Classifications

• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B41—PRINTING; LINING MACHINES; TYPEWRITERS; STAMPS
  • B41J—TYPEWRITERS; SELECTIVE PRINTING MECHANISMS, i.e. MECHANISMS PRINTING OTHERWISE THAN FROM A FORME; CORRECTION OF TYPOGRAPHICAL ERRORS
  • B41J2/00—Typewriters or selective printing mechanisms characterised by the printing or marking process for which they are designed
  • B41J2/005—Typewriters or selective printing mechanisms characterised by the printing or marking process for which they are designed characterised by bringing liquid or particles selectively into contact with a printing material
  • B41J2/01—Ink jet
• • B—PERFORMING OPERATIONS; TRANSPORTING
  • B41—PRINTING; LINING MACHINES; TYPEWRITERS; STAMPS
  • B41M—PRINTING, DUPLICATING, MARKING, OR COPYING PROCESSES; COLOUR PRINTING
  • B41M5/00—Duplicating or marking methods; Sheet materials for use therein
• • C—CHEMISTRY; METALLURGY
  • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
  • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
  • C09D11/00—Inks
  • C09D11/30—Inkjet printing inks
  • C09D11/32—Inkjet printing inks characterised by colouring agents
  • C09D11/328—Inkjet printing inks characterised by colouring agents characterised by dyes
• • C—CHEMISTRY; METALLURGY
  • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
  • C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
  • C09D11/00—Inks
  • C09D11/30—Inkjet printing inks
  • C09D11/38—Inkjet printing inks characterised by non-macromolecular additives other than solvents, pigments or dyes

Definitions

• the present invention relates to a water-based ink composition for inkjet, a method for suppressing discoloration of a printed image of a solid preparation, and a solid preparation, and more specifically, suppresses discoloration and discoloration of a printed image formed on the surface of a solid preparation such as pharmaceuticals and foods.
• the present invention relates to a water-based ink composition for inkjet, a method for suppressing discoloration of a printed image of a solid preparation, and a solid preparation.
• Ink jet inks for tablets and capsules are roughly classified into pigment inks in which pigments are dispersed and dye inks using dyes.
• dye ink is easy to penetrate into tablets and the like, and has an advantage that the dye is fixed to the inside.
• the pigment ink since the pigment ink has a low penetrating ability, the pigment ink can penetrate into the inner part of the uncoated tablet whose surface is not coated.
• FC tablets film-coated tablets
• the dye ink is prepared by mixing red, yellow, and blue dyes.
• the printed image turns green (green) when left on for a certain period of time after printing on a sugar-coated tablet using black dye ink.
• a red azo dye is used as a constituent component of the black dye, there is a problem that due to photolysis of the azo dye, the saturation of the printed image decreases with time and the light fades.
• the present invention has been made in view of the above problems, and its purpose is to provide a water-based inkjet ink composition capable of suppressing discoloration and discoloration of a printed image on the surface of a solid preparation such as pharmaceuticals and foods, and a solid preparation. It is providing the discoloration suppression method and solid formulation of a printed image.
• the inventor of the present application has found that one of the causes of fading and discoloration in images printed on the surface of a solid preparation is due to humidity. That is, it was confirmed that a certain dye has higher penetrability to a solid preparation than other dyes under a certain humidity even after printing. Therefore, for example, when printing on the surface of a solid preparation in a single color using only that specific dye, the color penetrates into the solid preparation as time passes, resulting in a decrease in the saturation of the printed image and generation of a fading. In addition, when printing on the surface of a solid preparation with a dye ink mixed with another dye, the specific dye is more permeable to the solid preparation than the other dye, so the two are separated and only the other dye is solid. It remains on the surface of the preparation. As a result, the print image is represented only by other dyes, and a discoloration of the print image occurs.
• An aqueous inkjet ink composition according to the present invention is an aqueous inkjet ink composition used for printing on a solid preparation in order to solve the above-described problem, and includes an edible dye and a fading inhibitor.
• the dye is at least one selected from the group consisting of Red No. 2, Red No. 4, Red No. 40, Red No. 102, Yellow No. 4, Yellow No. 5, Green No. 3, Blue No. 1 and copper chlorophyllin sodium.
• the discoloration inhibitor is at least one selected from the group consisting of monosaccharides, disaccharides, dextrins and sugar alcohols, and The content of the discoloration inhibitor is 50% by mass or less based on the total mass of the water-based ink composition.
• the specific dye such as Red No. 2 has a property of penetrating into the solid preparation over time due to humidity.
• monosaccharides, disaccharides, dextrins and sugar alcohols exhibit a function of suppressing penetration of the specific dyes into the solid preparation caused by humidity in the printed image. Therefore, in an image printed using only a specific dye, it is possible to suppress a decrease in saturation due to penetration of the specific dye into the solid preparation and reduce the occurrence of fading.
• the printed image is discolored as a result of preventing the specific dye from separating into the other dye and penetrating into the solid preparation. Can be reduced.
• azo dyes such as Red No. 2, Red No. 40, and Red No. 102 contained in the specific dye have the property of decomposing (photodecomposing) by light irradiation, so that the printed image is light. May fade.
• the fading inhibitor also exhibits a function of suppressing photodegradation with respect to such a specific dye. Therefore, in the water-based ink composition having the above-described configuration, it is possible to reduce the deterioration of the printed image due to the occurrence of light fading.
• the said fading inhibitor can fully melt
• the monosaccharide is preferably at least one of galactose and fructose.
• the disaccharide is preferably at least one of maltose and trehalose.
• the dextrins are preferably cyclodextrins.
• the sugar alcohol is preferably at least one selected from the group consisting of reduced isomaltulose, xylitol, and sorbitol.
• the method for suppressing discoloration of a printed image of a solid preparation includes a edible dye, a discoloration inhibitor, and a discoloration suppressing method for a printed image printed on a solid preparation.
• an ink-jet aqueous ink is prepared that includes a water-based ink composition containing a fading inhibitor such as a monosaccharide (preparation step), and further, the surface of the solid preparation by the ink-jet method using the water-based ink Printing is performed (printing process). Furthermore, the discoloration inhibitor in the printed image suppresses penetration into the solid preparation caused by the humidity of the specific dye (fading suppression step). Thereby, when the dye in a water-based ink composition is only a specific dye, generation
• the specific dye when included as the dye in the aqueous ink composition, the specific dye is prevented from separating from the other dye and penetrating into the solid preparation, and the printed image is discolored. Can be reduced. That is, with the above-described method, discoloration and discoloration of a printed image printed on a solid preparation by an inkjet method can be suppressed, and deterioration of the visibility of the printed image with a change with time can be reduced. As a result, for example, even when product information is printed, dispensing errors, accidental ingestion, and the like can be prevented.
• the discoloration suppressing step is based on the printed image in the solid preparation immediately after the printing step, and the printed image in the solid preparation after being stored for 24 hours in an atmosphere at a temperature of 25 ° C. and a relative humidity of 60%.
• the ⁇ a * of the L * a * b * color system conforming to JIS Z 8730 is set to ⁇ 18 or more.
• the fading inhibiting agent in the printed image may further include a photofading inhibiting step for inhibiting the photodecomposition of the specific dye.
• the light fading suppression step is based on the printed image in the solid preparation immediately after the printing step, and the JIS of the printed image in the solid preparation after irradiation with visible light having an integrated light amount of 1.2 million lux.
• the color difference ⁇ E * (ab) of the L * a * b * color system conforming to Z 8781 is set to 17 or less.
• the monosaccharide is preferably at least one of galactose and fructose.
• the disaccharide is preferably at least one of maltose and trehalose.
• the dextrins are preferably cyclodextrins.
• the sugar alcohol is preferably at least one selected from the group consisting of reduced isomaltulose, xylitol, and sorbitol.
• the solid preparation according to the present invention is a solid preparation having a dry film of an aqueous inkjet ink on the surface, and the aqueous inkjet ink comprises the aqueous ink composition described above. It is what is included.
• the discoloration inhibitor is contained in the dry film of the ink-jet ink, and the discoloration inhibitor suppresses penetration of the specific dye due to humidity into the solid preparation as described above. be able to. Therefore, when the dye in the water-based ink composition is only a specific dye, it is possible to reduce the occurrence of fading of the printed image formed by the dry film. In addition, when the dye in the water-based ink composition contains other dyes in addition to the specific dye, the specific dye is separated from the other dyes and prevented from penetrating into the solid preparation, and the printed image is discolored. Can be reduced.
• the fading inhibitor also suppresses the photodegradation of the specific dye by light irradiation, it is possible to reduce the occurrence of light fading in the printed image formed by the dry film. That is, when the solid preparation has the above-described configuration, it is possible to reduce discoloration (including light discoloration) and discoloration of the printed image formed by the dry film, and to suppress deterioration of the visibility of the printed image with time. be able to. As a result, it is possible to provide a solid preparation capable of preventing dispensing errors and accidental ingestion.
• the discoloration inhibitor composed of monosaccharides, disaccharides, dextrins and sugar alcohols can suppress the penetration into the solid preparation caused by the humidity by the specific dye such as Red No. 2. Therefore, it is possible to reduce discoloration or discoloration of the image printed on the solid preparation surface over time due to humidity. Further, it is possible to reduce the occurrence of light fading of the printed image due to light irradiation.
• an ink jet capable of suppressing discoloration (including light discoloration) and discoloration of a printed image in a solid preparation such as a pharmaceutical or food, and improving the moisture resistance and light resistance of the printed image.
• Water-based ink composition, method for suppressing discoloration of printed image of solid preparation, and solid preparation can be provided.
• water-based ink composition for inkjet The ink-jet aqueous ink composition (hereinafter referred to as “water-based ink composition”) according to the present embodiment will be described below.
• the water-based ink composition of the present embodiment is a water-based ink containing at least an edible dye and a fading inhibitor and having a main solvent of water.
• the water-based ink composition of the present embodiment may be made edible by using a material that complies with the standards of pharmaceutical additives, Japanese Pharmacopoeia, or Food Additives Standards specified by the Pharmaceutical Affairs Law. And can be suitably used for inkjet recording.
• Inkjet recording means a system in which an aqueous ink composition is ejected as droplets from a fine inkjet head, the droplets are fixed on a recording medium, and an image is formed.
• the “edible property” of the dye means a substance that is approved for oral administration as a pharmaceutical or a pharmaceutical additive and / or a food or a food additive.
• the dye is at least one specific selected from the group consisting of Red No. 2, Red No. 4, Red No. 40, Red No. 102, Yellow No. 4, Yellow No. 5, Green No. 3, Blue No. 1 and copper chlorophyllin sodium. Contains dye. Moreover, the said dye may contain another dye as needed other than a specific dye. Other dyes are not particularly limited as long as they have edible properties. Specific examples include xanthene dyes such as Red No. 3, Red No. 104, Red No. 105, and Red No. 106, and indigoid dyes such as Blue No. 2. In addition, edible natural pigments such as cochineal pigments, cacao pigments, and caramel pigments can also be used as other dyes.
• the content of the dye is preferably in the range of 0.5% by mass to 12% by mass with respect to the total mass of the aqueous ink composition. More preferably, it is within the range of 5% to 5% by mass.
• the content of the specific dye is 0.5% by mass or more, it is possible to prevent the density of the printed image from becoming insufficient with many dyes.
• the content of the specific dye is 12% by mass or less, it is possible to prevent the dye component from being deposited in the nozzle of the inkjet head.
• the content of the other dye can be appropriately set according to the type thereof.
• the discoloration inhibitor has a function of inhibiting the specific dye contained in the printed image from penetrating into the solid preparation with time change due to humidity. Therefore, when other dye is contained in the dye, the specific dye can be prevented from being separated from the other dye. Thereby, generation
• the fading inhibitor also has a function of suppressing the specific dye from photodegradation by light irradiation such as natural light.
• the specific dyes for example, azo dyes such as Red No. 2, Red No. 40 and Red No. 102 may be photodegraded by light irradiation, resulting in photo-fading of the printed image.
• the color fading inhibitor also suppresses the photodecomposition of such a specific dye, so that the occurrence of photofading in the printed image can be reduced.
• “amber” means that the saturation of the printed image is irreversibly lowered as a result of the penetration of the specific dye into the solid preparation due to humidity.
• “discoloration” means that the specific dye penetrates into the solid preparation due to humidity and the specific dye and other dyes are separated. As a result, the hue of the other dye is superior to that of the specific dye, and the entire printed image This means that the hue as irreversibly changes.
• Light fading means that the dye contained in the printed image is photodegraded due to the influence of natural light or the like, and thereby the color tone of the printed image is irreversibly changed or the printed image is deteriorated.
• the discoloration inhibitor is at least one selected from the group consisting of monosaccharides, disaccharides, dextrins and sugar alcohols.
• the monosaccharide is not particularly limited, and examples thereof include glucose, galactose, mannose, and fructose. Of these, galactose and fructose are preferred in the present invention.
• the disaccharide is not particularly limited, and examples thereof include sucrose (sucrose, sugar), lactose (lactose), maltose, trehalose, palatinose (isomaltulose), and the like. Of these, maltose and trehalose are preferred in the present invention.
• the dextrins are not particularly limited, and examples thereof include cyclodextrins.
• the cyclodextrin is not particularly limited, and examples thereof include ⁇ -cyclodextrin, ⁇ -cyclodextrin, ⁇ -cyclodextrin, and ⁇ -cyclodextrin.
• the sugar alcohols are not particularly limited, and examples thereof include mannitol, erythritol, reduced isomaltulose, xylitol, sorbitol and the like.
• the reduced isomaltulose is a compound obtained by reducing isomaltulose by hydrogenation or the like. Reduced isomaltulose includes ⁇ -D-glucopyranosyl-1,1-mannitol (hereinafter referred to as “GPM”) and ⁇ -D-glucopyranosyl-1,6-sorbitol (hereinafter referred to as “GPS-6”). And a mixture.
• the mixing ratio of GPM and GPS-6 is not particularly limited, but they are usually mixed in approximately equimolar amounts.
• reduced isomaltulose, xylitol and sorbitol are preferred in the present invention.
• Each of the above-mentioned fading inhibitors exemplified above can be used alone or in combination of two or more.
• the content of the fading inhibitor is 50% by mass or less, preferably 1% by mass to 15% by mass, more preferably 5% by mass to 10% by mass with respect to the total mass of the aqueous ink composition.
• their content is preferably 20% by mass or less, preferably 1% by mass to 15% by mass with respect to the total mass of the aqueous ink composition. More preferably, the content is 3% by mass to 8% by mass.
• the water-based ink composition of the present embodiment contains water (water as a main solvent).
• water water as a main solvent.
• water it is preferable to use water from which ionic impurities such as ion-exchanged water, ultrafiltered water, reverse osmosis water, distilled water, or ultrapure water have been removed.
• ionic impurities such as ion-exchanged water, ultrafiltered water, reverse osmosis water, distilled water, or ultrapure water have been removed.
• water sterilized by ultraviolet irradiation or addition of hydrogen peroxide is preferable because generation of mold and bacteria can be prevented over a long period of time.
• it does not specifically limit as content of water, It can set suitably as needed.
• additives are blended as long as they meet the standards of pharmaceutical additives, Japanese pharmacopoeia or official food additives specified by the Pharmaceutical Affairs Law. Also good.
• the additive include a surface tension adjusting agent, a wetting agent, a water-soluble resin, an organic amine, a surfactant, a pH adjusting agent, a chelating agent, an antiseptic, a viscosity adjusting agent, and an antifoaming agent.
• the content of these additives is not particularly limited, and can be set as appropriate (the contents of the surface tension adjusting agent and the wetting agent will be described later). .
• the surface tension adjusting agent is not particularly limited as long as it conforms to standards such as the Pharmaceutical Affairs Law, and specific examples include glycerin fatty acid esters.
• glycerin fatty acid ester include caprylic acid decaglyceryl, lauric acid hexaglycerin ester, oleic acid hexaglycerin ester, condensed linolenic acid tetraglycerin ester, fatty acid ester palm palm, lauric acid decaglyceryl having an HLB of 15 or less, and HLB.
• Examples include decaglyceryl oleate of less than 13. You may use these individually by 1 type or in mixture of 2 or more types.
• caprylic acid decaglyceryl As the caprylic acid decaglyceryl, it is possible to use a commercially available product.
• a commercially available product examples include Ryoto (registered trademark) polyglycerate CE19D (trade name, manufactured by Mitsubishi Chemical Foods Co., Ltd., HLB). Value 15), SY glister MCA750 (trade name, manufactured by Sakamoto Pharmaceutical Co., Ltd., HLB value 16), and the like.
• the HLB value is an HLB value according to the Griffin method and means a value obtained by the following equation.
• HLB value 20 ⁇ (sum of formula weight of hydrophilic group / molecular weight)
• the HLB value is a value in the range of 0 to 20. The larger the HLB value, the stronger the hydrophilicity, and the smaller the HLB value, the stronger the hydrophobicity.
• the decaglyceryl laurate those having an HLB of 15 or less can be used.
• the decaglyceryl laurate has an HLB of more than 15, the ejection stability is lowered, for example, the occurrence of fading due to clogging of the nozzles of the inkjet head.
• the lower limit of HLB is preferably 10 or more from the viewpoint of solubility in an aqueous solvent.
• a commercially available product can be used as decaglyceryl laurate having an HLB of 15 or less.
• NIKKOL registered trademark
• DECAGLYN 1-L trade name, Nikko Chemicals ( HLB value 14.5)
• SY Glister ML-750 trade name, manufactured by Sakamoto Pharmaceutical Co., Ltd., HLB value 14.8, and the like.
• the decaglyceryl oleate those having an HLB of less than 13 can be used.
• the HLB is 13 or more, the ejection stability is deteriorated, such as blurring due to clogging of the nozzles of the inkjet head.
• the minimum of HLB is 10 or more from a viewpoint of the solubility with respect to a water solvent.
• a commercially available product can be used as decaglyceryl oleate having an HLB of less than 13 as decaglyceryl oleate having an HLB of less than 13, a commercially available product can be used.
• Examples of such a commercially available product include NIKKOL (registered trademark) DECAGLYN 1-OV (trade name, Nikko Chemicals ( Co., Ltd., HLB value 12), SY Glister MO-7S (trade name, manufactured by Sakamoto Pharmaceutical Co., Ltd., HLB value 12.9), and the like.
• lauric acid hexaglycerin ester a commercially available product can be used, and as such a commercially available product, for example, NIKKOL (registered trademark) HEXAGLYN 1-L (trade name, manufactured by Nikko Chemicals Co., Ltd., HLB) Value 14.5), SY Glister ML-500 (trade name, manufactured by Sakamoto Pharmaceutical Co., Ltd., HLB value 13.5), and the like.
• NIKKOL registered trademark
• HEXAGLYN 1-L trade name, manufactured by Nikko Chemicals Co., Ltd., HLB Value 14.5
• SY Glister ML-500 trade name, manufactured by Sakamoto Pharmaceutical Co., Ltd., HLB value 13.5
• oleic acid hexaglycerin ester examples include SY Glyster MO-5S (trade name, manufactured by Sakamoto Pharmaceutical Co., Ltd., HLB value 11. 6) and the like.
• fatty acid ester palm palm a commercially available product can be used, and examples of such a commercially available product include Tirabazole W-01 (trade name, manufactured by Taiyo Kagaku Co., Ltd.).
• the content of the surface tension adjusting agent is preferably in the range of 0.1% by mass to 10% by mass, and preferably in the range of 0.5% by mass to 5% by mass with respect to the total mass of the aqueous ink composition. More preferably.
• the content of the surface tension adjusting agent is 0.1% by mass or more, when printing is performed by an inkjet method, ejection failure due to meniscus formation failure or the like at the nozzle in the inkjet head is prevented, and the nozzle is clogged. Can be prevented. As a result, the discharge stability can be improved.
• the content of the surface tension adjusting agent is 10% by mass or less, it is possible to prevent an adverse effect on discharge due to insoluble matter or poor emulsification of the surface tension adjusting agent.
• the wetting agent is not particularly limited as long as it conforms to standards such as the Pharmaceutical Affairs Law, and specific examples include propylene glycol and glycerin.
• the amount of the wetting agent added is preferably 3% by mass to 50% by mass and more preferably 10% by mass to 40% by mass with respect to the total mass of the aqueous ink composition.
• the method for suppressing discoloration of a printed image of a solid preparation of the present embodiment includes a preparation step of preparing an aqueous inkjet ink (hereinafter sometimes referred to as “aqueous ink”) containing the above-described aqueous ink composition, and an aqueous ink. And at least a discoloration suppressing step for suppressing discoloration of a printed image.
• aqueous ink aqueous inkjet ink
• the water-based ink preparation step may include a water-based ink composition manufacturing step.
• the production process of the water-based ink composition can be performed by mixing the above-described components by an appropriate method. That is, a dye, a fading inhibitor, water and, if necessary, an additive are mixed and sufficiently stirred. Furthermore, if necessary, filtration is performed to remove coarse particles and foreign matters that cause clogging. Thereby, the water-based ink composition which concerns on this Embodiment can be obtained.
• each material is not particularly limited, and for example, the materials can be sequentially added to a container equipped with a stirring device such as a mechanical stirrer or a magnetic stirrer to perform stirring and mixing. Moreover, it does not specifically limit as a filtration method, For example, centrifugal filtration, filter filtration, etc. are employable.
• the printing step is a step of printing an image on the surface of a solid preparation by an ink jet method. More specifically, aqueous ink is ejected as ink droplets onto a solid preparation from a fine nozzle, and the ink droplets are adhered to the surface of the solid preparation.
• the discharge method is not particularly limited, and for example, a known method such as a continuous injection type (charge control type, spray type, etc.), an on-demand type (piezo type, thermal type, electrostatic suction type, etc.) can be employed. .
• Printing conditions such as ink droplet ejection amount and printing speed are not particularly limited, and can be set as necessary.
• the printing process includes a drying process for drying ink droplets attached to the surface of the solid preparation. It does not specifically limit as a drying method, In addition to hot air drying, natural drying etc. can be performed. Also, drying conditions such as drying time and drying temperature are not particularly limited, and can be appropriately set according to the ejection amount of ink droplets, the type of the water-based ink composition, and the like.
• the discoloration suppressing step is a step in which the discoloration inhibitor contained in the printed image suppresses the penetration of the specific dye due to humidity into the solid preparation.
• the discoloration suppressing step is based on the printed image immediately after printing, based on the L * a * b * ⁇ a * 1 in the color system is suppressed to ⁇ 18 or more, preferably ⁇ 10 to +10, more preferably ⁇ 5 to +5.
• the print image immediately after printing means a print image after drying.
• the ⁇ a * 1 is based on JIS Z 8730 and is represented by the following general formula (1).
• ⁇ a * 1 a * 1 ⁇ a * 0 (1)
• the a * 0 represents a value in the L * a * b * color system of the printed image in the solid preparation immediately after the printing step
• the a * 1 is an atmosphere at a temperature of 25 ° C. and a relative humidity of 60%.
• the L * a * b * color system is a color space recommended by the International Commission on Illumination (CIE) in 1976, and is a color space called the CIE 1976 (L * a * b * ) color system.
• CIE International Commission on Illumination
• Japanese Industrial Standard it is defined in JIS Z 8730.
• a light fading suppressing step for suppressing the photodecomposition of the specific dye may be further included.
• the fading inhibitor has a function of suppressing the photodegradation of a specific dye such as an azo dye, so that the photofading of the printed image can be reduced.
• the light fading suppression step is performed using L * a * based on the printed image immediately after printing .
• ⁇ E * (ab) in the b * color system can be suppressed to 17 or less, preferably 0 to 10, more preferably 0 to 5.
• the print image immediately after printing means a print image after drying, as described above.
• ⁇ E * (ab) is based on JIS Z8781, and is represented by the following general formula (2).
• ⁇ E * (ab) (( ⁇ L * 2 ) 2 + ( ⁇ a * 2 ) 2 + ( ⁇ b * 2 ) 2 ) 1/2 (2)
• ⁇ L * 2 , ⁇ a * 2, and ⁇ b * 2 are respectively expressed as follows.
• ⁇ L * 2 L * 2- L * 0 (L * 0 represents the lightness of the L * a * b * color system immediately after the printing step in the printed image of the solid preparation, and L * 2 represents visible light with an integrated light amount of 1.2 million lux in the printed image of the solid preparation.
• solid preparation means food preparations and pharmaceutical preparations.
• solid preparation forms include OD tablets (orally disintegrating tablets), plain tablets, FC (film coat) tablets, and sugar-coated tablets. And tablets or capsules.
• the solid preparation may be used for pharmaceuticals or food.
• tablets for food use include health foods such as tablet confectionery and supplements.
• a print image composed of a dry film directly formed by an ink jet recording method using an aqueous ink containing the aqueous ink composition is formed.
• a dry film is comprised at least by the dye contained in the water-based ink composition, and the fading inhibitor.
• the anti-fading agent suppresses penetration of a specific dye into a solid preparation due to ambient humidity. This effect is particularly effective when the solid preparation is a sugar-coated tablet or an FC tablet.
• the sugar-coated tablet in which the discoloration inhibitor of the present invention is particularly easy to achieve the effect include those in which the sugar-coated layer is composed of sucrose (sucrose) or maltitol. The content of sucrose or maltitol in the sugar coating layer is not particularly limited, and can be set as necessary.
• examples of the FC tablet in which the discoloration inhibitor of the present invention is particularly easy to achieve the effect include those in which the film coat is made of a cellulose-based polymer compound such as hydroxypropylmethylcellulose.
• the solid preparation of the present invention it is possible to reduce the discoloration or discoloration of a printed image made of a dry film, or the light discoloration due to light irradiation such as natural light. Therefore, it is possible to prevent the deterioration of various information printed in order to improve identification for users, such as product information, and this ensures good visibility over a long period of time. Allows prevention.
• each material of the water-based ink composition for inkjet conforms to the standards of pharmaceutical additives, Japanese pharmacopoeia or official food additives specified by the Pharmaceutical Affairs Law.
• the water-based ink composition D for inkjet was prepared in the same manner as the water-based ink composition A except that no fading inhibitor was added and the blending ratio shown in Table 2 below was used.
• the water-based ink composition E for inkjet was prepared in the same manner as the water-based ink composition B except that no fading inhibitor was added and the blending ratio shown in Table 2 below was used.
• the water-based ink composition F for inkjet was prepared in the same manner as the water-based ink composition C, except that no fading inhibitor was added and the blending ratio shown in Table 2 below was used.
• Examples 1 to 24 The water-based ink compositions used in Examples 1 to 24 were as shown in Tables 3 to 5 below. In addition, as the fading inhibitor, those shown in Tables 3 to 5 below were used. As the reduced isomaltulose used in Examples 16 to 18, Palatinit (registered trademark, manufactured by Mitsui Sugar Co., Ltd.) was used.
• Comparative Examples 1 to 3 The aqueous ink compositions used in Comparative Examples 1 to 3 were as shown in Table 5 above.
• each sample was stored in a high-temperature and high-humidity tank set at a temperature of 25 ° C. and a relative humidity of 60% for 24 hours. Thereafter, the color difference meter was used again to measure L * 1 , a * 1 , and b * 1 in the L * a * b * color system of each sample (in Tables 6 to 14, storage time 24 L * , a * , b * values in time). The results are shown in Tables 6 to 14 below.
• the fading suppression property of the water-based ink composition of each example was evaluated by performing the following tests. That is, about the sugar-coated tablet (sample) after the inkjet printing by the water-based ink composition which concerns on each Example and a comparative example, respectively using a color difference meter (model number: VSS7700, Nippon Denshoku Industries Co., Ltd. make) L * a * L * 0 , a * 0 , and b * 0 in the b * color system were measured respectively (in Tables 15 to 23, the values of L * , a * , and b * at an integrated light amount of 0 lux).
• ⁇ E * (ab) 2 , ⁇ L * 2 , ⁇ a * 2 , ⁇ b * 2 , ⁇ C * (ab) 2 and ⁇ H * (ab) 2 shown in each table were calculated by the following general formulas.

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