoided.
  • the change in the impedance parameter or ventricular volume during the systole can also promote the blood through the circulation, in other words, to maintain or increase the total fluid volume flow contribute from the ventricle or the heart-time volume.
  • the determination of the change in the impedance parameter or ventricular volume is of particular importance.
  • a determination of the pulsatile impedance parameter or volume change of the ventricle takes place during the system. In other words, this means in particular that in step c) the (pulsatile or muscular) change in the impedance parameter or ventricular volume is preferably determined during systole.
  • the difference between the impedance parameter or ventricular volume at the beginning of the systole and the impedance parameter or ventricular volume at the end of the systole is particularly preferably formed.
  • the first time of the beginning of the systole and the second time of the systole can be the first time.
  • the sampling rate of the impedance parameter or ventricular volume should be high enough to meet the Nyquist theorem for expected ventricular contraction frequencies, for example 60 1 / s.
  • the minimum ventricular volume is preferably a defined or predetermined and / or constant minimum ventricle volume.
  • the minimum valve volume is in particular dimensioned so that a collapse of the ventricle and / or a suction effect, which leads to a fixed eye of the support system on the ventricle inner wall, can be avoided. The comparison can be performed in the processing unit.
  • the measuring device can provide the (first and / or second) impedance parameter or the (first and / or second) ventricular volume as the output variable of the processing unit.
  • the impedance parameter or the ventricular volume can represent a control parameter for the support system, which is preferably to be kept above the lower threshold value or the minimum valve volume.
  • an impedance parameter-to-threshold value or ventricle volume-to-minimum void volume difference may be a control parameter for the support system.
  • a processing unit of the support system can provide this control parameter as an output variable, in particular a control unit of the support system, which preferably controls the power of an electric motor of the support system and thus, in particular, the (blood) delivery rate of the support system.
  • the delivery rate of the support system can be reduced if it threatens to aspirate the ventricular wall.
  • the delivery rate of the support system can be increased if excessive expansion of the ventricular wall is imminent.
  • At least one model curve is adapted to the impedance parameters or ventricular volumes. Then it is still preferred if with the model parameters or the at least one model curve is further processed.
  • a ventricular volume be determined with the (respective) impedance parameter.
  • a first ventricular volume is determined with the first impedance parameter and a second ventricular volume is determined with the second impedance parameter.
  • the (respective) impedance parameters are measured via at least two electrodes, which are arranged on the support system.
  • the first and second impedance parameters are measured over at least two, advantageously four electrodes.
  • a (small) patient auxiliary current for example 50 kHz, 100 mA (alternating current) can be used for the measurement.
  • the electrodes are spaced apart from one another such that their detection range or detection volume comprises the ventricular volume.
  • the detection area or the acquisition volume relates in particular to the area or the volume which is covered by the current paths between the electrodes.
  • the at least two electrodes comprise at least two pairs of electrodes, in particular each comprising a current electrode and a voltage measuring electrode.
  • the electrodes of a pair should be close to each other. However, the pairs should be spaced apart from each other. An arrangement is advantageous in which the current electrodes are outside and the voltage measuring electrodes are inside (in the manner of a four-conductor measurement).
  • the detection range or the acquisition volume usually increases with increasing distance between the Electrode pairs The distance should preferably be determined so that as far as possible the entire volume of the ventricle can be detected, but surrounding tissue and / or surrounding organs, in particular the lungs, are preferably not within the detection range.
  • an impedance measurement is carried out at different (alternating current) frequencies.
  • This can advantageously contribute to the fact that the influence of surrounding tissue, in particular the heart muscle, can be reduced to the impedance measurement.
  • Particular preference is given to carrying out (bio) impedance spectroscopy.
  • the frequencies are selected such that a determination of the background impedance of the cardiac muscle, particularly preferably periodically, can take place or take place. This background impedance can be taken into account in the impedance measurement of the ventricular volume.
  • the conductivity of the fluid is determined by an impedance measurement in a defined volume of the support system.
  • the defined volume is inside a (inflow) cannula of the support system.
  • the defined volume is limited by the inner surface or part of the inner surface of the cannula of the support system.
  • the defined volume in one direction along the cannula
  • a fluid volume flow is determined, which flows through the support system.
  • this fluid volume flow is usually the so-called pump volume flow (Q p ), which only quantifies the flow through the support system itself. If this value is known in addition to the total volume flow or time-volume (QHZV), the so-called degree of support can be calculated from the ratio of Q p to QHZV (ie Q P / QHZV).
  • the pump flow rate can be determined on the basis of differential pressure and engine map or by explicit Doppler ultrasonic measurement.
  • the pump volume flow is determined by means of an ultrasonic sensor, which can be accommodated, for example, in a tip of the support system.
  • the time profile of the fluid volume flow or pump volume flow is determined. This can be compared with a time profile of the total fluid flow.
  • the support level can be provided as a control parameter for the support system.
  • the total heart-time volume (CO) can be estimated using the measured pump volume flow and the measured ventricular volume.
  • the total fluid volume flow or the heart-time volume is formed using a temporal sampling of the ventricular volume and of the fluid volume flow or pump volume flow.
  • the total fluid volume flow (QHZV) can, as a rule (in the case of continuously operating support systems), be determined from the following relationship between the time change of the ventricular volume (dV / dt) and the base pump volume flow (Qp , Diastole):
  • the determined total fluid volume flow is provided as a control parameter for the support system.
  • a processing unit of the support system can provide this control parameter as an output variable, in particular a control unit of the support system, which preferably controls the power of an electric motor of the support system and thus, in particular, also the (blood) delivery rate of the support system.
  • an aortic valve or bypass volume flow Q A is preferably determined.
  • the bypass flow (aortic valve volume or bypass volume flow) past the support system is quantified by means of the ventricular volume change and the pump volume flow through the aortic valve:
  • the bypass volume flow can be provided as a control parameter for the support system.
  • a processing unit is proposed, set up for carrying out a method proposed here.
  • the processing unit may include a microprocessor that can access a memory.
  • the processing unit preferably receives data from the measuring device.
  • an implantable ventricular assist system comprising:
  • a measuring device configured to determine a first impedance parameter at a first time and a second impedance parameter at a second time
  • a processing unit configured at least for determining a (temporal) change of the impedance parameter using the first impedance parameter and the second impedance parameter or for comparing at least the first or second impedance parameter with a threshold value.
  • the support system is preferably a left ventricular cardiac assist system (LVAD) or a percutaneous, minimally invasive left heart assist system. Furthermore, this is preferably fully implantable. In other words, this means, in particular, that the means required for detection, in particular an impedance sensor and / or the pump volume flow sensor, are located completely in the body of the patient and remain there.
  • the support system is particularly preferably set up or suitable for being at least partially in one Ventricle, preferably the left ventricle of a heart and / or an aorta, in particular in aortic valve position can be arranged.
  • the support system comprises a cannula, in particular inlet cannula, a turbomachine, such as a pump and / or an electric motor.
  • the electric motor is a regular part of the turbomachine.
  • the (inflow) cannula is preferably arranged so that, in the implanted state, it can deliver fluid from a (left) ventricle of a heart to the turbomachine.
  • the support system is preferably elongate and / or tubular.
  • the inlet cannula and the turbomachine are arranged in the region of mutually opposite ends of the support system.
  • the measuring device comprises at least two electrodes, via which an impedance can be measured.
  • at least four electrodes are provided for the measurement of a ventricular impedance.
  • the electrodes are arranged and arranged such that the impedance of the (entire) ventricle can be determined.
  • Fig. 2 shows an implanted, ventricular assistive system in one
  • FIG. 3 shows the support system of FIG. 2, FIG.
  • FIG. 4 shows an implanted ventricular assist system
  • 5 is a schematic flow diagram of the described method.
  • the support system 2 here is, for example, a left ventricular assist device (LVAD).
  • the support system 2 comprises a tip 10, which may contain sensors, a feed cage 1 1 with inlet openings 12 for the suction of fluid (here: blood), a flexible cannula 13, an impeller cage 14 with turbine wheel (not shown here) and outlet openings 15 for the Blood, an electric motor 16, a rear end 17 (so-called backend), which may contain sensors, and a connection cable 18.
  • LVAD left ventricular assist device
  • FIG. 2 schematically shows an implanted ventricular assist system 2 in a heart 19.
  • the assist system 2 assists the heart 19 by helping to deliver blood from the (left) ventricle 20 into the aorta 21.
  • the support system 2 is anchored in the aortic valve 22, as FIG. 2 illustrates.
  • Support System 2 (LVAD) promotes complete blood flow.
  • the degree of support describes the proportion of the by a funding such as a pump of the support system 2 and by the Support system 2 through the volume flow delivered to the total volume flow of blood from the ventricle 20 to the aorta 21st
  • the degree of support can thus be calculated from the ratio Q P / QHZV.
  • the heart 19 continues to function to a certain extent, so that during systole (heart muscle contracts and displaces the volume of the ventricle 20 blood into the aorta 21) a pulsatile volume flow component 24 (Bypass) through the heart or aortic valve 22 is formed.
  • systole heart muscle contracts and displaces the volume of the ventricle 20 blood into the aorta 21
  • a pulsatile volume flow component 24 Bopass
  • the pressure difference across the support system 2 decreases, in particular via the usually provided pump (not shown here) of the support system 2, so that accordingly the support system 2 also promotes an increased fluid volume flow 7 during systole.
  • FIG. 3 schematically shows the support system 2 from FIG. 2.
  • FIGS. 2 and 3 show an embodiment of an intracardiac impedance measurement (left ventricular).
  • the impedance measurement has the advantage that the entire fluid or liquid volume is detected and an electrical resistance measurement can be technically implemented relatively easily.
  • FIG. 3 illustrates by way of example that an ultrasound-based pump volume flow sensor 25 can be integrated in the tip 10.
  • the pump volume flow sensor 25 can detect the fluid volume flow 7 or the pump volume flow (Q p ) and make it available in a time-resolved manner.
  • At least two electrodes 4, 27 should be integrated in the area of the ventricle 20 so that the current paths 26 of the measurement current can capture the ventricle volume as well as possible.
  • the area of the feed cage 1 1 offers itself, for example, proximally or in front of and behind and / or behind the feed opening 12.
  • at least two electrodes 4, 27 are required to close the circuit.
  • the current electrodes 4, 27 are preferably placed on the outside and the voltage measurement electrodes 5, 28 are placed between them.
  • the current paths 26 extend from the electrode 4 to the electrode 27 (current electrodes). In between, equipotential lines (not shown here) form, which can be measured with high resistance via the voltage electrodes 28 and 5. Since the detection volume in particular from the distance of the measuring pairs (4 and
  • the measured electrical conductivity between the electrode pairs is dependent on the surrounding fluid or liquid volume and its conductivity.
  • a predetermined and / or constant conductivity can be assumed since the ion concentration in the blood is kept within a narrow framework by the kidneys. Nevertheless, the explicit determination of the blood conductivity is particularly preferred here.
  • a defined volume 6 is required, as is the case, for example, inside the (inflow) cannula 13. Accordingly, another one to four electrodes 29, 30, 31 and 32 may be placed inside the cannula 13 (which may also be referred to as a delivery tube). In this case, analogously to the measurement in the ventricle volume, the measurement can be made by current injection and voltage measurement in the electrode pair
  • Electrode pairs 5, 27 and the electrode pair 30, 32 a defined volume 6 inside the cannula 13. In the case of pure two-point measurements are thus in particular a minimum of three electrodes necessary.
  • the ventricular impedance measurement then takes place, for example, between the electrodes 4 and 5, the conductivity measurement between the electrodes 5 and 30.
  • a current electrode is to be understood here in particular as an electrode which can be connected or connected to a current source.
  • a voltage measurement electrode is to be understood here in particular as an electrode that can be connected or connected to a voltage measuring device. Any assignment is possible which can fulfill the purpose of impedance measurement (of the ventricular volume and / or the conductivity) shown here.
  • the voltage source and / or the voltage measuring device may be part of the measuring device 9. If the current source and the voltage measuring device are spatially separated from one another by an electrical supply line 18, then the supply cable is particularly advantageously embodied triaxially with active shielding.
  • (alternating) current can be impressed, for example, via a current electrode, and the resulting voltage drop can be measured, for example, at a voltage measurement electrode.
  • alternating current can be impressed, for example, via a current electrode, and the resulting voltage drop can be measured, for example, at a voltage measurement electrode.
  • the measurement can be done at a single (AC) frequency.
  • AC electrical impedance
  • values in the range of 50 kHz have become established.
  • the surrounding cardiac musculature contributes to a small extent to the measured impedance. Since it is cellular material with a different structure than cellular material in blood, the influence can be reduced by using so-called bioimpedance spectroscopy.
  • the measurement does not take place at a fixed frequency but at several frequencies. The result is the dependence of the electrical impedance on the frequency (see Dispersion, Cole diagram).
  • the measurement can take place, for example, in the range from 1 kHz to 1 MHz.
  • the spectroscopic measurement can be carried out, for example, by a sequence of sine frequencies, a so-called chirp (so-called chirp) or a broadband binary sequence (pseudo-random noise, so-called pseudo random noise).
  • the ventricular impedance sampling rate should be high enough to meet the Nyquist theorem for expected ventricular contraction frequencies, for example 60 1 / s.
  • changes in the impedance of the heart muscle can only be expected very slowly, so that a complete frequency range sweep (so-called frequency sweep) is not required for every measurement.
  • the determination of the background impedance of the heart muscle can be done periodically. It is also advantageous to determine the frequency measurement points of the background impedance over several heart beats. For this purpose, the measurement can be carried out at two frequencies with a high sampling rate.
  • the first frequency is preferably fixed, the second frequency changes, for example, from heartbeat to heartbeat (eg, determined on the basis of the impedance curve of the first frequency).
  • the spectrum of the separate measurements is combined by way of example via the impedance curve of the first frequency. Instead of the first frequency, synchronization with, for example, the pressure curve of a pressure sensor is also possible.
  • FIG. 4 schematically shows an implanted, ventricular assist system 2.
  • the resulting volume flows in the heart 19 are illustrated.
  • the left volume represents the ventricle or the ventricle volume 3
  • the right volume represents the aorta 21.
  • the (heart valve) volume flow 23 from the left atrium into the ventricle and the outflow in the aorta correspond to the total fluid volume flow 1 and the (total) CO, respectively.
  • Exceptions are valve insufficiency or hydraulic short circuits between the heart chambers.
  • the support system 2 (LVAD) conveys the delivery volume flow 33, for example, by the power of a pump (not shown) of the support system 2. In continuous support systems, this flow is constant, in pulsatile support systems, this flow is time modulated.
  • the contraction of the ventricle increases the pressure in the ventricle and the pressure difference across the support system 2 decreases, so that the support system 2 delivers an additional systole volume flow 34 at constant mechanical power during the systole. If the ventricular contraction is strong enough (for example in convalescent short-term support patients), the ventricular pressure may exceed the aortic blood pressure, resulting in the opening of the aortic valve (not shown here). An additional bypass flow (formula symbol Q a ) is formed, which is entered in FIG. 4 as aortic valve or bypass volume flow 24.
  • This flow component can not be detected (directly) by the flow sensor system of the sub-support system 2, for example the ultrasound sensor in the tip of the support system 2, but substantially corresponds to the difference between the ventricular volume change dV / dt and the pump volumetric flow Q p .
  • the pump volume flow Q p which quantifies only the flow through the support system 2 itself and here also referred to as fluid volume flow 7, results from the sum of the delivery volume flow 33 and the systole volume flow 34
  • the bypass flow ie the aortic valve or bypass volume flow 24 (equation QA)
  • the basic pump volume flow Qp , Di asto l e (Qp during diastole) the delivery volume flow 33 and the time-dependent pump flow rate Qp (t) of the sum of 33 delivery flow rate and systole Volume flow 34 corresponds.
  • O A ( ⁇ ) corresponds to the aortic valve or bypass volume flow 24.
  • QD flows exclusively through the pump (non-pulsatile equal part of the flow).
  • the pulsatile portion of the flow divides during systole to an increased Qp and a bypass flow through the aortic valve QA:
  • bypass flow Q A can be determined by:
  • heart-time volume QHZV can be determined by:
  • the support system in a special volume measurement mode.
  • the pump is over Integrated pressure sensors controlled so that the pressure on the feed cage and impeller cage are identical, so no flow rate flows and the pump rotates only so fast that there is no return from the aorta through the pump into the ventricle.
  • the stroke volume, end diastolic blood volume and / or the contraction strength of the ventricle can be determined based on the time profile of the (thereby acquired) impedance measurement data and / or used to control the support system.
  • the ventricular volume 3 is also an interesting parameter. Fully assisted systems (only the pump delivers blood) may cause suction or collapse of the ventricle.
  • the support system 2 promotes more blood than flows from the left atrium.
  • the support system 2 (or its pump) empties the ventricle. As a result, the ventricular wall approaches the feed cage and the support system 2 (or its pump) may become stuck. If the ventricular blood pressure falls below 50 mmHg, the ventricle may collapse due to higher ambient pressures.
  • the ventricular volume 3 can be used as a control parameter in order to reduce the power of the support system 2, in particular its delivery or pumping power, so that a minimum ventricle volume can be guaranteed.
  • Fig. 5 shows the described method again in schematic form.
  • the method steps a) determining a first impedance parameter at a first time by means of the support system 2, b) determining a second impedance parameter at a second time by means of the support system 2 and c) at least determining a change of the impedance parameter using the first impedance parameter and of the second impedance parameter or comparing at least one of the first and second impedance parameters with a threshold value are successively executed.
  • the solution proposed here makes possible one or more of the following advantages:
  • the method allows the determination of total heart-time volume as well as the determination of the degree of support (proportion of the pump volume flow in the total CO).
  • the procedure determines the ventricular volume, so that a support system can be throttled, for example, if the minimum ventricular volume is undershot.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Mechanical Engineering (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Anesthesiology (AREA)
  • Veterinary Medicine (AREA)
  • Medical Informatics (AREA)
  • Vascular Medicine (AREA)
  • External Artificial Organs (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
PCT/EP2019/064779 2018-06-06 2019-06-06 Implantierbares, ventrikuläres unterstützungssystem sowie verfahren zu dessen betrieb Ceased WO2019234148A1 (de)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CN201980051744.7A CN112584890B (zh) 2018-06-06 2019-06-06 可植入心室辅助系统及其操作方法
JP2020567819A JP7626431B2 (ja) 2018-06-06 2019-06-06 埋め込み可能な心室補助システムおよびその操作方法
US15/734,342 US12257424B2 (en) 2018-06-06 2019-06-06 Implantable ventricular assist system and method for operating same
EP19729720.3A EP3801674B1 (de) 2018-06-06 2019-06-06 Implantierbares, ventrikuläres unterstützungssystem
US19/088,678 US20250222247A1 (en) 2018-06-06 2025-03-24 Implantable ventricular assist system and method for operating same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102018208913.2A DE102018208913A1 (de) 2018-06-06 2018-06-06 Verfahren zum Betreiben eines implantierten, ventrikulären Unterstützungssystems
DE102018208913.2 2018-06-06

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US15/734,342 A-371-Of-International US12257424B2 (en) 2018-06-06 2019-06-06 Implantable ventricular assist system and method for operating same
US19/088,678 Continuation US20250222247A1 (en) 2018-06-06 2025-03-24 Implantable ventricular assist system and method for operating same

Publications (1)

Publication Number Publication Date
WO2019234148A1 true WO2019234148A1 (de) 2019-12-12

Family

ID=66821244

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2019/064779 Ceased WO2019234148A1 (de) 2018-06-06 2019-06-06 Implantierbares, ventrikuläres unterstützungssystem sowie verfahren zu dessen betrieb

Country Status (6)

Country Link
US (2) US12257424B2 (https=)
EP (1) EP3801674B1 (https=)
JP (1) JP7626431B2 (https=)
CN (1) CN112584890B (https=)
DE (1) DE102018208913A1 (https=)
WO (1) WO2019234148A1 (https=)

Cited By (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022109589A1 (en) 2020-11-20 2022-05-27 Kardion Gmbh Mechanical circulatory support system with guidewire aid
WO2022109591A2 (en) 2020-11-20 2022-05-27 Kardion Gmbh Mechanical circulatory support system with insertion tool
WO2022225950A1 (en) * 2021-04-22 2022-10-27 Cardio Vol, Llc Method and apparatus for assisting a heart
DE102022132114A1 (de) 2021-12-03 2023-06-07 Kardion Gmbh Herzpumpe mit Lichtleitfaser für Laser-Doppler
JP2023552946A (ja) * 2020-10-07 2023-12-20 アビオメド オイローパ ゲーエムベーハー コンダクタンスおよびアドミタンス測定のための電極アセンブリパッチ
DE102023118223A1 (de) 2022-07-11 2024-01-11 Kardion Gmbh Laser-doppler-velozimetrie-durchflussmessung
US20240198082A1 (en) * 2021-04-22 2024-06-20 Board Of Regents, The University Of Texas System Method and Apparatus for Assisting a Heart
US12144976B2 (en) 2018-06-21 2024-11-19 Kardion Gmbh Method and device for detecting a wear condition of a ventricular assist device and for operating same, and ventricular assist device
WO2024243154A1 (en) 2023-05-25 2024-11-28 Kardion Gmbh Heart pump tips and delivery system couplings for mechanical circulatory support systems
US12178554B2 (en) 2018-06-06 2024-12-31 Kardion Gmbh Systems and methods for determining a viscosity of a fluid
US12194287B2 (en) 2018-05-30 2025-01-14 Kardion Gmbh Method of manufacturing electrical conductor tracks in a region of an intravascular blood pump
US12201821B2 (en) 2018-06-06 2025-01-21 Kardion Gmbh Method for determining a flow rate of a fluid flowing through an implanted vascular support system, and implantable vascular support system
US12222267B2 (en) 2018-06-06 2025-02-11 Kardion Gmbh Analysis device and method for analyzing a viscosity of a fluid
US12257424B2 (en) 2018-06-06 2025-03-25 Kardion Gmbh Implantable ventricular assist system and method for operating same
EP4387708A4 (en) * 2021-08-19 2025-05-21 Cardiovol, LLC Method and device for assisting a heart
US12311160B2 (en) 2018-06-06 2025-05-27 Kardion Gmbh Method and system for determining the speed of sound in a fluid in the region of a cardiac support system
US12310708B2 (en) 2018-06-06 2025-05-27 Kardion Gmbh Systems and methods for determining a flow speed of a fluid flowing through a cardiac assist device
US12324906B2 (en) 2018-06-06 2025-06-10 Kardion Gmbh Systems and methods for determining a total blood volume flow in a cardiac support system and vascular support system
US12377256B2 (en) 2018-06-06 2025-08-05 Kardion Gmbh Cardiac support system flow measurement using pressure sensors
US12478267B2 (en) 2018-06-06 2025-11-25 Kardion Gmbh Sensor head device for a minimal invasive ventricular assist device and method for producing such a sensor head device
US12491357B2 (en) 2018-06-06 2025-12-09 Kardion Gmbh Systems and methods for determining a blood volume flow through a cardiac support system and vascular support system
US12508418B2 (en) 2018-08-08 2025-12-30 Kardion Gmbh Device and method for monitoring the state of health of a patient
US12569671B2 (en) 2018-06-06 2026-03-10 Kardion Gmbh Device and method for determination of a cardiac output for a cardiac assistance system

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USD1092716S1 (en) * 2019-12-31 2025-09-09 Abiomed, Inc. Outflow cage for blood pump
US11931563B2 (en) 2021-04-22 2024-03-19 Board Of Regents, The University Of Texas System Method and apparatus for assisting a heart
US11911602B2 (en) 2021-04-22 2024-02-27 Board Of Regents, The University Of Texas System Method and apparatus for assisting a heart
US12290675B2 (en) * 2021-04-22 2025-05-06 Board Of Regents, The University Of Texas System Method and apparatus for assisting a heart

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102009007216A1 (de) * 2009-02-03 2010-08-12 Siemens Aktiengesellschaft Blutpumpe und medizintechnische Vorrichtung
EP2570143A1 (de) * 2011-09-14 2013-03-20 BIOTRONIK SE & Co. KG Implantierbares kardiales Therapiergerät
WO2016066180A1 (en) * 2014-10-30 2016-05-06 Osypka Stiftung Peter Transmyocardial insertion unit and its use

Family Cites Families (592)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1707624A (en) 1927-05-25 1929-04-02 Brown Instr Co Gas-comparison apparatus
US2347624A (en) 1942-05-12 1944-04-25 Warren Carl Distributing means for coarse aggregates
US2989124A (en) 1960-01-14 1961-06-20 Roger H Lapp Pressure operated water valve
US3088323A (en) 1960-02-10 1963-05-07 Gulton Ind Inc Piezoresistive transducer
US4023562A (en) 1975-09-02 1977-05-17 Case Western Reserve University Miniature pressure transducer for medical use and assembly method
NO150015C (no) 1981-11-13 1984-08-08 Vingmed As Fremgangsmaate ved blodstroemhastighetsmaaling med ultralyd, kombinert med ekko-amplitudeavbildning, for undersoekelse av levende biologiske strukturer
JPS5980229A (ja) 1982-10-29 1984-05-09 株式会社島津製作所 パルスドツプラ−超音波血流計
JPS6015771A (ja) 1983-07-08 1985-01-26 Hitachi Ltd ベクトルプロセッサ
JPS61125329A (ja) 1984-11-21 1986-06-13 テルモ株式会社 心拍出量測定装置
JPS62113555A (ja) 1985-11-13 1987-05-25 Canon Inc インクジエツト記録装置
JPS62204733A (ja) 1986-03-04 1987-09-09 アロカ株式会社 超音波ドプラ診断装置
JPS62282284A (ja) 1986-05-30 1987-12-08 Tokyo Keiki Co Ltd 超音波による距離測定方法およびその装置
US4902272A (en) 1987-06-17 1990-02-20 Abiomed Cardiovascular, Inc. Intra-arterial cardiac support system
US4781525A (en) 1987-07-17 1988-11-01 Minnesota Mining And Manufacturing Company Flow measurement system
JPS6468236A (en) 1987-09-07 1989-03-14 Aisin Seiki Cannula equipped with detection electrode
US4889131A (en) 1987-12-03 1989-12-26 American Health Products, Inc. Portable belt monitor of physiological functions and sensors therefor
US4888011A (en) 1988-07-07 1989-12-19 Abiomed, Inc. Artificial heart
US4965713A (en) 1988-08-15 1990-10-23 Viking Pump Inc. Terminal element
US4989609A (en) 1989-01-26 1991-02-05 Minnesota Mining And Manufacturing Company Doppler blood flow system and method using special zero flow rate analysis
US5045051A (en) 1989-03-14 1991-09-03 Abiomed, Inc. Leak detector
CA2004295C (en) 1989-11-30 1998-02-10 William F. Hayes Primary fluid actuated, secondary fluid propelling system
WO1992015239A1 (en) 1991-02-04 1992-09-17 Kensey Nash Corporation Apparatus and method for determining viscosity of the blood of a living being
JP2952438B2 (ja) 1991-09-20 1999-09-27 トキコ株式会社 熱式流量計
US5676651A (en) 1992-08-06 1997-10-14 Electric Boat Corporation Surgically implantable pump arrangement and method for pumping body fluids
JP3312759B2 (ja) 1993-01-22 2002-08-12 テルモ株式会社 医療用ポンプ駆動装置
US5456715A (en) 1993-05-21 1995-10-10 Liotta; Domingo S. Implantable mechanical system for assisting blood circulation
US5289821A (en) 1993-06-30 1994-03-01 Swartz William M Method of ultrasonic Doppler monitoring of blood flow in a blood vessel
JPH0747025A (ja) 1993-08-06 1995-02-21 Itoki Co Ltd フレキシブルパ−ティション
US5527159A (en) 1993-11-10 1996-06-18 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Rotary blood pump
GB9404321D0 (en) 1994-03-04 1994-04-20 Thoratec Lab Corp Driver and method for driving pneumatic ventricular assist devices
US5581038A (en) 1994-04-04 1996-12-03 Sentir, Inc. Pressure measurement apparatus having a reverse mounted transducer and overpressure guard
NO942222D0 (no) 1994-06-14 1994-06-14 Vingmed Sound As Fremgangsmåte ved bestemmelse av hastighet/tid-spektrum ved blodströmning
JPH0857042A (ja) 1994-08-24 1996-03-05 Terumo Corp 医療用ポンプ
US5685989A (en) 1994-09-16 1997-11-11 Transonic Systems, Inc. Method and apparatus to measure blood flow and recirculation in hemodialysis shunts
US5453576A (en) 1994-10-24 1995-09-26 Transonic Systems Inc. Cardiovascular measurements by sound velocity dilution
US5613935A (en) 1994-12-16 1997-03-25 Jarvik; Robert High reliability cardiac assist system
JPH08327527A (ja) 1995-05-31 1996-12-13 Toyobo Co Ltd 細管式粘度計
WO1999015212A1 (en) 1997-09-24 1999-04-01 The Cleveland Clinic Foundation Flow controlled blood pump system
US5752976A (en) 1995-06-23 1998-05-19 Medtronic, Inc. World wide patient location and data telemetry system for implantable medical devices
US5720771A (en) 1995-08-02 1998-02-24 Pacesetter, Inc. Method and apparatus for monitoring physiological data from an implantable medical device
GB9604665D0 (en) 1996-03-05 1996-05-01 Montec Int Ltd Flow measurement
US5980465A (en) 1996-03-18 1999-11-09 Medtronic, Inc. Method for detecting changes in a patient s blood volume
US5911685A (en) 1996-04-03 1999-06-15 Guidant Corporation Method and apparatus for cardiac blood flow assistance
JPH1052489A (ja) 1996-08-12 1998-02-24 Buaayu:Kk カニューレ及び補助循環装置
US5888242A (en) 1996-11-01 1999-03-30 Nimbus, Inc. Speed control system for implanted blood pumps
WO1998029030A1 (en) 1997-01-03 1998-07-09 Biosense Inc. Pressure-sensing stent
US5957861A (en) 1997-01-31 1999-09-28 Medtronic, Inc. Impedance monitor for discerning edema through evaluation of respiratory rate
CN1222862A (zh) 1997-04-02 1999-07-14 激励心脏技术有限公司 心内泵装置
US5964694A (en) 1997-04-02 1999-10-12 Guidant Corporation Method and apparatus for cardiac blood flow assistance
US5865759A (en) 1997-04-11 1999-02-02 Texon Technologies Ltd. Method and apparatus for non-invasive assessment of cardiac function by monitoring acceleration of the heart
US5827203A (en) 1997-04-21 1998-10-27 Nita; Henry Ultrasound system and method for myocardial revascularization
US6731976B2 (en) 1997-09-03 2004-05-04 Medtronic, Inc. Device and method to measure and communicate body parameters
DE69836495T3 (de) 1997-10-02 2015-08-06 Micromed Technology, Inc. Steuermodul für implantierbares Pumpsystem
US6610004B2 (en) 1997-10-09 2003-08-26 Orqis Medical Corporation Implantable heart assist system and method of applying same
US6398734B1 (en) 1997-10-14 2002-06-04 Vascusense, Inc. Ultrasonic sensors for monitoring the condition of flow through a cardiac valve
US6007478A (en) 1997-11-13 1999-12-28 Impella Cardiotechnik Aktiengesellschaft Cannula having constant wall thickness with increasing distal flexibility and method of making
US6314322B1 (en) 1998-03-02 2001-11-06 Abiomed, Inc. System and method for treating dilated cardiomyopathy using end diastolic volume (EDV) sensing
US5904708A (en) 1998-03-19 1999-05-18 Medtronic, Inc. System and method for deriving relative physiologic signals
CN1192351A (zh) 1998-03-26 1998-09-09 王明时 血粘度快速测量仪
US6176822B1 (en) 1998-03-31 2001-01-23 Impella Cardiotechnik Gmbh Intracardiac blood pump
US5955924A (en) 1998-04-21 1999-09-21 Applied Micro Circuits Corporation Differential metal-oxide semiconductor (CMOS) push-pull buffer
US6023641A (en) 1998-04-29 2000-02-08 Medtronic, Inc. Power consumption reduction in medical devices employing multiple digital signal processors
US6024704A (en) 1998-04-30 2000-02-15 Medtronic, Inc Implantable medical device for sensing absolute blood pressure and barometric pressure
DE19821307C1 (de) 1998-05-13 1999-10-21 Impella Cardiotech Gmbh Intrakardiale Blutpumpe
US7083588B1 (en) 1998-05-26 2006-08-01 Medtronic Vascular, Inc. Apparatus for providing coronary retroperfusion and methods of use
US6167765B1 (en) 1998-09-25 2001-01-02 The Regents Of The University Of Michigan System and method for determining the flow rate of blood in a vessel using doppler frequency signals
US6575927B1 (en) 1998-09-25 2003-06-10 The Regents Of The University Of Michigan System and method for determining blood flow rate in a vessel
DE29821563U1 (de) 1998-12-02 2000-07-13 Impella Cardiotechnik AG, 52074 Aachen Drucksensor
US6245007B1 (en) 1999-01-28 2001-06-12 Terumo Cardiovascular Systems Corporation Blood pump
US6210318B1 (en) 1999-03-09 2001-04-03 Abiomed, Inc. Stented balloon pump system and method for using same
US6438409B1 (en) 1999-03-25 2002-08-20 Medtronic, Inc. Methods of characterizing ventricular operations and applications thereof
IT1315206B1 (it) 1999-04-27 2003-02-03 Salvatore Romano Metodo e apparato per la misura della portata cardiaca.
US6190324B1 (en) 1999-04-28 2001-02-20 Medtronic, Inc. Implantable medical device for tracking patient cardiac status
AUPQ090499A0 (en) 1999-06-10 1999-07-01 Peters, William S Heart assist device and system
US6890329B2 (en) 1999-06-15 2005-05-10 Cryocath Technologies Inc. Defined deflection structure
EP1063753B1 (de) 1999-06-22 2009-07-22 Levitronix LLC Elektrischer Drehantrieb mit einem magnetisch gelagerten Rotor
US6231498B1 (en) 1999-06-23 2001-05-15 Pulsion Medical Systems Ag Combined catheter system for IABP and determination of thermodilution cardiac output
US7138776B1 (en) 1999-07-08 2006-11-21 Heartware, Inc. Method and apparatus for controlling brushless DC motors in implantable medical devices
US6512949B1 (en) 1999-07-12 2003-01-28 Medtronic, Inc. Implantable medical device for measuring time varying physiologic conditions especially edema and for responding thereto
US7022100B1 (en) 1999-09-03 2006-04-04 A-Med Systems, Inc. Guidable intravascular blood pump and related methods
AU7354400A (en) 1999-09-03 2001-04-10 A-Med Systems, Inc. Guidable intravascular blood pump and related methods
US6579257B1 (en) 1999-09-21 2003-06-17 Medtronic, Inc. Automated occlusion clamp for centrifugal blood pumps
US20010039828A1 (en) 1999-11-12 2001-11-15 Visco Technologies, Inc. Mass detection capillary viscometer
EP1123687A3 (en) 2000-02-10 2004-02-04 Aloka Co., Ltd. Ultrasonic diagnostic apparatus
US6406422B1 (en) 2000-03-02 2002-06-18 Levram Medical Devices, Ltd. Ventricular-assist method and apparatus
US6561975B1 (en) 2000-04-19 2003-05-13 Medtronic, Inc. Method and apparatus for communicating with medical device systems
US6530876B1 (en) 2000-04-25 2003-03-11 Paul A. Spence Supplemental heart pump methods and systems for supplementing blood through the heart
US6432136B1 (en) 2000-04-25 2002-08-13 The Penn State Research Foundation Apparatus and method for removing a pocket of air from a blood pump
US6540658B1 (en) 2000-05-30 2003-04-01 Abiomed, Inc. Left-right flow control algorithm in a two chamber cardiac prosthesis
DE10040403A1 (de) 2000-08-18 2002-02-28 Impella Cardiotech Ag Intrakardiale Blutpumpe
IL138073A0 (en) 2000-08-24 2001-10-31 Glucon Inc Photoacoustic assay and imaging system
US6808508B1 (en) 2000-09-13 2004-10-26 Cardiacassist, Inc. Method and system for closed chest blood flow support
GB0023412D0 (en) 2000-09-23 2000-11-08 Khaghani Asghar Aortic counterpulsator
US6540659B1 (en) 2000-11-28 2003-04-01 Abiomed, Inc. Cardiac assistance systems having bi-directional pumping elements
US6602182B1 (en) 2000-11-28 2003-08-05 Abiomed, Inc. Cardiac assistance systems having multiple fluid plenums
DE10059714C1 (de) 2000-12-01 2002-05-08 Impella Cardiotech Ag Intravasale Pumpe
DE10060275A1 (de) 2000-12-05 2002-06-13 Impella Cardiotech Ag Verfahren zum Kalibrieren eines Drucksensors oder eines Flussensors an einer Rotationspumpe
US6912423B2 (en) 2000-12-15 2005-06-28 Cardiac Pacemakers, Inc. Terminal connector assembly for a medical device and method therefor
US20020147495A1 (en) 2001-04-09 2002-10-10 Christopher Petroff Reduced-size replacement heart
DE10164898B4 (de) 2001-04-30 2010-09-23 Berlin Heart Gmbh Verfahren zur Regelung einer Unterstützungspumpe für Fluidfördersysteme mit pulsatilem Druck
US6511413B2 (en) 2001-05-16 2003-01-28 Levram Medical Devices, Ltd. Single cannula ventricular-assist method and apparatus
US6879126B2 (en) 2001-06-29 2005-04-12 Medquest Products, Inc Method and system for positioning a movable body in a magnetic bearing system
JP3882069B2 (ja) 2001-07-06 2007-02-14 独立行政法人産業技術総合研究所 人工心臓用ポンプの異常判定方法及び異常判定装置
US7191000B2 (en) * 2001-07-31 2007-03-13 Cardiac Pacemakers, Inc. Cardiac rhythm management system for edema
JP4440499B2 (ja) 2001-08-29 2010-03-24 泉工医科工業株式会社 遠心ポンプ駆動装置
DE10144269A1 (de) 2001-09-08 2003-03-27 Bosch Gmbh Robert Sensorelement zur Erfassung einer physikalischen Messgröße zwischen tribologisch hoch beanspruchten Körpern
US6666826B2 (en) 2002-01-04 2003-12-23 Cardiac Pacemakers, Inc. Method and apparatus for measuring left ventricular pressure
US7396327B2 (en) 2002-01-07 2008-07-08 Micromed Technology, Inc. Blood pump system and method of operation
CN101816811A (zh) 2002-01-07 2010-09-01 麦克罗美德技术公司 泵系统
DE60334677D1 (de) 2002-01-08 2010-12-09 Micromed Technology Inc System zum nachweis von ventrikelkollaps
US7238165B2 (en) 2002-02-21 2007-07-03 Design Mentor, Inc. Fluid pump
US7238151B2 (en) 2002-02-26 2007-07-03 Frazier O Howard Permanent heart assist system
US6669624B2 (en) 2002-03-26 2003-12-30 O. Howard Frazier Temporary heart-assist system
US10155082B2 (en) 2002-04-10 2018-12-18 Baxter International Inc. Enhanced signal detection for access disconnection systems
US6991595B2 (en) 2002-04-19 2006-01-31 Thoratec Corporation Adaptive speed control for blood pump
US7024244B2 (en) 2002-04-22 2006-04-04 Medtronic, Inc. Estimation of stroke volume cardiac output using an intracardiac pressure sensor
US6969369B2 (en) 2002-04-22 2005-11-29 Medtronic, Inc. Implantable drug delivery system responsive to intra-cardiac pressure
DE10226305C1 (de) 2002-06-13 2003-10-30 Infratec Gmbh Infrarotsensorik Durchstimmbares, schmalbandiges Bandpassfilter für die Infrarot-Messtechnik
DE10227918A1 (de) 2002-06-21 2004-01-15 Bühler AG Verfahren zum Bestimmen rheologischer Parameter eines Fluids
WO2004000148A2 (en) 2002-06-25 2003-12-31 Glucon Inc. Method and apparatus for performing myocardial revascularization
US6949066B2 (en) 2002-08-21 2005-09-27 World Heart Corporation Rotary blood pump diagnostics and cardiac output controller
AU2002951685A0 (en) 2002-09-30 2002-10-17 Ventrassist Pty Ltd Physiological demand responsive control system
US7207939B2 (en) 2002-10-03 2007-04-24 Coulter International Corp. Apparatus and method for analyzing a liquid in a capillary tube of a hematology instrument
US6943434B2 (en) 2002-10-03 2005-09-13 Fairchild Semiconductor Corporation Method for maintaining solder thickness in flipchip attach packaging processes
US7204798B2 (en) 2003-01-24 2007-04-17 Proteus Biomedical, Inc. Methods and systems for measuring cardiac parameters
JP2006518631A (ja) 2003-01-31 2006-08-17 ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ 心不全をモニタリングするための尖部運動の検出
US6887207B2 (en) 2003-02-26 2005-05-03 Medtronic, Inc. Methods and apparatus for estimation of ventricular afterload based on ventricular pressure measurements
US20040199052A1 (en) 2003-04-01 2004-10-07 Scimed Life Systems, Inc. Endoscopic imaging system
CN1202871C (zh) 2003-04-18 2005-05-25 清华大学 微型轴流式血泵的优化非恒速控制方法
US7118525B2 (en) 2003-04-23 2006-10-10 Coleman Edward J Implantable cardiac assist device
US20080262289A1 (en) 2003-05-28 2008-10-23 Goldowsky Michael P Blood Pump Having A Passive Non-Contacting Bearing Suspension
US20040241019A1 (en) 2003-05-28 2004-12-02 Michael Goldowsky Passive non-contacting smart bearing suspension for turbo blood-pumps
US7078796B2 (en) 2003-07-01 2006-07-18 Freescale Semiconductor, Inc. Corrosion-resistant copper bond pad and integrated device
US7128538B2 (en) 2003-07-07 2006-10-31 Terumo Corporation Centrifugal fluid pump apparatus
AU2003903726A0 (en) 2003-07-18 2003-07-31 Ventracor Limited A device for detecting heart pumping state
US7951129B2 (en) 2003-08-07 2011-05-31 Medtronic, Inc. Diastolic coronary perfusion detection for timed delivery of therapeutic and/or diagnostic agents
DE10336902C5 (de) 2003-08-08 2019-04-25 Abiomed Europe Gmbh Intrakardiale Pumpvorrichtung
US7245117B1 (en) 2004-11-01 2007-07-17 Cardiomems, Inc. Communicating with implanted wireless sensor
US20140296677A1 (en) 2003-09-18 2014-10-02 New Paradigm Concepts, LLC Method of measuring total vascular hemoglobin mass
US7559894B2 (en) 2003-09-18 2009-07-14 New Paradigm Concepts, LLC Multiparameter whole blood monitor and method
US20050137614A1 (en) 2003-10-08 2005-06-23 Porter Christopher H. System and method for connecting implanted conduits
US8428717B2 (en) 2003-10-14 2013-04-23 Medtronic, Inc. Method and apparatus for monitoring tissue fluid content for use in an implantable cardiac device
ES2561354T3 (es) 2003-10-31 2016-02-25 Sunshine Heart Company Pty Ltd Sistema de control de sincronización
US7520850B2 (en) 2003-11-19 2009-04-21 Transoma Medical, Inc. Feedback control and ventricular assist devices
CN1906485B (zh) 2003-11-26 2010-12-08 分离技术公司 用于超声波确定血细胞比容和血红蛋白浓度的方法和设备
TWI231749B (en) 2003-12-24 2005-05-01 Mau-Chin Shen Restoring/positioning device for slide rail of drawer
JP2005192687A (ja) 2003-12-29 2005-07-21 Sunao Kitamura 回転型人工心臓ポンプを用いた部分補助における圧・流量・自然心拍出量の間接計測法
JP2005241546A (ja) 2004-02-27 2005-09-08 Fuji Electric Systems Co Ltd ドップラー式超音波流量計、その演算処理装置、プログラム
US11819192B2 (en) 2004-03-23 2023-11-21 Boston Scientific Scimed, Inc. In-vivo visualization system
US7160243B2 (en) 2004-03-25 2007-01-09 Terumo Corporation Method and system for controlling blood pump flow
US7591777B2 (en) 2004-05-25 2009-09-22 Heartware Inc. Sensorless flow estimation for implanted ventricle assist device
US7513864B2 (en) 2004-07-09 2009-04-07 Kantrowitz Allen B Synchronization system between aortic valve and cardiac assist device
WO2006006163A2 (en) 2004-07-12 2006-01-19 Coreolis Inc. Apparatus and method for multiple organ assist
US20070299325A1 (en) 2004-08-20 2007-12-27 Brian Farrell Physiological status monitoring system
US8303482B2 (en) 2004-09-07 2012-11-06 Micromed Method and system for physiologic control of a blood pump
WO2006049538A1 (en) 2004-11-02 2006-05-11 St. Jude Medical Ab Device for evaluating positions of an implantable medical device
WO2006055745A2 (en) 2004-11-16 2006-05-26 Micromed Cardivascular, Inc. Remote data monitor for heart pump system
US7339275B2 (en) 2004-11-22 2008-03-04 Freescale Semiconductor, Inc. Multi-chips semiconductor device assemblies and methods for fabricating the same
DE102005003632A1 (de) 2005-01-20 2006-08-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Katheter für die transvaskuläre Implantation von Herzklappenprothesen
WO2006080011A2 (en) 2005-01-25 2006-08-03 Ramot At Tel Aviv University Ltd. Using pulsed-wave ultrasonography for determining an aliasing-free radial velocity spectrum of matter moving in a region
US8594790B2 (en) 2005-01-27 2013-11-26 Medtronic, Inc. System and method for monitoring a ventricular pressure index to predict worsening heart failure
US20060217771A1 (en) 2005-02-07 2006-09-28 Medtronic, Inc. Potassium monitoring
US7563248B2 (en) 2005-03-17 2009-07-21 Smisson-Cartledge Biomedical Llc Infusion fluid heat exchanger and cartridge
DE102005017546A1 (de) 2005-04-16 2006-10-19 Impella Cardiosystems Gmbh Verfahren zur Steuerung einer Blutpumpe
EP1887940B1 (en) 2005-05-06 2013-06-26 Vasonova, Inc. Apparatus for endovascular device guiding and positioning
EP2438937B1 (en) 2005-06-06 2015-10-28 The Cleveland Clinic Foundation Blood pump
JP2008543378A (ja) 2005-06-08 2008-12-04 マイクロメッド・テクノロジー・インコーポレイテッド 人工心臓システム
US7527599B2 (en) 2005-06-17 2009-05-05 The Research Foundation Of State University Of New York Method of determining cardiac indicators
AU2006262287A1 (en) 2005-06-21 2007-01-04 Cardiomems, Inc. Method of manufacturing implantable wireless sensor for in vivo pressure measurement
DE102005039446B4 (de) 2005-08-18 2009-06-25 Ilias-Medical Gmbh Vorrichtung zur An- und Abreicherung von Stoffen in einer Flüssigkeit
DE102005046008B4 (de) 2005-09-26 2007-05-24 Infineon Technologies Ag Halbleitersensorbauteil mit Sensorchip und Verfahren zur Herstellung desselben
US8657875B2 (en) 2005-09-26 2014-02-25 Abiomed, Inc. Method and apparatus for pumping blood
US20070073352A1 (en) 2005-09-28 2007-03-29 Euler David E Method and apparatus for regulating a cardiac stimulation therapy
US20070088214A1 (en) 2005-10-14 2007-04-19 Cardiac Pacemakers Inc. Implantable physiologic monitoring system
US20070142923A1 (en) 2005-11-04 2007-06-21 Ayre Peter J Control systems for rotary blood pumps
EP1813302A1 (en) 2006-01-25 2007-08-01 Debiotech S.A. Fluid volume measurement device for medical use
DE102006001180B4 (de) 2006-01-06 2010-12-23 Technische Universität Chemnitz Rheometer und Auswerteverfahren zur Bestimmung von Fließkurve und Viskositätsfunktion von optisch transparenten Newtonschen und Nicht-Newtonschen Flüssigkeiten
US20110022057A1 (en) 2006-02-03 2011-01-27 Pacesetter, Inc. Apparatus and methods for transferring an implanted elongate body to a remote site
EP1990066B1 (en) 2006-02-23 2017-03-08 Thoratec Delaware LLC A pump-outflow-cannula and a blood managing system
CA2646277C (en) 2006-03-23 2016-01-12 The Penn State Research Foundation Heart assist device with expandable impeller pump
AU2007201127B2 (en) 2006-03-23 2012-02-09 Thoratec Corporation System For Preventing Diastolic Heart Failure
AT503628B1 (de) 2006-04-25 2008-06-15 Vc Trust Holding Gmbh Verfahren zur überwachung der maximalentfernung zweier objekte
US20070255352A1 (en) 2006-04-27 2007-11-01 Roline Glen M Implantable sensors having current-based switches for improved fault tolerance
US7549964B2 (en) 2006-05-04 2009-06-23 Viasys Healthcare, Inc. Multiple frequency doppler ultrasound probe
US7850594B2 (en) 2006-05-09 2010-12-14 Thoratec Corporation Pulsatile control system for a rotary blood pump
US7654424B1 (en) 2006-05-15 2010-02-02 Kramp David W All terrain vehicle utility storage box
EP2023807B1 (en) 2006-06-02 2013-08-14 Cook Medical Technologies LLC Adjustable tension cuff assembly
US7909770B2 (en) 2006-07-05 2011-03-22 Cardiomems, Inc. Method for using a wireless pressure sensor to monitor pressure inside the human heart
DE102006032583A1 (de) 2006-07-13 2008-01-17 Biotronik Crm Patent Ag Einführvorrichtung
DE102006035548B4 (de) 2006-07-27 2009-02-12 Deutsches Zentrum für Luft- und Raumfahrt e.V. Kunstherz
US20080097595A1 (en) 2006-08-22 2008-04-24 Shlomo Gabbay Intraventricular cardiac prosthesis
CA2663586C (en) 2006-09-14 2014-10-28 Circulite, Inc Intravascular blood pump and catheter
EP1903000B1 (fr) 2006-09-25 2019-09-18 Sorin CRM SAS Composant biocompatible implantable incorporant un élément actif intégré tel qu'un capteur de mesure d'un paramètre physiologique, microsystème électromécanique ou circuit électronique
US7963905B2 (en) 2006-10-11 2011-06-21 Thoratec Corporation Control system for a blood pump
US20080091239A1 (en) 2006-10-16 2008-04-17 St. Jude Medical Ab Cardiac assist device and method using epicardially placed microphone
US20080133006A1 (en) 2006-10-27 2008-06-05 Ventrassist Pty Ltd Blood Pump With An Ultrasonic Transducer
JP5283888B2 (ja) 2006-11-02 2013-09-04 株式会社東芝 超音波診断装置
WO2008057478A2 (en) 2006-11-03 2008-05-15 The Regents Of The University Of Michigan Method and system for determining volume flow in a blood conduit
US8202224B2 (en) 2006-11-13 2012-06-19 Pacesetter, Inc. System and method for calibrating cardiac pressure measurements derived from signals detected by an implantable medical device
AT504990B1 (de) 2007-02-27 2008-12-15 Miracor Medizintechnik Handels Katheter zur unterstützung der leistung eines herzens
US9974894B2 (en) 2007-04-05 2018-05-22 Reliantheart, Inc. Blood pump system
EP1987774A1 (de) 2007-05-03 2008-11-05 BrainLAB AG Messung der Sonographie-Schallgeschwindigkeit mittels Markereinrichtung
US8075472B2 (en) 2007-05-03 2011-12-13 Leviticus-Cardio Ltd. Permanent ventricular assist device for treating heart failure
JP5266464B2 (ja) 2007-05-10 2013-08-21 ライニッシュ−ヴェストフェリッシェ・テクニッシェ・ホッホシューレ・アーヘン 心機能変化評価装置
EP2000159A1 (en) 2007-06-07 2008-12-10 NewCorTec S.p.A. A duct for a ventricular assistance device
JP5201887B2 (ja) 2007-06-20 2013-06-05 テルモ株式会社 人工心臓用血液ポンプシステムおよび機器監視システム
US20090024042A1 (en) 2007-07-03 2009-01-22 Endotronix, Inc. Method and system for monitoring ventricular function of a heart
EP2016961B1 (en) 2007-07-18 2010-02-17 Surgery in Motion Ltd. Cardiac assist device
US20090025459A1 (en) 2007-07-23 2009-01-29 Cardiac Pacemakers, Inc. Implantable viscosity monitoring device and method therefor
EP2020246A1 (en) 2007-08-03 2009-02-04 Berlin Heart GmbH Control of rotary blood pump with selectable therapeutic options
EP2037236A3 (de) 2007-09-11 2011-01-19 Levitronix LLC Verfahren zur Kalibrierung einer Durchflussmessung in einem Strömungssystem, sowie ein Strömungssystem zur Durchführung des Verfahrens
US20160166747A1 (en) 2007-10-01 2016-06-16 Oscar H. Frazier Intraatrial ventricular assist device
US10226234B2 (en) 2011-12-01 2019-03-12 Maui Imaging, Inc. Motion detection using ping-based and multiple aperture doppler ultrasound
US8439859B2 (en) 2007-10-08 2013-05-14 Ais Gmbh Aachen Innovative Solutions Catheter device
US20090105799A1 (en) 2007-10-23 2009-04-23 Flowmedica, Inc. Renal assessment systems and methods
US8323202B2 (en) 2007-11-16 2012-12-04 Pneumrx, Inc. Method and system for measuring pulmonary artery circulation information
US7794384B2 (en) 2007-12-07 2010-09-14 Terumo Heart, Inc. Dual communication interface for artificial heart system
EP2072150B1 (en) 2007-12-19 2023-09-27 Ueda Japan Radio Co., Ltd. Ultrasonic transducer
CN101214158A (zh) 2007-12-29 2008-07-09 同济大学附属东方医院 可植入式实时流量检测仪
US7856335B2 (en) 2008-01-25 2010-12-21 Micromed Technology, Inc. Device, method, and system for calibration of a flow meter used in conjunction with a ventricular assist device
JP5211177B2 (ja) 2008-02-11 2013-06-12 カーディアック ペースメイカーズ， インコーポレイテッド 心臓内の調律識別のための血行動態の監視方法
JP5170751B2 (ja) 2008-03-28 2013-03-27 テルモ株式会社 血液ポンプ装置
US8211028B2 (en) 2008-04-30 2012-07-03 Medtronic, Inc. System and method of determining arterial blood pressure and ventricular fill parameters from ventricular blood pressure waveform data
CN101579233A (zh) 2008-05-14 2009-11-18 深圳市盛力康实业发展有限公司 一种心血管功能检测方法、系统及装置
US20090312650A1 (en) 2008-06-12 2009-12-17 Cardiac Pacemakers, Inc. Implantable pressure sensor with automatic measurement and storage capabilities
DE102008040266A1 (de) 2008-07-09 2010-01-14 Biotronik Crm Patent Ag Implantierbare Messanordnung
US9713701B2 (en) 2008-07-31 2017-07-25 Medtronic, Inc. Using multiple diagnostic parameters for predicting heart failure events
WO2010014066A1 (en) 2008-07-31 2010-02-04 Medtronic, Inc. Using multiple diagnostic parameters for predicting heart failure events
KR101686887B1 (ko) 2008-09-10 2016-12-15 하트웨어, 인코포레이티드 이식된 의료 기구용의 ｔｅｔ 장치
US20100087742A1 (en) 2008-09-30 2010-04-08 Ihc Intellectual Asset Management, Llc Physiological characteristic determination for a medical device user
EP2346401B1 (en) * 2008-09-30 2013-05-22 St. Jude Medical AB Heart failure detector
AU2009300538B2 (en) 2008-10-01 2015-12-10 Irumedi Co., Ltd. Cardiovascular analyzer
US8435182B1 (en) 2008-10-02 2013-05-07 Hitachi Aloka Medical, Ltd. Methods and apparatus for ultrasound imaging
WO2010080717A1 (en) 2009-01-12 2010-07-15 The Board Of Trustees Of The Leland Stanford Junior University Drainage device and method
US20100222878A1 (en) 2009-02-27 2010-09-02 Thoratec Corporation Blood pump system with arterial pressure monitoring
US20100222633A1 (en) 2009-02-27 2010-09-02 Victor Poirier Blood pump system with controlled weaning
US8449444B2 (en) 2009-02-27 2013-05-28 Thoratec Corporation Blood flow meter
US8562507B2 (en) 2009-02-27 2013-10-22 Thoratec Corporation Prevention of aortic valve fusion
US20100222635A1 (en) 2009-02-27 2010-09-02 Thoratec Corporation Maximizing blood pump flow while avoiding left ventricle collapse
DE102009011726A1 (de) 2009-03-04 2010-09-09 Siemens Aktiengesellschaft Medizintechnische Vorrichtung und Verfahren zur Kontrolle der Lage einer Blutpumpe
US20120095355A1 (en) 2009-03-13 2012-04-19 Proteus Biomedical, Inc. Volume Sensing
WO2010111355A1 (en) 2009-03-24 2010-09-30 Norcross Corporation In-line viscometer with no moving parts and methods and computer-readable media for maintaining a desired viscosity
CN201437016U (zh) 2009-03-26 2010-04-14 同济大学附属东方医院 植入式心室辅助装置
RU2536418C2 (ru) 2009-05-13 2014-12-20 Конинклейке Филипс Электроникс Н.В. Ультразвуковое допплеровское аудиоустройство контроля кровотока со смещением основного тона
US8231519B2 (en) 2009-05-20 2012-07-31 Thoratec Corporation Multi-lumen cannula
US9782527B2 (en) 2009-05-27 2017-10-10 Tc1 Llc Monitoring of redundant conductors
US8657748B2 (en) 2009-06-09 2014-02-25 National Institute Of Advanced Industrial Science And Technology Blood vessel function inspecting apparatus
WO2010142286A1 (de) 2009-06-12 2010-12-16 Technische Universität Dresden Anordnung und verfahren zur kombinierten bestimmung von schallgeschwindigkeiten und abständen in medien mittels ultraschall
DE102009025464A1 (de) 2009-06-12 2011-01-27 Technische Universität Dresden Anordnung und Verfahren zur kombinierten Bestimmung von Schallgeschwindigkeiten und Abständen in flüssigen und festen Medien mittels Ultraschall
US20100324378A1 (en) 2009-06-17 2010-12-23 Tran Binh C Physiologic signal monitoring using ultrasound signals from implanted devices
DE102009027195A1 (de) 2009-06-25 2010-12-30 Sorin Group Deutschland Gmbh Vorrichtung zur Förderung von Blut in einem extrakorporalen Kreislauf
WO2011002564A1 (en) 2009-07-02 2011-01-06 Cardiac Pacemakers, Inc. Vascular pressure sensor with electrocardiogram electrodes
US20160008531A1 (en) 2009-08-11 2016-01-14 W-Z Biotech, Llc Dual lumen cannula for artificial lung and right ventricular assist device
US8628460B2 (en) 2009-09-21 2014-01-14 Heartware, Inc. Hard-wired implanted controller system
DE102009047845A1 (de) 2009-09-30 2011-03-31 Abiomed Europe Gmbh Herzunterstützungssystem
US9943236B2 (en) 2009-09-30 2018-04-17 Medtronic, Inc. Methods for guiding heart failure decompensation therapy
CN101711683A (zh) 2009-10-30 2010-05-26 中国人民解放军第三军医大学第一附属医院 一种测量动脉血液流速的方法
CN201658687U (zh) 2009-11-17 2010-12-01 陈洵 一种微型螺杆式血泵
EP2333514A1 (de) 2009-11-30 2011-06-15 Berlin Heart GmbH Einrichtung und Verfahren zur Messung von strömungsmechanisch wirksamen Materialparametern eines Fluids
US8608798B2 (en) 2009-12-03 2013-12-17 Richard Wampler Total artificial heart
EP2338539A1 (de) 2009-12-23 2011-06-29 ECP Entwicklungsgesellschaft mbH Pumpeneinrichtung mit einer Detektionseinrichtung
DE102009060668A1 (de) 2009-12-28 2011-06-30 Fresenius Medical Care Deutschland GmbH, 61352 Vorrichtung und Verfahren zur Überwachung einer extrakorporalen Blutbehandlung
EP2525870B1 (en) 2010-01-19 2019-03-13 Heartware, Inc. Physiologically responsive vad
US9028413B2 (en) 2010-03-08 2015-05-12 Siemens Medical Solutions Usa, Inc. Prediction-based flow estimation for ultrasound diagnostic imaging
DE102010011798B4 (de) 2010-03-17 2017-07-13 Fresenius Medical Care Deutschland Gmbh Verfahren und Vorrichtung zur Druck- oder Volumenstrombestimmung von medizinischen Fluiden
DE102010012042B4 (de) 2010-03-19 2025-02-06 Tdk Corporation Bauelement mit einem Chip in einem Hohlraum und einer spannungsreduzierten Befestigung
DK3075402T3 (da) 2010-05-26 2019-10-28 Abiomed Inc Anatomisk tilpasing af en perkutan vad til højre hjertestøtte
JP5898190B2 (ja) 2010-06-22 2016-04-06 ソラテック コーポレーション 流体送達システム及び流体送達システムを監視するための方法
WO2012012552A1 (en) 2010-07-22 2012-01-26 Thoratec Corporation Controlling implanted blood pumps
US20120143141A1 (en) 2010-08-03 2012-06-07 Verkaik Josiah E Conformal cannula device and related methods
WO2012024493A1 (en) 2010-08-20 2012-02-23 Thoratec Corporation Implantable blood pump
WO2012040551A1 (en) 2010-09-24 2012-03-29 Thoratec Corporation Generating artificial pulse
US8608636B2 (en) * 2010-11-12 2013-12-17 Libraheart, Inc.V Ventricular assist device cannula and ventricular assist device including the same
US10517667B2 (en) 2014-05-16 2019-12-31 Biosense Webster (Israel) Ltd. Catheter tip with microelectrodes
AT510914B1 (de) 2011-01-03 2012-10-15 Lang Leonh Medizinische elektrode mit gedruckter zuleitung und verfahren zu ihrer herstellung
US8591393B2 (en) 2011-01-06 2013-11-26 Thoratec Corporation Catheter pump
US9492601B2 (en) 2011-01-21 2016-11-15 Heartware, Inc. Suction detection on an axial blood pump using BEMF data
EP2665499A4 (en) 2011-01-21 2017-06-07 Heartware, Inc. Flow estimation in a blood pump
US9283315B2 (en) 2011-02-08 2016-03-15 Fresenius Medical Care Holdings, Inc. Apparatus and method for real time measurement of a constituent of blood to monitor blood volume
WO2012112378A2 (en) 2011-02-18 2012-08-23 Vascor Inc. Blood flow assist systems
EP2693609B1 (en) 2011-03-28 2017-05-03 Thoratec Corporation Rotation and drive device and centrifugal pump device using same
EP2505847B1 (en) 2011-03-29 2019-09-18 ABB Schweiz AG Method of detecting wear in a pump driven with a frequency converter
US8818478B2 (en) 2011-03-31 2014-08-26 Adidas Ag Sensor garment
WO2012170837A2 (en) 2011-06-08 2012-12-13 Nader Najafi Implantable wireless sensor systems
DE102011106142A1 (de) 2011-06-10 2012-12-27 Rheinisch-Westfälische Technische Hochschule Aachen Blutentnahmekanüle einer die Herzfunktion ersetzenden oder unterstützenden Pumpe
EP2723416B1 (en) 2011-06-27 2019-07-31 Heartware, Inc. Flow estimation in a blood pump
WO2013009881A2 (en) 2011-07-11 2013-01-17 Vascor, Inc. Transcutaneous power transmission and communication for implanted heart assist and other devices
EP2739347B1 (en) 2011-08-05 2016-07-06 CircuLite, Inc. Cannula lined with tissue in-growth material and method of using the same
US8613696B2 (en) 2011-08-15 2013-12-24 Thoratec Corporation Non-invasive diagnostics for ventricle assist device
CA2845086C (en) 2011-08-17 2023-02-14 Novita Therapeutics, Llc Blood pump systems and methods
US8849398B2 (en) 2011-08-29 2014-09-30 Minnetronix, Inc. Expandable blood pump for cardiac support
EP2564771A1 (de) 2011-09-05 2013-03-06 ECP Entwicklungsgesellschaft mbH Medizinprodukt mit einem Funktionselement zum invasiven Einsatz im Körper eines Patienten
DE202011110389U1 (de) 2011-09-05 2013-11-21 Ecp Entwicklungsgesellschaft Mbh Medizinprodukt mit einem Funktionselement zum invasivenEinsatz im Körper eines Patienten
US9517348B2 (en) 2011-09-14 2016-12-13 Biotronik Se & Co. Kg Implantable cardiac therapy device
DE112012004282T5 (de) 2011-10-13 2014-07-03 Thoratec Corporation Pumpe und verfahren zum halbaxialpumpen von blut
WO2013061280A1 (en) 2011-10-28 2013-05-02 Hemodynamix Medical Systems Inc. Fluid temperature and flow sensor apparatus and system for cardiovascular and other medical applications
US20130116575A1 (en) 2011-11-04 2013-05-09 Marlin Mickle Implantable doppler blood flow monitor and doppler probe
US8714017B2 (en) 2011-11-15 2014-05-06 Hema-Q, Inc. Apparatus for non-invasive determination of sound velocity in a liquid and determining a parameter of the liquid from the sound velocity
AU2012340635B2 (en) 2011-11-23 2017-11-09 Abiomed, Inc. Counterpulsation device driver apparatus, method and system
WO2013096072A2 (en) 2011-12-22 2013-06-27 Uop Llc Layered conversion synthesis of zeolites
EP2617443B1 (en) 2012-01-17 2015-10-21 PulseCath B.V. Pressure actuated single-lumen blood pumping device
NL2008276C2 (en) 2012-02-13 2013-09-02 Egbert Jan Constant Ottevanger Method and system for detecting cardiac tamponade in a patient.
ES3041040T3 (en) 2012-03-26 2025-11-06 Procyrion Inc Systems and methods for fluid flows and/or pressures for circulation and perfusion enhancement
DE102012207049A1 (de) 2012-04-27 2015-08-13 Abiomed Europe Gmbh Intravasale rotationsblutpumpe
DE102012207056B4 (de) 2012-04-27 2021-11-11 Abiomed Europe Gmbh Kathethersystem und intravasale blutpumpe mit diesem kathetersystem
DE102012207053A1 (de) 2012-04-27 2013-10-31 Abiomed Europe Gmbh Intravasale rotationsblutpumpe
DE102012207042B4 (de) 2012-04-27 2017-09-07 Abiomed Europe Gmbh Pulsationsblutpumpe
US9826892B2 (en) 2012-06-13 2017-11-28 Boston Scientific Scimed, Inc. Medical device visualization system
TR201207222A2 (tr) 2012-06-21 2012-11-21 Oran B�Lent Damar içi kalp destek cihazı.
EP4186557A1 (en) 2012-07-03 2023-05-31 Tc1 Llc Motor assembly for catheter pump
US9212962B2 (en) 2012-07-11 2015-12-15 Robert Bosch Gmbh Self-powered pressure sensor assembly
WO2014015300A1 (en) 2012-07-19 2014-01-23 Regents Of The University Of Minnesota Cardiac assist device with pulse wave analysis
JP5660737B2 (ja) 2012-07-20 2015-01-28 日本ライフライン株式会社 電極カテーテルおよびその製造方法
CN104768589B (zh) 2012-09-05 2017-04-19 哈特威尔公司 集成流传感器的vad
WO2017013493A1 (en) 2015-07-20 2017-01-26 L.I.F.E. Corporation S.A. Flexible fabric ribbon connectors for garments with sensors and electronics
EP2895215A4 (en) 2012-09-13 2016-08-31 Circulite Inc BLOOD FLOW SYSTEM WITH VARIABLE SPEED CONTROL
WO2014044287A1 (en) 2012-09-21 2014-03-27 Rheinisch-Westfälische Technische Hochschule Aachen Method of controlling the speed of an ventricular assist device (vad) and ventricular assist device.
DE102013012391A1 (de) 2012-09-26 2014-03-27 CircuLite GmbH Pumpe, System mit einer Blutpumpe und Verfahren zur Herstellung einer Blutpumpe
US9585991B2 (en) 2012-10-16 2017-03-07 Heartware, Inc. Devices, systems, and methods for facilitating flow from the heart to a blood pump
US9925354B2 (en) 2012-10-24 2018-03-27 Evergreen Medical Technologies, Inc. Flex circuit ribbon based elongated members and attachments
WO2014070290A2 (en) 2012-11-01 2014-05-08 Boston Scientific Neuromodulation Corporation Systems and methods for voa model generation and use
WO2014085806A1 (en) 2012-11-30 2014-06-05 The Penn State Research Foundation Smart tip lvad inlet cannula
US8834345B2 (en) 2013-01-16 2014-09-16 Thoratec Corporation Backflow detection for centrifugal blood pump
US8968174B2 (en) 2013-01-16 2015-03-03 Thoratec Corporation Motor fault monitor for implantable blood pump
US9371826B2 (en) 2013-01-24 2016-06-21 Thoratec Corporation Impeller position compensation using field oriented control
US9556873B2 (en) 2013-02-27 2017-01-31 Tc1 Llc Startup sequence for centrifugal pump with levitated impeller
EP3834876B1 (en) 2013-03-13 2022-09-14 Tc1 Llc Fluid handling system
US10039874B2 (en) 2013-03-13 2018-08-07 Magenta Medical Ltd. Renal pump
US10583231B2 (en) 2013-03-13 2020-03-10 Magenta Medical Ltd. Blood pump
US11033728B2 (en) 2013-03-13 2021-06-15 Tc1 Llc Fluid handling system
US8882477B2 (en) 2013-03-14 2014-11-11 Circulite, Inc. Magnetically levitated and driven blood pump and method for using the same
US9789236B2 (en) 2013-03-14 2017-10-17 Yale University Implantable heart pump controller
US9919088B2 (en) 2013-03-14 2018-03-20 Yale University Implantable heart pump controller
US9848899B2 (en) 2013-03-15 2017-12-26 St. Jude Medical, Atrial Fibrillation Division, Inc. Pressure sensing of irrigant backpressure for aligning directional medical devices with target tissue
EP2968742B1 (en) 2013-03-15 2020-12-02 Tc1 Llc Catheter pump assembly including a stator
EP2968716B1 (en) 2013-03-15 2023-09-13 VASCOR, Inc. Thoracic aorta ventricular assist system
JP5608848B2 (ja) 2013-03-27 2014-10-15 株式会社サンメディカル技術研究所 人工心臓制御装置及び人工心臓システム
DE102013013700A1 (de) 2013-04-05 2014-10-09 CircuLite GmbH Implantierbare Blutpumpe, Blutpumpensystem und Verfahren zur Datenübertragung in einem Blutpumpensystem
EP2796156A1 (en) 2013-04-24 2014-10-29 ETH Zurich Biomedical apparatus for pumping blood of a human or an animal patient through a secondary intra- or extracorporeal blood circuit
US10052420B2 (en) 2013-04-30 2018-08-21 Tc1 Llc Heart beat identification and pump speed synchronization
US9713663B2 (en) 2013-04-30 2017-07-25 Tc1 Llc Cardiac pump with speed adapted for ventricle unloading
US9631997B2 (en) 2013-05-14 2017-04-25 Infineon Technologies Ag Apparatus for measuring a pressure, a method for manufacturing an apparatus for measuring a pressure and a battery
WO2014190195A1 (en) 2013-05-22 2014-11-27 Boston Scientific Scimed, Inc. Pressure sensing guidewire systems including an optical connector cable
US9427508B2 (en) 2013-06-04 2016-08-30 Heartware, Inc. Axial flow pump pressure algorithm
WO2014197558A2 (en) 2013-06-04 2014-12-11 Heartware, Inc. Suction detection in an axial blood pump using bemf data
DE102013106352A1 (de) 2013-06-18 2014-12-18 Universität Zu Lübeck Herzunterstützungssystem sowie Herzunterstützungsverfahren
GB201311494D0 (en) 2013-06-27 2013-08-14 Univ Oslo Hf Monitoring of a cardiac assist device
US9968719B2 (en) 2013-07-30 2018-05-15 Heartware, Inc. Wire scaffold device for ventricular assist device
EP2851099A1 (en) 2013-09-20 2015-03-25 Berlin Heart GmbH Blood pump control system for controlling a blood pump
EP2851100A1 (en) 2013-09-20 2015-03-25 Berlin Heart GmbH Blood pump control system and method for controlling a blood pump
EP2859911A1 (en) 2013-10-11 2015-04-15 qSTAR Medical SAS Vascular access port devices with incorporated sensors
EP2860399A1 (de) 2013-10-14 2015-04-15 ECP Entwicklungsgesellschaft mbH Verfahren zum Betrieb einer Versorgungseinrichtung, die einen Kanal mit einer Flüssigkeit beaufschlagt, sowie Versorgungseinrichtung
CN103519847A (zh) 2013-10-25 2014-01-22 中国科学院深圳先进技术研究院 基于超声回波射频信号的多普勒血流速度估测方法和系统
WO2015074511A1 (en) 2013-11-19 2015-05-28 Versitech Limited Apparatus for ultrasound flow vector imaging and methods thereof
JP6644687B2 (ja) 2013-12-06 2020-02-12 ボルケーノ コーポレイション 血管内圧を評価するデバイス、システム及び方法
US20150157216A1 (en) 2013-12-06 2015-06-11 Volcano Corporation Device, system, and method for assessing intravascular pressure
CN103709076B (zh) 2013-12-20 2015-09-16 万华化学集团股份有限公司 一种连续制备缩二脲多异氰酸酯的方法
JP2015122448A (ja) 2013-12-24 2015-07-02 住友電工プリントサーキット株式会社 フッ素樹脂基材、プリント配線板、生体情報測定デバイス及び人工臓器
US20150365738A1 (en) 2014-01-09 2015-12-17 Rick Purvis Telemetry arrangements for implantable devices
US9707402B2 (en) 2014-02-14 2017-07-18 Boston Scientific Neuromodulation Corporation Plug-in accessory for configuring a mobile device into an external controller for an implantable medical device
US9616159B2 (en) 2014-03-05 2017-04-11 Medtronic Vascular Galway Modular implantable ventricular assist device
JP6301696B2 (ja) 2014-03-25 2018-03-28 テルモ株式会社 流量センサ及び流量センサを備えた体外循環装置、及びその制御方法
DE102015004177A1 (de) 2014-04-02 2015-10-08 Em-Tec Gmbh lmplantierbare Sensorik zur lntegration in Herzunterstützungssysteme, Herzunterstützungssystem und Verfahren zur Kontrolle und Steuerung einer Sensorik
EP3131599B1 (en) 2014-04-15 2019-02-20 Tc1 Llc Catheter pump with access ports
EP3131596B1 (en) 2014-04-15 2020-07-22 Tc1 Llc Methods and systems for controlling a blood pump
US9849224B2 (en) 2014-04-15 2017-12-26 Tc1 Llc Ventricular assist devices
US10583232B2 (en) 2014-04-15 2020-03-10 Tc1 Llc Catheter pump with off-set motor position
US9786150B2 (en) 2014-04-15 2017-10-10 Tci Llc Methods and systems for providing battery feedback to patient
US10029037B2 (en) 2014-04-15 2018-07-24 Tc1 Llc Sensors for catheter pumps
DE102014105861B4 (de) 2014-04-25 2015-11-05 Infineon Technologies Ag Sensorvorrichtung und Verfahren zum Herstellen einer Sensorvorrichtung
US10293090B2 (en) 2014-04-25 2019-05-21 Yale University Percutaneous device and method for promoting movement of a bodily fluid
CN109381756B (zh) 2014-05-19 2021-08-17 马真塔医药有限公司 血液泵浦装置
EP3148604B1 (en) 2014-05-29 2020-09-30 St Vincent's Hospital Sydney Limited Ventricular assist device method and apparatus
DE102014108530A1 (de) 2014-06-17 2015-12-17 B. Braun Avitum Ag Verfahren zur Sterilisierung eines Hohlfaserfiltermoduls, Hohlfaserfiltermodul mit Verschluss und Sauerstoff absorbierender Verschluss
CN107073183A (zh) 2014-06-18 2017-08-18 心脏器械股份有限公司 用于识别抽吸事件的方法和设备
US9308305B2 (en) 2014-06-18 2016-04-12 Ch Biomedical (Usa) Inc. Implantable blood pump with integrated controller
US20160183808A1 (en) 2014-06-26 2016-06-30 Cardiovascular Systems, Inc. Methods, devices and systems for sensing, measuring and/or characterizing vessel and/or lesion compliance and/or elastance changes during vascular procedures
EP2962710A1 (de) 2014-07-03 2016-01-06 Berlin Heart GmbH Verfahren und Herzunterstützungssystem zur Bestimmung eines Auslassdrucks
US9345824B2 (en) 2014-07-07 2016-05-24 Assistocor Gmbh & Co Kg Ventricular assist device
DE102014213233A1 (de) 2014-07-08 2016-01-14 Continental Automotive Gmbh Vorrichtung zum Bestimmung einer Schallgeschwindigkeit eines Schallsignals in einem Fluid
DE102015112098A1 (de) 2014-07-25 2016-01-28 Minnetronix, Inc. Spulenparameter und Steuerung
AU2014402333A1 (en) 2014-08-01 2017-02-16 Vadovations, Inc. Coring dilator for defining an aperture in a tissue wall
US20160302672A1 (en) 2014-08-04 2016-10-20 Yamil Kuri System and Method for Determining Arterial Compliance and Stiffness
EP3182930B1 (en) 2014-08-18 2020-09-23 St. Jude Medical, Cardiology Division, Inc. Sensors for prosthetic heart devices
CN107223062B (zh) 2014-10-01 2019-12-17 心脏器械股份有限公司 具有更新的备用控制器系统
KR20170107428A (ko) * 2014-11-19 2017-09-25 어드밴스드 카디악 테라퓨틱스, 인크. 고분해능 전극 어셈블리를 이용한 절제 장치, 시스템 및 방법
US20160144166A1 (en) 2014-11-25 2016-05-26 Medtronic Bakken Research Center B.V. Medical lead with thin film
WO2016092913A1 (ja) 2014-12-12 2016-06-16 テルモ株式会社 体外循環装置
WO2016130846A1 (en) 2015-02-11 2016-08-18 Thoratec Corporation Heart beat identification and pump speed synchronization
US10371152B2 (en) 2015-02-12 2019-08-06 Tc1 Llc Alternating pump gaps
EP3261713B1 (en) 2015-02-24 2019-08-14 Heartware, Inc. Blood pump for treatment of bradycardia
EP3069741A1 (de) 2015-03-17 2016-09-21 Berlin Heart GmbH Herzpumpeneinrichtung und Verfahren zu ihrem Betrieb
EP3088016A1 (de) 2015-04-29 2016-11-02 Berlin Heart GmbH Pumpeneinrichtung sowie verfahren zum betrieb einer pumpe für flüssigkeiten
US20160317043A1 (en) 2015-04-30 2016-11-03 Withings Weighing scale with extended functions
IL294513B2 (en) 2015-05-11 2024-10-01 White Swell Medical Ltd Systems and methods for reducing pressure at an outflow of a duct
EP3103391B1 (de) 2015-05-21 2018-10-10 BIOTRONIK SE & Co. KG Implantierbare vorrichtung mit einem sauerstoffsensor
US10391683B2 (en) 2015-05-31 2019-08-27 Purdue Research Foundation Method to genberate an ultra-stretchable electrical and heat conductive arrangement
DE202015009422U1 (de) 2015-06-16 2017-07-12 Berlin Heart Gmbh Implantierbare Herzpumpe
EP3115755B1 (en) 2015-07-06 2022-02-16 ABB Schweiz AG System and method for measuring a speed of sound in a liquid or gaseous medium
CN106333707B (zh) 2015-07-09 2020-12-01 深圳迈瑞生物医疗电子股份有限公司 超声多普勒图谱校正方法、装置及超声诊断系统
EP3324840A4 (en) 2015-07-20 2019-03-20 Tc1 Llc MEASURING TEST STRIPS FOR FLOW ESTIMATION
US9901666B2 (en) 2015-07-20 2018-02-27 Tc1 Llc Flow estimation using hall-effect sensors for measuring impeller eccentricity
EP3135326A1 (de) 2015-08-24 2017-03-01 Berlin Heart GmbH Herzpumpe sowie verfahren zum betrieb einer herzpumpe
EP3135325A1 (de) 2015-08-24 2017-03-01 Berlin Heart GmbH Regeleinrichtung und verfahren für eine herzpumpe
CN108348180A (zh) 2015-09-04 2018-07-31 波士顿科学国际有限公司 压力传感导丝
EP4290081A3 (en) 2015-09-25 2024-02-21 Procyrion, Inc. Non-occluding intravascular blood pump providing reduced hemolysis
US10206651B2 (en) 2015-09-30 2019-02-19 General Electric Company Methods and systems for measuring cardiac output
DE102015219263A1 (de) 2015-10-06 2017-04-06 Robert Bosch Gmbh Pumpe für ein ventrikuläres Unterstützungssystem mit tribologischem Beanspruchungssensor und Verwendung
US20180271445A1 (en) 2015-10-14 2018-09-27 St. Jude Medical, Cardiology Division, Inc. Vascular sensor implantation devices and methods
WO2017070331A1 (en) 2015-10-23 2017-04-27 Heartware, Inc. Physiologically responsive blood pump for ischemia detection and treatment
US10444280B2 (en) 2015-10-27 2019-10-15 Nvidia Corporation Independent test partition clock coordination across multiple test partitions
CN108289984B (zh) 2015-11-02 2024-03-19 心脏器械股份有限公司 用于使用泵操作数据的不良事件预测的方法和系统
DE102015222199A1 (de) 2015-11-11 2017-05-11 Robert Bosch Gmbh Herzunterstützungspumpe, Verfahren zum Betreiben einer Herzunterstützungspumpe und Steuergerät
US10117983B2 (en) 2015-11-16 2018-11-06 Tc1 Llc Pressure/flow characteristic modification of a centrifugal pump in a ventricular assist device
US10130743B2 (en) 2015-11-17 2018-11-20 Dale J. Yeatts Wireless diagnostic system for indirect flow measurement in artificial heart pumps
EP3377136B1 (en) 2015-11-20 2020-05-06 Tc1 Llc Energy management of blood pump controllers
EP3377133B1 (en) 2015-11-20 2021-07-14 Tc1 Llc System architecture that allows patient replacement of vad controller/interface module without disconnection of old module
WO2017087717A1 (en) 2015-11-20 2017-05-26 Tc1 Llc Blood pump controllers having daisy-chained batteries
US11324442B1 (en) 2015-11-25 2022-05-10 Maquet Cardiovascular Llc Broadband impedance spectroscopy and its use for tissue welding
US10426879B2 (en) 2015-12-14 2019-10-01 Heartware, Inc. Blood pump with restart lockout
EP3181163A1 (de) 2015-12-14 2017-06-21 Berlin Heart GmbH Blutpumpe zur herzunterstützung und verfahren zu ihrem betrieb
CN108430532B (zh) 2015-12-28 2020-12-11 心脏器械股份有限公司 具有自适应启动的泵电机控制
JP6929854B2 (ja) 2015-12-28 2021-09-01 ボストン サイエンティフィック サイムド，インコーポレイテッドＢｏｓｔｏｎ Ｓｃｉｅｎｔｉｆｉｃ Ｓｃｉｍｅｄ，Ｉｎｃ． 抗血栓コーティングを有する医療装置
EP3397299B1 (en) 2015-12-28 2023-02-22 Heartware, Inc. Vad controller tester
US9883836B2 (en) 2016-02-08 2018-02-06 International Business Machines Corporation Embedded device for flow monitoring
EP3205359B1 (en) 2016-02-11 2018-08-29 Abiomed Europe GmbH Blood pump system
EP3205360B1 (en) 2016-02-11 2018-08-29 Abiomed Europe GmbH Blood pump
EP3419688A4 (en) 2016-02-24 2019-08-14 Oscar H. Frazier DEVICE FOR INTRACAVITARY VENTRICULAR ASSISTANCE
WO2017154270A1 (ja) 2016-03-08 2017-09-14 テルモ株式会社 成分測定装置、成分測定方法及び成分測定プログラム
JP2017176719A (ja) 2016-03-31 2017-10-05 日本ゼオン株式会社 カテーテル
AU2017257508B2 (en) 2016-04-29 2021-10-14 Artio Medical, Inc. Conduit tips and systems and methods for use
CN206007680U (zh) 2016-05-16 2017-03-15 北京精密机电控制设备研究所 一种植入式心室辅助装置
ES3036798T3 (en) 2016-06-06 2025-09-24 Abiomed Inc Blood pump assembly having a sensor and a sensor shield
EP3263148B1 (de) 2016-06-29 2019-05-08 Berlin Heart GmbH Verfahren zur ermittlung von betriebsparametern einer blutpumpe
WO2018005228A1 (en) 2016-07-01 2018-01-04 Heartware, Inc. Systems and methods for maintaining fluid balance
EP3487548B1 (en) 2016-07-19 2021-03-17 Heartware, Inc. Ventricular assist devices and integrated sensors thereof
EP3490628B1 (en) 2016-08-01 2021-02-24 Heartware, Inc. Vad with aortic valve opening detection
CN109562211B (zh) 2016-08-01 2021-07-06 心脏器械股份有限公司 基于vad电流波形的心率确定
US10660998B2 (en) 2016-08-12 2020-05-26 Tci Llc Devices and methods for monitoring bearing and seal performance
EP3287154B1 (en) 2016-08-23 2019-10-09 Abiomed Europe GmbH Ventricular assist device
EP3509662B1 (en) 2016-09-06 2020-12-30 Heartware, Inc. Integrated sensors for intraventricular vad
MX2019002735A (es) 2016-09-08 2019-08-26 Kk Advance Sistema de administracion de informacion de diferencias individuales en tratamiento de dialisis.
DK3515523T3 (da) 2016-09-19 2021-05-17 Abiomed Inc Kardiovaskulart hjælpesystem som kvantificerer hjertefunktion og fremmer hjerterestitution
WO2018061780A1 (ja) 2016-09-29 2018-04-05 テルモ株式会社 制御装置、画像診断装置、制御装置の処理方法およびプログラム
EP4585250A3 (en) 2016-10-05 2025-10-01 OrbusNeich Medical Pte. Ltd. Modular vascular catheter
EP3311859B1 (en) 2016-10-19 2019-12-04 Abiomed Europe GmbH Ventricular assist device control
DE102016013334B3 (de) 2016-11-10 2018-04-05 Fresenius Medical Care Deutschland Gmbh Medizinisches Gerät mit einem Verbindungsstück für die Herstellung einer Flüssigkeitsverbindung zwischen flüssigkeitsführenden Leitungen
EP3335741A1 (de) 2016-12-14 2018-06-20 Berlin Heart GmbH Steuervorrichtung für eine implantierbare herzpumpe mit zwei implantierbaren steuereinheiten und mit einem mit diesen verbundenen implantierbaren schalter
JP6309606B1 (ja) 2016-12-21 2018-04-11 三井電気精機株式会社 遠心分離システム
ES2856975T3 (es) 2017-02-07 2021-09-28 Abiomed Europe Gmbh Bomba de sangre
ES2980273T3 (es) 2017-03-21 2024-09-30 Abiomed Inc Sistema para determinar el gasto cardíaco nativo mientras se mantiene el soporte al corazón con una bomba de sangre intracardiaca dispuesta en un catéter que tiene un termistor incorporado
EP3600478B1 (en) 2017-03-29 2024-06-26 Tc1 Llc Pressure sensing ventricular assist devices
EP3600477B1 (en) 2017-03-29 2022-10-26 Tc1 Llc Communication architecture for heart treatment systems
EP3928830B1 (en) 2017-03-29 2024-07-10 Tc1 Llc Adjusting pump protocol based on irregular heart rhythm
AU2018242620B2 (en) 2017-03-31 2023-11-16 CorWave SA Implantable pump system having a rectangular membrane
WO2018195052A1 (en) 2017-04-18 2018-10-25 Boston Scientific Scimed Inc. Annotation histogram for electrophysiological signals
EP3615103B1 (en) 2017-04-25 2021-03-24 Heartware, Inc. Anti-thrombus surface potential ceramic element
US10404093B2 (en) 2017-04-26 2019-09-03 Biosense Webster (Israel) Ltd. Using location transmission signals for charging a wireless medical tool of an electromagnetic navigation system
EP3398626B1 (en) 2017-05-04 2021-02-24 Abiomed Europe GmbH Intravascular blood pump with balloon
CN110650756B (zh) 2017-05-16 2022-12-27 心脏器械股份有限公司 心室内流动可植入pv环路系统
WO2018220143A1 (en) 2017-05-31 2018-12-06 Foundry Innovation And Research 1, Ltd Implantable ultrasonic vascular sensor
CN115814262B (zh) 2017-06-09 2025-09-16 阿比奥梅德公司 用于调节血液泵支持的对心脏参数的确定
WO2018236815A1 (en) 2017-06-20 2018-12-27 Boston Scientific Scimed, Inc. DEVICES AND METHODS FOR DETERMINING BLOOD FLOW AROUND BODY LIGHT
US11217344B2 (en) 2017-06-23 2022-01-04 Abiomed, Inc. Systems and methods for capturing data from a medical device
JP7208896B2 (ja) 2017-07-10 2023-01-19 テルモ株式会社 圧力検知装置および体外循環装置
WO2019013794A1 (en) 2017-07-13 2019-01-17 Heartware, Inc. HVAD CIRCADIC MONITORING DEVICE (PHI +)
EP3443993A1 (de) 2017-08-17 2019-02-20 Berlin Heart GmbH Pumpe mit einem rotorsensor zur erfassung von physiologischen parametern, strömungs- und bewegungsparametern
US20190053816A1 (en) 2017-08-18 2019-02-21 Heartware, Inc. Thrombus detection and removal using a flexible electronic sensor and emitter
EP3668561B1 (en) 2017-08-18 2021-10-20 HeartWare, Inc. Therapeutic uv blood treatment in a blood pump
CN107632167B (zh) 2017-08-21 2019-12-06 天津大学 基于超声脉冲多普勒与电学多传感器的两相流流速测量方法
WO2019060281A1 (en) 2017-09-19 2019-03-28 Abiomed, Inc. SYSTEMS AND METHODS FOR SINGLE USE TEMPORARY PASSWORD MANAGEMENT FOR A MEDICAL DEVICE
US10786612B2 (en) 2017-09-26 2020-09-29 Heartware, Inc. Instrumented driveline using a flexible artificial skin sensory array
US10806840B2 (en) 2017-10-13 2020-10-20 Heartware, Inc. Dynamic HQ for closed loop control
EP3473279B1 (en) 2017-10-20 2020-07-08 PulseCath B.V. Catheter pump system
JP2019080749A (ja) 2017-10-30 2019-05-30 テルモ株式会社 治療方法
EP3720520B1 (en) 2017-12-05 2024-07-03 Heartware, Inc. Blood pump with impeller rinse operation
WO2019118522A1 (en) 2017-12-12 2019-06-20 Boston Scientific Scimed, Inc. Rotational medical device
EP4520359A3 (en) 2017-12-19 2025-04-30 Boston Scientific Scimed Inc. Heart rate measurement using blood pump impeller location
JP7339258B2 (ja) 2017-12-21 2023-09-05 アビオメド インコーポレイテッド 患者の健康状態を予測するためのシステムおよび方法
EP3508230A1 (en) 2018-01-09 2019-07-10 Abiomed Europe GmbH Method and apparatus for calibration and use in estimating blood flow in an intravascular blood pump
CN115192896A (zh) 2018-01-10 2022-10-18 马真塔医药有限公司 心室辅助装置
EP3737310B1 (en) 2018-01-10 2022-07-27 Boston Scientific Scimed, Inc. Rotational medical device
WO2019140073A1 (en) 2018-01-10 2019-07-18 Tufts Medical Center, Inc. Systems and methods for left ventricular unloading in treating myocardial infarction
US10905808B2 (en) 2018-01-10 2021-02-02 Magenta Medical Ltd. Drive cable for use with a blood pump
US11154702B2 (en) 2018-01-26 2021-10-26 Heartware, Inc. Early warning of LVAD thrombus formation
EP3746146A1 (en) 2018-01-31 2020-12-09 Heartware, Inc. Axial blood pump with impeller rinse operation
US11540732B2 (en) 2018-02-22 2023-01-03 Welling Medical B.V. Dual pressure sensor aortic-valve catheter
EP4070720B1 (en) 2018-02-23 2023-11-08 Boston Scientific Scimed, Inc. Methods for assessing a vessel with sequential physiological measurements
EP4461341A3 (en) 2018-03-15 2025-01-15 Tc1 Llc Systems for preventing right heart failure
CN119015594A (zh) 2018-03-16 2024-11-26 阿比奥梅德公司 用于估计心脏泵的位置的系统和方法
EP3768347B1 (en) 2018-03-20 2024-02-21 Tc1 Llc Ventricular assist systems
US11389641B2 (en) 2018-03-21 2022-07-19 Tc1 Llc Modular flying lead cable and methods for use with heart pump controllers
WO2019182691A1 (en) 2018-03-21 2019-09-26 Tc1 Llc Improved driveline connectors and methods for use with heart pump controllers
WO2019183432A1 (en) 2018-03-23 2019-09-26 Boston Scientific Scimed, Inc. Medical device with pressure sensor
JP7254773B2 (ja) 2018-03-29 2023-04-10 テルモ株式会社 撮像デバイス
EP3773783B1 (en) 2018-04-06 2025-11-05 Boston Scientific Scimed, Inc. Multi-input speed response algorithm for a blood pump
US12048797B2 (en) 2018-04-06 2024-07-30 Kanha Vijay SINGRU Ventricular decompression and assisting apparatus
CN119564167A (zh) 2018-04-18 2025-03-07 波士顿科学国际有限公司 用连续生理测量值评估脉管的系统
US11298519B2 (en) 2018-05-08 2022-04-12 Abiomed, Inc. Use of cardiac assist device to improve kidney function
CN111757761B (zh) 2018-05-10 2024-07-12 心脏器械股份有限公司 带有场定向控制的轴流泵压力算法
US11167121B2 (en) 2018-05-15 2021-11-09 Cardiovascular Systems, Inc. Intravascular pump with integrated isolated conductor(s) and methods thereof
US11141580B2 (en) 2018-05-15 2021-10-12 Cardiovascular Systems, Inc. Intravascular blood pump system with integrated conductor(s) in housing and methods thereof
DE102018207611A1 (de) 2018-05-16 2019-11-21 Kardion Gmbh Rotorlagerungssystem
US11235139B2 (en) 2018-05-17 2022-02-01 Heartware, Inc. Current-speed relationship for instantaneous suction detection algorithm in LVADS
EP3574932A1 (de) 2018-05-28 2019-12-04 Berlin Heart GmbH Blutpumpe
DE102018208538A1 (de) 2018-05-30 2019-12-05 Kardion Gmbh Intravasale Blutpumpe und Verfahren zur Herstellung von elektrischen Leiterbahnen
DE102018208536A1 (de) 2018-05-30 2019-12-05 Kardion Gmbh Leitungsvorrichtung zum Leiten eines Blutstroms für ein Herzunterstützungssystem, Verfahren zum Herstellen einer Leitungsvorrichtung und Verfahren zum Montieren eines Herzunterstützungssystems
WO2019232080A1 (en) 2018-05-31 2019-12-05 Tc1 Llc Improved blood pump controllers
WO2019229727A1 (en) 2018-06-01 2019-12-05 Jesus Flores Catheter pump with fixed-diameter impeller
DE102018208892A1 (de) 2018-06-06 2019-12-12 Kardion Gmbh Sensorkopfvorrichtung für ein minimalinvasives Herzunterstützungssystem und Verfahren zum Herstellen einer Sensorkopfvorrichtung für ein Herzunterstützungssystem
DE102018208870A1 (de) 2018-06-06 2019-12-12 Kardion Gmbh Verfahren zur Bestimmung eines Fluid-Volumenstroms durch ein implantiertes, vaskuläres Unterstützungssystem
DE102018208936A1 (de) 2018-06-06 2019-12-12 Kardion Gmbh Bestimmvorrichtung und Verfahren zum Bestimmen einer Viskosität eines Fluids
DE102018208931A1 (de) 2018-06-06 2019-12-12 Kardion Gmbh Vorrichtung zum Bestimmen eines Herzzeitvolumens für ein Herzunterstützungssystem, Herzunterstützungssystem und Verfahren zum Bestimmen eines Herzzeitvolumens
DE102018208929A1 (de) 2018-06-06 2019-12-12 Kardion Gmbh Verfahren zur Bestimmung einer Strömungsgeschwindigkeit eines durch ein implantiertes, vaskuläres Unterstützungssystem strömenden Fluids
DE102018208899A1 (de) 2018-06-06 2019-12-12 Kardion Gmbh Verfahren zum Ermitteln der Schallgeschwindigkeit in einem Fluid im Bereich eines implantierten, vaskulären Unterstützungssystems
DE102018208879A1 (de) 2018-06-06 2020-01-30 Kardion Gmbh Verfahren zur Bestimmung eines Fluid-Gesamtvolumenstroms im Bereich eines implantierten, vaskuläres Unterstützungssystems
DE102018208916A1 (de) 2018-06-06 2019-12-12 Kardion Gmbh Sensorikeinheit für ein Implantationssystem zur medizinischen Unterstützung eines Patienten und Verfahren zum Herstellen einer Sensorikeinheit
DE102018208862A1 (de) 2018-06-06 2019-12-12 Kardion Gmbh Implantierbares, vaskuläres Unterstützungssystem
DE102018208913A1 (de) 2018-06-06 2019-12-12 Kardion Gmbh Verfahren zum Betreiben eines implantierten, ventrikulären Unterstützungssystems
DE102018208911A1 (de) 2018-06-06 2019-12-12 Kardion Gmbh Leitungsvorrichtung für ein Herzunterstützungssystem und Verfahren zum Herstellen einer Leitungsvorrichtung
DE102018208927A1 (de) 2018-06-06 2019-12-12 Kardion Gmbh Implantierbare Einrichtung zum Ermitteln eines Fluid-Volumenstroms durch ein Blutgefäß
DE102018208933A1 (de) 2018-06-06 2019-12-12 Kardion Gmbh Verfahren zur Bestimmung einer Strömungsgeschwindigkeit eines durch ein implantiertes, vaskuläres Unterstützungssystem strömenden Fluids
DE102018208945A1 (de) 2018-06-06 2019-12-12 Kardion Gmbh Analysevorrichtung und Verfahren zum Analysieren einer Viskosität eines Fluids
ES3008910T3 (en) 2018-06-19 2025-03-25 Abiomed Inc Systems for system identification
DE102018210076A1 (de) 2018-06-21 2019-12-24 Kardion Gmbh Verfahren und Vorrichtung zum Erkennen eines Verschleißzustands eines Herzunterstützungssystems, Verfahren und Vorrichtung zum Betreiben eines Herzunterstützungssystems und Herzunterstützungssystem
US11241570B2 (en) 2018-07-17 2022-02-08 Tc1 Llc Systems and methods for inertial sensing for VAD diagnostics and closed loop control
DE102018212153A1 (de) 2018-07-20 2020-01-23 Kardion Gmbh Zulaufleitung für eine Pumpeneinheit eines Herzunterstützungssystems, Herzunterstützungssystem und Verfahren zum Herstellen einer Zulaufleitung für eine Pumpeneinheit eines Herzunterstützungssystems
DE102018213151A1 (de) 2018-08-07 2020-02-13 Kardion Gmbh Implantierbares, vaskuläres Unterstützungssystem
DE102018213350A1 (de) 2018-08-08 2020-02-13 Kardion Gmbh Vorrichtung und Verfahren zur Überwachung eines Gesundheitszustands des Patienten
US11120908B2 (en) 2018-09-20 2021-09-14 Abiomed, Inc. Data storage and retrieval system for non-contiguous medical device operational data
CN118526706A (zh) 2018-09-21 2024-08-23 阿比奥梅德公司 使用光纤传感器作为基于导管的医疗设备中的诊断工具
DE102018216305A1 (de) 2018-09-25 2020-03-26 Kardion Gmbh Verfahren zur Bestimmung einer Strömungsgeschwindigkeit eines durch ein implantiertes, vaskuläres Unterstützungssystem strömenden Fluids
EP4360691A3 (en) 2018-09-25 2024-07-17 Tc1 Llc Adaptive speed control algorithms and controllers for optimizing flow in ventricular assist devices
EP3856275B1 (en) 2018-09-27 2023-01-18 Heartware, Inc. Map estimation on vad patients
DE102018218770A1 (de) 2018-11-02 2020-05-07 Kardion Gmbh System und Verfahren zur Steuerung eines Herzunterstützungssystems
CN209790495U (zh) 2018-11-15 2019-12-17 安徽通灵仿生科技有限公司 一种辅助左心室功能的搏动式导管装置
EP3656411A1 (de) 2018-11-26 2020-05-27 Berlin Heart GmbH Blutpumpe zum unterstützen einer herzfunktion und verfahren zur herstellung eines pumpengehäuses einer blutpumpe
DE102018220658A1 (de) 2018-11-30 2020-06-04 Kardion Gmbh Herzunterstützungssystem und Verfahren zur optischen Spektroskopie unter Verwendung eines Herzunterstützungssystems
AU2019404039B2 (en) 2018-12-19 2022-07-07 Boston Scientific Scimed, Inc. Dampening element for fluid management system
DE102018222505A1 (de) 2018-12-20 2020-06-25 Kardion Gmbh Dehnbares Textil und Tragesystem zur Anwendung an einem Körper eines Patienten sowie Herzunterstützungssystem
US11521723B2 (en) 2018-12-21 2022-12-06 Abiomed, Inc. Using natural language processing to find adverse events
US11684769B2 (en) 2018-12-21 2023-06-27 Tc1 Llc Implantable blood pump assembly including pressure sensor and methods of assembling same
KR102922329B1 (ko) 2019-01-16 2026-02-05 아비오메드, 인크. 기계 학습 모델을 사용한 좌심실 용적 및 심박출량 추정
EP3858422B1 (en) 2019-01-24 2022-11-02 Magenta Medical Ltd. Ventricular assist device
CA3131860A1 (en) 2019-02-28 2020-09-03 Tc1 Llc Inflow cannula including expandable sleeve and methods of implanting same
US11413445B2 (en) 2019-03-12 2022-08-16 Heartware, Inc. Method of monitoring health conditions of a patient having an implantable blood pump
US12097016B2 (en) 2019-03-14 2024-09-24 Abiomed, Inc. Blood flow rate measurement system
US11337724B2 (en) 2019-03-15 2022-05-24 Terumo Kabushiki Kaisha Method and system for controlling rotational speed of an agitator or catheter
US10824898B2 (en) 2019-03-21 2020-11-03 Abiomed, Inc. Intelligent image segmentation prior to optical character recognition (OCR)
US12257021B2 (en) 2019-03-26 2025-03-25 Abiomed, Inc. Dynamically adjustable frame rate from medical device controller
US20200312450A1 (en) 2019-03-30 2020-10-01 Abiomed, Inc. Medical Device Location and Tracking System
CN109939282A (zh) 2019-04-23 2019-06-28 四川大学 一种经皮左心辅助循环系统
CN210020563U (zh) 2019-04-23 2020-02-07 四川大学 一种经皮左心辅助循环系统
US12364385B2 (en) 2019-04-30 2025-07-22 Gentuity, Llc Imaging probe with fluid pressurization element
CN113727656A (zh) 2019-05-17 2021-11-30 波士顿科学国际有限公司 为径向超声端口和冲洗端口提供可调整机构的设备
EP3968851B1 (en) 2019-05-17 2025-10-22 Opsens Inc. Pressure based structural heart assessment systems
EP3972661B1 (en) 2019-05-23 2024-09-11 Magenta Medical Ltd. Blood pumps
JP7564829B2 (ja) 2019-05-31 2024-10-09 アビオメド インコーポレイテッド 大動脈内圧の予測
EP3979940A1 (en) 2019-06-07 2022-04-13 Boston Scientific Scimed Inc. Zero force catheter
EP3753594A1 (en) 2019-06-18 2020-12-23 Abiomed Europe GmbH System and method for preparing a catheter before use
CA3143978A1 (en) 2019-06-28 2020-12-30 Abiomed, Inc. Blood pump with capability of electrocardiogram (ekg) monitoring, defibrillation and pacing
US11527322B2 (en) 2019-06-30 2022-12-13 Abiomed, Inc. Context-based user interface to medical database
US12102815B2 (en) 2019-09-25 2024-10-01 Shifamed Holdings, Llc Catheter blood pumps and collapsible pump housings
AU2020372991B2 (en) 2019-10-31 2024-09-19 Terumo Cardiovascular Systems Corporation Heart-lung machine with augmented reality display
JP7696894B2 (ja) 2019-11-01 2025-06-23 テルモ カーディオバスキュラー システムズ コーポレイション 半自律的な医療システムおよび方法
US11707617B2 (en) 2019-11-22 2023-07-25 Heartware, Inc. Method to extract and quantify the cardiac end diastolic point/mitral valve closing point from the HVAD estimated flow waveform
JP7686647B2 (ja) 2019-12-20 2025-06-02 ティーシー１ エルエルシー パーソナライズされた心血管分析のためのシステム及び方法
US11806518B2 (en) 2020-01-10 2023-11-07 Heartware, Inc. Passive thrust bearing angle
US11832868B2 (en) 2020-01-28 2023-12-05 Boston Scientific Scimed, Inc. Measuring the presence time of a catheter in a patient during a medical procedure
DE102020102473A1 (de) 2020-01-31 2021-08-05 Kardion Gmbh Pumpe zum Fördern eines Fluids und Verfahren zum Herstellen einer Pumpe
EP3884970A1 (en) 2020-03-27 2021-09-29 Abiomed Europe GmbH Device and method for determination of a co2 partial pressure value on a blood side of an oxygenator
KR102821548B1 (ko) 2020-04-06 2025-06-19 보스톤 싸이엔티픽 싸이메드 인코포레이티드 이미지 프로세싱 시스템들 및 이의 사용 방법들
EP3984589B1 (en) 2020-04-07 2023-08-23 Magenta Medical Ltd. Magnetic phase sensing
US11622695B1 (en) 2020-04-23 2023-04-11 Shifamed Holdings, Llc Intracardiac sensors with switchable configurations and associated systems and methods
US11694539B2 (en) 2020-06-16 2023-07-04 Heartware, Inc. Notification system for low-level preventative LVAD alerts
USD1017699S1 (en) 2020-09-25 2024-03-12 Boston Scientific Scimed, Inc. Indicator sticker with combined inner and outer portions
EP4216795A1 (en) 2020-09-25 2023-08-02 Boston Scientific Scimed, Inc. Medical imaging device
CA3197467A1 (en) 2020-09-30 2022-04-07 Boston Scientific Neuromodulation Corporation Adjustment of advertising interval in communications between an implantable medical device and an external device
CN116322501A (zh) 2020-10-07 2023-06-23 阿比奥梅德欧洲股份有限公司 用于电导和导纳测量的电极组件贴片
CA3199214A1 (en) 2020-11-20 2022-05-27 Marvin MITZE Mechanical circulatory support system with insertion tool
EP4291286A4 (en) 2021-02-10 2025-01-22 Shifamed Holdings, LLC Catheter blood pumps with collapsible pump housing and sensor system
US20240245902A1 (en) 2021-09-23 2024-07-25 Kardion Gmbh Method and apparatus for manufacturing a cardiac support system
US20230191141A1 (en) 2021-10-07 2023-06-22 Kardion Gmbh Transcutaneous energy transfer
EP4252827A3 (en) 2021-10-11 2024-01-10 Magenta Medical Ltd. Ventricular assist device
USD1017634S1 (en) 2021-11-02 2024-03-12 Abiomed, Inc. Display panel or portion thereof with graphical user interface
USD1014552S1 (en) 2021-11-02 2024-02-13 Abiomed, Inc. Display panel or portion thereof with graphical user interface
US12502524B2 (en) 2021-12-03 2025-12-23 Kardion Gmbh Cardiac pump with optical fiber for laser doppler
USD1001146S1 (en) 2021-12-10 2023-10-10 Abiomed, Inc. Display panel or portion thereof with graphical user interface
USD1001145S1 (en) 2021-12-10 2023-10-10 Abiomed, Inc. Display panel or portion thereof with graphical user interface
USD1012284S1 (en) 2022-02-09 2024-01-23 Boston Scientific Scimed, Inc. Medical device system and removable connectors set
US20240011808A1 (en) 2022-07-11 2024-01-11 Kardion Gmbh Laser doppler velocimetry flow measurement
US20240074828A1 (en) 2022-09-06 2024-03-07 Kardion Gmbh Medical device holding and mounting system

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102009007216A1 (de) * 2009-02-03 2010-08-12 Siemens Aktiengesellschaft Blutpumpe und medizintechnische Vorrichtung
EP2570143A1 (de) * 2011-09-14 2013-03-20 BIOTRONIK SE & Co. KG Implantierbares kardiales Therapiergerät
WO2016066180A1 (en) * 2014-10-30 2016-05-06 Osypka Stiftung Peter Transmyocardial insertion unit and its use

Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12194287B2 (en) 2018-05-30 2025-01-14 Kardion Gmbh Method of manufacturing electrical conductor tracks in a region of an intravascular blood pump
US12324906B2 (en) 2018-06-06 2025-06-10 Kardion Gmbh Systems and methods for determining a total blood volume flow in a cardiac support system and vascular support system
US12491357B2 (en) 2018-06-06 2025-12-09 Kardion Gmbh Systems and methods for determining a blood volume flow through a cardiac support system and vascular support system
US12478267B2 (en) 2018-06-06 2025-11-25 Kardion Gmbh Sensor head device for a minimal invasive ventricular assist device and method for producing such a sensor head device
US12377256B2 (en) 2018-06-06 2025-08-05 Kardion Gmbh Cardiac support system flow measurement using pressure sensors
US12311160B2 (en) 2018-06-06 2025-05-27 Kardion Gmbh Method and system for determining the speed of sound in a fluid in the region of a cardiac support system
US12310708B2 (en) 2018-06-06 2025-05-27 Kardion Gmbh Systems and methods for determining a flow speed of a fluid flowing through a cardiac assist device
US12178554B2 (en) 2018-06-06 2024-12-31 Kardion Gmbh Systems and methods for determining a viscosity of a fluid
US12569671B2 (en) 2018-06-06 2026-03-10 Kardion Gmbh Device and method for determination of a cardiac output for a cardiac assistance system
US12201821B2 (en) 2018-06-06 2025-01-21 Kardion Gmbh Method for determining a flow rate of a fluid flowing through an implanted vascular support system, and implantable vascular support system
US12222267B2 (en) 2018-06-06 2025-02-11 Kardion Gmbh Analysis device and method for analyzing a viscosity of a fluid
US12257424B2 (en) 2018-06-06 2025-03-25 Kardion Gmbh Implantable ventricular assist system and method for operating same
US12144976B2 (en) 2018-06-21 2024-11-19 Kardion Gmbh Method and device for detecting a wear condition of a ventricular assist device and for operating same, and ventricular assist device
US12508418B2 (en) 2018-08-08 2025-12-30 Kardion Gmbh Device and method for monitoring the state of health of a patient
US12318601B2 (en) 2020-10-07 2025-06-03 Abiomed Europe Gmbh Electrode assembly patch for conductance and admittance measurements
JP2023552946A (ja) * 2020-10-07 2023-12-20 アビオメド オイローパ ゲーエムベーハー コンダクタンスおよびアドミタンス測定のための電極アセンブリパッチ
JP7783267B2 (ja) 2020-10-07 2025-12-09 アビオメド オイローパ ゲーエムベーハー コンダクタンスおよびアドミタンス測定のための電極アセンブリパッチ
WO2022109589A1 (en) 2020-11-20 2022-05-27 Kardion Gmbh Mechanical circulatory support system with guidewire aid
WO2022109591A2 (en) 2020-11-20 2022-05-27 Kardion Gmbh Mechanical circulatory support system with insertion tool
EP4326385A4 (en) * 2021-04-22 2025-05-28 Cardio Vol, LLC Method and apparatus for assisting a heart
US20240198082A1 (en) * 2021-04-22 2024-06-20 Board Of Regents, The University Of Texas System Method and Apparatus for Assisting a Heart
WO2022225950A1 (en) * 2021-04-22 2022-10-27 Cardio Vol, Llc Method and apparatus for assisting a heart
EP4387708A4 (en) * 2021-08-19 2025-05-21 Cardiovol, LLC Method and device for assisting a heart
DE102022132114A1 (de) 2021-12-03 2023-06-07 Kardion Gmbh Herzpumpe mit Lichtleitfaser für Laser-Doppler
US12502524B2 (en) 2021-12-03 2025-12-23 Kardion Gmbh Cardiac pump with optical fiber for laser doppler
DE102023118223A1 (de) 2022-07-11 2024-01-11 Kardion Gmbh Laser-doppler-velozimetrie-durchflussmessung
WO2024243154A1 (en) 2023-05-25 2024-11-28 Kardion Gmbh Heart pump tips and delivery system couplings for mechanical circulatory support systems

Also Published As

Publication number Publication date
CN112584890A (zh) 2021-03-30
US20250222247A1 (en) 2025-07-10
EP3801674B1 (de) 2024-05-08
JP7626431B2 (ja) 2025-02-04
CN112584890B (zh) 2025-03-18
US20210346675A1 (en) 2021-11-11
DE102018208913A1 (de) 2019-12-12
EP3801674A1 (de) 2021-04-14
US12257424B2 (en) 2025-03-25
JP2021526880A (ja) 2021-10-11

Similar Documents

Publication Publication Date Title
EP3801674B1 (de) Implantierbares, ventrikuläres unterstützungssystem
EP2384138B1 (de) Vorrichtung zum ermitteln und/oder überwachen einer fisteldurchgängigkeit basierend auf einer amplitude des herzdrucksignals während einer blutbehandlung
DE60224315T2 (de) Vorrichtung und Verfahren zur Bestimmung von Schätzwerten des Herzschlagvolumens und des Herzzeitvolumens
EP1551290B1 (de) Impedanzbasiertes messverfahren für hämodynamische parameter
DE112012003687T5 (de) Medizinprodukt mit einem Funktionselement zum invasiven Einsatz im Körper eines Patienten
DE3732640C1 (de) Medizinisches Geraet zum Ermitteln von physiologischen Funktionsparametern
DE60124541T3 (de) Verfahren und vorrichtung zur darstellung von information die durch elektrische impedanz-tomografie erhalten ist
DE69713595T2 (de) Vorrichtung zur blutstrommessungsmittelsanalyse der biologischen impedanz
WO2019234153A1 (de) Implantierbares, vaskuläres unterstützungssystem
DE102012007081B4 (de) Verfahren sowie Mess- und Recheneinheit zur langfristigen Überwachung der arteriellen Gefäßsteifigkeit und Gefäßkalzifikation eines Patienten
DE102011106142A1 (de) Blutentnahmekanüle einer die Herzfunktion ersetzenden oder unterstützenden Pumpe
WO2019234161A1 (de) Verfahren zur bestimmung eines fluid-volumenstroms durch ein implantiertes, vaskuläres unterstützungssystem und vaskuläres unterstützungssystem
DE202011110389U1 (de) Medizinprodukt mit einem Funktionselement zum invasivenEinsatz im Körper eines Patienten
EP2415396B1 (de) Herzmonitor
DE102008008840A1 (de) Verfahren und Vorrichtung zur nicht-invasiven Messung von dynamischen Herz-Lungen Interaktionsparametern
WO2019001849A1 (de) Vorrichtung und verfahren zur verarbeitung und visualisierung von mittels eines elektro-impedanz-tomographie-gerätes (eit) gewonnenen daten hinsichtlich eines durchblutungszustandes von herz und lunge
EP3576805B1 (de) Anordnung mit einer blutpumpe, einer steuereinheit und einem gerät zur übermittlung der messwerte
EP3818996A1 (de) Pumpensystem, steuereinheit und verfahren zum betreiben eines pumpensystems
EP3090766B1 (de) Vorrichtung zur regulierung der vitalen parameter des herz-kreislaufsystems
DE60304202T2 (de) Überwachungsgerät für dekompensierte herzinsuffizienz
AT500676A1 (de) Verfahren und vorrichtung zur intermittierenden okklusion des koronarsinus
Rüschen et al. Continuous cardiac output estimation under left ventricular assistance
DE8713037U1 (de) Medizinisches Gerät zur Ermittlung von physiologischen Funktionsparametern
DE4434098A1 (de) Verfahren und Schaltungsanordnung zur Ermittlung der kardialen Leistungsfähigkeit
DE9422328U1 (de) Vorrichtung und Schaltungsanordnung zur Ermittlung der kardialen Leistungsfähigkeit

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 19729720

Country of ref document: EP

Kind code of ref document: A1

DPE1 Request for preliminary examination filed after expiration of 19th month from priority date (pct application filed from 20040101)
ENP Entry into the national phase

Ref document number: 2020567819

Country of ref document: JP

Kind code of ref document: A

NENP Non-entry into the national phase

Ref country code: DE

ENP Entry into the national phase

Ref document number: 2019729720

Country of ref document: EP

Effective date: 20210111

WWG Wipo information: grant in national office

Ref document number: 201980051744.7

Country of ref document: CN

WWG Wipo information: grant in national office

Ref document number: 15734342

Country of ref document: US